138.  Vogt J, Kirischuk S, Unichenko P, Schluter L, Pelosi A, Endle H, Yang JW, Schmarowski N, Cheng J, Thalman C, Strauss U, Prokudin A, Bharati BS, Aoki J, Chun J, Lutz B, Luhmann HJ, Nitsch R.  Synaptic phospholipid signaling modulates axon outgrowth via glutamate-dependent Ca2+-mediated molecular pathways.  Cereb Cortex epub ahead of print 2016 Nov 30.

137.  Funke M, Knudsen L, Lagares D, Ebener S, Probst CK, Fontaine BA, Franklin A, Kellner M, Kuhnel M, Matthieu S, Grothausmann, Chun J, Roberts JD Jr, Ochs M, Tager AM.  Lyosphosphatidic acid signaling through the lysophosphatidic acid-1 receptor is required for alveolarization.  Am J Respir Cell Mol Biol 2016;55(1):105-116.  PMC4942205

136.  Nishioka T, Arima N, Kano K, Hama K, Itai E, Yukiura H, Kise R, Inoue A, Kim SH, Solnica-Krezel L, Moolenaar WH, Chun J, Aoki J.  ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation.  Sci Rep 2016;6:23433. doi: 10.1038/srep23433.  PMC4804234

135.  Santos-Nogueira E, Lopez-Serrano C, Hernandez J, Lago N, Astudillo AM, Balsinde J, Estivill-Torrus G, de Fonseca FR, Chun J, Lopez-Vales R.  Activation of lysophosphatidic acid receptor type 1 contributes to pathophysiology of spinal cord injury.  J Neurosci 2015;35(28):10224-35.  doi:10.1523/JNEUROSCI.4703-14.2015.  PMC4502263  DOWNLOAD PDF

134.  Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J*, Stevens RC*, Hanson MA*.  Crystal structure of antagonist bound human lysophosphatidic acid receptor 1.  Cell 2015;161:1633-1643.  *co-senior authors.  PMC4476059  DOWNLOAD PDF

133.  Mirendil H, Thomas EA, De Loera C, Okada K, Inomata Y, Chun J.  LPA signaling initiates schizophrenia-like brain and behavioral changes in a mouse model of prenatal brain hemorrhage. Transl Psychiatry 2015;5:e541.  doi:10.1038/tp.2015.33.  PMC4462599  DOWNLOAD PDF

132.  Gonzalez de San Ramon E, Manuel I, Giralt MT, Chun J, Estivill-Torrus G, Rodridguez de Fonseca F, Santin LJ, Ferrer I, Rodriguez-Puertas R.  Anatomical location of LPA1 activation and LPA phospholipid precursors in rodent and human brain.  J Neurochem 2015;134(3):471-485.  doi:10.1111/jnc.13112.

131.  Suardiaz M, Galan-Arriero I, Avila-Martin G, Estivill-Torrus G, de Fonseca FR, Chun J, Gomez-Soriano J, Bravo-Esteban E, Taylor J.  Spinal cord compression injury in lysophosphatidic acid 1 receptor-null mice promotes maladaptive pronociceptive descending control.  Eur J Pain 2015.  doi:10.1002/ejp.695.

130.  Sheng X, Yung YC, Chen A, Chun J.  Lysophosphatidic acid signalling in development. Development 2015;142:1390-1395.  doi:10.1242/dev.121723.  PMC4392601  DOWNLOAD PDF

129.  Yung YC, Stoddard NC, Mirendil H, Chun J.  Lysophosphatidic acid signaling in the nervous system.  Neuron 2015;85(4):669-682.  doi:10.1016/j.neuron.2015.01/009.  PMC4400838  DOWNLOAD PDF

128.  Stoddard NC, Chun J.  Promising pharmacological directions in the world of lysophosphatidic acid signaling.  Biomol Ther (Seoul) 2015;23(1):1-11.  PMC4286743  DOWNLOAD PDF

127.  Kihara Y, Mizuno H, Chun J.  Lyosphospolipid receptors in drug discovery.  Exp Cell Res 2015;333(2):171-177.  doi:10.1016/j.yexcr.2014.11.020.  PMC4408218  DOWNLOAD PDF

126.  Garcia-Diaz B, Riquelme R, Varela-Nieto I, Jimenez AJ, de Diego I, Gomez-Conde AL, Matas-Rico E, Aguirre JA, Chun J, Pedraza C, Santin LJ, Fernandez O, Rodriguez de Fonseca F, Estivill-Torrus G.  Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex.  Brain Struct Funct 2015;220(6):3701-3720.

