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The DerMardirossian Lab

Selected Publications

Dagliyan O; Karginov A; Yagishita S; Gale M; Wang H; DerMardirossian c ; Wells C; Dokholyan N; Kasai H; Hahn K. 2017.
Engineering Pak1 allosteric switches.
ACS Synthetic Biology, ACS Synth Biol. 2017 Apr 6. PMID:28365983.

Hodgson L, Spiering D, Sabouri-Ghomi M, Dagliyan O, DerMardirosian C, Danuser G, Hahn K . 2016.
"FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions".
Nature Chemical Biology, 12:802-809. PMID:27501396.

Delorme-Walker V, Seo JY, Gohla A, Fowler B, Bohl B, DerMardirossian C. 2015.
"Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels".
Proc Natl Acad Sci U S A, 112: E5150-5159. PMID: 23624884.
Howell M, Brickner H, Delorme-Walker VD, Choi J, Saffin JM, Miller D, Panopoulos A, DerMardirossian C, Fotedar A, Margolis RL, Fotedar R. 2015.
"WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization and Cofilin-dependent motility".
Journal of Cell Biology, p961-74. PMID: 25800056 PDF

Lee HS, Cheerathodi M, Chaki SP, Reyes SB, Zheng Y, Lu Z, Paidassi H, DerMardirossian C, Lacy-Hulbert A, Rivera GM, McCarty JH. 2015.
"Protein Tyrosine Phosphatase-PEST and b8 Integrin Regulate Spatiotemporal Patterns of RhoGDl1 Activation in Migrating Cells".
Mol Cell Biol, p1401-13 PDF

Sakurai K, Talukdar I, Patil VS, Dang J, Li Z, Chang KY, Lu CC, Delorme-Walker V, DerMardirossian C, Anderson K, Hanein D, Yang CS, Wu D, Liu Y, Rana TM. 2014.
"Kinome-wide functional analysis highlights the role of cytoskeletal remodeling in somatic cell reprogramming".
Cell Stem Cell, p523-34. PMCID: PMC407116  PDF

Pathak R, DerMardirossian C.
"GEF-H1 :orchestrating the interplay between cytoskeleton and vesicle trafficking.2013".
Small GTPases , p174-9. PMCID: PMC3976975 PDF

Huang TY, Michael S, Xu T, Sarkeshik A, Moresco J, Yates JR 3rd, Masliah E, Bokoch GM, DerMardirossian C. 2013. 
"A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation".
Molecular Biology of the Cell, p194-209. PMCID: PMC3564530 PDF

Pathak R, Delorme-Walker V, Howell MC, Anselmo AN, White MA, Bokoch, GM and DerMardirossian C. 2012.
The Microtubule-associated Rho Activating Factor GEF-H1 interacts with Exocyst complex to regulate Vesicle Traffic.
Developmental Cell, p397-411. PMCID: PMC3422510. (‘Good’ by F1000 biology) PDF

Taulet N, Delorme-Walker V, and DerMardirossian C. 2012.
"Reactive Oxygen Species Regulate Protrusion Efficiency by Controlling Actin Dynamics".
PlosOne, 7(8):e41342. PMCID: PMC3410878 PDF
Delorme-Walker V, Peterson J, Chernoff J, Waterman C, Danuser G, *Bokoch GM and *DerMardirossian C. 2011.
"Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration".
Journal of Cell Biology, (7) 1289. MCID: PMC3216326. (‘Good’ by F1000 biology) PDF
Gianni D, Taulet N, DerMardirossian C*, and Bokoch GM. 2010.
"C-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells".
Molecular Biology of the Cell, 23 p4287-4298. PMCID: PMC2993755 PDF
Gianni D, Taulet N, Zhang H, DerMardirossian C, Kister J, Martinez L, Roush WR, Brown SJ, Bokoch GM, Rosen H. 2010.
"A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells". 
ACS Chem Biol, p981-93. PMCID: PMC2955773 PDF
Delorme V, Machacek M, DerMardirossian C, Anderson KL, Wittmann T, Hanein D, Waterman-Storer C, Danuser G, Bokoch GM. 2007.
"Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks".
Developmental Cell, p646-62PMCID: PMC2170459; ‘Good’ by F1000 biology PDF
DerMardirossian C, Rocklin G, Seo JY, Bokoch GM. 2006.
"Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling".
Molecular Biology of the Cell, 17:4760-4768. PMID:16943322 highlighted/front-page in Molecular Biology of the Cell"; 'Good' by F1000.

DerMardirossian C, Schnelzer A, Bokoch GM. 2004.
"Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase"
Molecular Cell, 15: 117-127.  PMID: 15225553 PDF

Zenke FT, Krendel M, DerMardirossian C, King CC, Bohl BP, Bokoch GM. 2004.
"p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor".  
Journal of Biological Chemistry, 279(18): 18392-18400. PMID: 14970201 PDF

Reviews

Pathak R and DerMardirossian C. 2013.
"GEF-H1: orchestrating the interplay between cytoskeleton and vesicle trafficking".
Small GTPases, 4: 174-179. PMID:23648943.

DerMardirossian C, Bokoch GM. 2006.
"Phosphorylation of RhoGDI by p21-activated kinase 1".Methods Enzymology, 406:80-90 PMID 16472651.

Stofega M, DerMardirossian C, Bokoch GM. 2006.
"Affinity-based assay of Rho guanosine triphosphatase activation".Methods in Molecular Biology, 332:269-79. PMID: 16878699.

DerMardirossian C, Bokoch GM. 2005.
"GDIs: central regulatory molecules in Rho GTPase activation".
Trends Cell Biol, 15:356-363.

Huang TY*, DerMardirossian C*, Bokoch GM. 2006.
"Cofilin phosphatases and regulation of actin dynamics".
Current Opinion in Cell Biology, 18:26-31. PMID:16337782.

DerMardirossian C, Bokoch GM. 2006.
"Phosphorylation of RhoGDI by p21-activated kinase 1". 
Methods Enzymol, p80-90. PMID: 16472651

Stofega MDerMardirossian C, Bokoch GM.2006.
"Affinity-based assay of Rho quanosine triphosphatase activation".
 Methods Mol Biol, p269-79. PMID: 16878699

DerMardirossian C, Bokoch GM. 2001.
"Regulation of cell function by Rho GTPases".

Drug News Perspective 14:389-95. PMID: 12813581.

Other Publications

Gianni D, DerMardirossian C, Bokoch GM. 2011
"Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation". 
Eur.J.Cell.Biol, p164-171. PMCID: PM3013238
Bielek H, Anselmo A, DerMardirossian C.2009.
"Morphological and proliferative abnormalities in renal mesangial cells lacking RhoGDI". 
Cell Signal, p1974-83. PMCID: PMC2903048
Khan AA, Mao XO, Banwait S, DerMardirossian C, Bokoch GM, Jin K, Greenberg DA. 2008.
"Regulation of hypoxic neuronal death signaling by neuroglobin".
FASEB J., p1737-47. PMCID: PMC2746758

Golovanov AP, Chuang TH, DerMardirossian C, Barsukov I, Hawkins D, Badii R, Bokoch GM, Lian LY, Roberts GC. 2001.
"Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI". 
J Mol Biol, p121-35