Transcriptional Activation

Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactionsI. Radhakrishnan, G. Perez-Alvarado, D. Parker, H.J. Dyson, M. Montminy and P.E. Wright (1997) Cell 91, 741-752.

High resolution solution structure of the retinoid X receptor DNA binding domain.S.M.A. Holmbeck, M. P. Foster, D. R. Casimiro, D. Sem, H. J. Dyson and P. E. Wright (1998) J. Mol. Biol. 281, 271-284.

Conformational preferences in the Ser133-phosphorylated and non-phosphorylated forms of the kinase inducible transactivation domain of CREBI. Radhakrishnan, G.C. Perez-Alvarado, H.J. Dyson and P.E. Wright (1998)FEBS Lett. 430, 317-322.

DNA-induced conformational changes are the basis for cooperative dimerization by the DNA binding domain of the retinoid X receptor. S.M.A. Holmbeck, H.J. Dyson and P.E. Wright (1998)J. Mol. Biol., 284, 533-539.

Structural analysis of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains.I. Radhakrishnan, G.C. Perez-Alvarado, D. Parker, H.J. Dyson, M.R. Montminy and P.E. Wright (1999) J. Mol. Biol. 287, 859-865.

DNA-induced α-helix capping in conserved linker sequences is a determinant of binding affinity in Cys₂-His₂ zinc fingers.J.H. Laity, H.J. Dyson and P.E. Wright (2000) J. Mol. Biol. 295, 719-727.

Identification of the regions involved in DNA binding by the mouse PEBP2a protein.G.C. Perez-Alvarado, A. Munnerlyn, H.J. Dyson,R. Grosschedl and P.E. Wright (2000) FEBS Lett. 470, 125-130.

Alternative splicing of Wilms tumor suppressor protein modulates DNA binding activity through isoform-specific DNA-induced conformational changes.J.H. Laity, J. Chung, H.J. Dyson, P.E. Wright (2000) Biochemistry 39, 5341-5348.

Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP.R.N. De Guzman, H.Y. Liu, M. Martinez-Yamout, H.J. Dyson and P.E. Wright (2000) J. Mol. Biol. 303, 243-253.

Molecular basis for modulation of biological function by alternate splicing of the Wilms tumor suppressor protein.J.H. Laity, H.J. Dyson and PE. Wright (2000) Proc. Natl. Acad. Sci. USA 97, 11932-11935.

Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain.B.P. Hudson, M.A. Martinez-Yamout, H.J. Dyson and P.E. Wright (2000).J. Mol. Biol. 304, 335-370.

Structure of the PHD zinc finger from human Williams-Beuren Syndrome transcription factor.J. Pascual, M. Martinez-Yamout, H.J. Dyson and P.E. Wright (2000).J. Mol. Biol. 304, 723-729.

Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators.S.J. Demarest, M. Martinez-Yamout, J. Chung, H. Chen, H.J. Dyson, R.M. Evans and P.E. Wright (2002) Nature 415, 549-553.

Assignment of a 15 kDa protein complex formed between the p160 coactivator ACTR and CREB binding protein.S.J. Demarest, J. Chung, H.J. Dyson and P.E. Wright (2002) J. Biomol. NMR 22, 377-378.

Structural basis for Hif-1a/CBP recognition in the cellular hypoxic response.S. Dames, M. Martinez-Yamout, R. N. DeGuzman, M. Allen, H.J. Dyson and P.E. Wright (2002) Proc. Natl. Acad. Sci. USA 99, 5271-5276.

Roles of phosphorylation and helix propensity in the binding of the KIX domain of CBP by constitutive (c-Myb) and inducible (CREB) activators.T. Zor, B.M. Mayr, H.J. Dyson and P.E. Wright (2002). J. Biol. Chem. 277, 42241-42248.

Cooperativity in transcription factor binding to the coactivator CREB-binding Protein (CBP): MLL binds to an allosteric site on the KIX domain.N.K. Goto, T. Zor, M. Martinez-Yamout, H.J. Dyson and P.E. Wright (2002).J. Biol. Chem. 277, 43168-43174.

Monomeric complex of human orphan estrogen related receptor-2 with DNA: A pseudodimer interface mediates extended half-site recognition.M.D. Gearhart, S.M.A. Holmbeck, R.M. Evans, H.J. Dyson and P.E. Wright (2003) J. Mol. Biol. 327, 819-832.

Structure of the nuclear factor ALY: insights into post-transcriptional regulatory and mRNA export processes. G.C. Perez-Alvarado, M. Martinez-Yamout, M. Allen, R. Grosschedl, H.J. Dyson and P.E. Wright (2003) Biochemistry 42, 7348-7357.

Packing, specificity and mutability at the binding interface between the p160 coactivator and CREB-binding protein.S.J. Demarest, S. Deechongkit, H.J. Dyson, R.M. Evans and P.E. Wright (2004).Protein Sci. 13, 203-210.

Interaction of the TAZ1 domain of CREB-binding protein with the activation domain of CITED2: Regulation by competition between intrinsically unstructured ligands for non-identical binding sites. R. N. De Guzman, M. A. Martinez-Yamout, H. J. Dyson, and P. E. Wright (2004).J. Biol. Chem. 279, 3042-3049.

