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Florida Faculty and Professional Staff
Michael Cameron
Associate Scientific Director I
Translational Research Institute
TSRI - 2005
Joint Appointments Assistant Professor, Molecular Therapeutics
Education
B.S., Gonzaga University
Ph.D., Utah State University
Post Doctoral, University of Washington
Awards & Activities
Member, International Society for the Study of Xenobiotics
Research Focus
Drug Metabolism and Pharmacokinetics (DMPK)
My laboratory works to evaluate the metabolic fate and identify compound liabilities of new chemical compounds. My laboratory collaborates with the medicinal chemistry, biology and pharmacology groups within the translational research group at Scripps Florida and with the NIH's Molecular Library Screening Center Network. We evaluate such factors as chemical and metabolic stability, solubility, oral absorption, pharmacokinetics, tissue distribution, protein binding, and metabolite formation. Data is used to refine molecules to enhance desired properties and eliminate undesirable properties. We also attempt to identify compounds that have the potential for metabolic based toxicities and drug-drug interactions. The laboratory researches methods to better predict compound behavior and metabolic based toxicities.
Selected References
Feng Y, Cameron MD, Frackowiak B, Griffin E, Lin L, Ruiz C, Schröter T, and LoGrasso P, "Structure Activity Relationships and Drug Metabolism and Pharmacokinetic Properties for Indazole Piperazine and Indazole Piperidine Inhibitors of ROCK-II" Bioorganic & Medicinal Chemistry Letters 2007, Apr 15;17(8):2355-60.
Miller BH, Schultz LE, Gulati A, Cameron MD, Pletcher MT, "Genetic regulation of behavioral and neuronal responses to fluoxetine." Neuropsychopharmacology. 2007, in press. Epub preview available on pubmed ID: 17609676.
Cameron MD, Wright J, Black CB, Ye N, "In vitro Prediction and in vivo Verification of Enantioselective Human Tofisopam Metabolite Profiles" Drug Metabolism and Disposition. 2007, Oct;35(10): 1894-1902.
Cameron MD, Wen B, Roberts AG, Atkins WM, A. Campbell AP, Nelson SD, "Cooperative Binding of Acetaminophen and Caffeine within the CYP3A4 Active Site" Chemical Research in Toxicology. Chem Res Toxicol. 2007, Oct;20(10):1434-41.
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