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Authors, Title Journal, Volume, Pages, (Year) |
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Meijler, M.M., Kaufmann, G.F., Qi, L., Mee, J.M., Coyle, A.R., Moss, J.A., Wirsching, P., Matsushita, M., Janda, K.D., "Fluorescent cocaine probes: A tool for the selection and engineering of therapeutic antibodies" J. Am. Chem. Soc., 127, 2477 (2005) |
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Brogan, A.P., Eubanks, L.M., Koob, G.F., Dickerson, T.J., Janda, K.D., "Antibody-catalyzed oxidation of delta-9-tetrahydrocannabinol" J. Am. Chem. Soc., 129, 3698 (2007) |
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De Lamo Marin, S., Xu, X., Meijler, M.M., Janda, K.D., "Antibody catalyzed hydrolysis of a quorum sensing signal found in Gram-negative bacteria" Bioorg. Med. Chem. Lett., 17, 1549 (2007) |
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Xu, Y., Hixon, M.S., Yamamoto, N., McAllister, L.A., Wentworth, A.D., Wentworth, Jr., P., Janda, K.D., "Antibody-catalyzed anaerobic destruction of methamphetamine" PNAS, 104(10), 3681 (2007) |
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Rogers, C.J., Eubanks, L.M., Dickerson, T.J., Janda, K.D., "Unexpected acetylcholinesterase activity of cocaine esterases" J. Am. Chem. Soc., 128, 15364 (2006) |
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McKenzie, K.M., Mee, J.M., Rogers, C.J., Hixon, M.S., Kaufmann, G.F., Janda, K.D., "Identification and characterization of single chain anti-cocaine catalytic antibodies" J.Mol. Bio., 365, 722 (2006) |
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Zhu, X., Dickerson, T.J., Rogers, C.J., Kaufmann, G.F., Mee, J.M., McKenzie, K.M., Janda, K.D., Wilson, I.A., "Complete reaction cycle of a cocaine catalytic antibody at atomic resolution" Structure, 14, 205 (2006) |
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Carrera, M.R.A., Trigo, J.M., Wirsching,P., Roberts, A.J., Janda, K.D., "Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose" Pharmacology, Biochemistry and Behavior, 81, 709 (2005) |
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Toker, J.D., Tremblay, M.R., Yli-Kauhaluoma, J., Wentworth, A.D., Zhou, B., Wentworth, Jr., P., Janda, K.D., "Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction" J. Org. Chem., 70, 7810 (2005) |
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Xu, Y., Yamamoto, N., Ruiz, D.I., Kubitz, D.S., Janda, K.D., "Squaric monoamide monoester as a new class of reactive immunization hapten for catalytic antibodies" Bioorg. Med. Chem. Lett., 15, 4304 (2005) |
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Kaufmann, G.F., Meijler, M.M., Sun, C., Chen, D.-W., Kujawa, D.P., Mee, J.M., Hoffman, T.Z., Wirsching, P., Lerner, R.A., Janda, K.D., "Enzymatic incorporation of an antibody-activated blue fluorophore into DNA" Angew. Chem. Int. Ed., 44, 2144 (2005) |
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McDunn, J.E., Dickerson, T.J., Janda, K.D., "Antibody Catalysis of Disfavored Chemical Reactions" Catalytic Antibodies, ed. Ehud Keinan, Wiley-VCH Verlag Gmbh & Co., Weinheim, Germany, 184 (2004) |
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Xu, Y., Yamamoto, N., Janda, K.D., "Catalytic antibodies: Hapten design stratagies and screening methods" Bioorg. Med. Chem., 12, 5247 (2004) |
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Chen, D.-W., Janda, K.D., "Catalytic Antibodies" Encyclopedia of Supramolecular Chemistry, Marcel Dekker, New York, NY, 193 (2004) |
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Ahn, J.-M., Wentworth, Jr., P., Janda, K.D., "Probing lipase/esterase libraries for lipid A hydrolysis - discovery of biocatalysts for the detoxification of bacterially-expressed recombinant protein" Chem. Commun., 364, (2004) |
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Matsushita, M., Yoshida, K., Yamamoto, N., Wirsching, P., Lerner, R.A., Janda, K.D., "High-throughput screening by using a blue-fluorescent antibody sensor" Angew. Chemie, Int. Ed., 42, 5984 (2003) |
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Dickerson, T.J., Tremblay, M.R., Hoffman, T.Z., Ruiz, D.I., Janda, K.D., "Catalysis of the Photo-Fries reaction: Antibody-mediated stabilization of high energy states" J. Amer. Chem. Soc., 125, 15395 (2003) |
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Wentworth, Jr., P., Nieva, J., Takeuchi, C., Galve, R., Wentworth, A.D., Dilley, R.B., DeLaria, G.A., Saven, A., Babior, B.M., Janda, K.D., Eschenmoser, A., Lerner, R.A., "Evidence for ozone formation in human atherosclerotic arteries" Science, 302, 1053 (2003) |
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Hasserodt, J., Janda, K.D., "Catalytic Antibodies" In: Encyclopedia of Catalysis, ed. I.T. Horvath, Wiley, N.Y., pp. 440-476 (2003) |
