Publications

1. Denery, J. R.; Nunes, A. A. K.; Dickerson , T. J. Characterization of differences between blood sample matrices in untargeted metabolomics. Anal. Chem., submitted.

2. Čapek, P.; Kirkconnell, K. S.; Dickerson, T. J. A bacteriophage-based platform for rapid trace detection of proteases. J. Am. Chem. Soc. 2010, 132, 13126-13128.

3. Denery, J. R.; Nunes, A. A. K.; Hixon, M.; Dickerson, T. J.; Janda, K. D. Mass spectrometry based metabolomics: Discovery of diagnostic biomarkers for onchocerciasis. PLOS Negl. Trop. Dis. 2010, 4, e834.

4. Moreno, A. Y.; Azar, M. R.; Warren, N. A.; Dickerson, T. J.; Koob, G. F.; Janda, K. D. A critical evaluation of a nicotine vaccine within a self-administration behavioral model. Mol. Pharmaceutics 2010, 7, 431-441.

5. Čapek, P.; Dickerson, T. J. Sensing the deadliest toxin: Technologies for botulinum neurotoxin detection. Toxins, 2010, 2, 24-53. (for “Neurotoxins of Biological Origin” special issue)

6. Frederick, M. O.; De Lamo Marin, S.; Janda, K. D.; Nicolaou, K. C.; Dickerson, T. J. Monoclonal antibodies with orthogonal azaspiracid epitopes. ChemBioChem 2009, 10, 1625-1629.

7. Treweek, J. T.; Dickerson, T. J.; Janda, K. D. Drugs of abuse that mediate advanced glycation endproduct formation: A chemical link to disease pathology. Acc. Chem. Res. 2009, 42, 659-696.

8. Fischer A.; Nakai, Y.; Eubanks, L. M.; Clancy, C. M.; Tepp, W. H.; Pellett, S.; Dickerson, T. J.; Johnson, E. A.; Janda, K. D.; Montal, M. Bimodal modulation of the botulinum neurotoxin protein-conducting channel. Proc. Natl. Acad. Sci. USA 2009, 106, 1330-1335

• Featured as a Research Highlight in Nature 2007, 448:390.
  

9. Nakai, Y.; Tepp, W. H.; Dickerson, T. J.; Johnson, E. A.; Janda, K. D. Function-oriented synthesis applied to the anti-botulinum natural product toosendanin. Bioorg. Med. Chem. 2009, 17, 1152-1157.

10. Rohrbach, A. S.; Dickerson, T. J. Predicting protein evolution in vitro by phage escape technology. Mol. BioSyst. 2009, 5, 128-133.

11. Treweek, J. B.; Sun, C.; Mayorov, A. V.; Qi, L.; Levy, C. L.; Roberts, A. J.; Dickerson, T. J.; Janda, K. D. Prevention of drug-induced memory impairment by immunopharmacotherapy. J. Med. Chem. 2008, 51, 6866-6875.

12. Willis, B.; Eubanks, L. M.; Dickerson, T. J.; Janda, K. D. The strange case of botulinum neurotoxin: Using chemistry and biology to modulate the most deadly poison. Angew. Chem. Intl. Ed. 2008, 47, 8360-8379.

13. Park, J.; Dickerson, T. J.; Janda, K. D. Major sperm protein as a diagnostic antigen for onchocerciasis. Bioorg. Med. Chem. 2008, 16, 7206-7209.

14. Lowery CA, Dickerson TJ, Janda KD. Interspecies and interkingdom communication mediated by bacterial quorum sensing. Chem Soc Rev 2008, 37:1337-1346.

15. Willis B, Eubanks LM, Wood MR, Janda KD, Dickerson TJ, Lerner RA. Biologically templated organic polymers with nanoscale order. Proc Natl Acad Sci USA 2008, 105:1416-1419.

16. Čapková K, Yoneda Y, Dickerson TJ, Janda KD. Synthesis and structure-activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors. Bioorg Med Chem Lett 2007, 17:6463-6466.

17. Yao Y, Dickerson TJ, Hixon MS, Dyson HJ. NMR detection of adventitious binding of xylose to the quorum-sensing protein SdiA of Escherichia coli. Bioorg Med Chem Lett 2007, 17:6202-6205.

