2013: Ulanovskaya OA, Zuhl AM, Cravatt BF. (2013) NNMT promotes epigenetic remodeling in cancer by creating a
metabolic methylation sink.
Hulce JJ, Cognetta AB, Niphakis MJ, Tully SE, Cravatt BF. (2013) Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells.
Kinsey SG, Wise LE, Ramesh D, Abdullah R, Selley DE, Cravatt BF, Lichtman AH. (2013) Repeated Low Dose
Administration of the Monoacylglycerol Lipase Inhibitor JZL184 Retains CB1 Receptor Mediated Antinociceptive
and Gastroprotective Effects.
French JB, Zhao H, An S, Niessen S, Deng Y, Cravatt BF, Benkovic SJ. (2013) Hsp70/Hsp90 chaperone
machinery is involved in the assembly of the purinosome.
Ramesh D, Gamage TF, Vanuytsel T, Owens RA, Abdullah RA, Niphakis MJ, Shea-Donohue T, Cravatt BF, Lichtman
AH.(2013) Dual Inhibition of Endocannabinoid Catabolic Enzymes Produces Enhanced Anti-Withdrawal Effects in
Morphine-Dependent Mice.
Cao Z, Mulvihill MM, Mukhopadhyay P, Xu H, Erdélyi K, Hao E, Holovac E, Haskó G, Cravatt BF, Nomura DK,
Pacher P. (2013) Monoacylglycerol Lipase Controls Endocannabinoid and Eicosanoid Signaling and Hepatic Injury
in Mice.
Blankman JL, Long JZ, Trauger SA, Siuzdak G, Cravatt BF. (2013) ABHD12 controls brain
lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC.
2012: Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder
P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF. (2012) Selective inhibitors and tailored
activity probes for lipoprotein-associated phospholipase A(2).
Hsu KL, Tsuboi K, Adibekian A, Pugh H, Masuda K, Cravatt BF. (2012) DAGLβ inhibition perturbs a lipid network
involved in macrophage inflammatory responses.
Ramya TN, Weerapana E, Cravatt BF, Paulson JC. (2012) Glycoproteomics enabled by tagging sialic acid or
galactose terminated glycans.
Benjamin DI, Cravatt BF, Nomura DK. (2012) Global Profiling Strategies for Mapping Dysregulated Metabolic
Pathways in Cancer.
Keow JY, Pond ED, Cisar JS, Cravatt BF, Crawford BD. (2012) Activity-based labeling of matrix
metalloproteinases in living vertebrate embryos.
Palumbo-Zerr K, Horn A, Distler A, Zerr P, Dees C, Beyer C, Selvi E, Cravatt BF, Distler O, Schett G, Distler
JH. (2012) Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced
endocannabinoid-mediated activation of CB1.
Brown WH, Gillum MP, Lee HY, Camporez JP, Zhang XM, Jeong JK, Alves TC, Erion DM, Guigni BA, Kahn M, Samuel
VT, Cravatt BF, Diano S, Shulman GI. (2012) Fatty acid amide hydrolase ablation promotes ectopic lipid storage
and insulin resistance due to centrally mediated hypothyroidism.
Liu X, Dix M, Speers AE, Bachovchin DA, Zuhl AM, Cravatt BF, Kodadek TJ. (2012) Rapid Development of a
Potent Photo-triggered Inhibitor of the Serine Hydrolase RBBP9.
Di Venere A, Dainese E, Fezza F, Angelucci BC, Rosato N, Cravatt BF, Finazzi-Agrò A, Mei G, Maccarrone
M. (2012) Rat and human fatty acid amide hydrolases: Overt similarities and hidden differences.
Dix MM, Simon GM, Wang C, Okerberg E, Patricelli MP, Cravatt BF. (2012) Functional Interplay between
Caspase Cleavage and Phosphorylation Sculpts the Apoptotic Proteome.
Stock K, Kumar J, Synowitz M, Petrosino S, Imperatore R, Smith ES, Wend P, Purfürst B, Nuber UA, Gurok U,
Matyash V, Wälzlein JH, Chirasani SR, Dittmar G, Cravatt BF, Momma S, Lewin GR, Ligresti A, Petrocellis LD,
Cristino L, Marzo VD, Kettenmann H, Glass R. (2012) Neural precursor cells induce cell death of high-grade
astrocytomas through stimulation of TRPV1.
Hill MN, Kumar SA, Filipski SB, Iverson M, Stuhr KL, Keith JM, Cravatt BF, Hillard CJ, Chattarji S, McEwen
BS. (2012) Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and
amygdalar microstructure.
Ghosh S, Wise LE, Chen Y, Gujjar R, Mahadevan A, Cravatt BF, Lichtman AH. (2012) The monoacylglycerol
lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model.
Saario SM, McKinney MK, Speers AE, Wang C, Cravatt BF. (2012) Clickable, photoreactive inhibitors to probe
the active site microenvironment of fatty acid amide hydrolase.
Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T,
Fernandez-Vega V, Ferguson J, Hodder PS, Rosen H, Cravatt BF (2012) Confirming Target Engagement for
Reversible Inhibitors in Vivo by Kinetically Tuned Activity-Based Probes.
Cisar JS and Cravatt BF (2012) Fully functionalized small-molecule probes for integrated phenotypic
screening and target identification.
Blankman JL and Cravatt BF (2012) The Endocannabinoid System: From Basic Research to
Translational Opportunity
Skaddan MB, Zhang L, Johnson DS, Zhu A, Zasadny KR, Coelho RV, Kuszpit K, Currier G, Fan KH, Beck EM, Chen
L, Drozda SE, Balan G, Niphakis M, Cravatt BF, Ahn K, Bocan T, Villalobos A. (2012). The synthesis and in vivo
evaluation of [(18)F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH).
Chang JW, Niphakis MJ, Lum KM, Cognetta AB 3rd, Wang C, Matthews ML, Niessen S, Buczynski MW, Parsons LH,
Cravatt BF. (2012). Highly Selective Inhibitors of Monoacylglycerol Lipase Bearing a Reactive Group that Is
Bioisosteric with Endocannabinoid Substrates.
Dillon MB, Bachovchin DA, Brown SJ, Finn MG, Rosen H, Cravatt BF, Mowen KA. (2012). Novel Inhibitors for
PRMT1 Discovered by High-Throughput Screening Using Activity-Based Fluorescence Polarization.
Wiskerke J, Irimia C, Cravatt BF, De Vries TJ, Schoffelmeer AN, Pattij T, Parsons LH. (2012)
Characterization of the Effects of Reuptake and Hydrolysis Inhibition on Interstitial Endocannabinoid Levels
in the Brain: An in Vivo Microdialysis Study.
Bashashati M, Storr MA, Nikas SP, Wood JT, Godlewski G, Liu J, Ho W, Keenan CM, Zhang H, Alapafuja SO, Cravatt
BF, Lutz B, Mackie K, Kunos G, Patel KD, Makriyannis A, Davison JS, Sharkey KA. (2012). Inhibiting fatty acid amide
hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in the mouse.
Zuhl AM, Mohr JT, Bachovchin DA, Niessen S, Hsu KL, Berlin JM, Dochnahl M, Lopez-Alberca MP, Fu GC,
Cravatt BF. (2012). Competitive Activity-Based Protein Profiling Identifies Aza-?-Lactams as a Versatile
Chemotype for Serine Hydrolase Inhibition.
Lim SK, Park MJ, Lim JC, Kim JC, Han HJ, Kim GY, Cravatt BF, Woo CH, Ma SJ, Yoon KC, Park SH. (2011).
