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The Feeney Lab

Selected Publications

Volpi, S.A., Verma-Gaur, J., Hassan. R., Ju, Z., Roa, S., Chatterjee, S., Werling, U., Hou, H. Jr, Will, B., Steidl, U., Scharff, M., Edelman, W., Feeney, A.J, Birshtein, B.K. Germline deletion of Igh 3¢ regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell specific regulation, rearrangement and insulation of the Igh locus. J. Immunol., 188:2556-2566, 2012.

Feeney, A.J., Verma-Gaur, J.. CTCF-cohesin complex: architect of chromatin structure regulates V(D)J rearrangement. Cell Research. 22:280-282, 2012.

Feeney, A.J. Epigenetic regulation of antigen receptor gene rearrangement.  Curr. Opin. Immunol. 23:171-177, 2011.

Degner, S.C., Verma-Gaur, J., Wong, T.P., Bossen, C., Iverson, G.M., Torkamani, A., Vettermann, C., Lin, Y.C., Ju, Z., Schulz, D., Murre, C.S., Birshtein, B.K., Schork, N.J., Schlissel, M.S., Riblet, R., Murre, C., Feeney, A.J. CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells. Proc Natl Acad Sci U S A. 108:9566-71, 2011.

Degner-Leisso, S.C., and Feeney, A. J. Epigenetic and 3-dimensional regulation of V(D)J rearrangement in immunoglobulin genes.  Seminars in Immunol. 22:346-52, 2010.

Lukin, K., Fields, S., Lopez, D., Cherrier, M., Ternyak, K., Ramirez, J., Feeney, A.J., Hagman, J. Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression. Proc Natl Acad Sci USA, 107:7869-7874, 2010.

Xu, C.-R. and Feeney, A.J. The epigenetic profile of immunoglobulin genes is dynamically regulated during B cell differentiation and is modulated by pre-BCR signaling. J. Immunol. 182:1362-1378, 2009. Chosen as a featured article in “In This Issue”.

Degner, S.C., Wong, T.P., Jankevicius, G., and Feeney, A.J. Cutting Edge: Developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development. J. Immunol. 182:44-48, 2009. Evaluated by the Faculty of 1000 Biology.

Feeney, A.J. Genetic and epigenetic control of V gene rearrangement frequency. Adv. Exp. Med. Biol. 650:73-81, 2009.

Carey, J.B., Moffatt-Blue, C.S., Watson, L.C., Gavin, A.L. and Feeney, A.J.   Repertoire-based selection into the marginal zone compartment during B cell development. J. Exp. Med. 205:2043-2045, 2008. Evaluated by the Faculty of 1000 Biology.

Xu, C.-R., Schaffer. L., Head, S.R. and Feeney, A.J. Reciprocal methylation of H3K27 and H3K36 on distal and proximal IgVH genes is modulated by IL7 and Pax5. Proc Natl Acad Sci USA 105:8685-8690, 2008.

Lamoureux, J.L., Watson, L.C., Cherrier, M.P., Skog, D., Nemazee, D. and Feeney, A.J. Reduced receptor editing in lupus-prone MRL/lpr mice. J Exp Med, 2007.