125.  Chun J.  An introduction to the JLR thematic series on lysophospholipids.  J Lipid Res 2014;55(5):798.  PMC3995457  DOWNLOAD PDF

124.  Yung YC, Stoddard NC, Chun J.  LPA receptor signaling:  Phamarcology, physiology, and pathophysiology.  J Lipid Res 2014;55(7):1192-1214.  PMC4076099  DOWNLOAD PDF

123.  Kihara Y, Maceyka M, Spiegel S, Chun J.  Lysophospholipid receptor nomenclature review:  IUPHAR Review 8.  Br J Pharmacol 2014;171(15):3575-3594.  PMC4128058  DOWNLOAD PDF

122.  David M, Machuca-Gayet I, Kikuta J, Ottewell P, Mima F, Leblanc R, Bonnelye E, Ribeiro J, Holen I, Vales RL, Jurdic P, Chun J, Clezardin P, Ishii M, Peyruchaud O.  Lysophosphatidic acid receptor type 1 (LPA₁) plays a functional role in osteoclast differentiation and bone resorption activity.  J Bio Chem 2014;289(10):6551-6564.  PMC3945319  DOWNLOAD PDF

121.  Wu DD, Zhang F, Hao F, Chun J, Xu X, Cui MZ.  Matricellular protein cyr61 bridges lysophosphatidic acid and integrin pathways leading to cell migration.  J Biol Chem 2014;289(9):5774-5783.  PMC3937649  DOWNLOAD PDF

120.  Anliker B, Choi JW, Lin ME, Gardell SE, Rivera R, Kennedy G, Chun J.  Lysophosphatidic acid (LPA) and its receptor, LPA₁, influence embryonic Schwann cell migration, myelination, and cell-to-axon segregation.  Glia 2013;61(12):2009-2022.  PMC3941654  DOWNLOAD PDF

117.  Huang LS, Fu P, Patel P, Harijith A, Sun T, Zhao Y, Garcia JG, Chun J, Natarajan V.  Lysophosphatidic acid receptor 2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice.  Am J Respir Cell Mol Biol 2013;49(6):912-922.  DOWNLOAD PDF

116.  Ma L, Nagai J, Chun J, Ueda H.  An LPA species (18:1 LPA) plays key roles in the self-amlification of spinal LPA production in the peripheral neuropathic pain model.  Mol Pain 2013;9(1):29. PMC3691926  DOWNLOAD PDF

115.  Miyabe Y, Miyabe C, Iwai Y, Takayasu A, Fukuda S, Yokoyama W, Nagai J, Jona M, Tokuhara Y, Ohkawa R, Albers HM, Ovaa H, Aoki J, Chun J, Yatomi Y, Ueda H, Miyasaka M, Miyasaka N, Nanki T.  Lysophosphatidic acid receptor 1 is essential for development of arthritis.  Arthritis Rheum 2013;65(8):2037-2047.  DOWNLOAD PDF

114.  Lee SJ, Leoni G, Neurmann PA, Chun J, Nusrat A, Yun CC.  Distinct phospholipase C-β isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostatis and wound closure.  Mol Cell Biol 2013;33(10):2016-2028.  PMC3647975  DOWNLOAD PDF

113.  Halder SK, Yano R, Chun J, Ueda H.  Involvement of LPA₁ receptor signaling in cerebral ischemia-induced neuropathic pain.  Neuroscience 2013;235:10-15.  DOWNLOAD PDF

112.  Sakai N, Chun J, Duffield JS, Wada T, Luster AD, Tager AM.  LPA₁-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation.  FASEB J 2013;27(5):1830-1846.  PMC3633809  DOWNLOAD PDF

111.  Zhao Y, Fu P, Zhao J, Mialki RK, Wei J, Huang L, Chun J, Leme AS, Shapiro SD, Natarajan V.  Sepsis by using cecal ligation and single puncture causes alveolar space enlargement in LPA₂ knockout mice. J Aller Ther 2012;S4 005.  doi:  10.4172/2155-6121.S4-005.  DOWNLOAD PDF

110.  Mirendil H, Lin ME, Chun J.  Lysophosphatidic acid (LPA) receptor signaling. In Lysophospholipid receptors: signaling and biochemistry. Edited by Chun J, Hla T, Spiegel S, Moolenaar W.  John Wiley & Sons, Inc., Hoboken, NJ. 2013.

109.  Lysophospholipid receptors:  signaling and biochemistry. Edited by Chun J, Hla T, Spiegel S, Moolenaar W.  John Wiley & Sons, Inc., Hoboken, NJ. 2013. 

