Selected publications, 2000 - present:

Curtiss, L.K., Bonnet, D.J., and Rye, K.  The conformation of apolipoprotein A-I in high density lipoproteins is influenced by core lipid composition and particle size: A surface plasmon resonance study.  Biochem., 39:5712-5721, 2000. PubMed Abstract

Sorci-Thomas, M.G., Thomas, M., Curtiss, L.K., and Landrum, M.  Single repeat deletion  in apoA-I blocks cholesterol esterification and results in rapid catabolism of D6 and wild-type apoA0I in transgenic mice.  J. Biol. Chem., 275:12156-12163, 2000. PubMed Abstract

Curtiss, L.K., Kubo, N., Schiller, N.K., and Boisvert, W.A.  Participation of innate and acquired immunity in atherosclerosis.  Immunol. Res., 21:167-176, 2000. PubMed Abstract

Boisvert, W.A., Curtiss, L.K., and  Terkeltaub, R.A.  IL-8 and its receptor CXCR2 in atherosclerosis.  Immunol. Res., 21:129-137, 2000. PubMed Abstract

Kubo, N., Boisvert, W.A., Ballantyne, C.M., and Curtiss, L.K.  Leukocyte CD11b  expression is not essential for the development of atherosclerosis in mice. J. Lipid Res., 41:1060-1066, 2000. PubMed Abstract

Curtiss, L.K., and Boisvert, W.A.  Apolipoprotein E and atherosclerosis.  Curr. Opin. Lipid.., 11:243-251, 2000. PubMed Abstract

Shaw, P.X., Hörkköl, S., Chang, M., Curtiss, L.K., Palinski, W., Silverman, G.J., and Witztum, J.L.  Natural antibodies with the T15 idiotype may  act in atherosclerosis, apoptotic clearance and protective immunity.  J. Clin. Invest., 105:1731-1740, 2000. PubMed Abstract

Curtiss, L.K.  Apolipoprotein E in atherosclerosis.  A protein with multiple hats.  Arterioscler. Thromb., Vas Biol., 20:1852-1853, 2000. PubMed Abstract

Chawla, A., Boisvert, W.A., Lee, C-H., Laffitte, B.A., Barak, Y., Joseph, S.B., Liao, D., Nagy, L., Edwards, P.A., Curtiss, L.K., Evans, R.M., and Tontonoz, P.  A PPAR(-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis.  Mol. Cell, 7:161-171, 2001. PubMed Abstract

Schiller, N.K., Kubo, N., Boisvert, W.A. and Curtiss, L.K.  Effect of gamma irradiation and bone marrow transplantation on atherosclerosis in LDL-receptor-deficient mice.   Arterioscler. Thromb. Vasc. Biol., 21:1674-1680, 2001. PubMed Abstract

Miyake, J.H., Duong, X-D., Strauss, W., Moore, G.L., Curtiss, L.K., Taylor, J.M., and Davis, R.A.  Increased production of apoB100-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol-7"-hydroxylase.  J. Biol. Chem., 276:23304-23311, 2001. PubMed Abstract

Settasatian, N., Duong, M., Curtiss, L.K., Ehnholm, C., Jauhiainen, M., Huuskonen, J., and Rye, K-A. The mechanism of the remodeling of high density lipoproteins by phospholipid transfer protein. J. Biol. Chem., 276:26898-26905, 2001. PubMed Abstract

Pinderski, L.J.P., Fischbein, M.P., Subbanagounder, G., Fishbein, M., Kubo, N., Cheroutre, H., Curtiss, L.K., Berliner, J.A., and Boisvert, W.A. Overexpression of Interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL-Receptor deficient mice by altering lymphocyte and macrophage phenotypes. Circ. Res. 31:1064-1071, 2002. PubMed Abstract

Schiller, N.K., Boisvert, W.A., and Curtiss, L.K. Inflammation in atherosclerosis: Lesion formation in LDL-receptor-deficient mice with Perforin and Lyst beige mutations. Arterioscler. Thromb. Vas. Biol., 22:1341-1346, 2002. PubMedAbstract

