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Detection of & Protection
from Warfare Agents
Biochemical Reactivity
of Drugs of Abuse
Catalytic Antibodies
Bacterial Cell-Cell Communication
Phage Display Technology
Drug Addiction & Abuse: Immunopharmacotherapy
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Authors, Title
Journal, Volume, Pages, (Year)
368
Meijler, M.M., Kaufmann, G.F., Qi, L., Mee, J.M., Coyle, A.R., Moss, J.A., Wirsching, P., Matsushita, M., Janda, K.D., "Fluorescent cocaine probes: A tool for the selection and engineering of therapeutic antibodies"
J. Am. Chem. Soc., 127, 2477 (2005)
351
Brogan, A.P., Eubanks, L.M., Koob, G.F., Dickerson, T.J., Janda, K.D., "Antibody-catalyzed oxidation of delta-9-tetrahydrocannabinol"
J. Am. Chem. Soc., 129, 3698 (2007)
350
De Lamo Marin, S., Xu, X., Meijler, M.M., Janda, K.D., "Antibody catalyzed hydrolysis of a quorum sensing signal found in Gram-negative bacteria"
Bioorg. Med. Chem. Lett., 17, 1549 (2007)
348
Xu, Y., Hixon, M.S., Yamamoto, N., McAllister, L.A., Wentworth, A.D., Wentworth, Jr., P., Janda, K.D., "Antibody-catalyzed anaerobic destruction of methamphetamine"
PNAS, 104(10), 3681 (2007)
345
Rogers, C.J., Eubanks, L.M., Dickerson, T.J., Janda, K.D., "Unexpected acetylcholinesterase activity of cocaine esterases"
J. Am. Chem. Soc., 128, 15364 (2006)
344
McKenzie, K.M., Mee, J.M., Rogers, C.J., Hixon, M.S., Kaufmann, G.F., Janda, K.D., "Identification and characterization of single chain anti-cocaine catalytic antibodies"
J.Mol. Bio., 365, 722 (2006)
328
Zhu, X., Dickerson, T.J., Rogers, C.J., Kaufmann, G.F., Mee, J.M., McKenzie, K.M., Janda, K.D., Wilson, I.A., "Complete reaction cycle of a cocaine catalytic antibody at atomic resolution"
Structure, 14, 205 (2006)
312
Carrera, M.R.A., Trigo, J.M., Wirsching,P., Roberts, A.J., Janda, K.D., "Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose"
Pharmacology, Biochemistry and Behavior, 81, 709 (2005)
310
Toker, J.D., Tremblay, M.R., Yli-Kauhaluoma, J., Wentworth, A.D., Zhou, B., Wentworth, Jr., P., Janda, K.D., "Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction"
J. Org. Chem., 70, 7810 (2005)
309
Xu, Y., Yamamoto, N., Ruiz, D.I., Kubitz, D.S., Janda, K.D., "Squaric monoamide monoester as a new class of reactive immunization hapten for catalytic antibodies"
Bioorg. Med. Chem. Lett., 15, 4304 (2005)
299
Kaufmann, G.F., Meijler, M.M., Sun, C., Chen, D.-W., Kujawa, D.P., Mee, J.M., Hoffman, T.Z., Wirsching, P., Lerner, R.A., Janda, K.D., "Enzymatic incorporation of an antibody-activated blue fluorophore into DNA"
Angew. Chem. Int. Ed., 44, 2144 (2005)
287
McDunn, J.E., Dickerson, T.J., Janda, K.D., "Antibody Catalysis of Disfavored Chemical Reactions"
Catalytic Antibodies, ed. Ehud Keinan, Wiley-VCH Verlag Gmbh & Co., Weinheim, Germany, 184 (2004)
286
Xu, Y., Yamamoto, N., Janda, K.D., "Catalytic antibodies: Hapten design stratagies and screening methods"
Bioorg. Med. Chem., 12, 5247 (2004)
278
Chen, D.-W., Janda, K.D., "Catalytic Antibodies"
Encyclopedia of Supramolecular Chemistry, Marcel Dekker, New York, NY, 193 (2004)
273
Ahn, J.-M., Wentworth, Jr., P., Janda, K.D., "Probing lipase/esterase libraries for lipid A hydrolysis - discovery of biocatalysts for the detoxification of bacterially-expressed recombinant protein"
Chem. Commun., 364, (2004)
270
