The Curtiss Lab
Welcome!
Occupants of the Curtiss laboratory study plasma lipoproteins, atherosclerosis and inflammation. The laboratory makes specific use of molecular biology, animal models of atherosclerosis, and plasma lipoprotein and lipid biochemistry to identify mechanisms involved in protection against atherosclerosis and cardiovascular disease. We are focusing on the influence of toll-like receptors in the chronic inflammation that exacerbates atherosclerosis induced by both endogenous and exogenous TLR agonists. Structure and function relationships of plasma apolipoprotein (apo) A-I are also being explored using monoclonal antibodies, genetic mutants of apo A-I and reconstituted populations of high density lipoproteins (HDL). These tools are used to identify how apo A-I and HDL participate in cellular cholesterol efflux.
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