108.  Choi JW, Chun J.  Lysophospholipids and their receptors in the central nervous system.  Biochim Biophys Acta 2013;1831(1):20-32. PMC3693945    DOWNLOAD PDF

107.  Garcia-Fernandez M, Castilla-Ortega E, Pedraza C, Blanco E, Hurtado-Guerrero I, Barbancho MA, Chun J, Rodriguez-de-Fonseca F, Estivill-Torrus G, Nunez LJ.  Chronic immobilization in the malpar1 knockout mice increases oxidative stress in the hippocampus.  Int J Neurosci 2012;122(10):583-589.  

106.  Castilla-Ortega E, Pedraza C, Chun J, Fonseca FR, Estivill-Torrus G, Santin LJ.  Hippocampal c-Fos activation in normal and LPA₁-null mice after two object recognition tasks with different memory demands.  Behav Brain Res 2012;232(2):400-405.    DOWNLOAD PDF

105.  Lin ME, Rivera RR, Chun J.  Targeted deletion of LPA₅ identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain.  J Biol Chem 2012;287(21):17608-17617. PMC3366844    DOWNLOAD PDF

104.  Ye X, Diao H, Chun J.  11-deoxy prostaglandin F(2a), a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3((-/-)) females.  Fertil Steril 2012;97(3):757-763. PMC3315158    DOWNLOAD PDF

103.  Funke M, Xhao Z, Xu Y, Chun J, Tager AM.  The lysophosphatidic acid receptor LPA1 promotes epithelial cell apoptosis following lung injury.  Am J Respir Cell Mol Biol 2012;46(3):355-364. PMC3326436    DOWNLOAD PDF

102.  Cheng HY, Dong A, Panchatcharam M, Mueller P, Yang F, Li Z, Mills G, Chun J, Morris AJ, Smyth SS.  Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia induced remodeling.  Arterioscler Thromb Vasc Biol 2012;32(1):24-32. PMC3241874   DOWNLOAD PDF

101.  Mutoh T, Rivera R, Chun J.  Insights into the pharmacological relevance of lysophospholipid receptors.  Br J Pharmacol 2012;165(4):829-844. PMC3312481    DOWNLOAD PDF

100.  Castillo-Badillo JA, Molina-Munoz T, Romero-Avila MT, Vazquez-Macias A, Rivera R, Chun J, Garcia-Sainz JA.  Sphingosine 1-phosphate-mediated a(1B)-adrenoceptor desensitization and phosphorylation:  Direct and paracrine/autocrine actions.  Biochim Biophys Acta 2011;1823(2):245-254. PMC22019450    DOWNLOAD PDF

99.  Castilla-Ortega E, Hoyo-Becerra C, Pedraza C, Chun J, Rodriguez De Fonseca F, Estivill-Torrus G, Santin LJ.  Aggravation of chronic stress effects on hippocampal neurogenesis and spatial memory in LPA(1) receptor knockout mice.  PLoS One 2011;6(9):e25522. PMC3183048.  Correction in PLoS One. 2011;6(11). doi: 10.1371/annotation/c105dab8-59b8-467a-9223-5bd92936e49a    DOWNLOAD PDF

98.  Yung YC, Mutoh T, Lin ME, Noguchi K, Rivera RR, Choi JW, Kingsbury MA, Chun J.  Lysophosphatidic acid signaling may initiate fetal hydrocephalus.  Sci Transl Med 2011;3:99ra87.  PMC3653407    DOWNLOAD PDF

97.  Herr KJ, Herr DR, Lee CW, Noguchi K, Chun J.  Stereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic acid receptor 1 (LPA₁) signaling.  Proc Natl Acad Sci USA 2011;108(37):15444-15449. PMC3174597    DOWNLOAD PDF

96.  Zhao J, He D, Su Y, Berdyshev EV, Chun J, Natarajan V, Zhao Y.  Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs.  Am J Physiol Physiol Lung Cell Mol Physiol 2011;301(4):L547-L556. PMC3191756    DOWNLOAD PDF

95.  Gennero I, Laurencin-Dalicieux S, Conte-Auriol F, Briand-Mesange F, Laurencin D, Rue J, Beton N, Malet N, Mus M, Tokumura A, Bourin P, Vico L, Brunel G, Oreffo RO, Chun J, Salles JP.  Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass.  Bone 2011;49(3):395-403. PMC3697734    DOWNLOAD PDF

94.  Zhou Z, Subramanian P, Sevilmis G, Globke B, Soehnlein O, Karshovska E, Megens R, Heyll K, Chun J, Saulnier-Blache JS, Reinholz M, van Zandvoort M, Weber C, Schober A.  Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium.  Cell Metab 2011;13(5):592-600.    DOWNLOAD PDF

