7",V**+++,,,,," ,, ,6,6,6,6,6 ,V,V,V,VTitle Goes Here [BMCL TITLE] Author(s) Go Here; place an asterisk by corresponding author [BMCL AUTHOR(S)] Address(es) Go Here; If there is more than one affiliation please use superscript a, b, c, etc. to designate with author's name [BMCL ADDRESS(ES)] This is where the receipt/accepted dates will go; Received Month XX, 2000; Accepted Month XX, 2000 [BMCL RECEIPT] AbstractType your abstract here. It should be no longer than 34 lines. [BMCL ABSTRACT] 2000 Elsevier Science Ltd. All rights reserved. This template can be used in two ways. You may use the different example paragraphs that are given below (a description of use is included) by typing within the paragraph. If you already have your document you may use the style gallery. This style gallery, which can be accessed in the tool bar in the upper left hand corner or by using the pull down menus ('Format' then 'Style'), can be used to apply styles to your own text. Style names are given in brackets within each different paragraph. Please contact the editorial office if you have questions. This is your standard paragraph [BMCL NORMAL]. Most of your text will use this formatting. If you have figures or schemes use the following paragraph as the legend. Please use section headers sparingly. There will be a single line between paragraphsparagraphs are not indented. Figure 1. Use this paragraph to type the legend(s) for your scheme(s) or figure(s), as well as the heading for a table and the table footer(s). [BMCL LEGEND FOR SCHEMES/FIGURES/TABLES] The above paragraph can be used for the Table heading and footer(s) as well. When creating tables use the table function provided with your word-processing program. Please do not create tables by tabulation. Tables created in ChemDraw are acceptable as long as they are saved as an EPS or TIFF file. All tables must be cited in the text, and numbered in order of appearance with Arabic numerals. All table columns should have a brief explanatory heading a where appropriate, units of measurements. Vertical lines should not be used. Footnotes to tables should be typed below the table and should be referred to by superscript letters. You may use the table below as a template (add or delete columns/rows using the Table functions). Table 1. Classical complement inhibition, cytotoxicity, and apoptosis assay results for compounds 15 and 919. CompdsComplement Inhibition IC50, mMaCytotoxicity IC50, mMaT.I.b172.3 (5.8)112 (8) 1.552577(103)35 (27)0.063nana4na70 (14)5nanaaValues are means of three experiments, standard deviation is given in parentheses (na = not active). bIn vitro therapeutic index (IC50 cytotoxicity/IC50 complement inhibition) Figures, schemes, and equations must be cited in the text and numbered in order of appearance with Arabic numerals. Other graphics, such as structures, do not need to be numbered, but please indicate in the text where these are to appear. All graphics (including chemical structures) must be provided at the actual size that they are to appear (single-column width is 8.4 cm, double-column width is 17.5 cm). Please arrange schematics so that they fill the column space (either single or double), so as not to leave a lot of unused white space. Please ensure that all illustrations within a paper are consistent in type, quality, and size. Captions should not be included as part of the graphic; instead all captions should be supplied at the end of the text. Reagents and conditions (unless incorporated into the actual schematic) should also be provided as text. All graphics must be labeled with the figure or scheme number, and the corresponding author's name. To help authors provide actual size graphics, it is suggested that the following settings be used with CSC ChemDraw and ISIS Draw; font 10 pt Helvetica, chain angle 120, bond spacing 18% of length, fixed length 10.08 pt (0.356 cm), bold width 1.4 pt (0.049 cm), line width 0.42 pt (0.015 cm), margin width 1.12 pt (0.04 cm), and hash spacing 1.75 pt (0.062 cm). Compound numbers should be boldface. In order to accurately design schematics to print out at the proper width, the original drawing cannot exceed a column width of 8.4 cm (for single column) and 17.7 cm (for double column). Computer-generated illustrations, halftones, and line/tones should also be provided where possible. The following points should be taken into consideration when preparing electronic graphic files: Tagged Image File Format (TIFF) or Encapsulated PostScript (EPS) files are preferred. Suggested packages for line graphics are ChemDraw, Adobe Illustrator (version 3.0 or above), Freehand, and Corel Draw. Graphics created in Wordperfect and Word generally have too low a resolution for our requirements. Files of scanned line graphics can be accepted at a minimum resolution of 1000 dpi, for scanned halftones, 300 dpi, and scanned line/tone, 500 dpi. Color should be scanned at 300 dpi (500 dpi for color line/tones). Some other guidelines: Use the subscript and superscript functions rather than raising and lowering numbers (for references chemical formulas), etc. When placing graphics please insert as EPS (encapsulated postscript) files or TIFF (tagged image file format) files. Do not just copy and paste ChemDraw files or ISIS Draw files. If the program you use does not allow you to save the files in one of these two formats use the copy and paste functions (alternative file format is jpeg). Manuscripts can be no longer that four printed pages. When you inserting graphics or tables that are of a double-column width you will need to insert a section break. This is done by using the pull down menus'Insert', 'Break', 'Section-continuous'. You will actually need the two section break lines, enter one break, enter a paragraph, enter another break. You will need to format this section as a single column. Do this by placing the marker on the paragraph and using the pull down menus'Format', 'Columns', 'One'. This is a section header paragraph [BMCL HEADER] References to the literature must follow the format outlined for ACS publications (Journal of the American Chemical Society style), and titles of journals are abbreviated according to Chemical Abstracts Service Source Index. For a detailed listing of journal abbreviations and citation formats, see: The ACS Style Guide; American Chemical Society: Washington, DC, 1997. References should be numbered consecutively as they appear throughout the text, and be indicated consecutively in the text with superscript numbers. Scientific Articles: 1. Doe, J. S.; Smith, J. J.; Roe, R. P. J. Am. Chem. Soc. 1968, 90, 8234. Books: 2. Doe, J. S.; Smith, J. J. In Medicinal Chemistry; Roe, P., Small, J. K., Eds.; Pergamon: Oxford, 1990; Vol. 1, pp 301-383. Patent/Chem. Abstract: 3. Lyle, F. R. U.S. Patent 6,973,257, 1995; Chem. Abstr. 1995, 123, 2870. Meeting Abstract: 4. Prasad, A.; Jackson, P. Abstracts of Papers, Part 2, 212th National Meeting of the American Chemical Society, Orlando, FL, Aug 2529, 1996; American Chemical Society: Washington, DC, 1996; PMSE 189. 1. This is the reference paragraph. If you have more than one reference use (a), (b), (c), etc., with a period at the end of each section. [BMCL REFERENCE] Any suggestions for improvement of this template are welcome. See our Instructions to Contributors for more detailed information regarding your submission. vxRRuvwxRRkpx?@H ; > C G I P [ h j l m n o p  ¿      5 S T r t ef{e   ;NOP)=>DIKu" @@@@@@@@@@@   >kp&'>?@ I P [ f p } Že]]]]8'4 @@@@@@@@@@@@@@@@8'4 @@@@@@@@@@@@@@@@88  ! S efШxppppHCC>9 '4 @@@@@@@@@@@@8'4 @@@@@@@@@@@@@@@@8'4 @@@@@@@@@@@@@@@@8'4 @@@@@@@@@@@@@@@@z{uv !"ľhh* BMCL TITLE BMCL NORMALBMCL AUTHOR(S)BMCL ADDRESS(ES) BMCL RECEIPT BMCL ABSTRACT BMCL HEADERBMCL REFERENCE&BMCL LEGEND FOR SCHEMES/FIGURES/TABLESQ$@! @! @8 8$h  h L""3 ""=/RrrD