Matsushita, M., Yoshida, K., Yamamoto, N., Wirsching, P., Lerner, R.A., Janda, K.D., "High-throughput screening by using a blue-fluorescent antibody sensor"
Angew. Chemie, Int. Ed., 42, 5984 (2003)
269
Dickerson, T.J., Tremblay, M.R., Hoffman, T.Z., Ruiz, D.I., Janda, K.D., "Catalysis of the Photo-Fries reaction: Antibody-mediated stabilization of high energy states"
J. Amer. Chem. Soc., 125, 15395 (2003)
267
Wentworth, Jr., P., Nieva, J., Takeuchi, C., Galve, R., Wentworth, A.D., Dilley, R.B., DeLaria, G.A., Saven, A., Babior, B.M., Janda, K.D., Eschenmoser, A., Lerner, R.A., "Evidence for ozone formation in human atherosclerotic arteries"
Science, 302, 1053 (2003)
263
Hasserodt, J., Janda, K.D., "Catalytic Antibodies"
In: Encyclopedia of Catalysis, ed. I.T. Horvath, Wiley, N.Y., pp. 440-476 (2003)
254
Wentworth, Jr., P., Wentworth, A.D., Zhu, X., Wilson, I.A., Janda, K.D., Eschenmoser, A., Lerner, R.A., "Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens"
Proc. Natl. Acad. Sci. USA, 100, 1490 (2003)
252
Cannizzaro, C.E., Ashley, J.A., Janda, K.D., Houk, K.N., "Experimental determination of the absolute enantioselectivity of an antibody-catalyzed Diels-Alder reaction and theoretical explorations of the origins of stereoselectivity"
J. Amer. Chem. Soc., 125(9), 2489 (2003)
250
Wang, Q., Krishnaswami, S.R., Janda, K.D., Lin, T., Finn, M.G., "Blue fluorescent antibodies as reporters of steric accessibility in virus conjugates"
Bioconjugate Chem., 14, 38 (2003)
249
Dickerson, T., Cordova, A., Chen, D.-W., Janda, K.D., "The Use of Enzymes and Catalytic Antibodies in the Asymmetric Aldol Reaction"
In: Encyclopedia of Catalysis, ed. I.T. Horvath, Wiley, N.Y., (2002)
248
Wentworth, Jr., P., McDunn, J.E., Wentworth, A.D., Takeuchi, C., Nieva, J., Jones, T., Bautista, C., Ruedi, J.M., Gutierrez, A., Janda, K.D., Babior, B.M., Eschenmoser, A., Lerner, R.A., "Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation"
Science, 298, 2195 (2002)
244
Jones, L.H., Altobell III, L.J., MacDonald, M.T., Boyle, N.A., Wentworth, Jr., P., Lerner, R.A., Janda, K.D., "Active immunization with a glycolipid transition state analogue protects against endotoxic shock"
Angew. Chem. Int. Ed., 41(22), 4241 (2002)
233
Delgado, M., Lee, K.J., Altobell, III, L., Spanka, C., Wentworth, Jr., P., Janda, K.D., "A parallel approach to the discovery of carrier delivery vehicles to enhance antigen immunogenicity"
J. Amer. Chem. Soc., 124, 4946 (2002)
229
Isomura, S., Ashley, J.A., Wirsching, P., Janda, K.D., "Antibody-catalyzed cleavage of the D-Ala-D-Lac depsipeptide: An immunological approach to the problem of vancomycin resistance"
Bioorg. Med. Chem. Lett., 12, 861 (2002)
227
Kim, G.-T., Wenz, M., Park, J.-I., Hasserodt, J., Janda, K.D., "Polyene substrates with unusual methylation patterns to probe the active sites of three catalytic antibodies"
Biorg. Med. Chem., 10, 1249 (2002)
219
Cannizzaro, C.E., Houk, K.N., Ashley, J.A., Janda, K.D., "Determination and origins of the enantioselectivity in antibody-catalyzed Diels-Alder reactions"
Book of Abstracts, 221st ACS National Meeting, SanDiego, CA, (2001)
218
Wentworth Jr., P., Jones, L.H., Wentworth, A.D., Zhu, X., Larsen, N.A., Wilson, I.A., Xu, X., Goddard III, W.A., Janda, K.D., Eschenmoser, A., Lerner, R.A., "Antibody catalysis of the oxidation of water"
Science, 293, 1806 (2001)
