Cell Reports 2016, Publication stage: In Press Corrected Proof

Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis

Alexandra M. Pinzaru, Robert A. Hom, Angela Beal, Aaron F. Phillips, Eric Ni, Timothy Cardozo, Nidhi Nair, Jaehyuk Choi,Deborah S. Wuttke, Agnel Sfeir, Eros Lazzerini Denchi


Nat Rev Mol Cell Biol. 2016 Jun;17(6):364-78. doi: 10.1038/nrm.2016.43. Epub 2016 May 11.

Stop pulling my strings - what telomeres taught us about the DNA damage response.

Eros Lazzerini Denchi, Agnel Sfeir


Nature. 2015 Feb 2. doi: 10.1038/nature14157. [Epub ahead of print]
Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.
Mateos-Gomez PA, Gong F, Nair N, Miller KM, Lazzerini Denchi E, Sfeir A.

Cell Rep. 2014 May 22 [Epub ahead of print].

Isolation of Chromatin from Dysfunctional Telomeres Reveals an Important Role for Ring1b in NHEJ-Mediated Chromosome Fusions.

Bartocci C, Diedrich JK, Ouzounov I, Li J, Piunti A, Pasini D, Yates JR 3rd, Lazzerini Denchi E. (2014)


EMBO Rep. 2014 15(5):601-8.

RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response.

Groocock LM, Nie M, Prudden J, Moiani D, Wang T, Cheltsov A, Rambo RP, Arvai AS, Hitomi C, Tainer JA, Luger K, Perry JJ, Lazzerini Denchi E, Boddy MN.


Cell Rep. 2013 14;5(3):826-38.

DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells.

Békés M, Okamoto K, Crist SB, Jones MJ, Chapman JR, Brasher BB, Melandri FD, Ueberheide BM, Lazzerini Denchi E, Huang TT.


Front Genet. 2013 4:128.

Put a RING on it: regulation and inhibition of RNF8 and RNF168 RING finger E3 ligases at DNA damage sites.

Bartocci C. and Lazzerini Denchi, E.


Nature. 2013 Feb 6. doi: 10.1038/nature11873. [Epub ahead of print]

A two-step mechanism for TRF2-mediated chromosome end protection.

Okamoto K, Bartocci C, Ouzounov I, Diedrich JK, Yates Iii JR, Lazzerini Denchi E.


Plos Genetics, 2013 9(2):e1003293. 

Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families. Plos Genetics

Bopp S.E.R., Manary M.J., Bright A.T., Johnston L.G., Dharia N.V., Luna F., McCormack S., Plouffe D., Case W. McNamara C.W.,Walker J.R., David A. Fidock D.A., Lazzerini Denchi E., Winzeler E.A.


Nature Structural and Molecular Biology, 2012 19(4), 387-394.

A telomere dependent DNA damage checkpoint induced by prolonged mitotic arrest.

Hayashi, M.T., Cesare, A.J., Fitzpatrick, J.A.J., Lazzerini Denchi, E., and Karlseder, J.


Cell. 2010 Apr 2;141(1):81-93.

Persistent telomere damage induces bypass of mitosis and tetraploidy.

Davoli T, Lazzerini Denchi E, de Lange T.


DNA Repair. 2009 Sep 2;8(9):1118-26. Give me a break: how telomeres suppress the DNA damage response.

Lazzerini Denchi E.


Nature. 2007 Aug 30;448(7157):1068-71. Epub 2007 Aug 8.

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

Lazzerini Denchi E, de Lange T.


Genes Dev. 2006 Oct 1;20(19):2648-53.

Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication.

Lazzerini Denchi E, Celli G, de Lange T.


Nat Cell Biol. 2006 Aug;8(8):885-90. Epub 2006 Jul 16.

Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination.

Celli GB, Lazzerini Denchi E, de Lange T.


Mol Cell Biol. 2005 Oct;25(20):8874-86.

Nucleophosmin is required for DNA integrity and p19Arf protein stability.

Colombo E, Bonetti P, Lazzerini Denchi E, Martinelli P, Zamponi R, Marine JC, Helin K, Falini B, Pelicci PG.


EMBO Rep. 2005 Jul;6(7):661-8.

E2F1 is crucial for E2F-dependent apoptosis.

Lazzerini Denchi E, Helin K.


Mol Cell Biol. 2005 Apr;25(7):2660-72.

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland.

Lazzerini Denchi E, Attwooll C, Pasini D, Helin K.


EMBO J. 2004 Dec 8;23(24):4709-16. Epub 2004 Nov 11.

The E2F family: specific functions and overlapping interests.

Attwooll C, Lazzerini Denchi E, Helin K.


EMBO J. 2004 Oct 13;23(20):4061-71. Epub 2004 Sep 23.

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.

Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K.


Cancer Cell. 2004 Jun;5(6):513-5.

Naturally death-resistant precursor cells revealed as the origin of retinoblastoma.

Trinh E, Lazzerini Denchi E, Helin K.


Mol Cell Biol. 2002 Aug;22(15):5527-38.

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.

Migliorini D, Lazzerini Denchi E, Danovi D, Jochemsen A, Capillo M, Gobbi A, Helin K, Pelicci PG, Marine JC.


Nat Cell Biol. 2001 Jun;3(6):552-8.

Apaf-1 is a transcriptional target for E2F and p53.

Moroni MC, Hickman ES, Lazzerini Denchi E, Caprara G, Colli E, Cecconi F, Müller H, Helin K.


Genes Dev. 2000 Sep 15;14(18):2330-43.

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1.

Petersen BO, Wagener C, Marinoni F, Kramer ER, Melixetian M, Lazzerini Denchi E, Gieffers C, Matteucci C, Peters JM, Helin K.




Science 2017. 
   TZAP: A telomere-associated protein involved in telomere length control.
   Li J., Miralles Fuste J., Simarovian T., Bartocci C., Tzai J., Karlseder J., Lazzerini Denchi E.