611. Molecular Design and Chemical Synthesis of a Highly Potent Epothilone, K.C. Nicolaou, B.A. Pratt, S. Arseniyadis, M. Wartmann, A. O’Brate, P. Giannakakou, ChemMedChem 1, 41-44 (2006).

612. Total Synthesis and Structural Elucidation of Azaspiracid-1. Construction of Key Building Blocks for Originally Proposed Structure, K.C. Nicolaou, P.M. Pihko, F. Bernal, M.O. Frederick, W. Qian, N. Uesaka, N. Diedrichs, J. Hinrichs, T.V. Koftis, E. Loizidou, G. Petrovic, M. Rodriquez, D. Sarlah, N. Zou, J. Am. Chem. Soc. 128, 2244-2257 (2006).

613. Total Synthesis and Structural Elucidation of Azaspiracid-1. Synthesis-based Analysis of Originally Proposed Structures and Indication of Their Non-Identity to the Natural Product, K.C. Nicolaou, D.Y.-K. Chen, Y. Li, N. Uesaka, G. Petrovic, T.V. Koftis, F. Bernal, M.O. Frederick, M. Govindasamy, T. Ling, P.M. Pihko, W. Tang, S. Vyskocil, J. Am. Chem. Soc. 128, 2258-2267 (2006).

614. Total Synthesis and Structural Elucidation of Azaspiracid-1. Final Assignment and Total Synthesis of the Correct Structure of Azaspiracid-1, K.C. Nicolaou, T.V. Koftis, S. Vyskocil, G. Petrovic, W. Tang, M.O. Frederick, D.Y.-K. Chen, Y. Li, T. Ling, Y.M.A. Yamada, J. Am. Chem. Soc. 128, 2859-2872 (2006).

615. Total Synthesis of Floresolide B and D6,7-Z-Floresolide B, K.C. Nicolaou, H. Xu, Chem. Commun., 600-602 (2006).

616. Stereocontrolled Synthesis of Model Core Systems of Lomaiviticins A and B, K.C. Nicolaou, R.M. Denton, A. Lenzen, A. Li, D.J. Edmonds, R.R. Milburn, S.T. Harrison, Angew. Chem. Int. Ed. 45, 2076-2081 (2006).

617. Total Synthesis and Biological Evaluation of Halipeptins A and D and Analogues, K.C. Nicolaou, D.E. Lizos, D.W. Kim, D. Schlawe, R.G. de Noronha, D.A. Longbottom, M. Rodriquez, M. Bucci, G. Cirino, J. Am. Chem. Soc. 128, 4460-4470 (2006).

618. Total Synthesis and Confirmation of the Revised Structures of Azaspiracid-2 and Azaspiracid-3, K.C. Nicolaou, M.O. Frederick, G. Petrovic, K.P. Cole, E. Loizidou, Angew. Chem. Int. Ed. 45, 2609-2615 (2006).

619. Total Synthesis of Abyssomicin C and atrop-Abyssomicin C, K.C. Nicolaou, S.T. Harrison, Angew. Chem. Int. Ed. 45,bstituted N-Hydroxyindoles through 1,5-Addition of Carbon Nucleophiles to In Situe Generated Unsaturated Nitrones, K.C. Nicolaou, A.A. Estrada, S.H. Lee, G.C. Freestone, Angew. Chem. Int. Ed. 45, 5364-5 3256-3260 (2006).

620. Second Generation Total Synthesis of Azaspiracids-1, -2 and -3, K.C. Nicolaou, M.O. Frederick, E.Z. Loizidou, G. Petrovic, K.P. Cole, T.V. Koftis, Y.M.A. Yamada, Chem. Asian J. 1–2, 245-263 (2006).

621. Synthesis of Highly Substituted N-Hydroxyindoles through 1,5-Addition of Carbon Nucleophiles to In Situe Generated Unsaturated Nitrones, K.C. Nicolaou, A.A. Estrada, S.H. Lee, G.C. Freestone, Angew. Chem. Int. Ed. 45, 5364-5368 (2006).

622. Structure Toxicity Relationships of Synthetic Azaspiracid-1 and Analogs in Mice, E. Ito, M.O. Frederick, T.V. Koftis, W. Tang, G. Petrovic, T. Ling, K.C. Nicolaou, Harmful Algae 5, 586-591 (October, 2006).

623. Total Synthesis of iso-Epoxy-Amphidinolide N and des-Epoxy-Caribenolide I Structures. Initial Forays, K.C. Nicolaou, W.E. Brenzovich, P.G. Bulger, T.M. Francis, Org. Biomol. Chem. 4, 2119-2157 (2006).