Hyperglycemia induces apoptosis via CB(1) activation through the decrease of FAAH 1 in retina pigment
epithelial cells.
Benito C, Tolon RM, Castillo AI, Ruiz-Valdepenas L, Martinez-Orgado JA, Fernandez-Sanchez FJ, Vazquez C,
Cravatt BF, Romero J. (2012). Beta Amyloid Exacerbates Inflammation in Astrocytes Lacking Fatty Acid Amide
Hydrolase through a Mechanism Involving Ppar-alpha, Ppar-gamma and Trpv1, But Not Cb(1) or Cb(2) Receptors.
Moellering RE, Cravatt BF. (2012). How chemoproteomics can enable drug discovery and development.
Kaschani F, Nickel S, Pandey B, Cravatt BF, Kaiser M, van der Hoorn RA. (2012). Selective inhibition of
plant serine hydrolases by agrochemicals revealed by competitive ABPP.
Wise LE, Long KA, Abdullah RA, Long JZ, Cravatt BF, Lichtman AH. (2012) Dual Fatty Acid Amide Hydrolase
and Monoacylglycerol Lipase Blockade Produces THC-Like Morris Water Maze Deficits in Mice.
Tai T, Tsuboi K, Uyama T, Masuda K, Cravatt BF, Houchi H, Ueda N. (2012) Endogenous Molecules Stimulating
N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA)
Kaczocha M, Lin Q, Nelson LD, McKinney MK, Cravatt BF, London E, Deutsch DG. (2012) Anandamide Externally
Added to Lipid Vesicles Containing-Trapped Fatty Acid Amide Hydrolase (FAAH) Is Readily Hydrolyzed in a
Sterol-Modulated Fashion.
Yu PT, Babicky M, Jaquish D, French R, Marayuma K, Mose E, Niessen S, Hoover H, Shields D, Cheresh D,
Cravatt BF, Lowy AM. (2012). The RON-Receptor regulates pancreatic cancer cell migration through
phosphorylation-dependent breakdown of the hemidesmosome.
Bachovchin DA, Cravatt BF. (2012). The pharmacological landscape and therapeutic potential of serine hydrolases.
Seeliger JC, Holsclaw CM, Schelle MW, Botyanszki Z, Gilmore SA, Tully SE, Niederweis M, Cravatt BF, Leary
JA, Bertozzi CR. (2012). Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis.
Chang JW, Moellering RE, Cravatt BF. (2012). An Activity-Based Imaging Probe for the Integral Membrane Hydrolase KIAA1363.
Rothmann M, Niessen S, Haushalter RW, Cravatt BF, Burkart MD. (2012). Resin-based investigation of acyl
carrier protein interaction networks in Escherichia coli.
2011: Rowland MM, Bostic HE, Gong D, Speers AE, Lucas N, Cho W, Cravatt BF, Best
MD. (2011). Phosphatidylinositol (3,4,5)-Trisphosphate Activity Probes for the Labeling
and Proteomic Characterization of Protein Binding Partners.
Li Y, Martin BR, Cravatt BF, Hofmann SL. (2011). DHHC5 palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured
cells.
Martin BR, Wang C, Adibekian A, Tully SE, Cravatt BF. (2011). Global profiling of dynamic protein palmitoylation.
Niphakis MJ, Johnson DS, Ballard TE, Stiff C, Cravatt BF (2011). O-Hydroxyacetamide Carbamates as a Highly
Potent and Selective Class of Endocannabinoid Hydrolase Inhibitors
Nomura DK, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Lichtman AH, Conti B,
Cravatt BF. (2011). Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation.
Pan B, Wang W, Zhong P, Blankman JL, Cravatt BF, Liu QS. (2011).Alterations of Endocannabinoid Signaling,
Synaptic Plasticity, Learning, and Memory in Monoacylglycerol Lipase Knock-out Mice.
Long JZ, Cisar JS, Milliken D, Niessen S, Wang C, Trauger SA, Siuzdak G, Cravatt BF. (2011). Metabolomics
annotates ABHD3 as a physiologic regulator of medium-chain phospholipids.
Zhong P, Pan B, Gao XP, Blankman JL, Cravatt BF, Liu QS. (2011). Genetic deletion of monoacylglycerol
lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum.
Tsuboi K, Bachovchin DA, Speers AE, Spicer TP, Fernandez-Vega V, Hodder P, Rosen H, Cravatt BF. (2011). Potent
and Selective Inhibitors of Glutathione S-transferase Omega 1 that Impair Cancer Drug Resistance.
Nomura DK, Lombardi DP, Chang JW, Niessen S, Ward AM, Long JZ, Hoover HH, Cravatt BF. (2011).
Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer.
Kaschani F, Nickel S, Pandey B, Cravatt BF, Kaiser M, van der Hoorn RA. (2012). Selective inhibition of
plant serine hydrolases by agrochemicals revealed by competitive ABPP.
Kinsey SG, Naidu PS, Cravatt BF, Dudley DT, Lichtman AH. (2011). Fatty acid amide hydrolase blockade
attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.
Ramesh D, Ross G, Schlosburg J, Owens RA, Abdullah R, Kinsey SG, Long J, Nomura D, Sim-Selley L, Cravatt
BF, Akbarali H, Lichtman AH. (2011). Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated
opioid withdrawal symptoms in mice.
Long JZ, Cravatt BF. (2011). The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease.
Lone AM, Bachovchin DA, Westwood D, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder P, Rosen H,
Cravatt BF, Saghatelian A. (2011). A substrate-free activity-based protein profiling screen for the discovery
of selective PREPL inhibitors.
Johnson DS, Stiff C, Lazerwith SE, Kesten SR, Fay LK, Morris M, Beidler D, Liimatta MB, Smith SE, Dudley
DT, Sadagopan N, Bhattachar SN, Kesten SJ, Nomanbhoy TK, Cravatt BF, Ahn K. (2011).
Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.
Hall CI, Reese ML, Weerapana E, Child MA, Bowyer PW, Albrow VE, Haraldsen JD, Phillips MR, Sandoval ED,
Ward GE, Cravatt BF, Boothroyd JC, Bogyo M. (2011).
Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and
invasion.
Kinsey SG, Nomura DK, O'Neal ST, Long JZ, Mahadevan A, Cravatt BF, Grider JR, Lichtman AH. (2011).
Inhibition of monoacylglycerol lipase (MAGL) attenuates NSAID-induced gastric hemorrhages in mice.
Bachovchin DA, Zuhl AM, Speers AE, Wolfe MR, Weerapana E, Brown SJ, Rosen H, Cravatt BF. (2011).
Discovery and Optimization of Sulfonyl Acrylonitriles as Selective, Covalent Inhibitors of Protein Phosphatase
Methylesterase-1.
Adibekian A, Martin BR, Wang C, Hsu KL, Bachovchin DA, Niessen S, Hoover H, Cravatt BF. (2011).
Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors.
Straiker A, Wager-Miller J, Hu S, Blankman J, Cravatt B, Mackie K. (2011).
COX-2 and FAAH can regulate the time course of depolarization induced suppression of excitation.
Chang JW, Nomura DK, Cravatt BF. (2011).
A Potent and Selective Inhibitor of KIAA1363/AADACL1 that Impairs Prostate Cancer Pathogenesis.
Booker L, Kinsey SG, Abdullah RA, Blankman JL, Long JZ, Ezzili C, Boger DL, Cravatt BF, Lichtman AH. (2011).
