"Near Beach, Golden Valley County, North Dakota, 1996" - by Maxwell MacKenzie

"Aquired motives can be as powerful as innate ones.
They can become the focus for the major behaviors of
an organism, even at the expense of innate needs"

  - "The Costs of Pleasure and the Benefits of Pain"

 - Richard L. Solomon, American Psychologist, August 1980 (courtesy of Dr. Barnard Carroll)

An upright house is a body in homeostasis.  A crooked house is still a house,  but is in a allostatic state - that is a body maintaining outside the normal range.  The load on the body from the allostatic state is referred to as allostatic load, which ultimately leads to pathophysiology.