Mak, P.A., Laffitte, B.A., Desrumaux, C., Joseph, S.B., Curtiss, L.K., Mangelsdorf, D.J., Tontonoz, P., and Edwards, P.A. Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear receptors alpha and beta. J. Biol. Chem., 30:31900-31908, 2002. PubMed Abstract

Rye, K-A., Duong, M.N., Psaltis, M., Curtiss, L.K., Bonnet, D.J., Stocker, R., and Barter, P.J. Evidence that phospholipids play a key role in pre-beta and apo AI formation and HDL remodeling. Biochemistry, 41:12538-12545, 2002. PubMed Abstract

Fujita, K., Curtiss, L.K., Sakurabayashi, I., Kameko, F., Okumura, N., Terasawa, F., Tozuka, M., and Katsuyama, T. Identification and properties of glycated monoclonal IgA that affect the fructosine assay. Clin. Chem., 49(5):805-808, 2003. PubMedAbstract

Desrumaux, C.M., Mak, P.A., Boisvert, W.A., Masson, D., Stupack, D., Jauhiainen, M., Ehnholm, C., and Curtiss, L.K. Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cells. J. Lipid Res., 44(8):1453-1461, 2003. PubMedAbstract

Schiller, N.K., and Curtiss, L.K. Health status influences plasma cholesterol and atherosclerosis in severely immunocompromised LDL-receptor deficient mice. IAS comments. 2003, on line.

Lee, C.H., Chawla, A., Urbiztondo, N., Liao, D., Boisvert, W.A., Evans, R.M. and Curtiss, L.K. Transcriptional repression of atherogenic inflammation: Modulation by PPARdelta. Science 302:453-457, 2003. Erratum in Science, Nov. 14, 302:1153, 2003. PubMedAbstract.

Tsimikas, S., Lau, H.K., Han, K-R., Shortal, B., Miller, E.R., Segev, A., Curtiss, L.K., Witztum, J.L., and Strauss, B.H. Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a); Short-term and long-term immunological responses to oxidized low-density lipoprotein. Circulation, 109:3164-3170, 2004. PubMedAbstract.

Schiller, N.K., Black, A.S., Bradshaw, G.P., Bonnet, D.J., and Curtiss, L.K. Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice. J. Lipid Res., 45:1398-1409, 2004. PubMedAbstract.

Wiedmer, T., Zhao, J., Li, L., Zhou, Q., Hevener, A., Olefsky, J.M., Curtiss, L.K., and Sims, P.J. Adiposity, dyslipidemia and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3). Proc. Natl. Acad. Sci., 101:13296-13301, 2004. PubMedAbstract.

Binder, C.J., Hartvigsen, K., Chang, M.K., Miller, M., Broide, D., Palinski, W., Curtiss, L.K., Corr, M., and Witztum, J.L. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J. Clin Invest., 114:317-319, 2004. PubMedAbstract.

Schneider, M., Witztum, J. L., Young S. G., Ludwig, E. H., Miller, E., Tsimikas, S., Curtiss, L.K., Marcovina, S. M., Taylor, J. M., Lawn, R. M., Innerarity, T. L., and Pitas, R. E. High level lipoprotein (a) expression in transgenic mice: Evidence for oxidized phospholipid in lipoprotein (a) but not in low density lipoprotein. J. Lipid Res., 46:769-778, 2005. PubMedAbstract.

Tobias, P. and Curtiss, L. K. Paying the price for pathogen protection: toll receptors in atherogenesis. J. Lipid Res., 46:404-411, 2005. PubMedAbstract.

Jahangiri, A., Rader, D. J., Marchadier, D., Curtiss, L. K., Bonnet, D. J., and Rye, K-A. Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I. J. Lipid Res., 46:896-903, 2005. PubMedAbstract.

Bradshaw, G., Gutierrez, A., Miyake, J. H., Davis, K. R., Li, A. C., Glass, C. K., Curtiss, L. K., and Davis, R. A. Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice. PNAS, 102:11029-11034, 2005. PubMedAbstract.

Mullick, A. E., Tobias, P. S., and Curtiss, L. K. Modulation of atherosclerosis in mice by toll-like Receptor 2. J. Clin. Invest., 115:3149-3156, 2005. PubMedAbstract.