The FAAH Inhibitor PF-3845 Acts in the Nervous System to Reverse Lipopolysaccharide-induced Tactile Allodynia in Mice.
Ahn K, Smith SE, Liimatta MB, Beidler D, Sadagopan N, Dudley DT, Young T, Wren P, Zhang Y, Swaney S, Van
Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stiff C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt
BF. (2011).Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective FAAH
inhibitor that reduces inflammatory and noninflammatory pain.
Rossi S, Furlan R, Chiara VD, Muzio L, Musella A, Motta C, Studer V, Cavasinni F, Bernardi G, Martino G,
Cravatt BF, Lutz B, Maccarrone M, Centonze D. (2011).
Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis.
Sticht MA, Long JZ, Rock EM, Limebeer CL, Mechoulam R, Cravatt BF, Parker LA. (2011).
The MAGL inhibitor, JZL184, attenuates LiCl-induced vomiting in the Suncus murinus and 2AG attenuates
LiCl-induced nausea-like behavior in rats.
Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt
BF, Bilsky EJ, Boger DL. (2011).
Reversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional
Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting Analgesics.
Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS,
Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF. (2011).Academic cross-fertilization by
public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
Mukhopadhyay B, Cinar R, Yin S, Liu J, Tam J, Godlewski G, Harvey-White J, Mordi I, Cravatt BF,
Lotersztajn S, Gao B, Yuan Q, Schuebel K, Goldman D, Kunos G. (2011).
Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1)
receptors in the regenerating liver.
Mileni M, Garfunkle J, Ezzili C, Cravatt BF, Stevens RC, Boger DL. (2011).
Fluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray
Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide
Hydrolase.
Nicolaou KC, Sanchini S, Sarlah D, Lu G, Wu TR, Nomura DK, Cravatt BF, Cubitt B, de la Torre JC, Hessell
AJ, Burton DR. (2011).
Organic Synthesis toward Small-Molecule Probes and Drugs Special Feature: Design, synthesis, and biological
evaluation of a biyouyanagin compound library.
Meier JL, Patel A, Niessen S, Meehan MJ, Kersten R, Yang J, Rothmann M, Cravatt BF, Dorrestein PC,
Burkart MD, Bafna V. (2011). Practical 4'-Phosphopantetheine Active Site Discovery from Proteomic Samples.
Mukhopadhyay P, Horváth B, Rajesh M, Matsumoto S, Saito K, Bátkai S, Patel V, Tanchian G, Gao RY, Cravatt
BF, Haskó G, Pacher P. (2011).
Fatty acid amide hydrolase is a key regulator of the endocannabinoid-induced myocardial tissue injury.
Long JZ, La Cava M, Jin X, Cravatt BF. (2011).
An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase.
Kinsey SG, O'Neal ST, Long JZ, Cravatt BF, Lichtman AH. (2011).
Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.
2010:Godlewski G, Alapafuja SO, Batkai S, Nikas SP, Cinar R, Offertaler L, Osei-Hyiaman D, Liu J, Mukhopadhyay
B,Harvey-White J, Tam J, Pacak K, Blankman JL, Cravatt BF, Makriyannis A, Kunos G. (2010)
Inhibitor of Fatty Acid Amide Hydrolase Normalizes Cardiovascular Function in Hypertension without Adverse
Metabolic Effects.
Weerapana E, Wang C, Simon GM, Richter F, Khare S, Dillon MB, Bachovchin DA, Mowen K, Baker D, Cravatt
BF. (2010) Quantitative reactivity profiling predicts functional cysteines in proteomes.
Bachovchin DA, Ji T, Li W, Simon GM, Blankman JL, Adibekian A, Hoover H, Niessen S, Cravatt BF. (2010)
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening.
Lichtman AH, Blankman JL, Cravatt BF. (2010) Endocannabinoid overload.
Bowyer PW, Simon GM, Cravatt BF, Bogyo M. (2010)
Global profiling of proteolysis during rupture of P. falciparum from the host erythrocyte.
Speers AE, Cravatt BF. (2010)
Ligands in crystal structures that aid in functional characterization.
Gaultier A, Simon G, Niessen S, Dix MM, Takimoto S, Cravatt BF, Gonias SL. (2010)
LDL Receptor-related Protein 1 Regulates the Abundance of Diverse Cell-signaling Proteins in the Plasma
Membrane Proteome.
Wurdak H, Zhu S, Min KH, Aimone L, Lairson LL, Watson J, Chopiuk G, Demas J, Charette B, Weerapana E,
Cravatt BF, Cline HT, Peters EC, Zhang J, Walker JR, Wu C, Chang J, Tuntland T, Cho CY, Schultz PG. (2010)
A small molecule accelerates neuronal differentiation in the adult rat.
Kopp F, Komatsu T, Nomura DK, Trauger SA, Thomas JR, Siuzdak G, Simon GM, Cravatt BF.(2010)
The Glycerophospho Metabolome and Its Influence on Amino Acid Homeostasis Revealed by Brain Metabolomics of
GDE1(-/-) Mice.
Knuckley B, Jones JE, Bachovchin DA, Slack J, Causey CP, Brown SJ, Rosen H, Cravatt BF, Thompson PR.(2010)
A fluopol-ABPP HTS assay to identify PAD inhibitors.
Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston
JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, Cravatt BF. (2010)
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system.
Nomura DK, Dix MM, Cravatt BF. (2010)
Activity-based protein profiling for biochemical pathway discovery in cancer.
Marrs WR, Blankman JL, Horne EA, Thomazeau A, Lin YH, Coy J, Bodor AL, Muccioli GG, Hu SS, Woodruff G,
FungS, Lafourcade M, Alexander JP, Long JZ, Li W, Xu C, Möller T, Mackie K, Manzoni OJ, Cravatt BF, Stella
N. (2010) The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors.
Shu-Jung Hu S, Arnold A, Hutchens JM, Radicke J, Cravatt BF, Wager-Miller J, Mackie K, Straiker A. (2010)
Architecture of cannabinoid signaling in mouse retina.
Steen PW, Tian S, Tully SE, Cravatt BF, Lemosy EK. (2010)
Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and
pipe-independent in Drosophila embryos.
Johnson DS, Weerapana E, Cravatt BF. (2010)
Strategies for discovering and derisking covalent, irreversibleenzyme inhibitors.
Buchebner M, Pfeifer T, Rathke N, Chandak PG, Lass A, Schreiber R, Kratzer A, Zimmermann R, Sattler W,
Koefeler H, Froehlich E, Kostner GM, Birner-Gruenberger R, Chiang KP, Haemmerle G, Zechner R, Levak-Frank S,
Cravatt BF, Kratky D. (2010)
Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking
KIAA1363.
Thors L, Burston JJ, Alter BJ, McKinney MK, Cravatt BF, Ross RA, Pertwee RG, Gereau RW 4th, Wiley JL,
Fowler CJ. (2010)
Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase.
Cravatt BF, Kodadek T. (2010)
The interface of chemical biology and the nervous system (related to the NIDA Chemical Genomics Symposium).
Kinsey SG, Long JZ, Cravatt BF, Lichtman AH. (2010)
Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Inhibitors Produce Anti-Allodynic Effects in Mice
Through Distinct Cannabinoid Receptor Mechanisms.
Mileni M, Kamtekar S, Wood DC, Benson TE, Cravatt BF, Stevens RC. (2010) Crystal structure of fatty acid
amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and
insight into enzyme inactivation.
