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Florida Faculty and Professional Staff
Laura Bohn
Associate Professor
Department of Molecular Therapeutics
TSRI - 2009
Education
1993 - BS, Biochemistry, Virginia Tech, Blacksburg, VA
1993 - BA, Chemistry, Virginia Tech, Blacksburg, VA
1999 - PhD, Biochemistry & Molecular Biology, St. Louis University School of Medicine (Mentor: Carmine Coscia, PhD)
1999-2003 Post-Doctoral Fellow/Assist. Research Prof., Duke University Medical Center with Marc Caron, PhD, Howard Hughes Medical Institute Investigator
Awards & Activities
2005 - Committee on Women in Neuroscience Career Development Award, sponsored by the Society for Neuroscience and Merck.
2006 - School of Biomedical Sciences Award for Excellence in Research, The Ohio State University
2007 - Featured as one of “30 in Their 30s”, Bio Ohio, The Voice of Bioscience in Ohio
2009 - The Joseph Cochin Young Investigator Award from the College on Problems of Drug Dependence
Research Focus
We seek to understand how opiate analgesics like morphine, act at receptors to generate beneficial effects such as pain relief, while at the same time produce undesired side effects such as addiction, constipation and respiratory failure. We are also very interested in how serotonin differs from hallucinogenic drug actions at its receptors and how this might impact on normal brain function.
Selected References
Groer CE, Tidgewell K, Moyer RA, Harding WW, Rothman RB, Prisinzano TE, Bohn LM. An opioid agonist that does not induce µ-opioid receptor--arrestin interactions or receptor internalization. Mol Pharmacol. 2007;71(2):549-57.
Schmid CL, Raehal KM, Bohn LM. Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo. Proc Natl Acad Sci U S A. 2008;105(3):1079-84. PMCID: 2242710.
Schmid CL, Bohn LM. Physiological and pharmacological implications of beta-arrestin regulation. Pharmacol Ther. 2009;121(3):285-93. PMCID: 2656564.
Raehal, KM, Schmid, CL, Medvedev, IO, Gainetdinov, RR, Premont, RT, and Bohn, LM. Morphine-Induced Physiological and Behavioral Responses in Mice Lacking G Protein-Coupled Receptor Kinase 6. Drug Alcohol Depend. (2009-In press).
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