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The Elder Lab


  1. Lin, Y.C., A. Brik, A. de Parseval, K. Tam, B.E. Torbett, C.H. Wong, J.H. Elder. (2006) Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system. Journal of Virology.80(16):7832-43, PMCID: PMC1563824.
  2. Whiting, M., J.C. Tripp, Y.C. Lin, W. Lindstrom, A.J. Olson, J.H. Elder, K.B. Sharpless, V.V.Fokin. (2006) Rapid discovery and structure-activity profiling of novel inhibitors of human immunodeficiency virus type 1 protease enabled by the copper(I)-catalyzed synthesis of 1,2,3-triazoles and their further functionalization. J. Med. Chem. 49, 7697-7710.
  3. Heaslet, H., Y.C. Lin, K. Tam, B.E. Torbett, J.H. Elder, C.D. Stout. (2007) Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3. Retrovirology 4:1, PMCID: PMC1781954.
  4. 30. Manuell, A.L., M.V. Beligni, J.H. Elder, D.T. Siefker, M. Tran, A. Weber, T.L. McDonald, S.P. Mayfield. (2007) Robust expression of a bioactive mammalian protein in Chlamydomonas chloroplast. Plant Biotechnology Journal, 5.
  5. Sundstrom M, Chatterji U, Schaffer L, de Rozières S, Elder JH. (2008) Feline immunodeficiency virus OrfA alters gene expression of splicing factors and proteasome-ubiquitination proteins. Virology.20;371(2):394-404, PMID: 18289701.
  6. Elder JH, Sundstrom M, de Rozieres S, de Parseval A, Grant CK, Lin YC. (2008) Molecular mechanisms of FIV infection. Vet Immunol Immunopathol. 2008 May 15;123(1-2):3-13 PMCID: PMC2409060.
  7. de Rozières S, Thompson J, Sundstrom M, Gruber J, Stump DS, de Parseval AP, Vandewoude S, Elder JH. (2008) Replication Properties of Clade A/C Chimeric FIVs and Evaluation of Infection Kinetics in the Domestic Cat. J Virol. 82:7953-7963, PMID: 18550665.
  8. Sundstrom M, White RL, de Parseval A, Sastry KJ, Morris G, Grant CK, Elder JH. (2008) Mapping of the CXCR4 Binding site within Variable Region 3 of the Feline Immunodeficiency Virus Surface Glycoprotein. J Virol. 2008 Jul 2, PMID: 18596086.
  9. Elder JH, Y.-C. Lin, E. Fink, and C.K. Grant. (2010) Feline Immunodeficiency Virus (FIV) as A Model for  Study off Lentivirus Infections: Parallels with HIV. Curr. HIV Research 28; 8: 73-80 PMCID: PMC2853889.
  10. Lin YC, B.E. Torbett, JH Elder. (2010) Generation of Infectious Feline Immunodeficiency Virus Encoding FIV/HIV Chimeric Protease. J. Virol. 84(13): 67-809. PMCID: PMC2903298
  11. Hong Y, E. Fink, Q.Y. Hu, W.B. Kiosses, JH Elder (2010) OrfA Down-regulates FIV Primary Receptor CD134 on Host Cell Surface and is Important in Viral Infection. J. Virol. 84(14):7225-32. PMCID: PMC2898258
  12. Hu QY, E. Fink, Y. Hong, C. Wang, CK Grant, JH Elder. (2010) Fine definition of the CXCR4-binding region on the V3 loop of feline immunlodeficiency virus surface glycoprotein. PLoSONE 18,5(5):e10689. PMCID: PMC2872658.
  13. Chang MW, M.J. Giffin, R. Muller, J. Savage, Y.C. Lin, S. Hong, W. Jin, L.R. Whitby, J.H. Elder, D.L. Boger, B.E. Torbett (2010) Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries. Biochem J. 1;429(3):527-32. PMCID: PMC3084599.
  14. Hu QY, E. Fink, M. Happer, J.H. Elder. (2011) Identification of Amino Acid Residues Important for Heparan Sulfate Proteoglycan (HSPG) Interaction within Variable Region 3 of the Feline Immunodeficiency Virus Surface Glycoprotein J. Virol. 84(14):7108-17. PMCID: PMC3126603.
  15. Lin YC, A.L. Perryman, A.J. Olson, B.E. Torbett, J.H. Elder, C.D. Stout. (2011) Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease Acta Cryst. D67, part 6, 540-548  PMCID: PMC3107052.