Freigang S, Zadorozhny V, McKinney MK, Krebs P, Herro R, Pawlak J, Kain L, Schrantz N, Masuda K, Liu Y,
Savage PB, Bendelac A, Cravatt BF, Teyton L. (2010)
Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in
mice.
Rossi S, De Chiara V, Musella A, Sacchetti L, Cantarella C, Castelli M, Cavasinni F, Motta C, Studer V,
Bernardi G, Cravatt BF, Maccarrone M, Usiello A, Centonze D. (2010)
Preservation of striatal cannabinoid CB1 receptor function correlates with the anti-anxiety effects of FAAH
inhibition.
Simon GM, Cravatt BF. (2010)
Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for
multiple pathways that contribute to endocannabinoid production in vivo.
Pattipati SN, Kinsey SG, Guo T, Cravatt BF, Lichtman AH. (2010)
Regulation of Inflammatory Pain by Inhibition of Fatty Acid Amide Hydrolase (FAAH).
Falenski KW, Thorpe AJ, Schlosburg JE, Cravatt BF, Abdullah RA, Smith TH, Selley DE, Lichtman AH,
Sim-Selley LJ. (2010)
FAAH(-/-) Mice Display Differential Tolerance, Dependence, and Cannabinoid Receptor Adaptation After
Delta(9)-Tetrahydrocannabinol and Anandamide Administration.
Bachovchin DA, Wolfe MR, Masuda K, Brown SJ, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H,
Cravatt BF. (2010)
Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9
(RBBP9).
Tully SE, Cravatt BF. (2010)
Activity-Based Probes That Target Functional Subclasses of Phospholipases in Proteomes.
Ramya TN, Weerapana E, Liao L, Zeng Y, Tateno H, Liao L, Yates JR 3rd, Cravatt BF, Paulson JC. (2010)
In situ trans ligands of CD22 identified by glycan-protein photo-cross-linking enabled proteomics.
Gottesfeld JM, Cravatt BF. (2010)
Introduction to Minireview Series Chemical Biology Meets Biological Chemistry.
Simon GM, Cravatt BF. (2010)
Activity-based proteomics of enzyme superfamilies -- serine hydrolases as a case study.
Long JZ, Jin X, Adibekian A, Li W, Cravatt BF. (2010)
Characterization of Tunable Piperidine and Piperazine Carbamates as Inhibitors of Endocannabinoid Hydrolases.
Sipe JC, Scott TM, Murray S, Harismendy O, Simon GM, Cravatt BF, Waalen J. (2010)
Biomarkers of endocannabinoid system activation in severe obesity.
Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier JS, Lau SK, Barnes LA, Lesperance J, Bouvet M,
Tarin D, Cravatt BF, Cheresh DA. (2010)
RBBP9: A tumor-associated serine hydrolase activity required for pancreatic neoplasia.
Nomura DK, Long JZ, Niessen S, Hoover HS, Ng S, Cravatt BF. (2010)
Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis.
2009:Ahn K, Johnson DS, Cravatt BF. (2009)
Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders.
Mileni M, Garfunkle J, Ezzili C, Kimball FS, Cravatt BF, Stevens RC, Boger DL. (2009)
X-ray Crystallographic Analysis of alpha-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty
AcidAmide Hydrolase.
Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley
JL, Cravatt BF. (2009)
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.
Hu SS, Bradshaw HB, Benton VM, Chen JS, Huang SM, Minassi A, Bisogno T, Masuda K, Tan B, Roskoski R Jr, Cravatt BF, Di Marzo V, Walker JM. (2009)
The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via
conjugation of arachidonic acid with dopamine. Meier J, Niessen S, Hoover H, Foley TL, Cravatt BF, Burkart MD. (2009) An orthogonal active site
identification system (OASIS) for proteomic profiling of natural product biosynthesis.
Sabido E, Tarrago T, Niessen S, Cravatt BF, Giralt E. (2009)
Activity-Based Probes for Monitoring Postproline Protease Activity. Straiker A, Hu SS, Long J, Arnold A, Wager-Miller J, Cravatt BF, Mackie K. (2009)
Monoacyl glycerol lipase (MGL) limits the duration of endocannabinoid-mediated depolarization-induced
suppression of excitation (DSE) in autaptic hippocampal neurons.
Kinsey SG, Long JZ, O'Neal ST, Abdullah RA, Poklis JL, Boger DL, Cravatt BF, Lichtman AH. (2009)
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.
Pan B, Wang W, Long J, Sun D, Hillard CJ, Cravatt BF, Liu QS. (2009)
Blockade of 2-AG hydrolysis by selective monoacylglycerol lipase inhibitor JZL184 enhances retrograde
endocannabinoid signaling.
Mileni M, Garfunkle J, DeMartino JK, Cravatt BF, Boger DL, Stevens RC. (2009)
Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by alpha-Ketoheterocycle
Inhibitors Revealed from Cocrystal Structures.
Wright AT, Song JD, Cravatt BF. (2009)
A Suite of Activity-Based Probes for Human Cytochrome P450 Enzymes.
Long JZ, Nomura DK, Cravatt BF. (2009)
Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral
endocannabinoid metabolism.
Simon GM, Dix MM, Cravatt BF. (2009)
Comparative Assessment of Large-Scale Proteomic Studies of Apoptotic Proteolysis.
Schlosburg JE, Carlson BL, Ramesh D, Abdullah RA, Long JZ, Cravatt BF, Lichtman AH. (2009)
Inhibitors of Endocannabinoid-Metabolizing Enzymes Reduce Precipitated Withdrawal Responses in THC-Dependent
Mice.
Bradshaw HB, Rimmerman N, Hu SS, Benton VM, Stuart JM, Masuda K, Cravatt BF, O'Dell DK, Walker JM. (2009)
The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonyl glycine through two
distinct pathways.
Johnson DS, Ahn K, Kesten S, Lazerwith SE, Song Y, Morris M, Fay L, Gregory T, Stiff C, Dunbar JB Jr,
Liimatta M, Beidler D, Smith S, Nomanbhoy TK, Cravatt BF. (2009)
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).
Kaschani F, Gu C, Niessen S, Hoover H, Cravatt BF, Van der Hoorn RA. (2009)
Diversity of serine hydrolase activities of unchallenged and Botrytis-infected Arabidopsis thaliana.
Ahn K, Johnson DS, Mileni M, Beidler D, Long JZ, McKinney MK, Weerapana E, Sadagopan N, Liimatta M, Smith
SE, Lazerwith S, Stiff C, Kamtekar S, Bhattacharya K, Zhang Y, Swaney S, Van Becelaere K, Stevens RC,
Cravatt BF. (2009)
Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory
Pain.
Schlosburg JE, Boger DL, Cravatt BF, Lichtman AH. (2009)
Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural
therapeutic target for pruritus.
Naidu PS, Booker L, Cravatt BF, Lichtman AH. (2009)
Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception.
Bachovchin DA, Brown SJ, Rosen H, Cravatt BF. (2009)
Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with
fluorescent activity-based probes.
Lever IJ, Robinson M, Cibelli M, Paule C, Santha P, Yee L, Hunt SP, Cravatt BF, Elphick MR, Nagy I, Rice
AS. (2009)
Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion
cells and its regulation after peripheral nerve injury.
Sun X, Wang H, Okabe M, Mackie K, Kingsley PJ, Marnett LJ, Cravatt BF, Dey SK. (2009)
Genetic loss of Faah compromises male fertility in mice.
