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Florida Faculty and Professional Staff
Theodore Kamenecka
Associate Scientific Director II
Translational Research Institute
TSRI - 2004
Education
B.S., Chemistry, University of Rochester,1990
Ph.D., Chemistry, University of California, Irvine, 1996
NIH Postdoctoral Fellow, Memorial Sloan-Kettering Cancer Center, 1998
Research Focus
Medicinal Chemistry and Drug Discovery
The research interest in my group is in the design, synthesis and evaluation of novel compounds of biological and therapeutic interest. Currently, we are involved in the design and synthesis of novel protein kinase inhibitors for the therapeutic treatment of human diseases such as stroke, Parkinson’s disease, and other neurodegenerative disorders. Protein kinases are critical elements of cellular signal transduction cascades and have become one of the most important target classes for drug development. Working closely with other departments such as biochemistry, molecular biology, pharmacology, and drug metabolism, we optimize lead compounds for potency, ADME (absorption, distribution, metabolism, and excretion), safety pharmacology, and toxicology in order to generate compounds suitable for preclinical development.
Selected References
Kamenecka, Theodore M., Park, You-Jung, Lin, Linus S., Lanza, Jr., Thomas, Hagmann, William K. Enantioselective Approach to 3-Substituted Prolines. Tetrahedron Lett. 2001, 42(49), 8571-8573.
Gutteridge, Clare E.; de Laszlo, Stephen E.; Kamenecka, Theodore M.; McCauley, Ermengilda; van Riper, Gail; Mumford, Richard A.; Kidambi, Usha; Egger, Linda A.; Tong, Sharon; Hagmann, William K. N-(3-Phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists. Bioorg. Med. Chem. Letters, 2003, 13(5), 885-890.
Bonnefous, Celine.; Vernier, Jean-Michel; Hutchinson, John. H.; Chung, Janice.; Reyes-Manalo, Grace.; Kamenecka, Theodore M. Dipyridyl Amides: Potent Metabotropic Glutamate Subtype 5 (mGlu5) Receptor Antagonists. Bioorg. Med. Chem. Letters, 2005, 15(4), 1197-1200.
Bonnefous, Celine; Vernier, Jean-Michel; Hutchinson, John H.; Gardner, Michael F.; Cramer, Merryl; James, Joyce K.; Rowe, Blake A.; Daggett, Lorrie P.; Schaffhauser, Herve; Kamenecka, Theodore M. Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor. Bioorg. Med. Chem. Letters, 2005, 15(19), 4354-4358.
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