Bohn, Laura
research is aimed at understanding how the molecular regulation of G protein coupled receptors (GPCR) can translate to overall therapeutic responsiveness in patients.
Bois, Philippe
works to determine the mechanisms that define and control recombinogenic regions in complex mammalian genomes.
Burris, Thomas
research focuses on chemical biology of nuclear receptors, protein molecules that mediate hormone activity inside the cell that are potential drug targets for a number of diseases including prostate, breast and colon cancers, as well as type 2 diabetes, atherosclerosis, metabolic syndrome and autoimmunity.
Conkright, Michael
studies the molecular events that govern the conversion of the cyclic AMP signaling cascade into transcriptional activation of target gene using cell-based high-throughput technologies.
Hodder, Peter
runs Scripps Research's high-throughput screening (HTS) laboratory. He is focused on implementing & executing HTS assays for pharmaceutical drug discovery as well as managing Scripps Research's HTS compound collection. He also has interest in developing novel HTS-related automation, detection and assay technologies.
Izard, Tina
studies the structural dynamics of signaling mediators of adhesion junctions.
Kishi, Shuji
aims to develop a high-throughput processing system for gene identification and phenotype characterization particularly associated with age-related disorders in humans, using zebarfish as an amenable vertebrate model system.
Paegel, Brian
studies the controlled synthesis and engineering of phospholipid vesicles and emulsions, microfluidic circuit design, and directed evolution of membrane-associated transporters, pores, and receptors.
Petrie, Howard
focuses on the production of specialized blood cells called T lymphocytes, which are central mediators of the immune response. Understanding this is central in developing treatments for immunodeficiencies resulting from environmental exposure (such as HIV/AIDS) or aging.
Roush, William
focuses on the total synthesis of structurally complex and biologically interesting natural products, development of new synthetic methods and strategies, and on problems in medicinal and bioorganic chemistry.
Scampavia, Louis
works at the high-throughput screening (HTS) robotics facility exploring novel instrumentation and technologies that advance HTS for drug discovery. His work also encompasses the development and transfer of novel biomedical assays for use in HTS campaigns.
Schroeter, Thomas
focuses on the development and characterization of small molecule kinase inhibitors and predictive toxicology screens to develop potent and safe drug candidates
Strosberg, Donny
by studying protein-protein interactions in HCV, identifies and characterizes peptides and small molecules that affect host-pathogen relations, e.g. inhibit HCV release from cultured hepatoma cells.