Nakai R, Salisbury CM, Rosen H, Cravatt BF. (2009)
Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case
study.
Martin BR, Cravatt BF. (2009)
Large-scale profiling of protein palmitoylation in mammalian cells.
Long JZ, Li W, Booker L, Burston JJ, Kinsey SH, Schlosburg JE, Pavon FJ, Serrano AM, Selley DE, Parsons
LH, Lichtman AH, Cravatt BF. (2009)
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects.
2008:Barglow KT, Saikatendu KS, Bracey MH, Huey R, Morris GM, Olson AJ, Stevens RC, Cravatt BF. (2008)
Functional proteomic and structural insights into molecular recognition in the nitrilase family
enzymes. Cravatt BF. (2008)
Tetrahedron Young Investigator Award 2008. Hoover HS, Blankman JL, Niessen S, Cravatt BF. (2008)
Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein
profiling.
Slaymaker IM, Bracey M, Mileni M, Garfunkle J, Cravatt BF, Boger DL, Stevens RC. (2008)
Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein
fatty acid amide hydrolase.
Demartino JK, Garfunkle J, Hochstatter DG, Cravatt BF, Boger DL. (2008)
Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and
selective inhibitors of fatty acid amide hydrolase.
Simon GM, Cravatt BF.(2008)
Challenges for the 'chemical-systems' biologist.
Conn EM, Madsen MA, Cravatt BF, Ruf W, Deryugina EI, Quigley JP. (2008)
Cell surface proteomics identifies molecules functionally linked to tumor cell intravasation.
Mileni M, Johnson DS, Wang Z, Everdeen DS, Liimatta M, Pabst B, Bhattacharya K, Nugent RA, Kamtekar S,
Cravatt BF, Ahn K, Stevens RC. (2008)
Structure-guided inhibitor design for human FAAH by interspecies active site conversion.
Dix MM, Simon GM, Cravatt BF. (2008)
Global mapping of the topography and magnitude of proteolytic events in
apoptosis.
Suarez J, Bermudez-Silva FJ, Mackie K, Ledent C, Zimmer A, Cravatt BF, de Fonseca FR. (2008)
Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally
related nuclei.
Ortega-Gutierez S, Leung D, Ficarro S, Peters EC, Cravatt BF. (2008)
Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in
mice.
Rimmerman N, Bradshaw HB, Hughes HV, Chen JS, Hu SS, McHugh D, Vefring E, Jahnsen JA, Thompson EL, Masuda
K, Cravatt BF, Burstein S, Vasko MR, Prieto AL, O'Dell DK, Walker JM. (2008)
N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide
production in sensory neurons.
Hegde VL, Hegde S, Cravatt BF, Hofseth LJ, Nagarkatti M, Nagarkatti PS. (2008)
Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of
regulatory T cells.
Wang P, Shim E, Cravatt BF, Jacobsen R, Schoeniger J, Kim AC, Paetzel M, Dalbey RE. (2008)
Escherichia coli signal peptide peptidase A is a serine-lysine protease with a lysine recruited to the
nonconserved amino-terminal domain in the S49 protease family.
Gaultier A, Arandjelovic S, Niessen S, Overton CD, Linton MF, Fazio S, Campana WM, Cravatt BF 3rd, Gonias
SL. (2008)
Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein
explains the antiinflammatory activity of this receptor.
Nomura DK, Blankman JL, Simon GM, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE. (2008)
Activation of the endocannabinoid system by organophosphorus nerve agents.
Ahn K, McKinney MK, Cravatt BF. (2008)
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system.
Simon GM, Cravatt BF. (2008)
Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl
ethanolamine precursors in mouse brain.
Nomura DK, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE. (2008)
Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate
detoxification.
Turman MV, Kingsley PJ, Rouzer CA, Cravatt BF, Marnett LJ. (2008)
Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid,
arachidonoyltaurine. Salisbury CM, Cravatt BF. (2008)
Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes.
Egertova M, Simon GM, Cravatt BF, Elphick MR. (2008)
Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD)
expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules.
Maccarrone M, Rossi S, Bari M, De Chiara V, Fezza F, Musella A, Gasperi V, Prosperetti C, Bernardi G,
Finazzi-Agro A, Cravatt BF, Centonze D. (2008)
Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum.
Nyilas R, Dudok B, Urban GM, Mackie K, Watanabe M, Cravatt BF, Freund TF, Katona I. (2008)
Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon
terminals.
Cravatt BF, Wright AT, Kozarich JW. (2008)
Activity-based protein profiling: from enzyme chemistry to proteomic chemistry.
Wise LE, Cannavacciulo R, Cravatt BF, Martin BF, Lichtman AH. (2008)
valuation of fatty acid amides in the carrageenan-induced paw edema model.
Cravatt BF, Simon GM, Yates JR 3rd (2007)
The biological impact of mass-spectrometry-based proteomics.
Chamero P, Marton TF, Logan DW, Flanagan K, Cruz JR, Saghatelian A, Cravatt BF, Stowers L. (2007)
Identification of protein pheromones that promote aggressive behaviour.
Carlson EE, Cravatt BF. (2007)
Enrichment tags for enhanced-resolution profiling of the polar metabolome.
Ahn K, Johnson DS, Fitzgerald LR, Liimatta M, Arendse A, Stevenson T, Lund ET, Nugent RA, Nomanbhoy TK,
Alexander JP, Cravatt BF. (2007)
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.
List K, Currie B, Scharschmidt TC, Szabo R, Shireman J, Molinolo A, Cravatt BF, Segre J, Bugge TH. (2007)
Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is
phenocopied in ST14 hypomorphic mice.
Barglow KT, Cravatt BF. (2007)
Activity-based protein profiling for the functional annotation of enzymes.
Wright AT, Cravatt BF. (2007)
Chemical proteomic probes for profiling cytochrome P450 activities and drug interactions in vivo.
Wan Y, Saghatelian A, Chong LW, Zhang CL, Cravatt BF, Evans RM. (2007)
Maternal PPAR-gamma protects nursing neonates by suppressing the production of inflammatory milk.
Li W, Blankman JL, Cravatt BF. (2007)
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases.
Everley PA, Gartner CA, Haas W, Saghatelian A, Elias JE, Cravatt BF, Zetter BR, Gygi SP. (2007)
Assessing enzyme activities using stable isotope labeling and mass spectrometry.
Evans MJ, Morris GM, Wu J, Olson AJ, Sorensen EJ, Cravatt BF. (2007)
Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides.
Hardouin C, Kelso MJ, Romero FA, Rayl TJ, Leung D, Hwang I, Cravatt BF, Boger DL. (2007)
Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.
Weerapana E, Speers AE, Cravatt BF. (2007)
Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)-a general method for mapping sites
of probe modification in proteomes.
Hanson SR, Hsu TL, Weerapana E, Kishikawa K, Simon GM, Cravatt BF, Wong CH. (2007)
Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes.
Batkai S, Rajesh M, Mukhopadhyay P, Hasko G, Liaudet L, Cravatt BF, Csiszar A, Ungvari ZI, Pacher
P. (2007) Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene
expressionand apoptosis in mice lacking fatty acid amide hydrolase.
Carlson EE, Cravatt BF (2007)
Chemoselective probes for metabolite enrichment and profiling.
Romero FA, Du W, Hwang I, Rayl TJ, Kimball FS, Leung D, Hoover HS, Apodaca RL, Breitenbucher JG, Cravatt
BF, Boger DL. (2007) Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and
oleamide catabolizing enzyme, fatty acid amide hydrolase.
