Department of Chemical Physiology
Mowen Lab
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Welcome to the Mowen Lab (established 1 /01/2005) |
| Posttranslational modifications within signaling cascades allows for the rapid response to environmental changes. Within the immune system, signaling downstream of antigen receptors iniates programs which shape the immune response.
Arginine Methylation & Citrullination Our lab is interested in studying how the unique posttranslational modifications of arginine methylation by protein arginine methylstransferases (PRMT) and the conversion of arginine to citrulline by the peptidylarginine deiminases (PAD) function downstream of the T cell receptor and the IgE receptor on mast cells to modulate the function of these cell types. We are particularly interested in these modifications in the context of autoimmunity as we have found that PRMTs can promote proinflammatory cytokine production and autoantibodies to the PAD citrulline product are prominent in Rhuematoid Arthritis. read more |
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Mast cells and T helper cells express many of the same cytokines. Yet, they are regulated by different pathways.
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