Curtiss, L. K., Valenta, D. T., Hime, N. J., and Rye, K-A. What is so special about apolipoprotein AI in reverse cholesterol transport? Arterioscler. Thromb. Vasc. Biol., 26:12-19, 2006. PubMedAbstract.

Tilley, R. E., Pedersen, B., Pawlinski, R., Sato, Y., Erlich, J. H., Shen, Y., Day, S., Huang, Y., Eitzmar, D. T., Boisvert, W. A., Curtiss, L.K., Fay, W. P., and Mackman, N. Atherosclerosis in mice is not affected by a reduction in tissue factor expression. Arterioscler. Thromb. Vasc. Biol., 26:555-562, 2006. PubMedAbstract.

Boisvert, W. A., Rose, D. M., Boullier, A., Quehenberger, O., Sydlaske, A., Johnson, K. A., Curtiss, L. K., and Terkeltaub, R. Leukocyte transglutaminase 2 expression limits atherosclerotic lesion size. Arterioscler. Thromb. Vasc. Biol., 26:563-569, 2006. PubMedAbstract.

Boisvert, W. A., Rose, D., Johnson, K. A., Fuentes, M. E., Lira, S. A., Curtiss, L. K., and Terkeltaub, R. A. Up-regulated expression of the CXCR2 ligand, KC/GRO-alpha, in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression. Am. J. Pathol., 168:1385-1395, 2006. PubMedAbstract.

Valenta, D. T., Ogier, N., Bradshaw, G., Black, A., Bonnet, D. J., Lagrost, L., Curtiss, L. K., and Desrumaux, C. M. Atheroprotective potential of macrophage-derived phospholipid transfer protein in low-density lipoprotein receptor-deficient mice is overcome by apoAI overexpression. Arterioscler. Thromb. Vasc. Biol., 26:1572-1578, 2006. PubMedAbstract.

Mullick, A. E., Tobias, P. S., and Curtiss, L. K. Toll-like receptors and atherosclerosis: key contributors in disease and health? Immunol. Res., 34(3):193-209, 2006. PubMedAbstract.

Valenta, D. T., Bulgrien, J. J., Banka, C. L., and Curtiss, L. K. Overexpression of human apoAI transgene provides long-term atheroprotection in LDL receptor-deficient mice. Atherosclerosis, 189:255-263, 2006. PubMedAbstract.

Curtiss, L. K. Is two out of three enough for ABCG1? Arterioscler. Thromb. Vasc. Biol., 26:2175-2177, 2006. PubMedAbstract.

Nobecourt, E., Davies, M. J., Brown, B. E., Curtiss, L. K., Bonnet, D. J., Charlton, F., Januszewski, A. S., Jenkins, A. J., Barter, P. J., and Rye, K.-A. The impact of glycation on apolipoprotein A-I structure and its ability to activate lecithin:cholesterol acyltransferase. Diabetologia, 50(3):643-653, 2007. PubMedAbstract.

Petrovan, R. J., Kaplan, C. D., Reisfeld, R. A., and Curtiss, L. K. DNA vaccination against VEGF receptor 2 reduces atherosclerosis in LDL receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol., 27(5):1095-1100, 2007. PubMedAbstract.

Tobias, P. S. and Curtiss, L. K. Toll-like receptors in atherosclerosis, Biochem. Soc. Trans., 35:1453-1455, 2007. PubMedAbstract.

Curtiss, L. K. and Tobias, P. S. The toll of toll-like receptors, especially toll-like receptor 2, on murine atherosclerosis. Current Drug Targets, 8(12):1230-1238, 2007. PubMedAbstract.

Valenta, D. T., Bulgrien, J. J., Bonnet, D. J., and Curtiss, L. K. Macrophage PLTP is atheroprotective in LDLr-/- mice with systemic PLTP deficiency. J. Lipid Res., 49(1):24-32, 2007. PubMedAbstract.

Petrovan, R. J., Yuan, Y., and Curtiss, L. K. Expression of the Lystbeige mutation is atheroprotective in chow-fed apolipoprotein E-deficient mice. J. Lipid Res., 49(2):429-437, 2008. PubMedAbstract.