Naidu PS, Varvel SA, Ahn K, Cravatt BF, Martin BR, Lichtman AH. (2007) Evaluation of fatty acid amide
hydrolase inhibition in murine models of emotionality.
Wang H, Xie H, Sun X, Kingsley PJ, Marnett LJ, Cravatt BF, Dey SK. (2007) Differential regulation of
endocannabinoid synthesis and degradation in the uterus during embryo implantation.
Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF, Patapoutian A. (2007) Noxious compounds
activate TRPA1 ion channels through covalent modification of cysteines.
Salisbury CM, Cravatt BF. (2007) Activity-based probes for proteomic profiling of histone deacetylase
complexes.
Bogyo M, Cravatt BF. (2007) Genomics and proteomics - From genes to function: advances in applications of
chemical and systems biology.
Blednov YA, Cravatt BF, Boehm SL 2nd, Walker D, Harris RA. (2007) Role of endocannabinoids in alcohol
consumption and intoxication: Studies of mice lacking fatty acid amide hydrolase.
2006: Wise LE, Shelton CC, Cravatt BF, Martin BR, Lichtman AH. (2006) Assessment of anandamide's
pharmacologicaleffects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB(1) receptors.
Mei G, Di Venere A, Gasperi V, Nicolai E, Masuda KR, Finazzi-Agro' A, Cravatt BF, Maccarrone M. (2006)
Closing the gate to the active site: Effect of the inhibitor MAFP on the conformation and membrane binding of
fatty acid amide hydrolase.
Fu J, Astarita G, Gaetani S, Kim J, Cravatt BF, Mackie K, Piomelli D. (2006) Food intake regulates
oleoylethanolamide formation and degradation in the proximal small intestine.
Varvel SA, Wise LE, Niyuhire F, Cravatt BF, Lichtman AH. (2007) Inhibition of fatty-acid amide hydrolase
accelerates acquisition and extinction rates in a spatial memory task.
Barglow KT, Cravatt BF. (2006) Substrate mimicry in an activity-based probe that targets the nitrilase
family of enzymes.
Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF. (2006) A second fatty acid amide hydrolase with
variable distribution among placental mammals.
Mulder AM, Cravatt BF. (2006) Endocannabinoid metabolism in the absence of fatty acid amide hydrolase
(FAAH): Discovery of phosphorylcholine derivatives of N-acyl ethanolamines.
Nomura DK, Durkin KA, Chiang KP, Quistad GB, Cravatt BF, Casida JE. (2006) Serine hydrolase KIAA1363:
Toxicological and structural features with emphasis on organophosphate interactions.
Evans MJ, Cravatt BF. (2006) Mechanism-based profiling of enzyme families.
Wang H, Xie H, Guo Y, Zhang H, Takahashi T, Kingsley PJ, Marnett LJ, Das SK, Cravatt BF, Dey SK. (2006)
Fatty acid amide hydrolase deficiency limits early pregnancy events.
Alexander JP, Cravatt BF. (2006) The putative endocannabinoid transport blocker LY2183240 is a potent
inhibitor of FAAH and several other brain serine hydrolases.
McKinney MK, Cravatt BF. (2006) Structure-based design of a FAAH variant that discriminates between the
N-acyl ethanolamine and taurine families of signaling lipids.
Saghatelian A, McKinney MK, Bandell M, Patapoutian A, Cravatt BF. (2006) A FAAH-regulated class of N-acyl
taurines that activates TRP ion channels.
Simon GM, Cravatt BF. (2006) Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl
ethanolamine and a role for alpha/beta hydrolase 4 in this pathway.
Safo PK, Cravatt BF, Regehr WG. (2006) Retrograde endocannabinoid signaling in the cerebellar cortex.
Sieber SA, Cravatt BF. (2006) Analytical platforms for activity-based protein profiling - exploiting the
versatility of chemistry for functional proteomics.
Madsen MA, Deryugina EI, Niessen S, Cravatt BF, Quigley JP. (2006) Activity based protein profiling
implicates urokinase (uPA) activation as a key step in human fibrosarcoma intravasation.
Leung D, Saghatelian A, Simon GM, Cravatt BF. (2006) Inactivation of N-acyl phosphatidylethanolamine
phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids.
Sieber SA, Niessen S, Hoover HS, Cravatt BF. (2006) Proteomic profiling of metalloprotease activities
withcocktails of active-site probes.
Balakrishnan A, Patel B, Sieber SA, Chen D, Pachikara N, Zhong G, Cravatt BF, Fan H. (2006)
Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia
trachomatis by targeting peptide deformylase of the bacterium.
Milner JM, Kevorkian L, Young DA, Jones D, Wait R, Donell ST, Barksby E, Patterson AM, Middleton J,
Cravatt BF, Clark IM, Rowan AD, Cawston TE. (2006) Fibroblast activation protein alpha is expressed by
chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis.
Basavarajappa BS, Yalamanchili R, Cravatt BF, Cooper TB, Hungund BL. (2006) Increased ethanol consumption
and preference and decreased ethanol sensitivity in female FAAH knockout mice.
Siegmund SV, Seki E, Osawa Y, Uchinami H, Cravatt BF, Schwabe RF. (2006)
Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. 2005: Saghatelian A, Cravatt BF. (2005) Assignment of protein function in the postgenomic era.
Varvel SA, Cravatt BF, Engram AE, Lichtman AH. (2005) FAAH (-/-) mice exhibit an increased sensitivity to
the disruptive effects of anandamide or oleamide in a working memory water maze task.
Want EJ, Cravatt BF, Siuzdak G. (2005) The expanding role of mass spectrometry in metabolite profiling
and characterization.
Evans MJ, Saghatelian A, Sorensen EJ, Cravatt BF (2005) Target discovery in small-molecule cell-based
screens by in situ proteome reactivity profiling.
Cravatt BF. (2005) Live chemical reports from the cell surface.
Drahl C, Cravatt BF, Sorensen EJ. (2005) Protein-reactive natural products.
Osei-Hyiaman D, Depetrillo M, Harvey-White J, Bannon AW, Cravatt BF, Kuhar MJ, Mackie K, Palkovits M,
Kunos G. (2005) Cocaine- and amphetamine-related transcript peptide is involved in the orexigenic effect of
endogenous anandamide.
Jessani N, Niessen S, Wei BQ, Nicolau M, Humphrey M, Ji Y, Han W, Noh DY, Yates JR 3rd, Jeffrey SS,
CravattBF. (2005) A streamlined platform for high-content functional proteomics of primary human specimens.
Speers AE, Cravatt BF. (2005) A tandem orthogonal proteolysis strategy for high-content chemical
proteomics.
Hogestatt ED, Jonsson BA, Ermund A, Andersson DA, Bjork H, Alexander JP, Cravatt BF, Basbaum AI, Zygmunt
PM. (2005) Conversion of acetaminophen to the bioactive N-acyl phenolamine AM404 via fatty acid amide
hydrolase-dependent arachidonic acid conjugation in the nervous system.
Saghatelian A, Cravatt BF. (2005) Discovery metabolite profiling - forging functional connections between
the proteome and metabolome.
Cravatt BF (2005) Kinase chemical genomics--a new rule for the exceptions.
Lichtman AH, Cravatt BF. (2005) Food for thought: endocannabinoid modulation of lipogenesis.
Nomura DK, Leung D, Chiang KP, Quistad GB, Cravatt BF, Casida JE. (2005) A brain detoxifying enzyme for
organophosphorus nerve poisons.
