Chi-Huey Wong

 

Professor of Chemistry at The Scripps Research Institute

President, Academia Sinica

128 Academia Road, Section 2, Nankang, Taipei, Taiwan

Tel:+886-2-2789-9400  Fax: +886-2-2785-3852 

E-mail: chwong@gate.sinica.edu.tw; wong@scripps.edu

 

Degree and Field Dates Institution

B.S. Chem./Biochem. Sci.             1966–1970              National Taiwan University

M.S. Biochem. Sci.                       1975–1977              National Taiwan University

Ph.D. Organic Chemistry               1979–1982              MIT (with G.M. Whitesides)

Postdoctoral Fellow                      1982–1983              Harvard University (with G.M.Whitesides)

Academic Appointments

Assistant Professor (1983–1986), Associate Professor (1986–1987), and Professor (1987–1989) of Chemistry, Texas A&M University.

Professor, Department of Biochemistry and Biophysics and the Institute of Biosciences and Technology, Texas A&M University, 1987–1989.

Head, Frontier Research Program on Glycotechnolgy, Institute of Physical and Che mical Research (RIKEN), Japan, 1991–1999.

Professor and Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 1989–2006.

Member, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 1996–2006.

Director, The Genomic Research Center, Acadmia Sinica, Taipei, Taiwan, 2003–2006.

President, Academia Sinica, Taipei, Taiwan, 2006-present.

Professor of Chemistry, The Scripps Research Institute, 2006-present.

Distinguished Professor of Chemistry and Biochemical Sciences, National Taiwan University, 2006-present.

 



Honors and Professional Activities


Award


·               Searle Scholar Award in Biomedical Sciences (1985–1988).

·               Presidential Young Investigator Award in Chemistry (1986–1991).

·               American Chemical Society Arthur C. Cope Scholar Award (1993).

·               The Roy Whistler Award of International Carbohydrate Organization (1994).

·               The Chinese American Chemical Society Distinguished Research Achievement Award (1994).

·               The ACS Division of Carbohydrate Chemistry Melville L. Wolfrom Award (1995).

·               The Taiwanese American Foundation Prize in Science and Engineering (1997).

·               The American Chemical Society Harrison Howe Award in Chemistry (1998).

·               The American Chemical Society Claude S. Hudson Award in Carbohydrate Chemistry (1999).

·               The American Chemical Society San Diego Section Outstanding Scientist Award (1999).

·               The International Enzyme Engineering Award (1999).

·               The Presidential Green Chemistry Challenge Award, USA (2000).

·               The American Chemical Society Award for Creative Work in Synthetic Organic Chemistry (2005).

·               The Georges Smets Chair Award for Organic or Polymer Chemistry, Louvain-la-Neuve, Belgium (2006).

·               Humboldt Research Award for Senior Scientists (2006).



Membership


·               Elected Member of Academia Sinica, Taipei (1994).

·               Elected Member of The American Academy of Arts and Sciences (1996).

·               Elected Member of the US National Academy of Sciences (2002).

·               Elected Fellow of the American Association for the Advancement of Science (2005)



Advisory Activity


·               Chairman of Executive Board of Editors – Tetrahedron Publications (2007 – 2008)

·               Advisory Board Member: Journal of Organic Chemistry (1993–1997); Journal of Chemical Society, Perkin Transaction 1 (1993–2002); The Journal of the American Chemical Society (2005–present); Chemistry–An Asian Journal (2006–present).

·               Editorial Board Member: Biocatalysis (1991–present); Carbohydrate Letters (1995–present); Drug Discovery Today (1996–1999); Current Opinion in Chemical Biology (1998–present); Advanced Synthesis and Catalysis (2000–present).

·               Founder, Combichem, Inc., San Diego, CA (1994); Founder, Board Member, and Chairman of the Scientific Advisory Board, Optimer Pharmaceuticals, Inc, San Diego (1999–present).

·               Consultant for Dow Chemical (1983–1988), W.R. Grace (1984–1987), Amgen (1991–1993), Dow Corning (1992–1994), Abbott Laboratories (1991–1994), Lilly Research Laboratories (1991–1993), Mitsubishi Chemical Group Science and Technology Research Center, Japan (2005–present).

·               Scientific Advisor for Amylin (1989–1993), Oncogene Science (1993–1998), Cytel (1991–1997), Affymax (1992–1995), ArQule (1994–1995), RedCell (1993–1997), Medinox (1996–present), Kosan Biosciences (1997–2002), Pharmanex (1997–present), Advanced Medicine (now Theravance) (1997–2000), Combichem (1994–1998), Momenta (2001–2003), Optimer (1999–present), Diversa (2001–present), Serenex (2001–present), Institute of Chemistry (1992–2000; Chairman of the Board, 1994–2000) and Institute of Biological Chemistry (1994–2002), Academia Sinica, Taipei; Institute of Molecular and Cell Biology, National University of Singapore (1994–1997), Industrial Technology Research Institute (ITRI), Taiwan (2004–present), Development Center for Biotechnology (DCB), Taiwan (2004–present).

