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Multiple Sclerosis Publications
Publications by Subject
MS Publications
74. Kihara Y, Groves A, Rivera RR, Chun J. Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models. Ann Clin Transl Neurol 2015;2(10):978-983. doi:10.1002/acn3.251. PMC4603381 DOWNLOAD PDF
73. Anliker B, Choi JW, Lin ME, Gardell SE, Rivera R, Kennedy G, Chun J. Lysophosphatidic acid (LPA) and its receptor, LPA1, influence embryonic Schwann cell migration, myelination, and cell-to-axon segregation. Glia 2013;61(12):2009-2022. PMC3941654 DOWNLOAD PDF
72. Mirendil H, Lin ME, Chun J. Lysophosphatidic acid (LPA) receptor signaling. In Lysophospholipid receptors: signaling and biochemistry. Edited by Chun J, Hla T, Spiegel S, Moolenaar W. John Wiley & Sons, Inc., Hoboken, NJ. 2013.
71. Lysophospholipid receptors: signaling and biochemistry. Edited by Chun J, Hla T, Spiegel S, Moolenaar W. John Wiley & Sons, Inc., Hoboken, NJ. 2013.
70. Groves A, Kihara Y, Chun J. Fingolimod: Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy. J Neurol Sci 2013;328(1-2):9-18. PMC3640626 DOWNLOAD PDF
69. Choi JW, Chun J. Lysophospholipids and their receptors in the central nervous system. Biochim Biophys Acta 2013;1831(1):20-32. PMC3693945 DOWNLOAD PDF
68. Mutoh T, Rivera R, Chun J. Insights into the pharmacological relevance of lysophospholipid receptors. Br J Pharmacol 2012;165(4):829-844. PMC3312481 DOWNLOAD PDF
67. Zhao C, Sardella A, Chun J, Poubelle PE, Fernandes MJ, Bourgoin SG. TNF-a promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines. J Lipid Res 2011;52(7):1307-1318. PMC3111742 DOWNLOAD PDF
66. Soliven B, Miron V, Chun J. The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. Neurol Suppl 2011;76(8 Suppl 3):S9-14.
65. Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, Noguchi K, Teo ST, Yung YC, Lu M, Kennedy G, Chun J. FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor (S1P1) modulation. Proc Natl Acad Sci USA 2011;108(2):751-756. PMC3021041 DOWNLOAD PDF
64. Cohen JA, Chun J. Reply. Ann Neurol 2011;70(4):674.
63. Chun J, Brinkmann V. A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya). Discov Med 2011;12(64):213-228. PMC3694567 DOWNLOAD PDF
62. Cohen JA, Chun J. Mechanisms of fingolimod’s efficacy and adverse effects in multiple sclerosis. Ann Neurol 2011;69(5):759-777. DOWNLOAD PDF
61. Noguchi K, Chun J. Roles for lysophospholipid S1P receptors in Multiple Sclerosis. Crit Rev Biochem Mol Bio 2011;46(1):2-10. DOWNLOAD PDF
60. Lee CW, Choi JW, Chun J. Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (Fingolimod) in multiple sclerosis. Arch Pharm Res 2010;33(10):1567-1574. DOWNLOAD PDF
59. Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid Receptor Nomenclature. Pharmacol Rev 2010;62(4):579-587. PMC2993255 DOWNLOAD PDF
58. Chun J. Targeting the lysophospholipid S1P receptor for the treatment of Multiple Sclerosis. Drugs Future 2010;35(6):495-501.
57. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J. LPA receptors: Subtypes and biological actions. Ann Rev Pharmacol Toxicol 2010;50:157–186. DOWNLOAD PDF
56. Chun J, Hartung H-P. Mechanism of action of oral Fingolimod (FTY720) in multiple sclerosis. Clin Neuropharm 2010;33(2):91-101. PMC2859693 DOWNLOAD PDF
55. Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke NJ, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J. T-bet dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exper Med 2009;206(11):2469-2481. PMC2768857 DOWNLOAD PDF
54. Yung YC, Kennedy G, Chun J. Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR. In Current Protocols in Neuroscience, Unit 3.8, Taylor G (Ed.), John Wiley & Sons, July 2009. PMC2774705 DOWNLOAD PDF
53. Teo ST, Yung YC, Herr DR, Chun J. Lysophosphatidic acid in vascular development and disease. IUBMB Life 2009;61(8):791-799. DOWNLOAD PDF
52. Mutoh T, Chun J. Lysophosphatidic acid and sphingosine 1-phosphate activation of G Protein-Coupled Receptors. In Bradshaw RA & Dennis EA (eds.) Handbook of Cell Signaling, second edition, Elsevier, 2009.
51. Noguchi K, Herr D, Mutoh T, Chun J. Lysophosphatidic acid (LPA) and its receptors. Curr Opin Pharmacol 2009;9(1):15-23. DOWNLOAD PDF
50. Paczkowski C, Chun J. Genomic disorder and gene expression in the developing CNS. In Squire LR (eds), Encyclopedia of Neuroscience, vol. 4, pp. 679-684. Oxford: Academic Press, 2009.
49. Tölle M, Pawlak A, Schuchardt M, Kawamura A, Tietge UJ, Lorkowski S, Keul P, Assmann G, Chun J, Levkau B, van der Giet M, Nofer JR. HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production. Arterioscler Thromb Vasc Biol 2008;28(8):1542-1548. PMC2723752 DOWNLOAD PDF
48. Choi JW, Lee CW, Chun J. Biological roles of lysophospholipid receptors revealed by genetic null mice: an update. Biochem Biophys Acta 2008;1781:531-539. PMC2657083 DOWNLOAD PDF
47. Means CK, Miyamoto S, Chun J, Brown JH. S1P1 receptor localization confers selectivity for Gi mediated camp and contractile responses. J Biol Chem 2008;283(18):11954-11963. PMC2335351 DOWNLOAD PDF
46. Niessen F, Schaffner F, Furlan-Freguia C, Pawlinski R, Bhattacharjee G, Chun J, Derian CK, Andrade-Gordon P, Rosen H, Ruf W. Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature 2008;452(7187):654-658. DOWNLOAD PDF
45. Spohr TC, Choi JW, Gardell SE, Herr D, Rehen SK, Gomes FC, Chun J. LPA receptor-dependent secondary effects via astrocytes promote neuronal differentiation. J Biol Chem 2008;283(12):7470-7479. PMC2276323 DOWNLOAD PDF
44. Salomone S, Potts EM, Tyndall S, Ip PC, Chun J, Brinkmann V, Waeber C. Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools. Br J Pharm 2008;153(1):140-147. DOWNLOAD PDF
43. Shano S, Moriyama R, Chun J, Fukushima N. Lysophosphatidic acid stimulates astrocyte proliferation through LPA1. Neurochem Intl 2008;52(1-2):216-220. PMC17692995 DOWNLOAD PDF
42. Mutoh T, Chun J. Lysophospholipid activation of g protein-coupled receptors. Subcell Biochem 2008;49:269-297.
41. Chun J. “Extracellular Lipid Signals.” In the Wiley Encyclopedia of Chemical Biology, Tadhg P. Begley (ed.), 2008.
40. Chun J. How the lysophospholipid got its receptor. The Scientist 2007;21(9):48-54. DOWNLOAD PDF
39. Chun J. The sources of a lipid conundrum. Science 2007;316:208-210. DOWNLOAD PDF
38. Walter DH, Rochwalsky U, Reinhold J, Seeger F, Aicher A, Urbich C, Spyridopoulos I, Chun J, Brinkmann V, Keul P, Levkau B, Zeiher AM, Dimmeler S, Haendeler J. Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor. Arterioscler Thromb Vasc Biol 2007;27:275-282. DOWNLOAD PDF
37. Keller CD, Gil PR, Tolle M, van der Giet M, Chun J, Radeke HH, Schafer-Korting M, Kleuser B. Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling. Am J Path 2007;170(1):281-292. PMC1762708 DOWNLOAD PDF
36. Rivera R, Chun J. Potential therapeutic roles of lysophospholipid signaling in autoimmune related disease. Future Lipidology 2007;2(5):535-545.