Pacher P, Batkai S, Osei-Hyiaman D, Offertaler L, Liu J, Harvey-White J, Brassai A, Jarai Z, Cravatt BF,
Kunos G. (2005) Hemodynamic profile, responsiveness to anandamide and baroreflex sensitivity of mice lacking
fatty acide amide hydrolase.
Go EP, Apon JV, Luo G, Saghatelian A, Daniels RH, Sahi V, Dubrow R, Cravatt BF, Vertes A, Siuzdak
G. (2005)Desorption/ionization on silicon nanowires.
Jessani N, Young JA, Diaz SL, Patricelli MP, Varki A, Cravatt BF. (2005)
Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling. Boger DL, Miyauchi H, Du W, Hardouin C, Fecik RA, Cheng H, Hwang I, Hedrick MP, Leung D, Acevedo O,
Guimaraes CRW, Jorgensen WL, CravattBF. (2005) Discovery of a potent, selective, and efficacious class of
reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.
McKinney MK, Cravatt BF. (2005) Structure and function of fatty acid amide hydrolase.
Patel S, Cravatt BF, Hillard CJ. (2005) Synergistic interactions between cannabinoids and environmental
stress in the activation of the central amygdala.
Leung D, Du W, Hardouin C, Cheng H, Hwang I, Cravatt BF, Boger DL. (2005) Discovery of an exceptionally
potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity
screening: concurrent optimization of enzyme inhibitor potency and selectivity.
Saghatelian A, Cravatt BF. (2005) Global strategies to integrate the proteome and metabolome.
Cravatt BF, Kodadek T. (2005) Proteomics and genomics.
Jessani N, Niessen S, Mueller BM, Cravatt BF. (2005) Breast cancer cell lines grown in vivo: what goes in
isn't always the same as what comes out.
Patel S, Carrier EJ, Ho WS, Rademacher DJ, Cunningham S, Reddy DS, Falck JR, Cravatt BF, Hillard
CJ. (2005) The post-mortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon
fatty acid amide hydrolase activity.
2004: Sieber SA, Mondala TS, Head SR, Cravatt BF. (2004) Microarray platform for profiling enzyme activities in
complex proteomes.
Barglow KT, Cravatt BF. (2004) Discovering disease-associated enzymes by proteome reactivity profiling.
Saghatelian A, Trauger SA, Want EJ, Hawkins EG, Siuzdak G, and Cravatt BF. (2004) Assignment of
endogenoussubstrates to enzymes by global metabolite profiling.
Azad SC, Monory K, Marsicano G, Cravatt BF, Lutz B, Zieglgansberger W, Rammes G. (2004) Circuitry for
associative plasticity in the amygdala involves endocannabinoid signaling.
Egertova M, Michael GJ, Cravatt BF, Elphick MR. (2004) Fatty acid amide hydrolase in brain ventricular
epithelium: mutually exclusive patterns of expression in mouse and rat.
Huitron-Resendiz S, Sanchez-Alavez M, Wills DN, Cravatt BF, Henriksen SJ. (2004) Characterization of the
sleep-wake patterns in mice lacking fatty acid amide hydrolase.
Cravatt BF, Lichtman AH. (2004) The endogenous cannabinoid system and its role in nociceptive behavior.
Jessani N, Humphrey M, McDonald WH, Niessen S, Masuda K, Gangadharan B, Yates JR 3rd, Mueller BM, Cravatt
BF. (2004) Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo.
Chiang KP, Gerber AL, Sipe J, Cravatt BF. (2004) Reduced cellular expression and activity of the P129T
mutant of human fatty acid amide hydrolase - evidence for a link between defects in the endocannabinoid
system and problem drug use.
Cravatt BF, Saghatelian A, Hawkins EG, Clement AB, Bracey MH, Lichtman AH. (2004) Functional
disassociation of the central and peripheral fatty acid amide signaling systems.
Gulyas AI, Cravatt BF, Bracey MH, Dinh TP, Piomelli D, Boscia F, Freund TF. (2004) Segregation of two
endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus,
cerebellum and amygdala.
Lichtman AH, Leung D, Shelton C, Saghatelian A, Hardouin C, Boger D, Cravatt BF. (2004) Reversible
inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of
potency and selectivity.
Saghatelian A, Jessani N, Joseph A, Humphrey M, Cravatt BF. (2004) Activity-based probes for the
proteomic profiling of metalloproteases.
Ortega-Gutierrez S, Hawkins EG, Viso A, Lopez-Rodriguez ML, Cravatt BF. (2004) Comparison of anandamide
transport in FAAH wild-type and knockout neurons: Evidence for contributions by both FAAH and the CB1
receptor to anandamide uptake.
Bracey MH, Cravatt BF, Stevens RC. (2004) Structural commonalities among integral membrane enzymes.
Lichtman AH, Shelton CC, Advani T, Cravatt BF. (2004) Mice lacking fatty acid amide hydrolase exhibit a
cannabinoid receptor-mediated phenotypic hypoalgesia.
Speers AE, Cravatt BF. (2004) Profiling enzyme activities in vivo using click chemistry methods.
Massa F, Marsicano G, Hermann H, Cannich A, Monory K, Cravatt BF, Ferri GL, Sibaev A, Storr M, Lutz
B. (2004) The endogenous cannabinoid system protects against colonic inflammation.
Jessani N, Cravatt BF. (2004) The development and application of methods for activity-based protein
profiling.
Adam GC, Burbaum J, Kozarich JW, Patricelli MP, Cravatt BF. (2004) Mapping enzyme active sites in complex
proteomes.
Weber A, Ni J, Ling KH, Acheampong A, Tang-Liu DD, Burk R, Cravatt BF, Woodward D. (2004) Formation of
prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry.
Speers AE, Cravatt BF. (2004) Chemical strategies for activity-based proteomics.
2003: Kustedjo K, Deechongkit S, Kelly JW, Cravatt BF. (2003) Recombinant expression, purification, and
comparative characterization of torsinA and its torsion dystonia-associated variant deltaE-torsinA.
Adam GC, Vanderwal CD, Sorensen EJ, Cravatt BF. (2003) (-)-FR182877 is a potent and selective inhibitor
of carboxylesterase-1.
Liu J, Batkai S, Pacher P, Harvey-White J, Wagner JA, Cravatt BF, Gao B, Kunos G. (2003) LPS Induces
anandamide synthesis in macrophages via CD14/MAPK/PI3K/NF-kappaB independently of platelet activating factor.
Cravatt BF, Lichtman AH. (2003) Fatty acid amide hydrolase: an emerging therapeutic target in the
endocannabinoid system.
Egertova M, Cravatt BF, Elphick MR. (2003) Comparative analysis of fatty acid amide hydrolase and cb(1)
cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide
hydrolase in regulation of endocannabinoid signaling.
Leung D, Hardouin C, Boger DL, Cravatt BF. (2003) Discovering potent and selective reversible inhibitors
of enzymes in complex proteomes.
McKinney MK, Cravatt BF. (2003) Evidence for distinct roles in catalysis for residues of the
serine-serine-lysine catalytic triad of fatty acid amide hydrolase.
Clement AB, Hawkins EG, Lichtman AH, Cravatt BF. (2003) Increased seizure susceptibility and
proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase.
Speers AE, Adam GC, Cravatt BF. (2003) Activity-based protein profiling in vivo using a
copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition.
2002: Aebersold R, Cravatt BF (2002) Proteomics--advances, applications and the challenges that remain.