Structural basis for recognition of the mRNA Type II AU-rich element by the tandem zinc finger domain of TIS11d.B.P. Hudson, M.A. Martinez-Yamout, J. Chung, H.J. Dyson, P.E. Wright (2004). Nature Struct. Biol. 11,257-264.

Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb.T. Zor, R.N. De Guzman, H.J. Dyson and P.E. Wright (2004).J. Mol. Biol.337, 521-534.

The CBP/p300 TAZ1 domain in its native state is not a binding partner of MDM2.T. Matt, M.A. Martinez-Yamout, H.J. Dyson and P.E. Wright (2004). Biochem. J. 381, 685-691.

The LEF-1 HMG domain undergoes a disorder-to-order transition upon formation of a complex with cognate DNA.J.J. Love, X. Li, J. Chung, H.J. Dyson and P.E. Wright (2004).Biochemistry 43, 8725-8734.

The isolated CBP/p300 TAZ1 domain folds into a three dimensional structure in the absence of its binding partners.R.N. De Guzman, J.M. Wojciak, M.A. Martinez-Yamout, H.J. Dyson and P.E. Wright (2004).Biochemistry, (in press).

ZZ Domain of CBP - a novel fold for a protein interaction module. G.B. Legge, M.A. Martinez-Yamout, G.J.A. Kroon, D. Hambly, H. J. Dyson and P.E. Wright (2004).J. Mol. Biol. 343, 1081-1093.

The isolated CBP/p300 TAZ1 domain folds into a three dimensional structure in the absence of its binding partners.R.N. De Guzman, J.M. Wojciak, M.A. Martinez-Yamout, H.J. Dyson and P.E. Wright (2005).Biochemistry, 44, 490-497.

Solution structure of the first two zinc finger domains of the double-stranded RNA-binding protein dsRBP-zfa. H. M. Möller, Maria A. Martinez-Yamout, H. J. Dyson and P. E. Wright (2005). J. Mol. Biol. 351, 718-730.

Structural basis for cooperative transcription factor binding to the CBP coactivator. R.N. De Guzman, N. Goto, H.J. Dyson and P.E. Wright (2006). J. Mol. Biol. 355, 1005-1013.

Induced fit and lock-and-key recognition of 5S RNA by zinc fingers of transcription factor IIIA. B.M. Lee, J. Xu, M.D. Gearhart, B.K. Clarkson, M.A. MartinezYamout, H.J. Dyson, D.A. Case, J.M. Gottesfeld, and P.E. Wright (2006). J. Mol. Biol. 357, 275-291.

Solution structure of the Hdm2 C2H2C4 RING finger, a domain critical for ubiquitination of p53. M. Kostic, T. Matt, H.J. Dyson and P.E. Wright (2006). J. Mol. Biol. 363, 433-450.

Embryonic neural inducing factor Churchill is not a DNA-binding zinc finger: solution structure reveals a solvent-exposed b-sheet and zinc binuclear cluster. B.M. Lee, B.A. Buck-Koehntop, M.A. Martinez-Yamout, H.J. Dyson and P.E. Wright (2007) J. Mol. Biol. 371, 1274-1289.

Structure of the zinc finger domain of the Wilms’ Tumor suppressor protein bound to DNA.R. Stoll, B.M. Lee, E. Debler, J.H. Laity, I.A. Wilson, H.J. Dyson and P.E. Wright (2007)J. Mol. Biol. 372, 1227-1245.

NMR relaxation study of the complex formed between the nuclear coactivator binding domain of CBP and a fragment of the nuclear hormone receptor coactivator ACTR. M.-O. Ebert, S.-H. Bae, H.J. Dyson, P.E. Wright (2008) Biochemistry 47, 1299-1308.

Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains. J.M. Wojciak, M.A. Martinez-Yamout, H.J. Dyson and P.E. Wright (2009) EMBO J. 28, 948-958.

Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP. C.W. Lee, M. Arai, M.A. Martinez-Yamout, H.J. Dyson and P.E. Wright (2009) Biochemistry28, 948-958

Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2. J. C. Ferreon, C.W. Lee, M. Arai, M.A. Martinez-Yamout, H.J. Dyson and P.E. Wright (2009) Proc. Natl. Acad. Sci. USA 106, 6591-6596.

Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein. J.C. Ferreon, M. Martinez-Yamout, H.J. Dyson, and P.E. Wright (2009) Proc. Natl. Acad. Sci. USA 106, 13260-13265.

Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain. M. Arai, H.J. Dyson and P.E. Wright (2010) FEBS Lett. 584, 4500-4504.

Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of CREB binding protein. C.W. Lee, M.A. Martinez-Yamout, H.J. Dyson and P.E. Wright (2010) Biochemistry 49, 9964-9971.

Kaiso uses all three zinc fingers and adjacent sequence motifs for high affinity binding to sequence-specific and methyl CpG targets. B.A. Buck-Koehntop, M.A. Martinez-Yamout, H.J. Dyson and P.E. Wright (2012) FEBS Lett. 586, 734-739.