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The Feeney Lab

Selected Publications

Kleiman, E., Jia, H., Loguercio, S., Su, A.I. and Feeney, A.J.  YY1 plays an essential role at all stages of B-cell differentiation. Proc Natl Acad Sci U S A 113:E3911-3920 (2016). 

Gerasimova, T., Guo, C., Ghosh, A., Qiu, X., Montefiori, L., Verma-Gaur, J., Choi, N.M., Feeney, A.J. and Sen, R.  A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation. Genes Dev. 29:1683-1695 (2015). 

Predeus, A.V., Gopalakrishnan, S., Huang, Y., Tang, J., Feeney, A.J., Oltz, E.M. and Artyomov, M.N.  Targeted chromatin profiling reveals novel enhancers in Ig H and Ig L chain Loci. J. Immunol. 192:1064-1070 (2014). 

Kumar, S., Wuerffel, R., Achour, I., Lajoie, B., Sen, R., Dekker, J., Feeney, A.J. and Kenter, A.L.  Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny. Genes Dev. 27:2439-2444 (2013).  

Gopalakrishnan, S., Majumder, K., Predeus, A., Huang, Y., Koues, O.I., Verma-Gaur, J., Loguercio, S., Su, A.I., Feeney, A.J., Artyomov, M.N. and Oltz, E.M.  Unifying model for molecular determinants of the preselection Vbeta repertoire. Proc Natl Acad Sci USA 110:E3206-3215 (2013). 

Choi, N.M., Loguercio, S., Verma-Gaur, J., Degner, S.C., Torkamani, A., Su, A.I., Oltz, E.M., Artyomov, M. and Feeney, A.J.  Deep sequencing of the murine Igh repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies. J. Immunol. 191:2393-2402 (2013). 

Shih, H.-Y., Verma-Gaur, J., Torkamani, A., Feeney, A.J., Galjart, N. and Krangel, M.S.  Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub. Proc Natl Acad Sci USA 109:E3943-E3502 (2012). 

Verma-Gaur, J., Torkamani, A., Schaffer, L., Head, S.R., Schork, N.J. and Feeney, A.J.  Noncoding transcription within the Igh distal VH region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells. Proc Natl Acad Sci USA 109:17004-17009 (2012). 

Volpi, S.A., Verma-Gaur, J., Hassan, R., Ju, Z., Roa, S., Chatterjee, S., Werling, U., Hou, H., Jr., Will, B., Steidl, U., Scharff, M., Edelman, W., Feeney, A.J. and Birshtein, B.K.  Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus. J. Immunol. 188:2556-2566 (2012). 

Feeney, A.J. and Verma-Gaur, J.  CTCF-cohesin complex: architect of chromatin structure regulates V(D)J rearrangement. Cell Res. 22:280-282 (2012). 

Degner, S.C., Verma-Gaur, J., Wong, T.P., Bossen, C., Iverson, G.M., Torkamani, A., Vettermann, C., Lin, Y.C., Ju, Z., Schulz, D., Murre, C.S., Birshtein, B.K., Schork, N.J., Schlissel, M.S., Riblet, R., Murre, C. and Feeney, A.J.  CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells. Proc Natl Acad Sci USA 108:9566-9571 (2011). 

Feeney, A.J.  Epigenetic regulation of antigen receptor gene rearrangement. Curr. Opin. Immunol. 23:171-177 (2011). 

Lukin, K., Fields, S., Lopez, D., Cherrier, M., Ternyak, K., Ramirez, J., Feeney, A.J. and Hagman, J.  Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression. Proc Natl Acad Sci USA 107:7869-7874 (2010). 

Xu, C.R. and Feeney, A.J.  The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling. J. Immunol. 182:1362-1369 (2009).  Chosen as a featured article in "In This Issue".

Degner, S.C., Wong, T.P., Jankevicius, G. and Feeney, A.J.  Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development. J. Immunol. 182:44-48 (2009).  Evaluated by the Faculty of 1000 Biology.

Carey, J.B., Moffatt-Blue, C.S., Watson, L.C., Gavin, A.L. and Feeney, A.J.  Repertoire-based selection into the marginal zone compartment during B cell development. J. Exp. Med. 205:2043-2052 (2008).  Evaluated by the Faculty of 1000 Biology.

Xu, C.R., Schaffer, L., Head, S.R. and Feeney, A.J.  Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5. Proc Natl Acad Sci USA 105:8685-8690 (2008).