35. Herr D, Chun J. Effects of LPA and S1P on the nervous system and implications for their involvement in disease. Cur Drug Targ 2007;8:155-167. DOWNLOAD PDF
34. Birgbauer E, Chun J. New developments in the biological functions of lysophospholipids. Cell Mol Life Sci 2006;63:2695-2701. DOWNLOAD PDF
33. Rivera R, Chun J. Biological effects of lysophospholipids. Rev Physiol Biochem Pharmacol 2008;160:25-46. DOWNLOAD PDF
32. Gardell SE, Dubin AE, Chun J. Emerging medicinal roles for lysophospholipid receptors. Trends in Mol Med 2006;12:65-75. DOWNLOAD PDF
31. Tölle M, Levkau B, Keul P, Brinkmann V, Giebing G, Schönfelder G, Schäfers M, von Wnuck Lipinski K, Jankowski J, Jankowski V, Chun J, Zidek W, van der Giet M. The immunomodulator FTY720 induces eNOS-dependent arterial vasodilation via the lysophospholipid receptor S1P3. Circ Res 2005;96:913-920. DOWNLOAD PDF
30. Chun J. Lysophospholipids in the nervous system. J Prostagland Lipid Mediators 2005;77:46-51. DOWNLOAD PDF
29. Girkontaite I, SakkV, Wagner M, Borggrefe T, Tedford K, Chun J, Fischer K-D. The sphingosine-1-phosphate lysophospholipid receptor S1P3 regulates MAdCAM-1+ endothelial cells in splenic marginal sinus organization. J Exp Med 2004;200:1491-1501. PMC2211946 DOWNLOAD PDF
28. Webb M, Tham C-S, Lin F-F, Lariosa-Willingham K, Yu N, Hale J, Mandala S, Chun J, Rao TS. Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. J Neuroimmunol 2004;153:108-121. DOWNLOAD PDF
27. Rao TS, Lariosa-Willingham KD, Lin F-F, Yu N, Tham C-S, Chun J, Webb M. Growth factor pre-treatment differentially regulates phosphoinositide turnover downstream of lysophospholipid receptor and metabotropic glutamate receptors in cultured rat cerebrocortical astrocytes. Int J Devel Neurosci 2004;22:131-135. DOWNLOAD PDF
26. Anliker B, Chun J. Lysophospholipid G protein-coupled receptors. J Biol Chem 2004;279:20555-20558. DOWNLOAD PDF
25. Anliker B, Chun J. Cell surface receptors in lysophospholipid signaling. Sem Cell and Devel Biol 2004;15:457-465. DOWNLOAD PDF
24. Ishii I, Fukushima N, Ye X, Chun J. Lysophospholipid receptors: Signaling and biology. Ann Rev Biochem 2004;73:321-354. DOWNLOAD PDF
23. Kingsbury MA, Rehen SK, Ye X, Chun J. Genetics and cell biology of lysophosphatidic acid receptor-mediated signaling during cortical neurogenesis. J Cell Biochem 2004;92:1004-12. DOWNLOAD PDF
22. Olivera A, Rosenfeldt H, Bektas M, Wang F, Ishii I, Chun J, Milstien S, Spiegel S. Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation yet promotes growth and survival independent of G protein coupled receptors. J Biol Chem 2003;278:46452-46460. DOWNLOAD PDF
21. Rao TS, Lariosa-Willingham KD, Lin F-F, Palfreyman EL, Yu N, Chun J, Webb M. Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes. Brain Res 2003;990:182-194. DOWNLOAD PDF
20. Liu H, Toman RE, Goparaju S, Maceyka M, Nava VE, Sankala H, Payne SG, Bektas M, Ishii I, Chun J, Milstien S, Spiegel S. Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J Biol Chem 2003;278:40330-40336. DOWNLOAD PDF
19. McGiffert C, Contos JJA, Friedman B, Chun J. Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1-3 in angiogenesis. FEBS Lett 2002;531:103-108. DOWNLOAD PDF
18. Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J. Genetic mosaicism in the brain: A new paradigm for neuronal diversity. Dir in Science 2002;1:53-55.
