Scripps Florida Faculty and
Professional Staff
Ayad, Nagi G.
studies the cell biological basis of cell cycle exit and differentiation of neuronal precursors as it relates to cancer and nerve regeneration.
Bannister, Thomas
uses all modern synthesis techniques to help our interdisciplinary Drug Discovery team rapidly design potential drug candidates for treating multiple sclerosis, diabetes, and addiction.
Bois, Philippe
works to determine the mechanisms that define and control recombinogenic regions in complex mammalian genomes.
Busby, Jennifer Ann
Cameron, Michael
investigates the metabolism of small molecules in vitro and in vivo to evaluate pharmacokinetic and pharmacodynamic properties and potential toxicity.
Castilla, Joaquin
works on in vitro and in vivo studies of the mechanisms involved in prion replication. Infectivity, strain and species barrier phenomena.
Cleveland, John L.
studies the molecular basis of cancer with a focus on malignancies having myc involvement, which is activated in 70% of all human cancers. Target discovery validation using mouse models, and cancer prevention and therapeutics are the major focuses of the laboratory.
Conkright, Michael
studies the molecular events that govern the conversion of the cyclic AMP signaling cascade into transcriptional activation of target gene using cell-based high-throughput technologies.
Duckett, Derek
investigates the mechanism of action of small molecule kinase inhibitors with the aim of developing a drug candidate suitable for first time in human studies.
Feng, Yangbo
focuses on the lead identification and optimization of drug candidates.
Griffin, Patrick
focuses on the application of mass spectrometry technology to probe protein-ligand and protein-protein interactions.
Hodder, Peter
runs Scripps Research's high-throughput screening (HTS) laboratory. He is focused on implementing & executing HTS assays for pharmaceutical drug discovery as well as managing Scripps Research's HTS compound collection. He also has interest in developing novel HTS-related automation, detection and assay technologies.
Izard, Tina
studies the structural dynamics of signaling mediators of adhesion junctions.
Kamenecka, Theodore
focuses on the design, synthesis and evaluation of novel compounds of biological and therapeutic interest.
Kenny, Paul
employs a multidisciplinary approach to investigate the underlying neurobiology of psychiatric disorders.
Lasmezas, Corinne
studies the mechanisms of prion propagation and neurotoxicity, and investigates novel approaches to the therapeutics and prophylaxy of prion diseases.
Liang, Chris
Design, synthesis, and testing of novel small molecular therapeutics.
Lo Grasso, Philip
studies structure function relationships of enzymes for drug discovery and development.
McDonald, Patricia
Focuses on the development of biochemical and cell-based functional assays to identify and develop small molecule modulators of GPCRs for the treatment of metabolic and CNS disorders.
Nettles, Kendall
Periana, Roy
focuses on the design, discovery and study of new coordination catalysts for the selective reaction of strong bonds with the goal of developing new Energy and Material chemistries that is cleaner, lower cost and allows the use of alternative feed stocks.
Petrie, Howard
focuses on the production of specialized blood cells called T lymphocytes, which are central mediators of the immune response. Understanding this is central in developing treatments for immunodeficiencies resulting from environmental exposure (such as HIV/AIDS) or aging.
Pletcher, Mathew
works to understand the genetic and molecular basis of complex behavioral disorders like depression and anxiety utilizing high-throughput genotyping, cDNA and siRNA cell-based screening, expression QTL mapping, and in silico genetics.
Roush, William
focuses on the total synthesis of structurally complex and biologically interesting natural products, development of new synthetic methods and strategies, and on problems in medicinal and bioorganic chemistry.
Scampavia, Louis
works at the high-throughput screening (HTS) robotics facility exploring novel instrumentation and technologies that advance HTS for drug discovery. His work also encompasses the development and transfer of novel biomedical assays for use in HTS campaigns.
Strosberg, Donny
by studying protein-protein interactions in HCV, identifies and characterizes peptides and small molecules that affect host-pathogen relations, e.g. inhibit HCV release from cultured hepatoma cells.
Tam, James
focuses on developing peptides and proteins as pharmaceutics and as tools to dissect underlying causes and mechanisms of diseases. Current focuses include development of HIV entry inhibitors and vaccines as well as orally active peptides.
Tellinghuisen, Timothy
focuses on understanding the assembly, composition, and activities of the RNA replication machinery of the hepatitis c virus
Wahlestedt, Claes
is taking a multidisciplinary approach to drug discovery in diseases of the brain (ranging from addiction, pain, affective disorders, Alzheimer's to ADHD), involving aspects of chemistry, pharmacology, behavior, pharmacogenomics, RNA biology and clinical medicine.
Weissmann, Charles
elucidates the structure of prions, the mechanism of their replication and the processes by which they enter cells and are released from them.
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