93.  Zhao C, Sardella A, Chun J, Poubelle PE, Fernandes MJ, Bourgoin SG.  TNF-a promotes LPA₁- and LPA₃-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines.  J Lipid Res 2011;52(7):1307-1318. PMC3111742    DOWNLOAD PDF

92.  Ye X, Herr DR, Diao H, Rivera R, Chun J.  Unique uterine localization and regulation may differentiate LPA3 from other lysophospholipid receptors for its role in embryo implantation.  Fertil Steril 2011;95(6):2107-2113. PMC308461    DOWNLOAD PDF

91.  Castelino FV, Seiders J, Bain G, Brooks SF, King CD, Swaney JS, Lorrain DS, Chun J, Luster AD, Tager AM.  Amerlioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma.  Arthritis Rheum 2011;63(5):1405-1415.  PMC3086986    DOWNLOAD PDF

90.  Diao H, Aplin JD, Xiao S, Chun J, Li Z, Chen S, Ye X.  Altered spatiotemporal expression of collagen types I, III, IV, and VI in Lpar3-deficient peri-implantation mouse uterus. Biol Reprod 2011;84(2):255-265. PMC3071265    DOWNLOAD PDF

89.  Nagai J, Uchida H, Matsushita Y, Yano R, Ueda M, Niwa M, Aoki J, Chun J, Ueda H.  Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidycholine.  Mol Pain 2010;6:78. PMC2989310    DOWNLOAD PDF

88.  Lin S, Lee SJ, Shim H, Chun J, Yun CC.  The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine.  Am J Physiol Gastrointest Liver Physiol 2010;299(5):G1128-G1138. PMC2993170    DOWNLOAD PDF

87.  Dubin AE, Herr DR, Chun J.  Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis.  J Neuroscience 2010;30(21):7300-7039.  PMC2932640    DOWNLOAD PDF

86.  Castilla-Ortega E, Sánchez-López J, Hoyo-Becerra C, Matas-Rico E, Zambrana-Infantes E, Chun J, Fonseca FR, Pedraza C, Estivill-Torrús G, Santin LJ.  Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA₁ receptor.  Neurobiol Learn Mem 2010;94(1):73-82.  PMC3684252    DOWNLOAD PDF

85.  Xie W, Uchida H, Nagai J, Ueda M, Chun J, Ueda H.  Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain.  J Neurochem 2010;113(4):1002-1011. PMC2908211    DOWNLOAD PDF

84.  Diao H, Xiao S, Cui J, Chun J, Xu Y, Ye X.  Progesterone receptor-mediated up-regulation of transthyretin (TTR) in preimplantation mouse uterus.  Fertil Steril 2010;93(8):2750-2753.  PMC3646416    DOWNLOAD PDF

83.  Lin S, Yeruva S, He P, Singh AK, Zhang H, Chen M, Lamprecht G, de Jonge HR, Tse M, Donowitz M, Hogema BM, Chun J, Seidler U, Yun CC.  Lysophosphatidic acid stimulates the intestinal brush border Na⁺/H⁺ exchanger 3 and fluid absorption via LPA₅ and NHERF2.  Gastroenterology 2010;138(2):649-658. PMC2976485    DOWNLOAD PDF

82.  Birgbauer E, Chun J.  Lysophospholipid receptors LPA_1-3 are not required for the inhibitory effects of LPA on mouse retinal growth cones.  Eye and Brain 2010;2:1-13.    DOWNLOAD PDF    Click here to see the supplemental video for Figure 1.

81.  Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH.  International Union of Basic and Clinical Pharmacology. LXXVIII.  Lysophospholipid Receptor Nomenclature. Pharmacol Rev 2010;62(4):579-587. PMC2993255   LINK TO PDF

80.  Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J.  LPA receptors:  Subtypes and biological actions.  Ann Rev Pharmacol Toxicol 2010;50:157–186.    DOWNLOAD PDF

79.  Ye X, Chun J.  Lysophosphatidic acid (LPA) signaling in vertebrate reproduction.  Trends Endocrin Metab 2010;21(1):17-24. PMC2818173    DOWNLOAD PDF

78.  Lin ME, Herr DR, Chun J.  Lysophosphatidic acid (LPA) receptors:  signaling properties and disease relevance. Prostaglandins Other Lipid Mediat 2010;91(3-4):130-138.  PMC2845529.    DOWNLOAD PDF

77.  Zhao Y, Tong J, He D, Pendyala S, Evgeny B, Chun J, Sperling AI, Natarajan V.  Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma.  Respiratory Res 2009;10:114.  PMC2788521    DOWNLOAD PDF

