Scripps Florida

















 

Florida Faculty and Professional Staff

Louis Scampavia

Senior Scientist II
Translational Research Institute
TSRI - 2005

Joint Appointments 

Associate Professor, Molecular Therapeutics

Education 

B.S., Genetics, University of California, Berkeley 1979
B.S., Chemistry, University of Washington, 1991
Ph.D., Chemistry, University of Washington, 1996
2005 Instructor: Chemistry 132 (Spring); Seattle University,
  Seattle WA
2003-1998 Lecturer; Chemistry 520-Current Problems in Analytical Chemistry; Chemistry 321-Quantitative Analysis; General Chemistry 120-Principles of Chemistry, University of Washington, Seattle, WA
1997: Instructor, General Chemistry 161 and Laboratory,
   University of Washington, Seattle, WA
2005-2003: Principal Investigator at FIAsolutions Inc.
2005- 1996: Analytical Research Scientist, University of
  Washington: Department of Chemistry
2005-1997: Instructor and Lecturer, University of
  Washington, Seattle University
1991-1996: Research Associate, University of Washington-
   Department of Chemistry

Research Focus 

Progress in drug discovery is often coupled to parallel advancements in instrument technology. In our department, High Throughput Screening (HTS) robotics is employed to accelerate the drug discovery process thorough full automation of large scale screening experiments. HTS technology can be used to execute and analyze hundreds of thousand of experiments against large compound libraries to identify a few select compounds of therapeutic value. These "therapeutic leads" provide important insight and basis for the medicinal development of novel drugs for clinical application.

Research efforts are currently focused on:

  • Working with collaborators to develop biological assays for HTS compatibility.
  • Performing exploratory HTS campaigns for drug lead discovery.
  • Research and development of novel instruments and technologies for the advancement of HTS robotics.
Collaborative efforts are coordinated with a large community of scientists and include TSRI faculty, Florida researchers, and scientists funded through the National Institutes of Health sponsored Molecular Library Screening Center Network program (http://nihroadmap.nih.gov/).

Selected References 

Mesiwala AH, Scampavia LD, Rabinovitch PS, Ruzicka J, Rostomily RC. On-line flow cytometry for real-time surgical guidance. Neurosurgery. 2004 Sep; 55(3):551-60; discussion 560-1.

Ogata Y, Scampavia L, Carter TL, Fan E, Turecek F. Automated affinity chromatography measurements of compound mixtures using a lab-on-valve apparatus coupled to electrospray ionization mass spectrometry. Anal Biochem. 2004 Aug 1; 331(1):161-8.

Carroll AD, Scampavia L, Luo D, Lernmark A, Ruzicka J. Bead injection ELISA for the determination of antibodies implicated in type 1 diabetes mellitus. Analyst. 2003 Sep; 128(9):1157-62.

Wu CH, Scampavia L, Ruzicka J. Related Articles, Links Micro sequential injection: automated insulin derivatization and separation using a lab-on-valve capillary electrophoresis system. Analyst. 2003 Sep; 128(9):1123-30.