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Wentworth, Jr., P., Wentworth, A.D., Zhu, X., Wilson, I.A., Janda, K.D., Eschenmoser, A., Lerner, R.A., "Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens" Proc. Natl. Acad. Sci. USA, 100, 1490 (2003) |
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Cannizzaro, C.E., Ashley, J.A., Janda, K.D., Houk, K.N., "Experimental determination of the absolute enantioselectivity of an antibody-catalyzed Diels-Alder reaction and theoretical explorations of the origins of stereoselectivity" J. Amer. Chem. Soc., 125(9), 2489 (2003) |
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Wang, Q., Krishnaswami, S.R., Janda, K.D., Lin, T., Finn, M.G., "Blue fluorescent antibodies as reporters of steric accessibility in virus conjugates" Bioconjugate Chem., 14, 38 (2003) |
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Dickerson, T., Cordova, A., Chen, D.-W., Janda, K.D., "The Use of Enzymes and Catalytic Antibodies in the Asymmetric Aldol Reaction" In: Encyclopedia of Catalysis, ed. I.T. Horvath, Wiley, N.Y., (2002) |
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Wentworth, Jr., P., McDunn, J.E., Wentworth, A.D., Takeuchi, C., Nieva, J., Jones, T., Bautista, C., Ruedi, J.M., Gutierrez, A., Janda, K.D., Babior, B.M., Eschenmoser, A., Lerner, R.A., "Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation" Science, 298, 2195 (2002) |
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Jones, L.H., Altobell III, L.J., MacDonald, M.T., Boyle, N.A., Wentworth, Jr., P., Lerner, R.A., Janda, K.D., "Active immunization with a glycolipid transition state analogue protects against endotoxic shock" Angew. Chem. Int. Ed., 41(22), 4241 (2002) |
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Delgado, M., Lee, K.J., Altobell, III, L., Spanka, C., Wentworth, Jr., P., Janda, K.D., "A parallel approach to the discovery of carrier delivery vehicles to enhance antigen immunogenicity" J. Amer. Chem. Soc., 124, 4946 (2002) |
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Isomura, S., Ashley, J.A., Wirsching, P., Janda, K.D., "Antibody-catalyzed cleavage of the D-Ala-D-Lac depsipeptide: An immunological approach to the problem of vancomycin resistance" Bioorg. Med. Chem. Lett., 12, 861 (2002) |
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Kim, G.-T., Wenz, M., Park, J.-I., Hasserodt, J., Janda, K.D., "Polyene substrates with unusual methylation patterns to probe the active sites of three catalytic antibodies" Biorg. Med. Chem., 10, 1249 (2002) |
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Cannizzaro, C.E., Houk, K.N., Ashley, J.A., Janda, K.D., "Determination and origins of the enantioselectivity in antibody-catalyzed Diels-Alder reactions" Book of Abstracts, 221st ACS National Meeting, SanDiego, CA, (2001) |
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Wentworth Jr., P., Jones, L.H., Wentworth, A.D., Zhu, X., Larsen, N.A., Wilson, I.A., Xu, X., Goddard III, W.A., Janda, K.D., Eschenmoser, A., Lerner, R.A., "Antibody catalysis of the oxidation of water" Science, 293, 1806 (2001) |
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Brummer, O., Hoffman, T.Z., Janda, K.D., "Metalloantibodies: Mercury(II)-dependent acyl transferases" Bioorg. Med. Chem., 9, 2253 (2001) |
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Chen, D.-W., Kubiak, R.J., Ashley, J.A., Janda, K.D., "Reactive immunization elicits catalytic antibodies for polyester hydrolysis" J. Chem. Soc., Perkin Trans., 1, 2796 (2001) |
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Tremblay, M.R., Dickerson, T.J., Janda, K.D., "Advances in antibody catalysis of cycloaddition reactions" Adv. Synth. Catal., 343, 577 (2001) |
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Cordova, A., Tremblay, M.R., Clapham, B., Janda, K.D., "A sequential application of kinetic resolution and polymer-supported scavenging for the isolation of chiral secondary alcohols" J. Org. Chem., 66, 5645 (2001) |
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Cordova, A., Janda, K.D., "Synthesis and catalytic antibody functionalization of dendrimers" J. Am. Chem. Soc., 123, 8248 (2001) |
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Wentworth, P. Jr., Janda, K.D., "Catalytic antibodies: Structure and function" Cell Biochem. Biophys., 35, 63 (2001) |
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Jones, L.H., Harwig, C.W., Wentworth, P. Jr., Simeonov, A., Wentworth, A.D., Py, S., Ashley, J.A., Lerner, R.A., Janda, K.D., "Conversion of enediynes into quinones by antibody catalysis and in aqueous buffers: Implications for an alternative enediyne therapeutic mechanism" J. Am. Chem. Soc., 123, 3607 (2001) |