  16. Miller C, H. Bielefeldt-Ohmann, M. Macmillan, S. Huitron-Resendiz, S. Henriksen, J.H.  Elder , S. Vandewoude (2011) Strain-specific viral distribution and neuropathology of feline immunodeficiency virus Vet  Immunol Immunopathol.143(3-4):282-91 PMCID:PMC3167954.
  17. Bucy DS, M.S. Brown, H. Bielefeldt-Ohmann, J. Thompson, A.M. Bachand, M. Morges, J.H. Elder, S. VandeWoude, Kraft S.L. (2011) Early detection of neuropathophysiology using diffusion-weighted magnetic resonance imaging in asymptomatic cats with feline immunodeficiency viral infection J. Neurovirol.,17(4) 341-52 PMCID:PMC3749835.
  18. Thompson J, M. MacMillan, K.Boegler, C. Wood, J.H. Elder, S. VandeWoude. (2011) Pathogenicity and rapid growth kinetics of feline immunodeficiency virus are linked to 3' elements PLoS One, 6(8) e24020 PMCID:PMC3162592.
  19. Hu Q-Y, E. Fink, J.H. Elder. (2012) J. Mapping of Receptor Binding Interactions with the FIV Surface Glycoprotein (SU); Implications Regarding Immune Surveillance and Cellular Targets of Infection, Retrovirology (4): 1-11 PMCID:PMC3523734.
  20. Tiefenbrunn T, S. Forli, M.M. Baksh, M.W. Chang, M. Happer, A.L. Perryman, B.E. Torbett, A.J. Olson, J.H. Elder, J.H., C.D. Stout (2012) Small Molecule Regulation of Protein Conformation by Binding inthe Flap of HIV Protease ACS Chemical Biology (8): 1223- 1231 . PMCID:PMC3769432.
  21. Lin Y-C, M. Happer, J.H. Elder. (2013)  Selection of Drug-resistant Feline Immunodeficiency Virus (FIV) Encoding FIV/HIV Chimeric Protease in The Presence of HIV-specific Protease Inhibitors, J. Virology. 87(15):8524-34 PMICD:PMC3719837.
  22. Troyer RM, J. Thompson, J.H. Elder, S. VandeWoude. (2013) Accessory Genes Confer a High Replication Rate to Virulent Feline Immunodeficiency Virus, J. Virology, 87(14):7940-51 PMCID: PMC3700203 .
  23. Wood BA, S. Carver, J.H. Elder, S. VandeWoude. (2013) Domestic cat microsphere immunoassays: detection of antibodies during feline immunodeficiency virus infection, J. of Imm. Methods, 396(1-2):74-86 PMCID:PMC3823060.
  24. Tefenbrunn T, S. Foril, M. Happer, A. Gonzalez, Y. Teal, M. Soltis, J.H. Elder, A.J. Olson, D.C. Stout. (2013) Crystallographic Fragment-Based Drug Discovery: Uus of a Brominated Fragment Library Targeting HIV Protease, Chem. Biol. Drug Design 83(2):141-8 PMCID: PMC3898673.
  25. Hu Q-Y, E. Fink, C.K. Grant, J.H. Elder. (2014) Selective Interraction of Heparin with the Variable Region 3 within Surface Gylcoprotein of Laboratory-adapted Feline Immunodeficiency Virus PLoS One 18;9(12):e115252. PMCID:PMC4270745.
  26. Logan, C., K. Todorof, S.P. Fioriilo, T.B. Campbell, J.H. Elder, M. Borok, I. Gudza, L. Gwanzura, B. Ndermera, M.J. Lochhead, C.A., Benson, R.T. Schooley. (2016) Rapid Multiplexed Immunosassay for Detection of Antibodies to Kaposi's Sarcoma-Associated Herpesvirus, PLOS ONE DOi:10.137/journal.pone.0163616 PMCID:PMC5036886.
  27. Fink,E., K. Fuller, B. Agan,  E.A. Berger, A. Saphire, G.V. Quinnan, J.H. Elder. (2016) Humoral Antibody Responses to HIV Viral Proteins and to CD4 Among HIV controllers, Rapid and Typical Progressor in an HIV-Positive Patient Cohort, AIDS Research & Human Retroviruses Dec;32(12):1187-1197. PMID:27771962.    
  28. Bashratyan R., D. Regn, M.J. Rahman, K. Marquardt, E. Fink, W.Y. Hu, J.H. Elder, J. Binley, L.A. Sherman, Y.D. Dai. (2017) Type 1 diabetes pathogenesis is modulated by spontaneous auoimmune responses to endogenous retrovirus antigens in NOD mice, European Journal of Immunology March;47(3)575-584. PMID:28083937.




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