624. Total Synthesis of iso-Epoxy-Amphidinolide N and des-Epoxy-Caribenolide I Structures. Revised Strategy and Final Stages, K.C. Nicolaou, P.G. Bulger, W.E. Brenzovich, Org. Biomol. Chem. 4, 158-2183 (2006).

625. Azaspiracids Modulate Intracellular pH Levels in Human Lymphocytes, A. Alfonso, M.R. Vieytes, K. Ofuji, M. Satake, K.C. Nicolaou, M.O. Frederick, L.M. Botana, Biochem. Biophys. Res. Commun. 346, 1091-1099 (2006).

626. Total Synthesis of Marinomycins A–C, K.C. Nicolaou, A.L. Nold, R.R. Milburn, Angew. Chem. Int. Ed. 45, 6527-6532 (2006).

627. Total Synthesis of Platensimycin, K.C. Nicolaou, A. Li, D.J. Edmonds, Angew. Chem. Int. Ed. 45, 7086-7090 (2006).

628. Cascade Reactions in Total Synthesis, K.C. Nicolaou, D.J. Edmonds, P.G. Bulger, Angew. Chem. Int. Ed. 45, 7134-7186 (2006).

629. Total Synthesis of Antibiotics GE2270A and GE2270T, K.C. Nicolaou, B. Zou, D.H. Dethe, D.B. Li, D.Y.-K. Chen, Angew. Chem. Int. Ed. 45, 7786-7792 (2006).

630. Asymmetric Reactions in Total Synthesis, K.C. Nicolaou, P.G. Bulger, in Asymmetric Synthesis – The Essentials, M. Christmann, S. Bräse, Eds., Wiley-VCH, Weinheim, Part IV, 2006, Ch. 42, pp. 225-240.

631. Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly, E. Hamel, B.W. Day, J.H. Miller, M.K. Jung, P.T. Northcote, A.K. Ghosh, D.P. Curran, M. Cushman, K.C. Nicolaou, I. Paterson, E.J. Sorensen, Mol. Pharm. 70, 1555-1564 (2006).

632. Cell Growth Inhbition and Actin Cytoskeleton Disorganization Induced by Azaspiracid-1 Structure–Activity Studies, N. Vilariño, K.C. Nicolaou, M.O. Frederick, E. Cagide, I.M. Ares, M.C. Louzao, M.R. Vieytes, L.M. Botana, Chem. Res. Toxicol. 19, 1459-1466 (2006).

633. Total Synthesis of Abyssomicin C, Atrop-abyssomicin C, and Abyssomicin D: Implications for Natural Origins of Atrop-abyssomicin C, K.C. Nicolaou, S.T. Harrison, J. Am. Chem. Soc. 129, 429-440 (2007).

634. Total Synthesis of Marinomycins A–C and of Their Monomeric Counterparts mono-Marinomycin A and iso-mono-Marinomycin A, K.C. Nicolaou, A.L. Nold, R.R. Milburn, C.S. Schindler, K.P. Cole, J. Yamaguchi, J. Am. Chem. Soc. 129, 1760-1768 (2007).

635. The Chemistry and Biology of Epothilones – The Wheel Keeps Turning, K.-H. Altmann, B. Pfeiffer, S. Arseniyadis, B.A. Pratt, K.C. Nicolaou, ChemMedChem 2, 396-423 (2007).

636. Effects of Azaspiracid-1, a Potent Cytotoxic Agent, on Primary Neuronal Cultures. A Structure-Activity Relationship Study, C. Vale, K.C. Nicolaou, M.O. Frederick, B. Gomez-Limia, A. Alfonso, M.R. Vieytes, L.M. Botana, J. Med. Chem. 50, 356-363 (2007).

637. Total Synthesis of 2,2¢-epi-Cytoskyrin A, Rugulosin and the Alleged Structure of Rugulin, K.C. Nicolaou, Y.H. Lim, J.L. Piper, C.D. Papageorgiou, J. Am. Chem. Soc. 129, 4001-4013 (2007).

638. Asymmetric Syntheses of Platensimycin, K.C. Nicolaou, D.J. Edmonds, A. Li, G.S. Tria, Angew. Chem. Int. Ed. 46, 3942-3945 (2007).

639. Formal Synthesis of (±)-Platensimycin, K.C. Nicolaou, Y. Tang, J. Wang, Chem. Commun., 1922-1923 (2007).

640. Structural Assignment and Total Synthesis of Azaspiracid-1, M.O. Frederick, K.P. Cole, G. Petrovic, E. Loizidou, K.C. Nicolaou, in Phycotoxins: Chemistry and Biochemistry Ed., L.M. Botana, Blackwell Publishing, Ames, Iowa, Ch. 16, pp. 297-309, 2007.

