Structure of INIA- An Overview

 

The structure of INIA is envisioned as two domains, Dependence-induced drinking and Binge drinking, comprised of multiple U01 research grants. The flow of information within each domain moves from molecular, to cellular, to neurocircuitry levels of analysis. These U01s share information with the core facilities, which act as data depositories. The Administrative Core coordinates the flow of information among the Domains and Cores and disseminates the information back to the U01s (see Figure 1).

A Pilot Project program will identify exciting new areas for research and the continual recruitment of new investigators to the alcohol field. The INIA program is directed by an Administrative Core in close cooperation with the Animal Models, Gene Array and Neurocircuitry Cores via a Steering Committee and with the continual advice of the Scientific Advisory Committee.

Detailed Structure

Administrative Core :

PI and Consortium Director,
Chair of the Steering Committee:
George F. Koob

Co-Chair of the Steering Committee,
Scientific Director Steering Committee:
Adron Harris

Administrative Specialist
Program Coordinator
Technical Writer
Michael Arends

Administrative Core Coordinator
Lisa Maturin

Steering Committee:

John Crabbe - Oregon Health & Science University
Debrorah Finn - Oregon Health & Science University
Adron Harris (Co-Chair) - University of Texas, Waggoner Center (Executive Committee - Co-Chair)
Robert Hitzemann - Oregon Health & Science University
Paula Hoffman - University of Colorado Health Sciences Center
George Koob (Chair) - The Scripps Research Institute (Executive Committee - Chair)
Bill McBride - Indiana University School of Medicine
Antonio Noronha - National Institute on Alcohol Abuse and Alcoholism (Executive Committe)
Adolf Pfefferbaum - SRI International
Edie Sullivan - Stanford University School of Medicine
Boris Tabakoff - University of Colorado Health Sciences Center
Sam Zakhari -  National Institute on Alcohol Abuse & Alcoholism

Cores:

- Administrative Core, George F. Koob, The Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute
- Rat Animal Models Core, Richard Bell, Indiana University School of Medicine, Institute of Psychiatric Research
- Indiana Gene Array Core, Howard Edenberg, Indiana University School of Medicine
- Texas Gene Array Core, Adron Harris, Orly Alter & Vishy Iyer, University of Texas Austin, Waggoner Center for Alcohol and Addiction Research
- Neurocircuitry Mapping and Genotyping Core, Robert Hitzemann, Dept of Behavioral Neuroscience, Oregon Health Sciences University
- Mouse Animal Models Core, Amanda Roberts, Molecular and Integrative Neurosciences Dept, The Scripps Research Institute
- Colorado Gene Array Core, Boris Tabakoff, University of Colorado Health Sciences Center
- RNAi Core, Mike Zawada, University of Colorado Health Sciences Center, Div of Clinical Pharmacology

Research U01 Grants:

- Molecular Basis of Excessive Alcohol Drinking, Susan Bergeson, Univ of Texas Austin Waggoner Center for Alcohol and Addiction Research
- Biochemical & Genetic Determinants of Differences in Alcohol Consumption, Yuri Blednov, Univ of Texas Austin, Waggoner Center for Alcohol & Addiction Research
- Selective Breeding for Drinking in the Circadian Dark, John Crabbe & Pamela Metten, VAMC Portland
- Dependence Driven Alterations in Ethanol Reinforcement, Christopher Cunningham, Oregon Health & Science University
- Neuroadaptations to Ethanol in Drosophila, Ron Davis, Baylor College of Medicine, Dept of Psychiatry
- Neural Basis of Ethanol Sensitization/Drinking in Mice, Nicholas Grahame, Indiana University School of Medicine
- Alcohol Drinking after Modulation of Differentially Expressed Genes in HAP and LAP Mice, Paula Hoffman, Univ of Colorado Health Sciences Center Fitzsimons
- Inactivation of mu Opiod and CRF₁ Receptors Genes in the Extended Amygdala, Brigitte Kieffer, IGBMC, France
- Alcohol-Responsive Protein Networks Underlying Excessive Ethanol Consumption, Dayne Mayfield, Univ of Texas Austin, Waggoner Center for Alcohol & Addiction Research
- Excessive Alcohol Drinking and CNS Regional Changes in Gene Expression, William McBride, Indiana University Medical Center, Institute for Psychiatric Research
- Accumbal Synaptic Regulation and Bistability in the WID Mouse Model, Richard Morrisett, Univ of Texas Austin College of Pharmacy
- Neuroimaging in Animal Models of Alcoholism, Adolf Pfefferbaum & Edith Sullivan, SRI International
- Mapping and Microarray Gene Expression Analysis in a Model of Excessive Drinking, Tamara Phillips, VAMC, Oregon Healt & Science University
- Excessive Drinking and Urocortin 1 Neurocircuit, Andrey Ryabinin, Dept of Behavioral Neuroscience, Oregon Health & Science University
- Electrophysiology of Alcohol in the Extended Amygdala, George Siggins, The Scripps Research Institute, Molecular & Integrated Neurosciences Dept
- mGluR-Homer Interactions in Excessive Drinking (3-year Developmental U01), Karen Szumlinski, Univ of California Santa Barbara
- Proteomic Dissection of Withdrawal-Induced Excessive Drinking, Christine Wu, Univ of Colorado Health Sciences Center Denver

Current Pilot Projects:

- Alcohol and Neuropeptides in GABAergic Transmission in the Extended Amygdala, Marisa Roberto, The Scripps Research Institute
- Analysis of mu opiod receptor function in ethanol drinking behavior using virally-medicated RNA intererence, Ulrike Heberlein, U
- Pharmacological Manipulation of Withdrawal-Induced Drinking Mice, Deborah Finn, Oregon Health & Science University
- Effects of Acute Alcohol Exposure on Rat Brain Metabolites Detected in vivo Using Magnetic Resonance, Dirk Mayer, U
- Gene Regulation of High and Low Drinkers, Nigel Atkinson, U
- A Meta-Analytic Approach to Identify Genes Associated with Alcohol Actions and Interactive Software Environment for DNA Microarray Analysis Visualization, Igor Ponomarev and Orly Alter, University of Texas, Austin Waggoner Center for Alcohol & Addiction Research

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