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John Cleveland, Ph.D.

Chairman
Professor
Department of Cancer Biology
Florida Campus
Laboratory Website
jcleve@scripps.edu
(561) 228-3220

Scripps Research Joint Appointments

Faculty, Graduate Program

Research Focus

Cancer genetics, apoptosis, cancer prevention and therapeutics.

Education

Ph.D., Wayne State University

Selected References

Nilsson JA, Keller UB, Baudino TA, Yang C, Norton S, Brennan JA, Neale G, Porter CW, Kramer DL, Cleveland JL. Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation. Cancer Cell. 7:433-444, 2005.

Carew JS, Nawrocki ST, Kahue CN, Zhang H, Yang C, Chung L, Houghton JA, Huang P, Giles FJ, Cleveland JL. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood 110:313-322, 2007. PMCID: 1896119.

Keller U, Old JB, Nilsson JA, Nilsson L, Maclean KH, Yang C, Spruck C, Nakayama KI, Reed SI, Cleveland JL. Myc Targets Cks1 to Provoke the Suppression of p27Kip1, Proliferation and Lymphomagenesis. EMBO J. 26:2562-74, 2007. Commentary: Nature Rev. Cancer 7:7, 2007. PMCID: 1868903.

Maclean KH*, Dorsey FC*, Cleveland JL**, Kastan MB**. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J. Clin. Investigation 118:79-88, 2008. PMCID: 2148253. (** co-senior author)

Rounbehler RJ, Li W, Hall MA, Yang C, Fallahi M, Cleveland JL. Targeting Ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma. Cancer Res. 69:547-553, 2009. PMCID: 2749594.