The DerMardirossian Lab

Publications

Reactive oxygen species regulate protrusion efficiency by controlling actin dynamics.
N. Taulet , V. Delorme-Walker, C. DerMardirossian.
Plos One

Microtubule-associated Rho Activating Factor GEF-H1 interacts with Exocyst complex to regulate Vesicle Traffic
Ritu Pathak, Violaine D. Delorme-Walker, Michael C. Howell, Anthony N. Anselmo, Michael A. White, Gary M. Bokoch and Céline DerMardirossian.
Developmental Cell

Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.
Delorme-Walker VD, Peterson JR, Chernoff J, Waterman CM, Danuser G, DerMardirossian C, Bokoch GM.
J Cell Biol. 2011 Jun 27;193(7):1289-303.
Pubmed Link

c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells.
Gianni D, Taulet N, DerMardirossian C, Bokoch GM.
Mol Biol Cell. 2010 Dec;21(23):4287-98. Epub 2010 Oct 13.
Pubmed Link

A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells.
Gianni D, Taulet N, Zhang H, DerMardirossian C, Kister J, Martinez L, Roush WR, Brown SJ, Bokoch GM, Rosen H.
ACS Chem Biol. 2010 Oct 15;5(10):981-93.
Pubmed Link

Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.
Gianni D, DerMardirossian C, Bokoch GM.
Eur J Cell Biol. 2011 Feb-Mar;90(2-3):164-71. Epub 2010 Jul 6.
Pubmed Link

Morphological and proliferative abnormalities in renal mesangial cells lacking RhoGDI.
Bielek H, Anselmo A, Dermardirossian C.
Cell Signal. 2009 Dec;21(12):1974-83. Epub 2009 Sep 15.
Pubmed Link

Regulation of hypoxic neuronal death signaling by neuroglobin.
Khan AA, Mao XO, Banwait S, DerMardirossian CM, Bokoch GM, Jin K, Greenberg DA.
FASEB J. 2008 Jun;22(6):1737-47. Epub 2008 Jan 15.
Pubmed Link

Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks.
Delorme V, Machacek M, DerMardirossian C, Anderson KL, Wittmann T, Hanein D, Waterman-Storer C, Danuser G, Bokoch GM.
Dev Cell. 2007 Nov;13(5):646-62.
Pubmed Link

Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling.
DerMardirossian C, Rocklin G, Seo JY, Bokoch GM.
Mol Biol Cell. 2006 Nov;17(11):4760-8. Epub 2006 Aug 30.
Pubmed Link

Affinity-based assay of Rho guanosine triphosphatase activation.
Stofega M, DerMardirossian C, Bokoch GM.
Methods Mol Biol. 2006;332:269-79.
Pubmed Link

Phosphorylation of RhoGDI by p21-activated kinase 1.
DerMardirossian CM, Bokoch GM.
Methods Enzymol. 2006;406:80-90.
Pubmed Link

Cofilin phosphatases and regulation of actin dynamics.
Huang TY, DerMardirossian C, Bokoch GM.
Curr Opin Cell Biol. 2006 Feb;18(1):26-31. Epub 2005 Dec 7. Review.
Pubmed Link

GDIs: central regulatory molecules in Rho GTPase activation.
DerMardirossian C, Bokoch GM.
Trends Cell Biol. 2005 Jul;15(7):356-63. Review.
Pubmed Link

Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase.
DerMardirossian C, Schnelzer A, Bokoch GM.
Mol Cell. 2004 Jul 2;15(1):117-27.
Pubmed Link

p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.
Zenke FT, Krendel M, DerMardirossian C, King CC, Bohl BP, Bokoch GM.
J Biol Chem. 2004 Apr 30;279(18):18392-400. Epub 2004 Feb 17.
Pubmed Link