216
Brummer, O., Hoffman, T.Z., Janda, K.D., "Metalloantibodies: Mercury(II)-dependent acyl transferases"
Bioorg. Med. Chem., 9, 2253 (2001)
215
Chen, D.-W., Kubiak, R.J., Ashley, J.A., Janda, K.D., "Reactive immunization elicits catalytic antibodies for polyester hydrolysis"
J. Chem. Soc., Perkin Trans., 1, 2796 (2001)
214
Tremblay, M.R., Dickerson, T.J., Janda, K.D., "Advances in antibody catalysis of cycloaddition reactions"
Adv. Synth. Catal., 343, 577 (2001)
213
Cordova, A., Tremblay, M.R., Clapham, B., Janda, K.D., "A sequential application of kinetic resolution and polymer-supported scavenging for the isolation of chiral secondary alcohols"
J. Org. Chem., 66, 5645 (2001)
211
Cordova, A., Janda, K.D., "Synthesis and catalytic antibody functionalization of dendrimers"
J. Am. Chem. Soc., 123, 8248 (2001)
207
Wentworth, P. Jr., Janda, K.D., "Catalytic antibodies: Structure and function"
Cell Biochem. Biophys., 35, 63 (2001)
203
Jones, L.H., Harwig, C.W., Wentworth, P. Jr., Simeonov, A., Wentworth, A.D., Py, S., Ashley, J.A., Lerner, R.A., Janda, K.D., "Conversion of enediynes into quinones by antibody catalysis and in aqueous buffers: Implications for an alternative enediyne therapeutic mechanism"
J. Am. Chem. Soc., 123, 3607 (2001)
200
Chen, D.-W., Beuscher IV, A.E., Stevens, R.C., Wirsching, P., Lerner, R.A., Janda,K.D., "Preparation of stilbene-tethered nonnatural nucleosides for use with blue-fluorescent antibodies"
J. Org. Chem., 66, 1725 (2001)
199
Matsushita, M., Hoffman, T.Z., Ashley, J.A., Zhou, B., Wirsching, P., Janda, K.D., "Cocaine catalytic antibodies: The primary importance of linker effects"
Bioorg. Med. Chem. Lett., 11, 87 (2001)
195
Brummer, O., Hoffman, T.Z., Chen, D.-W., Janda, K.D., "Antibody-catalyzed hydrolysis of oligomeric esters: A model for the degradation of polymeric materials"
Chem. Commun., 1, 19 (2001)
189
Simeonov, A., Matsushita, M., Juban, E.A., Thompson, E.H.Z., Hoffman, T.Z., Beuscher IV, A.E., Taylor, M.J., Wirsching, P., Rettig, W., McCusker, J.K., Stevens, R.C., Millar, D.P., Schultz, P.G., Lerner, R.A., Janda, K.D., "Blue-fluorescent antibodies"
Science, 290, 307 (2000)
188
Wentworth, A.D., Jones, L.H., Wentworth, P. Jr., Janda, K.D., Lerner, R.A., "Antibodies have the intrinsic capacity to destroy antigens"
Proc. Natl. Acad. Sci. USA, 97, 10930 (2000)
182
Hasserodt, J., Janda, K.D., Lerner, R.A., "A class of 4-aza-lithocholic acid-derived haptens for the generation of catalytic antibodies with steroid synthase capabilities"
Bioorg. Med. Chem., 8, 995 (2000)
181
Harwig, C.W., Hoffman, T.Z., Wentworth, A.D., Janda, K.D., "A one-pot multistep approach to alpha-azido-phospohonate and phosphonothioate diesters: Key intermediates in the synthesis of haptens for the generation of antibody ligases"
Bioorg. Med. Chem. Lett., 10, 915 (2000)
170
Toker, J.D., Wentworth, P. Jr., Hu, Y., Houk, K.N., Janda, K.D., "Antibody catalysis of a bimolecular asymmetric 1,3-Dipolar cycloaddition reaction"
J. Am. Chem. Soc., 122, 3244 (2000)
168
Hasserodt, J., Janda, K.D., Lerner, R.A., "Antibodies mimic natural oxidosqualene-cyclase action in steroid ring A formation"
J. Am. Chem. Soc., 122, 40 (2000)
166
Datta, A., Wentworth, P. Jr., Shaw, J.P., Simeonov, A., Janda, K.D., "Catalytically distinct antibodies prepared by the reactive immunization versus transition state analogue hapten manifolds"