76.  Ma L, Uchida H, Nagai J, Inoue M, Chun J, Aoki J, Ueda H.  Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid:  an initiator of nerve injury-induced neuropathic pain.  Mol Pain 2009;5:64.  PMC2780384    DOWNLOAD PDF

75.  Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M, Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Brauer AU, Chun J, Ninnemann O, Schmitz D, Nitsch R.  Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.  Cell 2009;138(6):1222-1235. PMC3716297  DOWNLOAD PDF

74.  Santin L, Bilbao A, Pedraza C, Matas-Rico E, Lopez-Barroso D, Castilla-Ortega E, Sanchez-Lopez J, Riquelme R, Varela-Nieto I, de la Villa P, Suardiaz M, Chun J, Fonseca FR, Estivill-Torrus G.  Behavioral phenotype of maLPA1-null mice:  Increased anxiety-like behavior and spatial memory deficits.  Genes Brain Behav 2009;8(8):772-784.    DOWNLOAD PDF

73.  Lin S, Wang D, Iver S, Ghaleb AM, Shim H, Yang VW, Chun J, Yun CC.  The absence of LPA(2) attenuates tumor formation in an experimental model of colitis-associated cancer.  Gastroenterology 2009;136(5):1711-20.  PMC2691721    DOWNLOAD PDF

72.  Teo ST, Yung YC, Herr DR, Chun J.  Lysophosphatidic acid in vascular development and disease.  IUBMB Life 2009;61(8):791-799.   DOWNLOAD PDF

71.  Mutoh T, Chun J.  Lysophosphatidic acid and sphingosine 1-phosphate activation of G Protein-Coupled Receptors.  In Bradshaw RA & Dennis EA (eds.) Handbook of Cell Signaling, second edition, Elsevier, 2009.

70.  Noguchi K, Herr D, Mutoh T, Chun J.  Lysophosphatidic acid (LPA) and its receptors.  Curr Opin Pharmacol 2009;9(1):15-23.    DOWNLOAD PDF

69.  Xie W, Matsumoto M, Chun J, Ueda H.  Involvement of LPA₁ receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury.  Mol Pain 2008;4:46.  PMC2599895    DOWNLOAD PDF

68.  Matas-Rico E, Garcia-Diaz B, Llebrez-Zayas P, Lopez-Barroso D, Santin L, Pedraza C, Smith-Fernandez A, Fernandez-Llebrez P, Tellez T, Redondo M, Chun J, Rodriguez de Fonseca F, Estivill-Torrus G.  Deletion of lysophosphatidic acid receptor LPA₁ reduces neurogenesis in the mouse dentate gyrus.  Mol Cell Neurosci 2008;39(3):342-355.  PMC3667670    DOWNLOAD PDF

67.  Panchatcharam M, Miriyala S, Yang F, Rojas M, Vallant C, Dong A, Lynch K, Chun J, Morris AJ, Smyth SS.  Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure.  Circ Res 2008;103(6):662-670.  PMC2637300    DOWNLOAD PDF

66.  Ye X, Skinner MK, Kennedy G, Chun J.  Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling.  Biol Reprod 2008;79(2):328-336.  PMC257497    DOWNLOAD PDF

65.  Choi JW, Lee CW, Chun J.  Biological roles of lysophospholipid receptors revealed by genetic null mice:  an update.  Biochem Biophys Acta 2008;1781:531-539.  PMC2657083    DOWNLOAD PDF

64.  Inoue M, Xie W, Matsushita Y, Chun J, Aoki J, Ueda H.  Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.  Neurosci 2008;152(2):296-298.    DOWNLOAD PDF

63.  Niessen F, Schaffner F, Furlan-Freguia C, Pawlinski R, Bhattacharjee G, Chun J, Derian CK, Andrade-Gordon P, Rosen H, Ruf W.  Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation.  Nature 2008;452(7187):654-658.    DOWNLOAD PDF

62.  Inoue M, Ma L, Aoki J, Chun J, Ueda H.  Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain.  Mol Pain 2008;4(1):6.  PMC2277392    DOWNLOAD PDF

61.  Spohr TC, Choi JW, Gardell SE, Herr D, Rehen SK, Gomes FC, Chun J. LPA receptor-dependent secondary effects via astrocytes promote neuronal differentiation.  J Biol Chem 2008;283(12):7470-7479. PMC2276323    DOWNLOAD PDF

60.  Lee CW, Kim NH, Choi HK, Sun Y, Nam JS, Rhee HJ, Chun J, Huh SO. Lysophosphatidic acid-induced c-fos up-regulation involves cyclic AMP response element-binding protein activated 60 mitogen- and stress-activated protein kinase-1. J Cell Biochem 2008;104(3):785-94.    DOWNLOAD PDF