17. Chun J, Goetzl EJ, Hla,TL, Igarashi Y, Lynch KR, Moolenaar WH, Pyne S, Tigyi G. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev 2002;54:265-269. DOWNLOAD PDF
16. Weiner JAW, Fukushima N, Contos JJA, Scherer SS, Chun J. Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling. J Neurosci 2001;21:7069-7078. DOWNLOAD PDF
15. Chun J, Weiner JA, Fukushima N, Contos JJA, Zhang G, Kumura Y, Dubin A, Ishii I, Hecht JH, Akita C, Kaushal D. Neurobiology of receptor-mediated lysophospholipid signaling: From the first lysophospholipid (LP) receptor to roles in nervous system function and development. Ann NY Acad Sci 2000;905:110-117. DOWNLOAD PDF
14. Weiner JA, Chun J. Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid. Proc Natl Acad Sci 1999;96:5233-5238. PMC21847 DOWNLOAD PDF
13. Weiner JA, Hecht JH, Chun J. The lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. J Comp Neurol 1998;398:587-589. DOWNLOAD PDF
12. Fukushima N, Kimura Y, Chun J. A single receptor encoded by vzg-1/lpa1/edg-2 couples to G-proteins and mediates multiple cellular responses to lysophosphatidic acid (LPA). Proc Natl Acad Sci USA 1998;95:6151-6156. PMC27607 DOWNLOAD PDF
11. Staley K, Blaschke AJ, Chun J. Apoptotic DNA fragmentation is detected by a semi-quantitative ligation-mediated PCR of blunt DNA ends. Cell Death and Differen 1997;4:66-75. DOWNLOAD PDF
10. Hecht JH, Weiner JA, Post SR, Chun J. Ventricular zone gene -1 (Vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol 1996;135:1071-1083. PMC2133395 DOWNLOAD PDF
9. Blaschke AJ, Staley K, Chun J. Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development 1996;122:1165-1174 (see comment in Neuron 1996;16:693). DOWNLOAD PDF
8. Chun J. Lysophospholipid receptors: Implications for neural signaling. Crit Rev Neurobiol 1999;13:151-168.
7. Chun J. The first cloned and identified lysophospholipid (LP) receptor gene, vzg-1: Implications for the nervous system and related receptors. Adv Exp Med Biol 1999;469:357-62.
6. Chun J, Schatz DG. Developmental neurobiology: Alternative “ends” to a familiar story? Curr Biol 1999;9:R251-R253. DOWNLOAD PDF
5. Chun J, Contos JJA, Munroe D. A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs). Cell Biochem Biophys 1999;30:213-242.
4. Chun J, Schatz DG. Rearranging views on neurogenesis: Neuronal death in the absence of DNA end-joining proteins. Neuron 1999;22:7-10. DOWNLOAD PDF
3. Chun J. Detection of cells undergoing programmed cell death using in situ end labeling plus (ISEL+). In Apoptosis Detection, CHAPTER 5, pp. 35-45, in “Apoptosis detection and assay methods.” Zhu L, Chun J (eds.). BioTechniques Books, Natick, MA, 1998.
2. Chun J. Apoptotic DNA fragmentation detection using ligation mediated PCR (LMPCR). In Apopotosis Detection, CHAPTER 4, pp. 23-33, in “Apoptosis detection and assay methods.” Zhu L, Chun J (eds.). BioTechniques Books, Natick, MA, 1998.
1. Chun J, Blaschke AJ. Unit 3.8, Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR. In Current Protocols in Neuroscience. Gerfen C, Mckay R (eds.). John Wiley and Sons, Inc., 1997. PMC2774705