J. Am. Chem. Soc., 121, 10461 (1999)
162
Brummer, O., Wentworth, P. Jr., Weiner, D.P., Janda, K.D., "Phosphorodithioates: Synthesis and evaluation of new haptens for the generation of antibody acyl transferases"
Tetrahedron Letters, 40, 7307 (1999)
161
Brummer, O., Gao, C., Mao, S., Weiner, D.P., Janda, K.D., "Design, synthesis and characterization of panning agents for the selection of metalloantibodies"
Letters in Peptide Science, 6, 295 (1999)
160
Gao, C., Brummer, O., Mao, S., Janda, K.D., "Selection of human metalloantibodies from a combinatorial phage single-chain antibody library"
J. Am. Chem. Soc., 121, 6517 (1999)
157
Janda, K.D., Wentworth, A.D., "A merging of chemistry and biology in terms of antibody catalysis"
Phosphorus, Sulfur and Silicon, 144-146, 117 (1999)
156
Wentworth, P., Janda, K.D., "Antibody catalysis of phosphodiester hydrolysis: A survey of hapten strategies"
Phosphorus, Sulfur and Silicon, 144-146, 247 (1999)
153
Taylor, M.J., Yli-Kauhaluoma, J.T., Ashley, J.A., Wirsching, P., Lerner, R.A., Janda, K.D., "The alpha-ketoamide group: A new motif for the elicitation of catalytic antibodies for acyl-transfer reactions"
J. Chem. Soc., Perkin Trans., 1, 1133 (1999)
149
Paschall, C.M., Hasserodt, J., Jones, T., Lerner, R.A., Janda, K.D., Christianson, D.W., "Convergence of catalytic antibody and terpene cyclase mechanisms: Polyene cyclization directed by carbocation-pi interactions"
Angew. Chem. Int. Ed., 38, 1743 (1999)
148
Spivak, D.A., Hoffman, T.Z., Moore, A.H., Taylor, M.J., Janda, K.D., "A comparison of flexible and constrained haptens in eliciting antibody catalysts for paraoxon hydrolysis"
Bioorg. Med. Chem., 7, 1145 (1999)
146
Wentworth, P. Jr., Janda, K.D., "Catalytic Antibodies"
In: Comprehensive Asymmetric Catalysis, eds., E.N. Jacobsen, A. Pfaltz, H. Yamamoto, Springer-Verlag, N.Y., Vol. III, p. 1403 (1999)
139
Taylor, M.J., Hoffman, T.Z., Yli-Kauhaluoma, J.T., Lerner, R.A., Janda, K.D., "A light-activated antibody catalyst"
J. Am. Chem. Soc., 120, 12783 (1998)
135
Wentworth, P. Jr., Liu, Y., Wentworth, A.D., Fan, P., Foley, M.J., Janda, K.D., "A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis"
Proc. Natl. Acad. Sci. USA, 95, 5971 (1998)
134
Lin, C.-H., Hoffman, T.Z., Xie, Y., Wirsching, P., Janda, K.D., "An antibody transesterase derived from reactive immunization that utilizes a wide variety of alcohol substrates"
Chem. Commun., 1075 (1998)
133
Lerner, R.A., Barbas III, C.F., Janda, K.D., "Making Enzymes, The Harvey Lectures"
Series 92, Wiley-Liss, Inc., p. 1 (1998)
129
Gao, C., Lavey, B.J., Lo, C.-H.L., Datta, A., Wentworth, P. Jr., Janda, K.D., "Direct selection for catalysis from combinatorial antibody libraries using a boronic acid probe: Primary amide bond hydrolysis"
J. Am. Chem. Soc., 120, 2211 (1998)
126
Heine, A., Stura, E.A., Yli-Kauhaluoma, J.T., Gao, C. Deng, Q., Beno, B.R., Houk, K.N., Janda, K.D., Wilson, I.A., "An antibody exo-Diels-Alderase inhibitor complex at 1.95 Angstrom resolution"
Science, 279, 1934 (1998)
124
Wentworth, P. Jr., Janda, K.D., "Catalytic antibodies"
Current Opinion in Chemical Biology, 2, 138 (1998)
117
Lin, C.-H., Hoffman, T.Z., Wirsching, P., Barbas III, C.F., Janda, K.D., Lerner, R.A., "On roads not taken in the evolution of protein catalysts: Antibody steroid isomerases that use an enamine mechanism"