59.  Tager AM, LaCamera P, Shea BS, Campanella GK, Selman M, Zhao Z, Polosukhin Z, Wain J, Karimi-Shah BA, Kim ND, Hart WK, Pardo A, Blackwell TS, Xu Y, Chun J, Luster AD.  The lysophosphatidic acid receptor LPA₁ links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.  Nat Med 2008;14(1):45-54.    Download PDF

58.  Shano S, Moriyama R, Chun J, Fukushima N.  Lysophosphatidic acid stimulates astrocyte proliferation through LPA₁.  Neurochem Intl 2008;52(1-2):216-220.  PMC17692995    Download PDF

57.  Estivill-Torrus G, Llebrez-Zayas P, Matas-Rico E, Santin L, Pedraza C, De Diego I, Del Arco I, Fernandez-Llebrez P, Chun J, Rodriguez De Fonseca F.  Absence of LPA₁ signaling results in defective cortical development.  Cerebral Cortex 2008;18(4):938-950.    DOWNLOAD PDF

56.  Mutoh T, Chun J.  Lysophospholipid activation of g protein-coupled receptors.  Subcell Biochem 2008;49:269-297. 

55.  Chun J.  “Extracellular Lipid Signals.” In the Wiley Encyclopedia of Chemical Biology, Tadhg P. Begley (ed.), 2008.

54.  Hama K, Aoki J, Inoue A, Endo T, Amano T, Motoki R, Kanai M, Ye X, Chun J, Matsuji N, Suzuki H, Shibasaski M, Arai H.  Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling.  Biol Reprod 2007;77(6):954-9.  DOWNLOAD PDF

53.  Chun J.  How the lysophospholipid got its receptor.  The Scientist 2007;21(9):48-54.     DOWNLOAD PDF

52.  Chan LC, Peters W, Xu Y, Chun J, Farese Jr. RV, Cases S.  LPA₃ receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA).  J Leukocyte Biol 2007;82(5):1193-1200.    DOWNLOAD PDF

51.  Pradere J-P, Klein J, Gres S, Guigne C, Neau E, Valet P, Calise D, Chun J, Bascands J-L, Saulnier-Blache J-S, Schanstra JP. LPA₁ receptor activation promotes renal interstitial fibrosis.  J Am Soc Nephrology 2007;18(12):3110-3118.    DOWNLOAD PDF

50.  Lee CW, Rivera R, Dubin AE, Chun J.  LPA₄/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing Gs, Gq/Gi-mediated calcium signaling and G12/13-mediated Rho activation.  J Biol Chem 2007;281(33):23589-23597.    DOWNLOAD PDF

49.  Rivera R, Chun J.  Potential therapeutic roles of lysophospholipid signaling in autoimmune related disease.  Future Lipidology 2007;2(5):535-545.

48.  Herr D, Chun J.  Effects of LPA and S1P on the nervous system and implications for their involvement in disease.  Cur Drug Targ 2007;8:155-167  .  DOWNLOAD PDF

47.  Fukushima N, Shano S, Moriyama R, Chun J.  Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA₁-G_i/o pathway.  Neurochem Int 2007;50:302-307.    DOWNLOAD PDF

46.  Lee CW, Rivera R, Gardell S, Dubin AE, Chun J.  GPR92 as a new G12/13 and Gq coupled lysophosphatidic acid receptor that increases cAMP:  LPA₅.  J Biol Chem 2006;281:23589-23597.    DOWNLOAD PDF

45.  Birgbauer E, Chun J.  New developments in the biological functions of lysophospholipids.  Cell Mol Life Sci 2006;63:2695-2701.   DOWNLOAD PDF

44.  Rivera R, Chun J.  Biological effects of lysophospholipids.  Rev Physiol Biochem Pharmacol 2008;160:25-46.    DOWNLOAD PDF

43.  Gardell SE, Dubin AE, Chun J.  Emerging medicinal roles for lysophospholipid receptors.  Trends in Mol Med 2006;12:65-75.    DOWNLOAD PDF

42.  Ye X, Hama K, Contos JJ, Anliker B, Inoue A, Skinner MK, Suzuki H, Amano T, Arai H, Aoki J, Chun J.  LPA₃-mediated lysophosphatidic acid signalling in embryo implantation and spacing.  Nature 2005;435:104-108.  (See also News & Views.)  PMC1369590    DOWNLOAD PDF

