Izard Lab
Publications St-Jean M, Izard T, Sygusch J (2007). A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein. Journal of Biological Chemistry 282:14309-14315
Ramarao N, Le Clainche C, Izard T, Bourdet-Sicard R, Ageron E, Sansonetti PJ, Carlier MF, Tran Van Nhieu, G (2007). Capping of actin filaments by vinculin activated by the Shigella IpaA carboxyl-terminal domain. FEBS Letters 581:853-857
Izard T , Tran Van Nhieu G, Bois PR. Shigella applies molecular mimicry to subvert vinculin and invade host cells. Journal of Cell Biology 175:465-475, 2006.
Bois PR, O'Hara BP, Nietlispach D, Kirkpatrick J, Izard T*. The vinculin binding sites of talin and α-actinin are sufficient to activate vinculin. Journal of Biological Chemistry 281:7228-7236, 2006.
Brown DT, Izard T, Misteli T. Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo. Nature Structural & Molecular Biology 13:250-255.
Bois PRJ, Borgon RA, Vonrhein C, Izard T*. Structural dynamics of α-actinin-vinculin interactions. 25:6112-6122, 2005.
Molecular and Cellular Biology Morris VK, Izard T*. Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase. Protein Science 13:2547-52, 2004.
Borgon RA, Vonrhein C, Bricogne G, Bois PRJ, Izard T*. Crystal structure of human vinculin. Structure 12:1189-1197, 2004.
Izard T*, Vonrhein C. Structural basis for amplifying vinculin activation by talin. Journal of Biological Chemistry 279:27667-78, 2004.
Rush CL, Izard T*. Rhombohedral crystals of the human vinculin head domain in complex with a vinculin-binding site of talin. Acta Crystallographica D60:945-947, 2004.
Izard T*, Evans G, Borgon RA, Rush CL, Bricogne G, Bois PRJ. Vinculin activation by talin through helical bundle conversion. Nature 427:171-175, 2004.
Izard T, Sygusch J. Induced fit movements and metal cofactor selectivity of class II aldolases: Structure of thermus aquaticus fructose-1,6-bisphosphate aldolase. Journal of Biological Chemistry 279:11825-11822, 2004.
Brown KL, Morris VK, Izard T*. Rhombohedral crystals of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase. Acta Crystallographica D60:195-196, 2004.
Izard T*, Evans G, Borgon RA, Rush CL, Bricogne G, Bois PRJ. Vinculin activation by talin through helical bundle conversion. Nature 427:171-175, 2004.
Izard T, Sygusch J. Induced fit movements and metal cofactor selectivity of class II aldolases: Structure of thermus aquaticus fructose-1,6-bisphosphate aldolase. Journal of Biological Chemistry 279:11825-11822, 2004.
Brown KL, Morris VK, Izard T*. Rhombohedral crystals of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase. Acta Crystallographica D60:195-196, 2004.
Izard T*. A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with Coenzyme A. Journal of Bacteriology 185:4174-4080, 2003.
Hurlbert J, Izard T*. Crystallization of HLA-DR4 complexed with a collagen II peptide. Acta Crystallographica D58:1749-1751, 2002.
Izard T*. The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism. Journal of Molecular Biology 315:487-495, 2002.
Izard T*. Structural basis for chloramphenicol tolerance in Streptomyces venezuelae by chloramphenicol phosphotransferase activity. Protein Science 10:1508-1513, 2001.
Izard T*, Blackwell N. Crystal structures of the metal-dependent 2-dehydro-3-deoxy-galactarate aldolase suggest a novel reaction mechanism. The EMBO Journal 19:3849-3856, 2000.
Izard T*, Ellis J. The crystal structures of chloramphenicol phosphotransferase reveal a novel inactivation mechanism. The EMBO Journal 19:2690-2700, 2000.
Blackwell NC, Cullis PM, Cooper RA, Izard T*. Rhombohedral crystals of 2-dehydro-3-deoxy glucarate aldolase Escherichia coli. Acta Crystallographica D55:1368-1369, 1999.
Izard T*, Geerlof A, Lewendon A, Barker JJ. Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia coli. Acta Crystallographica D55:1226-1228, 1999.
Ellis J, Campopiano DJ, Izard T*. Cubic crystals of chloramphenicol phosphotransferase from Streptomyces venezuelae. Acta Crystallographica D55:1086-1088, 1999.
Izard T*, Geerlof A. The crystal structure of a novel bacterial adenylyltransferase reveals half of sites reactivity. The EMBO Journal 18:2021-2030, 1999.
Izard T, Ævarsson A, Allen MD, Westphal AH, Perham RN, de Kok A, Hol WGJ. Principles of quasi-equivalence and euclidean geometry govern the assembly of cubic and dodecahedral cores of pyruvate dehydrogenase complexes. Proceedings of the National Academy of Sciences USA 96:1240-1245, 1999.
Izard T, Sarfaty S, de Kok A, Westphal A, Hol WGJ. Improvement of diffraction quality upon rehydration of dehydrated icosahedral E. faecalis pyruvate dehydrogenase core crystals. Protein Science 6:913-915, 1997.
Izard T, Lawrence MC, Malby RL, Lilley, GG, Colman PM. The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli. Structure 2:361-369, 1994.
Lawrence MC, Izard T, Beuchat M, Blagrove RJ, Colman PM. The structure of phaseolin at 2.2 Å resolution: Implications for a common vicilin/legumin structure and the genetic engineering of seed storage proteins. Journal of Molecular Biology 238:748-776, 1994.
Izard T, Fol B, Pauptit RA, Jansonius JN. Trigonal crystals of porcine mitochondrial aspartate aminotransferase. Journal of Molecular Biology 215:341-344, 1990.
PhD Thesis: "Three Dimensional Fourier Synthesis of N-neuraminate Lyase from Escherichia coli."
Last update: December 2006
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