·               Member, NIH Biomedical Sciences Study Section (1993–1995), NIH Bioorganic and Natural Products Chemistry Study Section (1995–1999).

·               Visiting Professor, Chemical Center, University of Lund, Sweden (1995–1998).

·               Member of Board of Directors: Optimer Pharmaceuticals, Inc., San Diego (1999–present), Industrial Technology Research Institute (ITRI), Taiwan (2004–present), Development Center for Biotechnology (DCB), Taiwan (2005–present).

·               Member, Scripps/Novartis Joint Scientific Council (1993–present).

·               Editor-in-Chief, Bioorganic & Medicinal Chemistry (1993–present).

·               Member of Executive Board of Editors for the Tetrahedron Publications (1993–present).

·               Distinguished Visiting Scholar, Institute of Chemistry (1999–2002) and Corresponding Research Fellow, Institute of Biological Chemistry, Academia Sinica, Taipei (1996–2002).

·               Honorary Professor, Shanghai Institute of Organic Chemistry, The Chinese Academy of Sciences, (1999–present).

·               Scientific Advisor for Max-Planck-Institut at Dortmund, Germany (2000–present).

·               Board member of the National Research Council on Chemical Sciences & Technology, USA (2000–2004).

·               Selected by ISI as one of the 100 most cited chemists in the world for the period 1981–1999.


Plenary and Named Lectures


1984:   188th ACS National Meeting.

1985:   NATO Advanced Research Workshop.

1986:   US/Japan Biotechnology Conference, Japan. International Symposium on “Biocatalysis in Organic Media,” Wageningen, the Netherlands; 5th International Symposium on Life Science: Prospects for Enzyme Technology, Kyoto.

1987:   The Pittsburg–Cleveland Catalysis Society Meeting: Frontiers in Catalysis. Gordon Research Conference on Organic Reactions and Processes; The 18th Annual NSF Workshop on Organic Synthesis and Natural Products Chemistry; The 87th American Society of Microbiology Meeting, Atlanta. 194th ACS National Meeting, New Orleans. Biotechnica ‘87, Hannover.

1988:   Symposium on Biotransformation, The Society of General Microbiology, University of Southampton, UK (2/2); Symposium on Bioorganic Synthesis, Swedish Academy of Sciences (2/3). ACS Regional Meeting, 22nd MARM Symposium on Organic Synthesis (5/24); ACS central regional meeting, Symposium on New Synthetic Strategy, West Virginia (6/2); Gordon Research Conference on Stereochemistry, New Port (7/4); Conference on Biocatalytic Synthesis of Organic Compounds, New York (8/8); Symposium on Molecular Recognition Phenoma, Royal Society of Chemistry and Swiss Chemical Society (9/11).

1989:   French–American Chemical Society 1st Meeting, Paris (6/5–6/8).

1990:   University of Illinois, Frontier in Enzyme Chemistry (3/17); Texas A&M IUCCP Program (3/19); ACS National Meeting, Boston, Division of Carbohydrate Chemistry (4/25); Gordon Conference on Natural Products (7/22); IUMS Congress, Osaka (9/16); Society for Complex Carbohydrates, La Jolla (10/12).

1991:   US–Japan Conference on Biotechnology, Hawaii (1/6); The 13th Annual Conference on Clinical Laboratory Molecular Analysis (2/14); Frontiers in Biomedical Research, Annenberg Center, Palm Springs (2/18); Merck lecturer, University of Alberta, Chemistry (3/18); US–Japan Conference on Selectivity in Synthetic and Bioorganic Chemistry, Tokyo (6/3); ASM Biotechnology Conference, New York (6/27); ACS National Meeting/Fourth North American Congress (8/28); European Peptide Society, Enzymes in Peptide Synthesis, IEC-Bogensee, Germany (9/2); Enzyme Engineering, Hawaii (9/25); International Biotechnology Conference, San Francisco (10/27); Rhone-Poulenc’s 14th Scientific Sessions, Frontiers in Chemistry and Biology, Paris (11/19); International Symposium on Bioorganic Chemistry, University of Chicago (11/22).