18. Dickerson TJ, McKenzie KM, Hoyt AS, Wood MR, Janda KD, Brenner S, Lerner RA. Phage escape libraries for checkmate analysis. Proc Natl Acad Sci. USA 2007, 104:12703-12708.

• Featured as a Research Highlight in Nature 2007, 448:390.
  
• Featured as a Research Highlight in Nature Methods, 4:686.

19. Eubanks LM, Dickerson TJ. Investigating novel therapeutic targets and molecular mechanisms to treat botulinum neurotoxin A intoxication. Future Microbiol 2007, 2:677-687.

20. Brogan AP, Dickerson TJ, Janda KD. Nornicotine-organocatalyzed aqueous reduction of α,β-unsaturated aldehydes. Chem Commun 2007, 4952-4954.

21. Treweek JB, Wee S, Koob GF, Dickerson TJ, Janda KD. Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease. Proc Natl Acad Sci USA 2007, 104:11580-11584.

22. Brogan AP, Eubanks LM, Koob GF, Dickerson TJ, Janda KD. Antibody-catalyzed oxidation of D9-tetrahydrocannabinol. J Am Chem Soc 2007, 129:3698-3702.

23. Eubanks LM, Hixon MS, Jin W, Hong S, Clancy CM, Tepp WH, Baldwin MR, Malizio CJ, Goodnough MC, Barbieri JT, Johnson EA, Boger DL, Dickerson TJ, Janda KD. An in vitro and in vivo disconnect uncovered through high throughput identification of botulinum neurotoxin A antagonists. Proc Natl Acad Sci USA 2007, 104:2602-2607.

• Featured as a Science Concentrate in Chemical & Engineering News 2007, 85:69.

24. Eubanks LM, Dickerson TJ, Janda KD. Technological advancements for the detection of and protection against biological and chemical warfare agents. Chem Soc Rev 2007, 36:458-470.

• Graphic selected for the cover of Chem Soc Rev

25. Ino A, Dickerson TJ, Janda KD. Positional linker effects in haptens for cocaine immunopharmacotherapy. Bioorg Med Chem Lett 2007, 17:4280-4283.

26. Brogan AP, Dickerson TJ, Janda KD. Catalytic antibodies: Past, present, and future. In: Wiley Encyclopedia of Chemical Biology; Wiley: New York, 2006.

27. Brogan AP, Dickerson TJ, Janda KD. Enamine-based aldol organocatalysis in water: Are they really “all wet”? Angew Chem Intl Ed 2006, 45:8100-8102.

28. Eubanks LM, Rogers CJ, Beuscher AE IV, Koob GF, Olson AJ, Dickerson TJ, Janda KD. A molecular link between the active component of marijuana and Alzheimer’s disease pathology. Mol Pharm 2006, 3:773-777.

• Most accessed article in Mol Pharm July 2006-December 2007.
  
• Selected for press release by American Chemical Society (“Marijuana's active ingredient may slow progression of Alzheimer's disease”)

29. Kaufmann GF, Sartorio R, Lee SH, Rogers CJ, Moss JA, Meijler MM, Clapham B, Brogan AP, Dickerson TJ, Janda KD. Discovering additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones. In: Understanding Biology Using Peptides. Proceedings of the 19th American Peptide Symposium, Blondelle, S. E., Ed.; Springer: New York, 2006, pp. 252-254.

30. Dickerson TJ. Combinatorial Chemistry and Technologies: Methods and Applications, 2nd Edition Edited by Giorgio Fassina (XEPTAGEN S.p.A., Pozzuoli, Italy) and Stanislav Miertus (University of Trieste, Italy). CRC Press (an imprint of Taylor and Francis). J Am Chem Soc 2006, 128:8365-8366. (Book Review)

31. Rogers CJ, Eubanks LM, Dickerson TJ, Janda KD. Unexpected acetylcholinesterase activity of cocaine esterases. J Am Chem Soc 2006, 128:15364-15365.

32. Dickerson TJ, Janda KD. The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication. ACS Chem Biol 2006, 1:359-369.