41.  Li H, Ye X, Mahanivong C, Bian D, Chun J, Huang S.  Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells.  J Biol Chem 2005;280:10564-10571.    DOWNLOAD PDF

40.  Simon MF, Daviaud D, Pradere JP, Gres S, Guigne C, Wabitsch M, Chun J, Valet P, Saulnier-Blache JS.  Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2.  J Biol Chem 2005;280:14656-14662.    DOWNLOAD PDF

39.  Chun J.  Lysophospholipids in the nervous system.  J Prostagland Lipid Mediators 2005;77:46-51.    DOWNLOAD PDF

38.  Inoue M, Rashid H, Ryousuke Fujita R, Contos JJA, Chun J, Ueda H.  Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling.  Nature Med 2004;10:712-718.    Download PDF

37.  Rao TS, Lariosa-Willingham KD, Lin F-F, Yu N, Tham C-S, Chun J, Webb M.  Growth factor pre-treatment differentially regulates phosphoinositide turnover downstream of  lysophospholipid receptor and metabotropic glutamate receptors in cultured rat cerebrocortical astrocytes.  Int J Devel Neurosci 2004;22:131-135.    DOWNLOAD PDF

36.  Hama K, Aoki J, Fukay M, Kishi Y, Ohta H, Sakai T, Suzuki R, Watanabe M, Chun J, Arai H. Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA₁.  J Biol Chem 2004;279:17634-17639.    DOWNLOAD PDF

35.  Anliker B, Chun J. Lysophospholipid G protein-coupled receptors.  J Biol Chem 2004;279:20555-20558.    DOWNLOAD PDF

34.  Anliker B, Chun J.  Cell surface receptors in lysophospholipid signaling.  Sem Cell and Devel Biol 2004;15:457-465.    DOWNLOAD PDF

33.  Ishii I, Fukushima N, Ye X, Chun J.  Lysophospholipid receptors:  Signaling and biology.  Ann Rev Biochem 2004;73:321-354.    Download PDF

32.  Kingsbury MA, Rehen SK, Ye X, Chun J.  Genetics and cell biology of lysophosphatidic acid receptor-mediated signaling during cortical neurogenesis. J Cell Biochem 2004;92:1004-12.    DOWNLOAD PDF

31.  Kingsbury MA, Rehen SK, Contos JJA, Higgins C, Chun J.  Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding.  Nature Neurosci 2003;6:1292-1299.  (See also News & Views).    DOWNLOAD PDF

30.  Rao TS, Lariosa-Willingham KD, Lin F-F, Palfreyman EL, Yu N, Chun J, Webb M.  Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes.  Brain Res 2003;990:182-194.    DOWNLOAD PDF

29.  Contos JJA, Ishii I, Fukushima N, Kingsbury MA, Ye X, Kawamura S, Brown JH, Chun J.  Characterization of LPA2 (EDG-4) and LPA1/LPA2 (EDG-2/EDG-4) lysophosphatidic acid receptor knockout mice:  signaling deficits without obvious phenotypic abnormality attributable to LPA2.  Mol Cell Biol 2002;22:6921-6929.  PMC134025    DOWNLOAD PDF

28.  Fukushima N, Ishii I, Habara Y, Allen CB, Chun J.  Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines.  Mol Biol Cell 2002;13:2692-2705.  PMC117935    DOWNLOAD PDF

27.  Fukushima N, Weiner JA, Kaushal J, Contos JJA, Rehen SK, Kingsbury MA, Kim KY, Chun J.  Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons.  Mol Cell Neurosci 2002;20:271-282.    DOWNLOAD PDF

26.  Ishii I, Chun J.  Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors.  Neuroreport 2002;13:593-596.  

25.  Ye X, Ishii I,  Kingsbury MA, Chun J.  Lysophosphatidic acid as a novel cell survival/apoptotic factor.  Biochim Biophys Acta 2002;1585:108-113.    DOWNLOAD PDF

24.  Ye X, Fukushima N, Kingsbury MA, Chun J.  Lysophosphatidic acid in neural signaling.  Neuroreport 2002;13:2169-2175.    DOWNLOAD PDF

23.  Fukushima N, Ye X, Chun J.  Neurobiology of lysophosphatidic acid signaling.  The Neuroscientist 2002;8:540-550. 

22.  Yang AH, Ishii I, Chun J.  In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice.  Biochim Biophys Acta 2002;1582:197-203.    DOWNLOAD PDF

21.  Chun J, Goetzl EJ, Hla,TL, Igarashi Y, Lynch KR, Moolenaar WH, Pyne S, Tigyi G.  International Union of Pharmacology.  XXXIV.  Lysophospholipid receptor nomenclature.  Pharmacol Rev 2002;54:265-269.   LINK TO PDF

