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The Elder Lab

Publications

  1. Lin, Y.C., A. Brik, A. de Parseval, K. Tam, B.E. Torbett, C.H. Wong, J.H. Elder. (2006) Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system. Journal of Virology.80(16):7832-43, PMCID: PMC1563824.
  2. Whiting, M., J.C. Tripp, Y.C. Lin, W. Lindstrom, A.J. Olson, J.H. Elder, K.B. Sharpless, V.V.Fokin. (2006) Rapid discovery and structure-activity profiling of novel inhibitors of human immunodeficiency virus type 1 protease enabled by the copper(I)-catalyzed synthesis of 1,2,3-triazoles and their further functionalization. J. Med. Chem. 49, 7697-7710.
  3. Heaslet, H., Y.C. Lin, K. Tam, B.E. Torbett, J.H. Elder, C.D. Stout. (2007) Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3. Retrovirology 4:1, PMCID: PMC1781954.
  4. 30. Manuell, A.L., M.V. Beligni, J.H. Elder, D.T. Siefker, M. Tran, A. Weber, T.L. McDonald, S.P. Mayfield. (2007) Robust expression of a bioactive mammalian protein in Chlamydomonas chloroplast. Plant Biotechnology Journal, 5.
  5. Sundstrom M, Chatterji U, Schaffer L, de Rozières S, Elder JH. (2008) Feline immunodeficiency virus OrfA alters gene expression of splicing factors and proteasome-ubiquitination proteins. Virology.20;371(2):394-404, PMID: 18289701.
  6. Elder JH, Sundstrom M, de Rozieres S, de Parseval A, Grant CK, Lin YC. (2008) Molecular mechanisms of FIV infection. Vet Immunol Immunopathol. 2008 May 15;123(1-2):3-13 PMCID: PMC2409060.
  7. de Rozières S, Thompson J, Sundstrom M, Gruber J, Stump DS, de Parseval AP, Vandewoude S, Elder JH. (2008) Replication Properties of Clade A/C Chimeric FIVs and Evaluation of Infection Kinetics in the Domestic Cat. J Virol. 82:7953-7963, PMID: 18550665.
  8. Sundstrom M, White RL, de Parseval A, Sastry KJ, Morris G, Grant CK, Elder JH. (2008) Mapping of the CXCR4 Binding site within Variable Region 3 of the Feline Immunodeficiency Virus Surface Glycoprotein. J Virol. 2008 Jul 2, PMID: 18596086.
  9. Elder JH, Y.-C. Lin, E. Fink, and C.K. Grant (2010) Feline Immunodeficiency Virus (FIV) as A Model for  Study off Lentivirus Infections: Parallels with HIV. Curr. HIV Research 28; 8: 73-80 PMCID: PMC2853889.
  10. Lin YC, B.E. Torbett, JH Elder (2010) Generation of Infectious Feline Immunodeficiency Virus Encoding FIV/HIV Chimeric Protease. J. Virol. 84(13): 67-809. PMCID: PMC2903298
  11. Hong Y, E. Fink, Q.Y. Hu, W.B. Kiosses, JH Elder (2010) OrfA Down-regulates FIV Primary Receptor CD134 on Host Cell Surface and is Important in Viral Infection. J. Virol. 84(14):7225-32. PMCID: PMC2898258
  12. Hu QY, E. Fink, Y. Hong, C. Wang, CK Grant, JH Elder (2010) Fine definition of the CXCR4-binding region on the V3 loop of feline immunlodeficiency virus surface glycoprotein. PLoSONE 18,5(5):e10689. PMCID: PMC2872658.
  13. Chang MW, M.J. Giffin, R. Muller, J. Savage, Y.C. Lin, S. Hong, W. Jin, L.R. Whitby, J.H. Elder, D.L. Boger, B.E. Torbett (2010) Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries. Biochem J. 1;429(3):527-32. PMCID: PMC3084599.
  14. Hu QY, E. Fink, M. Happer, J.H. Elder (2011) Identification of Amino Acid Residues Important for Heparan Sulfate Proteoglycan (HSPG) Interaction within Variable Region 3 of the Feline Immunodeficiency Virus Surface Glycoprotein J. Virol. 84(14):7108-17. PMCID: PMC3126603.
  15. Lin YC, A.L. Perryman, A.J. Olson, B.E. Torbett, J.H. Elder, C.D. Stout. (2011) Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease Acta Cryst. D67, part 6, 540-548  PMCID: PMC3107052.

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