33. McAllister LA, Hixon MS, Kennedy JP, Dickerson TJ, Janda KD. Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: A new wrinkle in botulinum neurotoxin. J Am Chem Soc 2006, 128:4176-4177.

• Selected for press release by American Chemical Society (“New ‘wrinkle’ in Botox treatment could lead to lower doses, better safety”)

34. Yao Y, Martinez-Yamout M, Dickerson TJ, Brogan AP, Wright PE, Dyson HJ. Homoserine lactone “folding switches” for the Escherichia coli quorum sensing protein SdiA. J Mol Biol 2006, 355:262-273.

35. Rogers CJ, Dickerson TJ, Janda KD. Kinetic isotope and thermodynamic analysis of the nornicotine catalyzed aqueous aldol reaction. Tetrahedron 2006, 2-3:352-356. (for Organocatalysis Symposium-in-Print)

36. Zhu X, Dickerson TJ, Rogers CJ, Kaufmann GF, Mee JM, Janda KD, Wilson IA. Complete reaction cycle of a cocaine catalytic antibody at atomic resolution. Structure 2006, 14:205-216.

• Featured in NIH NIGMS Biomedical Beat

37. Boldt GE, Dickerson TJ, Janda KD. Emerging chemical and biological approaches for the preparation of discovery libraries. Drug Discov Today 2006, 11:143-148.

38. Shute TS, Matsushita M, Dickerson TJ, La Clair JJ, Janda KD, Burkart MD. A site-specific bifunctional protein labeling system for affinity and fluorescent analysis. Bioconjug Chem 2005, 16:1352-1355.

39. Rogers CJ, Dickerson TJ, Wentworth P. Jr, Janda KD. A high-swelling reagent scaffold suitable for use in aqueous and organic media. Tetrahedron 2005, 61:12140-12144 (for Polymeric Reagents and Catalysts Symposium-in-Print)

40. Dickerson TJ, Janda KD. Recent advances for the treatment of cocaine abuse: Central nervous system immunopharmacotherapy. AAPS J 2005, 7:E579-E586.

41. Kaufmann GF, Sartorio R, Lee SH, Rogers CJ, Moss JA, Meijler MM, Clapham B, Brogan AP, Dickerson TJ, Janda KD. Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones. Proc Natl Acad Sci USA 2005, 102:309-314.

• Featured in Chemical & Engineering News 2005, 83:38.
  
• Featured in Nature Rev Microbiology 2005, 3:192.

42. Reed NN, Dickerson TJ, Boldt GE, Janda KD. Enantioreversal in the Sharpless asymmetric epoxidation reaction controlled by the molecular weight of a covalently appended achiral polymer. J Org Chem 2005, 70:1728-1731.

43. Rogers CJ, Dickerson TJ, Brogan AP, Janda KD. Hammett correlation of nornicotine analogs in the aqueous aldol reaction: Implications for green organocatalysis. J Org Chem 2005, 70:3705-3708.

44. Dickerson TJ, Beuscher AE IV, Rogers CJ, Hixon MS, Yamamoto N, Xu Y, Olson AJ, Janda KD. Discovery of acetylcholinesterase ligands through computational refinement of a directed library. Biochemistry 2005, 44:14845-14853.

45. Eubanks LM, Dickerson TJ, Janda KD. Vitamin B2-mediated cellular photoinhibition of botulinum neurotoxin A. FEBS Lett 2005, 579:5361-5364.

46. Brogan AP, Dickerson TJ, Boldt GE, Janda KD. Altered retinoid homeostasis catalyzed by a nicotine metabolite: Implications in macular degeneration and normal development. Proc Natl Acad Sci USA 2005, 102:10433-10438.

47. Rogers CJ, Mee JM, Kaufmann GF, Dickerson TJ, Janda KD. Towards cocaine esterase therapeutics. J Am Chem Soc 2005, 127:10016-10017.

48. Dickerson TJ, Kaufmann GF, Janda KD. Bacteriophage-mediated protein delivery into the central nervous system and its application in immunopharmacotherapy. Expert Opin Biol Ther 2005, 5:773-791.