Proc. Natl. Acad. Sci. USA, 94, 11773 (1997)
116
Gao, C., Lin, C.-H., Lo, C.-H.L., Mao, S., Wirsching, P., Lerner, R.A., Janda, K.D., "Making chemistry selectable by linking it to infectivity"
Proc. Natl. Acad. Sci. USA, 94, 11777 (1997)
115
Lo, C.-H.L., Wentworth, P. Jr., Jung, K.W., Yoon, J., Ashley, J.A., Janda, K.D., "Reactive immunization strategy generates antibodies with high catalytic proficiencies"
J. Am. Chem. Soc., 119, 10251 (1997)
113
Hasserodt, J., Janda, K.D., Lerner, R.A., "Formation of bridge-methylated decalins by antibody-catalyzed tandem cationic cyclization"
J. Am. Chem. Soc., 119, 5993 (1997)
112
Hasserodt, J., Janda, K.D., "Syntheses of octahydroquinoline-N-oxides: Haptens designed to elicit catalytic antibodies that control a terpenoid-like cascade cyclization"
Tetrahedron, 53, 11237 (1997)
109
Wentworth, P. Jr., Janda, K.D., "Synthesis of oxorhenium (V) and oxotechnetium (V) complexes as inhibitors of ribonucleases and for the generation of catalytic antibodies"
Synlett, 5, 537 (1997)
107
Weiner, D.P., Wiemann, T., Wolfe, M.M., Wentworth, P. Jr., Janda, K.D., "A pentacoordinate oxorhenium (V) metallochelate elicits antibody catalysts for phosphodiester cleavage"
J. Am. Chem. Soc., 119, 4088 (1997)
103
Li, T., Lerner, R.A., Janda, K.D., "Antibody-catalyzed cationic reactions: The rerouting of chemical transformations via antibody catalysis"
Acc. Chem. Res., 30, 115 (1997)
101
Janda, K.D., Lo, L.-C., Lo, C.-H.L., Sim, M.-M., Wang, R., Wong, C.-H., Lerner, R.A., "Chemical selection for catalysis in combinatorial antibody libraries"
Science, 275, 945 (1997)
97
Hasserodt, J., Janda, K.D., Lerner, R.A., "Antibody catalyzed terpenoid cyclization"
J. Am. Chem. Soc., 118, 11654 (1996)
96
Lo, C.-H.L., Gao, C., Mao, S., Matsui, K., Janda, K.D., "Chain shuffling: Investigations into the specificity and selectivity of antibody catalysis"
Israel Journal of Chemistry, 36, 195 (1996)
93
Lavey, B.J., Janda, K.D., "Catalytic antibody mediated hydrolysis of paraoxon"
J. Org. Chem., 61, 7633 (1996)
90
Janda, K.D., Shevlin, C.G., Lo, C.-H.L., "Catalytic Antibodies: Chemical and Biological Approaches"
In: Comprehensive Supramolecular Chemistry, eds., J.M. Lehn, J.C. Atwood, J.E.D. Davies, D.D. MacNicol, F. Vogtle, Pergamon, UK, USA, Vol. 4, p. 43 (1996)
87
Lo, L.-C., Lo, C.-H.L., Kassel, D.B., Raushel, F.M., Janda, K.D., "A versatile mechanism based reaction probe for the direct selection of biocatalysis"
Bioorg. & Med. Chem. Lett., 6, 2117 (1996)
85
Yli-Kauhaluoma, J.T., Janda, K.D., "Catalytic antibodies: The rerouting of chemical reactions towards electrophilic aromatic substitution by carbon dioxide"
N.Y. Academy of Sciences, 799, 26 (1996)
84
Lavey, B.J., Janda, K.D., "Antibody catalyzed hydrolysis of a phosphotriester"
Bioorg. Med. Chem. Lett., 6, 1523 (1996)
80
Yli-Kauhaluoma, J.T., Ashley, J.A., Lo, C.-H.L., Coakley, J., Wirsching, P., Janda, K.D., "Catalytic antibodies with peptidyl-prolyl cis-trans isomerase activity"
J. Am. Chem. Soc., 118, 5496 (1996)
79
Sakurai, M., Wirsching, P., Janda, K.D., "Synthesis of a nucleoside hapten with a [P(O)-O-N] linkage to elicit catalytic antibodies with phosphodiesterase activity"
Bioorg. Med. Chem. Lett., 6, 1055 (1996)
76
Li, T., Janda, K.D., Lerner, R.A., "Cationic cyclopropanation by antibody catalysis"
Nature, 379, 326 (1996)
74