Mullick, A. E., Soldau, K., Kiosses, W. B., Tobias, P. S., Bell, T. A., and Curtiss, L. K. Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events. J. Exp. Med., 205(2):373-383, 2008. PubMedAbstract.

Tobias, P. S. and Curtiss, L. K. TLR2 in murine atherosclerosis. Semin. Immunopathol., 30(1):23-27, 2008. PubMedAbstract.

Barish, G.D., Atkins, A.R., Downes, M., Olson, P., Chong, L.W., Nelson, M., Zou, Y., Hwang, H., Kang, H., Curtiss L.K., Evans, R.M., and Lee, C-H. PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis. Proc. Natl. Acad. Sci., USA, 105(11):4271-4276, 2008. PubMedAbstract.

Hime, N.J., Black, A.S., Bulgrien, J.J., and Curtiss, L.K. Deficiency of leukocyte-derived hepatic lipase in human CETP transgenic, LDL receptor knockout mice decreases plasma HDL concentrations, increases atherosclerosis and emphasizes the inverse association between plasma HDL-cholesterol concentration and disease severity. J. Lipid Res., 49(10):2113-2123, 2008. PubMedAbstract.

Gitlin, J.M., Homeister, J.W., Bulgrien, J., Counselman, J., Curtiss, L.K., Lowe, J.B., and Boisvert, W.A. Disruption of tissue-specific fucosyltransferase VII, an enzyme necessary for selectin lignad synthesis, suppresses atherosclerosis in mice. Am. J. Pathol., 174:343-350, 2009. PubMedAbstract.

Curtiss, L.K. and Tobias, P.S. Emerging role of Toll-like receptors in atherosclerosis. J. Lipid Res., S340-S345. PMCID: PMC2674724, 2009. PubMedAbstract.

Curtiss, L.K. Reversing Atherosclerosis? N. Engl. J. Med. 360(11):1144-1146, 2009.

Nobecourt, E., Tabet, F., Lambert, G., Puranik, R., Bao, S., Yan, L., Davies, M.J., Brown, B.E., Jenkins, A.J., Dusting, G.J., Bonnet, D.J., Curtiss, L.K., Barter, P.J., and Rye, K-A.  Nonenzymatic glycation impairs the anti-inflammatory properties of apolipoprotein A-I.  Arterioscler. Thromb. Vasc. Biol. 30(4):766-772, 2010. PubMedAbstract

Huang, R., Gangani, D. S., Jerome, W. G., Kontush, A., Chapman M. J., Curtiss, L. K., Hodges, T. J., and Davidson, W. S.  Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma.  Nat. Struc. Mol. Biol. 18:416-422, 2011. PubMedAbstract

Marcondes, M.C.G., Zhukov, V., Bradlow, H., Sanchez-Alavez, M., Curtiss, L.K. and Conti, B.  Effects of chronic mental stress and atherogenic diet on the immune inflammatory environment in mouse aorta.  Brain, Behav. Immun., 25:1649-1657, 2011. PubMedAbstract

Pitman, J.L., Bonnet, D.J., Curtiss, L.K. and Gekakis, N.  Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites.  J. Lipid Res., 52:1775-1786, 2011. PubMedAbstract

Owens, A. Philip, III, Howatt, Deborah A., Moore, Kathryn J., Tobias, Peter S., Curtiss, Linda K., Cassis, Lisa A. and Daugherty, Alan. MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through toll-like receptors 2 and 4.  Arterioscler. Thromb. Vasc. Biol., 31:2813-2819, 2011. PubMedAbstract

Owens III, A. P.,  Passam, F., Antoniak, S., Marshall, S. M., McDaniel, A. L., Rudel, L., Williams, J. C., Hubbard, B. K., Dutton, J-A., Wang, J., Tobias, P. S., Curtiss, L. K., Daugherty, A., Kirchhofer, D., Luyendyk, J. P., Moriarty, P. M., Nagaraja, S., Furie, B. C., Furie, B., Johns, D. G., Temel, R. E. and Mackman, N.  Simvastatin attenuates hypercholesterolemic induction of monocyte tissue factor expression and coagulation in mice and monkeys.  J. Clin. Invest., in press, 2011.

 

 

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