49. Dickerson TJ, Reed NN, La Clair JJ, Janda KD. A precipitator for the detection of thiophilic metals in aqua. J Am Chem Soc 2004, 126:16582-16586.

50. Dickerson TJ, Lovell T, Meijler MM, Noodleman L, Janda KD. Nornicotine aqueous aldol reactions: Synthetic and theoretical investigations into the origins of catalysis. J Org Chem 2004, 69:6603-6609.

51. Dickerson TJ, Yamamoto N, Ruiz D, Janda KD. Immunological consequences of methamphetamine protein glycation. J Am Chem Soc 2004, 126:11446-11447.

• Selected for press release by American Chemical Society (“Chemists identify immune system mechanism for methamphetamine binges”)

52. McDunn JE, Dickerson TJ, Janda KD. Antibody catalysis of disfavored chemical reactions. Chapter 7 in: Catalytic Antibodies, Keinan, E., Ed.; Wiley: New York, 2004, pp. 184-216.

53. Dickerson TJ, Yamamoto N, Janda KD. Antibody-catalyzed oxidative degradation of nicotine by riboflavin. Bioorg Med Chem 2004, 12:4981-4987.

54. Dickerson TJ, Tremblay MR, Hoffman TZ, Ruiz DI, Janda KD. Catalysis of the photo-Fries reaction: Antibody-mediated stabilization of high energy states. J Am Chem Soc 2003, 125:15395.

55. Dickerson TJ, Janda KD. Glycation of the amyloid b-protein by a nicotine metabolite: A fortuitous chemical dynamic between smoking and Alzheimer’s disease. Proc Natl Acad Sci USA 2003, 100:8182-8187.

• Featured on Scientific American.com, June 17, 2003.
  
• Featured in Chemical & Engineering News 2003, 81:38.
  
• Featured in The Economist, June 19, 2003.
  
• Featured in Nature Rev Drug Disc 2003, 2:690.

56. Dickerson TJ, Cordova A, Chen DW, Janda KD. The use of enzymes and catalytic antibodies in the asymmetric aldol reaction. In: Encyclopedia of Catalysis, ed. I. T. Horvath, Wiley, N.Y., 2003.

57. Dickerson TJ, Reed NN, Janda KD. Soluble polymers as catalyst & reagent platforms: Liquid-phase methodologies. Chapter 5 in: Polymeric Materials in Organic Synthesis and Catalysis, Buchmeiser MR, Ed.; Wiley: New York, 2003, pp. 241-276.

58. Gambs C, Dickerson TJ, Mahajan S, Pasternack LB, Janda KD. High resolution diffusion ordered spectroscopy to probe the microenvironment of JandaJelTM and Merrifield resins. J Org Chem 2003, 68:3673-3678.

59. Dickerson TJ, Janda KD. A previously undescribed chemical link between smoking and metabolic disease. Proc Natl Acad Sci USA 2002, 99:15084-15088.

• Featured on BBC News, October 29, 2002.
  
• Featured on Scientific American.com, October 30, 2002.
  
• Featured in U.S. News and World Reports, November 11, 2002.
  
• Featured in Environmental Health Perspectives, 2003, 111 (NIH Publication)

60. Dickerson TJ, Reed NN, Janda KD. Soluble polymers as scaffolds for recoverable reagents and catalysts. Chem Rev 2002, 102:3325-3344.

61. Dickerson TJ, Janda KD. Aqueous aldol catalysis by a nicotine metabolite. J Am Chem Soc. 2002, 124:3220-3221.

• Featured as a Science Concentrate in Chemical & Engineering News 2002, 80:52.
  
• Featured as an Editor’s Choice in Science 2002, 296:15.

62. Moss JA, Dickerson TJ, Janda KD. Solid phase peptide synthesis on JandaJel™ resin. Tetrahedron Lett 2002, 43:37-40.

63. Tremblay MR, Dickerson TJ, Janda KD. Advances in antibody catalysis of cycloaddition reactions. Adv Synth Catal 2001, 6/7:577-585.

64. Dickerson TJ, Reed NN, Janda KD. Regio-reactive resin: A platform for orthogonal loading on the polymer backbone and cross-linker. Bioorg Med Chem Lett 2001, 11:1507-1509.