641. Total Synthesis and Stereochemistry of Uncialamycin, K.C. Nicolaou, H. Zhang, J.S. Chen, J. Crawford, L. Pasunoori, Angew. Chem. Int. Ed. 46, 4704-4707 (2007).

642. Total Synthesis and Revised Structure of Biyouyanagin A, K.C. Nicolaou, D. Shaw, D. Sarlah, Angew. Chem. Int. Ed. 46, 4708-4711 (2007).

643. Total Synthesis of Adamantaplatensimycin: A Bioactive Platensimycin Analogue, K.C. Nicolaou, T. Lister, R.M. Denton, A. Montero, D.J. Edmonds, Angew. Chem. Int. Ed. 46, 4712-4714 (2007).

644. Construction of the “Left-domain” of Haplophytine, K.C. Nicolaou, U. Majumder, S. Philippe Roche, D. Y.-K. Chen, Angew. Chem. Int. Ed. 46,4715-4718 (2007).

645. New Synthetic Technology for the Construction of N-Hydroxyindoles and Synthesis of Nocathiacin I Model Systems, K.C. Nicolaou, A.A. Estrada, G.C. Freestone, S.H. Lee, X.M. Alvarez, Tetrahedron 63, 6088-6114 (2007).

646. On the Structure of Maitotoxin, K.C. Nicolaou, M.O. Frederick, Angew. Chem. Int. Ed. 46, 5278-5282 (2007).

647. Irreversible Cytoskeletal Disarrangement is Independent of Caspase Activation During In Vitro Azaspiracid Toxicity in Human Neuroblastoma Cells, N. Vilarino, K.C. Nicolaou, M.O. Frederick, M.R. Vieytes, L.M. Botana, Biochem. Pharm., in press.

648. Total Synthesis of the Originally Proposed and Revised Structures of Palmerolide A, K.C. Nicolaou, R. Guduru, Y.-P. Sun, B. Banerji, D.Y.-K. Chen, Angew. Chem. Int. Ed. 46, 5896-5900 (2007).

649. The c-Jun-N-Terminal Kinase is Involved in the Neurotoxic Effect of Azaspiracid-1, C. Vale, B. Gómez-Limia, K.C. Nicolaou, M.O. Frederick, M.R. Vieytes, L. M. Botana, Cell. Physiol. Biochem. 20, 957-966 (2007).

650. Cascade Reactions Involving [2+2] Thermal Cycloadditions. Total Synthesis of Artochamins F, H, I and J, K.C. Nicolaou, T. Lister, R.M. Denton, C.F. Gelin, Angew. Chem. Int. Ed., 7501-7505 (2007).

651. Total Synthesis of Kinamycins C, F, and J, K.C. Nicolaou, H. Li, A.L. Nold, D. Pappo, A. Lenzen, J. Am. Chem. Soc. 129, 10356-10357 (2007).

652. Total Synthesis of Complex Heterocyclic Natural Products, K.C. Nicolaou, J.S. Chen, Symposium in Print, 21st International Congress of Heterocyclic Chemistry, submitted.

653. Metathesis Reactions in the Synthesis of Complex Molecules, K.C. Nicolaou, A. Ortiz, R.M. Denton, Chemistry Today 25, 70-76 (2007).

654. Total Synthesis and Antibacterial Properties of Carbaplatensimycin, K.C. Nicolaou, Y. Tang, J. Wang, A.F. Stepan, A. Li, A. Montero, J. Am. Chem. Soc. 129, 14850-14851 (2007).

655. Chemical Synthesis of the GHIJK Ring System and Further Experimental Support for the Originally Assigned Structure of Maitotoxin, K.C. Nicolaou, K.P. Cole, M.O. Frederick, R.J. Aversa, R.M. Denton, Angew. Chem. Int. Ed. 46, 8875-8879 (2007).

656. Asymmetric Synthesis and Biological Properties of Uncialamycin and 26-epi-Uncialamycin, K.C. Nicolaou, J.S. Chen, H. Zhang, A. Montero, Angew. Chem. Int. Ed. 47, 185-189 (2008).

657. A Chiral Pool Based Synthesis of Platensimycin, K.C. Nicolaou, D. Pappo, K.Y. Tsang, R. Gibe, D.Y.-K. Chen, Angew. Chem. Int. Ed. 47, 944-946 (2008).

658. Total Synthesis of Thiopeptide Antibiotics GE2270A, GE2270T, and GE2270C, K.C. Nicolaou, D.H. Dethe, G.Y.C. Leung, B. Zou, D.Y.-K. Chen, Chem. Asian J. 3, 413-429 (2008).

