Scripps Florida Faculty and
Professional Staff
Ayad, Nagi G.
studies the cell biological basis of cell cycle exit and differentiation of neuronal precursors as it relates to cancer and nerve regeneration.
Bannister, Thomas
uses all modern synthesis techniques to help our interdisciplinary Drug Discovery team rapidly design potential drug candidates for treating multiple sclerosis, diabetes, and addiction.
Bohn, Laura
research is aimed at understanding how the molecular regulation of G protein coupled receptors (GPCR) can translate to overall therapeutic responsiveness in patients.
Bois, Philippe
works to determine the mechanisms that define and control recombinogenic regions in complex mammalian genomes.
Burris, Thomas
research focuses on chemical biology of nuclear receptors, protein molecules that mediate hormone activity inside the cell that are potential drug targets for a number of diseases including prostate, breast and colon cancers, as well as type 2 diabetes, atherosclerosis, metabolic syndrome and autoimmunity.
Busby, Jennifer Ann
is responsible for advancing the use of mass spectrometry and high performance liquid chromatography in the study and analysis of proteins.
Butler, Andrew
focuses on two areas of the neuroendocrine basis of metabolic diseases that are associated with obesity - how signals of energy status regulate circadian rhythms and the function of novel circulating factors that regulate the metabolic adaptation to changes in energy status.
Cameron, Michael
investigates the metabolism of small molecules in vitro and in vivo to evaluate pharmacokinetic and pharmacodynamic properties and potential toxicity.
Cleveland, John L.
studies the molecular basis of cancer with a focus on malignancies having myc involvement, which is activated in 70% of all human cancers. Target discovery validation using mouse models, and cancer prevention and therapeutics are the major focuses of the laboratory.
Conkright, Michael
studies the molecular events that govern the conversion of the cyclic AMP signaling cascade into transcriptional activation of target gene using cell-based high-throughput technologies.
Duckett, Derek
investigates the mechanism of action of small molecule kinase inhibitors with the aim of developing a drug candidate suitable for first time in human studies.
Feng, Yangbo
focuses on the lead identification and optimization of drug candidates.
Griffin, Patrick
focuses on the application of mass spectrometry technology to probe protein-ligand and protein-protein interactions.
Hodder, Peter
runs Scripps Research's high-throughput screening (HTS) laboratory. He is focused on implementing & executing HTS assays for pharmaceutical drug discovery as well as managing Scripps Research's HTS compound collection. He also has interest in developing novel HTS-related automation, detection and assay technologies.
Izard, Tina
studies the structural dynamics of signaling mediators of adhesion junctions.
Kamenecka, Theodore
focuses on the design, synthesis and evaluation of novel compounds of biological and therapeutic interest.
Kenny, Paul
employs a multidisciplinary approach to investigate the underlying neurobiology of psychiatric disorders.
Kishi, Shuji
aims to develop a high-throughput processing system for gene identification and phenotype characterization particularly associated with age-related disorders in humans, using zebarfish as an amenable vertebrate model system.
Kodadek, Thomas
focuses his research in the area of chemical biology, deciphering the roles of the proteasome in transcription and understanding the mechanism of action of the hormone orexin.
Lasmezas, Corinne
studies the mechanisms of prion propagation and neurotoxicity, and investigates novel approaches to the therapeutics and prophylaxy of prion diseases.
Lo Grasso, Philip
studies structure function relationships of enzymes for drug discovery and development.
Luo, Junli
focuses on mechanistic and translational research in molecular signaling that connects epigenetic factors with genetic events during tumor genesis, progression and metastasis
McDonald, Patricia
Focuses on the development of biochemical and cell-based functional assays to identify and develop small molecule modulators of GPCRs for the treatment of metabolic and CNS disorders.
Micalizio, Glenn
focuses research on the development of new chemical methods and strategies for the total synthesis of complex biologically interesting natural products, and for the discovery of small molecules with interesting biological properties.
Miller, Courtney
is working to develop novel therapeutics for the treatment of memory disorders by targeting the epigenetic and synaptic contributors.
Nettles, Kendall
researches small molecule ligands, and their interaction with nuclear receptors in the cell’s interior, that may be targets for hormone-driven diseases such as breast and prostate cancers.
Paegel, Brian
studies the controlled synthesis and engineering of phospholipid vesicles and emulsions, microfluidic circuit design, and directed evolution of membrane-associated transporters, pores, and receptors.
Periana, Roy
focuses on the design, discovery and study of new coordination catalysts for the selective reaction of strong bonds with the goal of developing new Energy and Material chemistries that is cleaner, lower cost and allows the use of alternative feed stocks.
Petrie, Howard
focuses on the production of specialized blood cells called T lymphocytes, which are central mediators of the immune response. Understanding this is central in developing treatments for immunodeficiencies resulting from environmental exposure (such as HIV/AIDS) or aging.
Roush, William
focuses on the total synthesis of structurally complex and biologically interesting natural products, development of new synthetic methods and strategies, and on problems in medicinal and bioorganic chemistry.
Scampavia, Louis
works at the high-throughput screening (HTS) robotics facility exploring novel instrumentation and technologies that advance HTS for drug discovery. His work also encompasses the development and transfer of novel biomedical assays for use in HTS campaigns.
Schroeter, Thomas
focuses on the development and characterization of small molecule kinase inhibitors and predictive toxicology screens to develop potent and safe drug candidates
Smith, Roy
focuses on understanding the basis of metabolic diseases and identifying the physiological changes that cause loss of function during aging, including diseases and disorders such as obesity, non-insulin dependent diabetes, atherosclerosis and heart disease, osteoarthritis and neurodegeneration.
Strosberg, Donny
by studying protein-protein interactions in HCV, identifies and characterizes peptides and small molecules that affect host-pathogen relations, e.g. inhibit HCV release from cultured hepatoma cells.
Tellinghuisen, Timothy
focuses on understanding the assembly, composition, and activities of the RNA replication machinery of the hepatitis c virus
Valente, Susana
focuses on the discovery and characterization of molecular interactions occurring within a host cell that are critical for HIV replication - the interactions so identified can be tailored to develop therapeutic targets and provide novel antiviral approaches.
Wahlestedt, Claes
is taking a multidisciplinary approach to drug discovery in diseases of the brain (ranging from addiction, pain, affective disorders, Alzheimer's to ADHD), involving aspects of chemistry, pharmacology, behavior, pharmacogenomics, RNA biology and clinical medicine.
Weissmann, Charles
elucidates the structure of prions, the mechanism of their replication and the processes by which they enter cells and are released from them.
|