1992:   Symposium on Enzymes in organic synthesis, IUPAC meeting in New Delhi, India (1/6); NATO Meeting on Microbial Reagents in Organic Synthesis (3/23); Symposium on Enzymes in organic chemistry: Synthetic and mechanistic aspects, The Organic Chemistry Division, The Royal Netherlands Chemical Society (4/9); Monsanto lecturer, Purdue University (5/4); International Workshop on New Aspects of Biocatalysis, Kyoto University (6/12); 4th International SCBA Symposium, Singapore (6/14); IUPAC International Carbohydrate Symposium, Paris (7/5–7/10); Syntex lecturer, Colorado State University (11/19–11/20); Symposium on the Preparation of Enantiomerically Pure Compounds, Societe Royale de Chimie, Belgium (10/22–10/23); International Symposium on Gangliosides, Tokyo (11/5).

1993:   Merck-Frosst lecturer, University of Victoria (1/21); International Symposium on Bioorganic Chemistry, Interlaken, Switzerland (3/31–4/2); the 28th ESF/EUCHEM Conference on Stereochemistry-Burgenstock (5/2–5/8); Harvard University Mini Symposium in Organic Chemistry (5/17); Complex Carbohydrate for Drug Research, Denmark (6/6–6/10); Carbohydrate Gordon Research Conference (7/5–7/8); Chiron lecturer, UC-Berkeley (9/7).

1994:   Bristol-Myers Squibb Distinguished Lecturer, Syracuse University, New York (4/5); Sino-American Symposium on Asymmetric Synthesis, Taiwan (4/8); New Perspective in drug design, Thurnberry, Scotland (4/11); CHI’s Glycotechnology Conference, San Diego (5/16);  Organizer and Planary Lecturer, Table Ronde on Biomolecular Recognition and Catalysis, Paris (7/8–7/9); International Carbohydrate Award lecturer, International Carbohydrate Symposium, Ottawa (7/18); IASOC Conference, Ischia, Italy (9/25); W.S. Johnson Symposium in Organic Chemistry, Stanford University (10/7); 6th Annual Klaxo-UNC Frontiers in Chemistry and Medicine Symposium (11/7).

1995:   International Symposium on Protein Structure and Function, U. Exeter, UK (4/19); Contemporary Challenges in Carbohydrate Chemistry, 1995 UM/PD Symposium, Ann Arbor (4/28); Merck lecturer, University of Cambridge, England (5/10); Tetrahedron Symposium, Kyoto (5/26); The 10th Nozaki Conference, Nagoya (6/15); International Heterocycle Chemistry, Taipei (8/7); Nobel Symposium on Catalytic Asymmetric Synthesis, Stockholm (9/3); The 7th International Symposium on Chiral Discrimination (ISCD), Jerusalem (11/12).

1996:   Swiss Chemical Society (5/23); IUPAC Conference on Organic Synthesis, Amsterdam (6/30); Keynote speaker, the 4th International Symposium for Chinese Organic Chemists, Hong Kong (4/5); Wyeth-Ayerst lecturer, Columbia University (4/19); Keynote speaker, the Royal Society of Chemistry Annual Meeting, Perthshire, Scotland (9/12); ACS Princeton Organic Chemistry Symposium (9/27).

1997:   Israel Chemical Society (2/3); Distinguished Visiting Professor, Department of Chemistry, University of Florida (2/12); the Royal Society of Chemistry Carbohydrate Division (3/24); ACS William Johnson Symposium (4/14); Keynote lecturer, 2nd Carbohydrate Bioengineering, La Rochelle, France (4/15); C.H. Li Memorial lecturer, Academia Sinica, Taipei (5/2); 9th European Carbohydrate Symposium (6/11); 35th ACS National Organic Chemistry Symposium (6/22); Sponsored lecturer, 6th International Symposium on the synthesis and application of isotopes and isotopically labeled compounds, Philadelphia (9/14); Frontier in Chemical Research Program, Texas A&M University (10/13).

1998:   Allelix lecurer, Department of Chemistry, University of Toronto, (5/7); 26th National Medicinal Chemistry Symposium, Richmond, Virginia, (6/15); 20th Japanese Carbohydrate Symposium (7/15); ACS Symposium on Asymmetric synthesis of Fluoroorganic Compounds, Boston (8/23); Tetrahedron Prize Symposium, Boston (8/26); The 17th International Symposium on the Life Sciences, Kyoto (11/4).

1999:   Paul Gassman lecturer, Department of Chemisry, University of Minnesota, Minneapolis (6/1); The 37th IUPAC Congress, Berlin (8/14); The 1999 Naff Symposium on Carbohydrates and Cell Recognition (4/16); Enzyme Engineering XV (10/10). Frontiers in Bioorganic Chemistry 2000, Taipei (10/29).