659. Synthesis of the Sporolide Ring Framework through a Cascade Sequence Involving an Intramolecular [4+2] Cycloaddition Reaction of an o-Quinone, K.C. Nicolaou, J. Wang, Y. Tang, Angew. Chem. Int. Ed. 47, 1432-1435 (2008).

660. Total Synthesis of Platencin, K.C. Nicolaou, G.S. Tria, D.J. Edmonds, Angew. Chem. Int. Ed. 47, 1780-1783 (2008).

661. Total Synthesis of the Originally Proposed and Revised Structures of Palmerolide A and Isomers Thereof, K.C. Nicolaou, Y.-P. Sun, R. Guduru, B. Banerji, D.Y.-K. Chen, J. Am. Chem. Soc. 130, 3633-3644 (2008).

662. Total Synthesis of Artochamins F, H, I and J through Cascade Reactions, K.C. Nicolaou, T. Lister, R.M. Denton, C.F. Gelin, Tetrahedron 64, 4736-4757 (2008).

663. Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin, K.C. Nicolaou, M.O. Frederick, A.C.B. Burtoloso, R.M. Denton, F. Rivas, K.P. Cole, R.J. Aversa, R. Gibe, T. Umezawa, T. Suzuki, J. Am. Chem. Soc. 130, 7466-7476 (2008).

664. An Expedient Strategy for the Synthesis of Tryptamines and Other Heterocycles, K.C. Nicolaou, A. Krasovskiy, V.É. Trépanier, D.Y.-K. Chen, Angew. Chem. Int. Ed. 47, 4217-4280 (2008).

665. Total Syntheses of Amythiamicins A, B and C, K.C. Nicolaou, D.H. Dethe, D.Y.-K. Chen, Chem. Commun., 2632-2634 (2008).

666. Chemical Synthesis and Biological Evaluation of Palmerolide A Analogues, K.C. Nicolaou, G.Y.C. Leung, D.H. Dethe, R. Guduru, Y.-P. Sun, C.S. Lim, D.Y.-K. Chen, J. Am. Chem. Soc., 130, 10019-10023 (2008).

667. Total Syntheses and Structural Revisions of a- and b-Diversonolic Esters and Total Syntheses of Diversonol and Blennolide C, K.C. Nicolaou, A. Li, Angew. Chem. Int. Ed., 47, 6579-6582 (2008).

668. Total Synthesis, Revised Structure, and Biological Evaluation of Biyouyanagin A and Analogues Thereof, K.C. Nicolaou, T.R. Wu, D. Sarlah, D. Shaw, E. Rowcliffe, D.R. Burton, J. Am. Chem. Soc. 130, 11114-11121 (2008).

669. An Expedient Asymmetric Synthesis of Platencin, K.C. Nicolaou, Q.-Y. Toh, D.Y.-K. Chen, J. Am. Chem. Soc. 130, 11292-11293 (2008).

670. Cytotoxic Effect of Azaspiracid-2 and Azadspiracid-2-Methyl Ester in Cultured Neurons: Involvement of the c-Jun N-Terminal Kinase, C. Vale, C. Wandscheer, K.C. Nicolaou, M.O. Frederick, C. Alfonso, M.R. Vieytes, L.M. Botana, J. Neurosci. Res., 86, 2952-2962 (2008).

671. The Continuing Saga of the Marine Polyether Biotoxins, K.C. Nicolaou, M.O. Frederick, R.J. Aversa, Angew. Chem. Int. Ed. 47, 7182-7225 (2008).

672. Total Synthesis of (+)-Cortistatin, K.C. Nicolaou, Y.-P. Sun, X.-S. Peng, D. Polet, D.Y.-K. Chen, Angew. Chem. Int. Ed. 47, 7310-7313 (2008).

673. Azaspiracid Substituent at C1 Is Relevant to In Vitro Toxicity, N. Vilarino, K.C. Nicolaou, M.O. Frederick, E. Cagide, C. Alfonso, E. Alonso, M.R. Vieytes, L.M. Botana, Chem. Res. Toxicol. 21, 1823-1831 (2008).

674. Design, Synthesis and Biological Evaluation of Platensimycin Analogues with Varying Degrees of Molecular Complexity, K.C. Nicolaou, A.F. Stepan, T. Lister, A. Montero, G.S. Tria, C.I. Turner, Y. Tang, J. Wang, R.M. Denton, D.J. Edmonds, J. Am. Chem. Soc. 130, 13110-13119 (2008).

675. Total Synthesis of the Originally Assigned Structure of Vannusal B, K.C. Nicolaou, H. Zhang, A. Ortiz, P. Dagneau, Angew. Chem. Int. Ed. 47, 8605-8610 (2008).