Cravatt BF, Lichtman AH (2002) The enzymatic inactivation of the fatty acid amide class of signaling
lipids.
Bracey MH, Hanson MA, Masuda KR, Stevens RC, Cravatt BF. (2002) Structural adaptations in a membrane
enzyme that terminates endocannabinoid signaling.
Adam GC, Sorensen EJ, Cravatt BF. (2002) Trifunctional chemical probes for the consolidated detection and
identification of enzyme activities from complex proteomes.
Adam GC, Sorensen EJ, Cravatt BF. (2002) Chemical strategies for functional proteomics.
Jessani N, Liu Y, Humphrey M, Cravatt BF. (2002) Enzyme activity profiles of the secreted and membrane
proteome that depict cancer cell invasiveness.
Waleh NS, Cravatt BF, Apte-Deshpande A, Terao A, Kilduff TS. (2002) Transcriptional regulation of the
mouse fatty acid amide hydrolase gene.
Adam GC, Sorensen EJ, Cravatt BF. (2002) Proteomic profiling of mechanistically distinct enzyme classes
using a common chemotype.
Lichtman AH, Hawkins EG, Griffin G, Cravatt BF. (2002) Pharmacological activity of fatty acid amides is
regulated, but not mediated, by fatty acid amide hydrolase in vivo.
Sipe JC, Chiang K, Gerber AL, Beutler E, Cravatt BF. (2002) A missense mutation in human fatty acid amide
hydrolase associated with problem drug use.
2001: Larsen NA, Heine A, Crane L, Cravatt BF, Lerner RA, Wilson IA. (2001) Structural basis for a disfavored
elimination reaction in catalytic antibody 1D4.
Huitron-Resendiz S, Gombart L, Cravatt BF, Henriksen SJ. (2001) Effect of oleamide on sleep and its
relationship to blood pressure, body temperature, and locomotor activity in rats.
Cravatt BF, Demarest K, Patricelli MP, Bracey MH, Giang DK, Martin BR, Lichtman AH. (2001)
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide
hydrolase.
Patricelli MP, Cravatt BF. (2001) Characterization and manipulation of the acyl chain selectivity of
fatty acid amide hydrolase.
Patricelli MP, Cravatt BF. (2001) Proteins regulating the biosynthesis and inactivation of
neuromodulatory fatty acid amides.
Kidd D, Liu Y, Cravatt BF (2001) Profiling serine hydrolase activities in complex proteomes.
Adam GC, Cravatt BF, Sorensen EJ. (2001) Profiling the specific reactivity of the proteome with
non-directed activity-based probes.
2000: Boger DL, Fecik RA, Patterson JE, Miyauchi H, Patricelli MP, Cravatt BF. (2000) Fatty acid amide
hydrolase substrate specificity.
Cravatt BF, Sorensen EJ. (2000) Chemical strategies for the global analysis of protein function.
Wang EW, Kessler BM, Borodovsky A, Cravatt BF, Bogyo M, Ploegh HL, Glas R. (2000) Integration of the
ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity.
Kustedjo K, Bracey MH, Cravatt BF. (2000) Torsin A and its torsion dystonia-associated mutant forms are
lumenal glycoproteins that exhibit distinct subcellular localizations.
Boger DL, Sato H, Lerner AE, Hedrick MP, Fecik RA, Miyauchi H, Wilkie GD, Austin BJ, Patricelli MP,
Cravatt BF. (2000) Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for
degradation of endogenous oleamide and anandamide.
Patricelli MP, Cravatt BF. (2000) Clarifying the catalytic roles of conserved residues in the amidase
signature family.
Egertova M, Cravatt BF, Elphick MR. (2000) Fatty acid amide hydrolase expression in rat choroid plexus:
possible role in regulation of the sleep-inducing action of oleamide.
1999: Liu Y, Patricelli MP, Cravatt BF. (1999) Activity-based protein profiling: The serine hydrolases.
Patricelli MP, Cravatt BF. (1999) Fatty acid amide hydrolase competitively degrades bioactive amides and
esters through a nonconventional catalytic mechanism.
Patricelli MP, Lovato MA, Cravatt BF. (1999) Chemical and mutagenic investigations of fatty acid amide
hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties.
Thomas EA, Cravatt BF, Sutcliffe JG. (1999) The endogenous lipid oleamide activates serotonin 5-HT7
neurons in mouse thalamus and hypothalamus.
Boger DL, Sato H, Lerner AE, Austin BJ, Patterson JE, Patricelli MP, Cravatt BF. (1999) Trifluoromethyl
ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features
contributing to inhibition.
1998: Boger DL, Henriksen SJ, Cravatt BF. (1998) Oleamide: an endogenous sleep-inducing lipid and
prototypical member of a new class of biological signaling molecules.
Wan M, Cravatt BF, Ring HZ, Zhang X, Francke U. (1998) Conserved chromosomal location and genomic
structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate
neurological mutation.
Patricelli MP, Patterson JE, Boger DL, Cravatt BF.(1998) An endogenous sleep-inducing compound is a novel
competitive inhibitor of fatty acid amide hydrolase.
Egertova M, Giang DK, Cravatt BF, Elphick MR.(1998) A new perspective on cannabinoid signalling:
complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain.
Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF.(1998) Comparative characterization of a wild
type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain
as a site for oligomerization.
Boger DL, Patterson JE, Guan X, Cravatt BF, Lerner RA, Gilula NB. (1998)
Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide. Giang DK, Cravatt BF. (1998) A second mammalian N-myristoyltransferase.
1997:Guan X, Cravatt BF, Ehring GR, Hall JE, Boger DL, Lerner RA, Gilula NB. (1997) The sleep-inducing lipid
oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells.
Thomas EA, Cravatt BF, Danielson PE, Gilula NB, Sutcliffe JG. (1997) Fatty acid amide hydrolase, the
degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central
nervous system.
Arreaza G, Devane WA, Omeir RL, Sajnani G, Kunz J, Cravatt BF, Deutsch DG. (1997) The cloned rat
hydrolytic enzyme responsible for the breakdown of anandamide also catalyzes its formation via the
condensation of arachidonic acid and ethanolamine.
Giang DK, Cravatt BF. (1997) Molecular characterization of human and mouse fatty acid amide hydrolases.
1996:Cravatt BF, Lerner RA, Boge DL. (1996) Structure Determination of an Endogenous Sleep-Inducing Lipid,
cis-9-Octadecenamide (Oleamide): A Synthetic Approach to the Chemical Analysis of Trace Quantities of a
Natural Product.
Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB. (1996) Molecular characterization of
an enzyme that degrades neuromodulatory fatty-acid amides.
1995:Cravatt BF, Prospero-Garcia O, Siuzdak G, Gilula NB, Henriksen SJ, Boger DL, Lerner RA. (1995) Chemical
characterization of a family of brain lipids that induce sleep.
1994:Boger DL, Lerner RA, Cravatt BF. (1994) Synthesis of a Functionalized Rigid Bicyclo[2.2.1] Heptane - A
Useful Hapten for Eliciting Catalytic Antibodies.
Cravatt BF, Ashley JA, Janda KD, Boger DL, Lerner RA. (1994) Crossing Extreme Mechanistic Barriers by
Antibody Catalysis - Syn Elimination to a Cis Olefin.
Lerner RA, Siuzdak G, Prospero-Garcia O, Henriksen SJ, Boger DL, Cravatt BF. (1994) Cerebrodiene: a
brain lipid isolated from sleep-deprived cats.
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