2000:   The Knud Lind Larsen Symposium on Chirality, Danish Academy of Technical Sciences (1/27); The Eighth International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-8), Kyoto (7/11); the Gordon Conference on Green Chemistry, Connecticut (7/18); International Carbohydrate Conference, Hamberg (8/22); The Novartis lecturer, Budapest (10/22); International Chemical Congress of Pacific Basin Societies, Honolulu (12/18).

2001:   the Royal Society of Chemistry Carbohydrate Group, Dublin, Ireland (4/4); the International Conference on Green Chemistry, Wales Swansea, UK (4/6); Gordon Research Conference on Bioorganic Chemistry, New Hampshire (6/17); Enzyme Engineering XVI Conference, Potsdam, Germany (10/7); Robert A. Welch Foundation Conference on Chemistry for the 21st Century, Houston (10/29); Merck lecturer, Wayne State University (11/4).

2002:   International Conference on Industrial Applications of Biocatalysis, San Diego (3/21); Health Care Ventures Scientific Advisory Board Retreat, Palm Beach (4/10); First ICI Conference on Contemporary Asymmetric Catalysis (9/12); The Merck lecturer, University of Cambridge, UK (9/22). IUPAC Conference on Natural Products, Florence, Italy (7/29).

2003:   Treat B. Johnson Lecture, Yale University (2/19); International Bioinspiring Conference, Haifa, Israel (12/8); International Enzyme Engineering Conference, Santa Fe, New Mexico (11/9).

2004:   3rd International Proteomics Conference, Taipei, Taiwan (5/17); Ralph and Helen Oesper Symposium, Univeristy of Cincinnati (10/15); The 4th Tateshima Conference in Organic Chemistry, Tokyo, Japan (11/12); Yousei University lectureship, Seoul, Korea (11/16); International Symposium on Current Therapeutics Development for Infectious Diseases, Taipei, Taiwan (12/16).

2005:   Keynote lecturer, 3rd Annual Conference on Glycomics–Carbohdrates in Drug Development, San Diego (3/21); American Society for Biochemistry and Molecular Biology (ASBMS), San Diego (4/2); Wyeth Ayerst lecturer, University of Pennsylvania (4/12); Arnold O. Beckman lecturer, California Institute of Technology (5/18); Commissariat a L’energie Atomique u Centre de Sacly, Paris, France (6/27); Tetrahedron Symposium, Bordeaux, France (6/28); Tetrahedron Prize Symposium, 2005 Amercian Chemical Society Meeting, Washington D.C. (8/29); Royal Society of Chemistry-Fluroine Group, Oxford, UK (9/1–9/2); Harry Day lecturer, Indiana University (9/14).

2006:   Recipient, Smets Chair Award, Louvain-la-Neuve, Belgium (3/13-3/14); Keynote speaker, Glycomics and Carbohydrates, San Diego (3/23–3/24); Keynote lecturer, CACS 25th Anniversary Symposium, Atlanta (3/27);  Trends in Organic Chemistry: Enzymatic Synthesis, Stockholm (9/4); 3rd Brazilian Symposium on Medicinal Chemistry (11/12–11/15), Keynote speaker, Joint third AOHUPO and Fourth International Structural Biology and Functional Genomics Conference, Singapore (12/4-12/7).

2007:   Novartis Lecturer, Columbia University (1/29); Claude S. Hudson Award Symposium, 234th ACS National Meeting, Chicago (3/25); Organic Chemistry—Present & Future, Louvain-la-Neuve, Belgium (4/10-4/13); 24th Herbert C. Brown Lecture, Purdue University (4/19); Carbohydrate Gordon Conference, Tilton School, New Hampshire (6/17); EMBO Workshop: Chemistry and Biochemistry of Enzyme Catalysis by Biological Systems, Hamburg, Germany (6/20); International Meeting on Glycoconjugates, Academia Sinica, Taipei (7/9); The 4th Foundation Symposium on Pharma Sciences, Tokyo (12/3).

Principal areas of research interest

Chemical Biology and Synthetic Chemistry: Development of New Synthetic Methods Based on Enzymatic and Chemo-enzymatic Approaches; Directed Evolution of Enzymes; Rational Design, Synthesis and Evaluation of Enzyme Inhibitors; Structure–Function and Synthetic Study of Carbohydrates, Glycoproteins, and Related Substances; Programmable One-Pot Oligosaccharide Synthesis; Development of Small Molecules Targeting RNA and the Immune System; Genomic and Proteomic Approach to Drug Discovery; Development of Carbohydrate Mimetics as Inhibitors of Carbohydrate Receptors; Molecular Cloning and Protein Engineering; Synthesis of Oligosaccharide and Aminoglycoside Microarrays for High-throughput Screening; Mechanism.



 

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For more information, please refer to the Wong lab homepage.