20.  Weiner JAW, Fukushima N, Contos JJA, Scherer SS, Chun J.  Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling.  J Neurosci 2001;21:7069-7078.    DOWNLOAD PDF

19.  Moeller T, Contos JJ, Musante DB, Chun J, Ransom BR.  Expression and function of lysophosphatidic acid receptors in cultured rodent microglial cells.  J Biol Chem 2001;276:25946-25952.    DOWNLOAD PDF

18.  Contos JJA, Chun J.  The mouse lpA3/Edg7 lysophosphatidic acid receptor gene:  sequence, genomic structure, chromosomal location and expression pattern. Gene 2001;267:243-253.    DOWNLOAD PDF

17.  Kimura Y, Schmitt A, Fukushima N, Ishii I, Kimura H, Nebreda AR, Chun J.  Two novel Xenopus homologs of mammalian LP_A1/edg-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells.  J Biol Chem 2001;276:15028-15215.    DOWNLOAD PDF

16.  Fukushima N, Chun J.  The LPA receptors.  J Prostagland Lipid Mediat 2001;64:21-31.    DOWNLOAD PDF

15.  Fukushima N, Ishii I, Contos JJA, Weiner JA, Chun J.  Lysophospholipid receptors. Ann Rev Pharmacol Toxicol 2001;41:507-534.  DOWNLOAD PDF

14.  Contos JJA, Ishii I, Chun J.  Lysophosphatidic acid receptors.  Mol Pharmacol 2000;58:1188-1196.   DOWNLOAD PDF

13.  Contos JJ, Fukushima N, Weiner JA, Kaushal D, Chun J.  Requirement for the lp_A1 lysophosphatidic acid receptor gene in normal suckling behavior.  Proc Natl Acad Sci USA 2000;97:13384-13389.  PMC27233    DOWNLOAD PDF

12.  Fukushima N, Weiner JA, Chun J.  Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology.  Dev Biol 2000;228:6-18.    DOWNLOAD PDF

11.  Ishii I, Contos JJA, Fukushima N, Chun J.  Functional comparisons of the lysophosphatidic acid receptors LP_A1, LP_A2 and LP_A3 in neuronal cell lines using a retrovirus expression system.  Mol Pharmacol 2000;58:895-902.    DOWNLOAD PDF

10.  Contos JJA, Chun J.  Genomic characterization of the lysophosphatidic acid receptor gene, lpA2/Edg4, and identification of a frameshift mutation in a previously characterized cDNA.  Genomics 2000;64:155-169.    DOWNLOAD PDF

9.  Chun J, Weiner JA, Fukushima N, Contos JJA, Zhang G, Kumura Y, Dubin A, Ishii I, Hecht JH, Akita C, Kaushal D.  Neurobiology of receptor-mediated lysophospholipid signaling:  From the first lysophospholipid (LP) receptor to roles in nervous system function and development.  Ann NY Acad Sci 2000;905:110-117.    DOWNLOAD PDF

8.  Weiner JA, Chun J.  Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid.  Proc Natl Acad Sci 1999;96:5233-5238.  PMC21847    DOWNLOAD PDF

7.  Dubin AE, Bahnson T, Weiner JA, Fukushima N, Chun J.  Lysophosphatidic acid (LPA) stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts.  J Neurosci 1999;19:1371-1381.    Download PDF

6.  Contos JJA, Chun J.  Complete cDNA sequence, genomic structure and chromosomal localization of the LPA receptor gene, vzg-1/lpA1/Gpcr26.  Genomics 1998;51:364-378.    DOWNLOAD PDF

5.  Weiner JA, Hecht JH, Chun J.  The lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain.  J Comp Neurol 1998;398:587-589.    DOWNLOAD PDF

4.  Fukushima N, Kimura Y, Chun J.  A single receptor encoded by vzg-1/lpa1/edg-2 couples to G-proteins and mediates multiple cellular responses to lysophosphatidic acid (LPA).  Proc Natl Acad Sci USA 1998;95:6151-6156.  PMC27607    DOWNLOAD PDF

3.  Hecht JH, Weiner JA, Post SR, Chun J.  Ventricular zone gene -1 (Vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.  J Cell Biol 1996;135:1071-1083.  PMC2133395    DOWNLOAD PDF

2.  Chun J.  The first cloned and identified lysophospholipid (LP) receptor gene, vzg-1:  Implications for the nervous system and related receptors. Adv Exp Med Biol 1999;469:357-62.

1.  Chun J, Contos JJA, Munroe D.  A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs).  Cell Biochem Biophys 1999;30:213-242.

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