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Chen, D.-W., Beuscher IV, A.E., Stevens, R.C., Wirsching, P., Lerner, R.A., Janda,K.D., "Preparation of stilbene-tethered nonnatural nucleosides for use with blue-fluorescent antibodies" J. Org. Chem., 66, 1725 (2001) |
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Matsushita, M., Hoffman, T.Z., Ashley, J.A., Zhou, B., Wirsching, P., Janda, K.D., "Cocaine catalytic antibodies: The primary importance of linker effects" Bioorg. Med. Chem. Lett., 11, 87 (2001) |
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Brummer, O., Hoffman, T.Z., Chen, D.-W., Janda, K.D., "Antibody-catalyzed hydrolysis of oligomeric esters: A model for the degradation of polymeric materials" Chem. Commun., 1, 19 (2001) |
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Simeonov, A., Matsushita, M., Juban, E.A., Thompson, E.H.Z., Hoffman, T.Z., Beuscher IV, A.E., Taylor, M.J., Wirsching, P., Rettig, W., McCusker, J.K., Stevens, R.C., Millar, D.P., Schultz, P.G., Lerner, R.A., Janda, K.D., "Blue-fluorescent antibodies" Science, 290, 307 (2000) |
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Wentworth, A.D., Jones, L.H., Wentworth, P. Jr., Janda, K.D., Lerner, R.A., "Antibodies have the intrinsic capacity to destroy antigens" Proc. Natl. Acad. Sci. USA, 97, 10930 (2000) |
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Hasserodt, J., Janda, K.D., Lerner, R.A., "A class of 4-aza-lithocholic acid-derived haptens for the generation of catalytic antibodies with steroid synthase capabilities" Bioorg. Med. Chem., 8, 995 (2000) |
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Harwig, C.W., Hoffman, T.Z., Wentworth, A.D., Janda, K.D., "A one-pot multistep approach to alpha-azido-phospohonate and phosphonothioate diesters: Key intermediates in the synthesis of haptens for the generation of antibody ligases" Bioorg. Med. Chem. Lett., 10, 915 (2000) |
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Toker, J.D., Wentworth, P. Jr., Hu, Y., Houk, K.N., Janda, K.D., "Antibody catalysis of a bimolecular asymmetric 1,3-Dipolar cycloaddition reaction" J. Am. Chem. Soc., 122, 3244 (2000) |
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Hasserodt, J., Janda, K.D., Lerner, R.A., "Antibodies mimic natural oxidosqualene-cyclase action in steroid ring A formation" J. Am. Chem. Soc., 122, 40 (2000) |
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Datta, A., Wentworth, P. Jr., Shaw, J.P., Simeonov, A., Janda, K.D., "Catalytically distinct antibodies prepared by the reactive immunization versus transition state analogue hapten manifolds" J. Am. Chem. Soc., 121, 10461 (1999) |
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Brummer, O., Wentworth, P. Jr., Weiner, D.P., Janda, K.D., "Phosphorodithioates: Synthesis and evaluation of new haptens for the generation of antibody acyl transferases" Tetrahedron Letters, 40, 7307 (1999) |
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Brummer, O., Gao, C., Mao, S., Weiner, D.P., Janda, K.D., "Design, synthesis and characterization of panning agents for the selection of metalloantibodies" Letters in Peptide Science, 6, 295 (1999) |
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Gao, C., Brummer, O., Mao, S., Janda, K.D., "Selection of human metalloantibodies from a combinatorial phage single-chain antibody library" J. Am. Chem. Soc., 121, 6517 (1999) |
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Janda, K.D., Wentworth, A.D., "A merging of chemistry and biology in terms of antibody catalysis" Phosphorus, Sulfur and Silicon, 144-146, 117 (1999) |
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Wentworth, P., Janda, K.D., "Antibody catalysis of phosphodiester hydrolysis: A survey of hapten strategies" Phosphorus, Sulfur and Silicon, 144-146, 247 (1999) |
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Taylor, M.J., Yli-Kauhaluoma, J.T., Ashley, J.A., Wirsching, P., Lerner, R.A., Janda, K.D., "The alpha-ketoamide group: A new motif for the elicitation of catalytic antibodies for acyl-transfer reactions" J. Chem. Soc., Perkin Trans., 1, 1133 (1999) |
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Paschall, C.M., Hasserodt, J., Jones, T., Lerner, R.A., Janda, K.D., Christianson, D.W., "Convergence of catalytic antibody and terpene cyclase mechanisms: Polyene cyclization directed by carbocation-pi interactions" Angew. Chem. Int. Ed., 38, 1743 (1999) |
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Spivak, D.A., Hoffman, T.Z., Moore, A.H., Taylor, M.J., Janda, K.D., "A comparison of flexible and constrained haptens in eliciting antibody catalysts for paraoxon hydrolysis" Bioorg. Med. Chem., 7, 1145 (1999) |
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Wentworth, P. Jr., Janda, K.D., "Catalytic Antibodies" In: Comprehensive Asymmetric Catalysis, eds., E.N. Jacobsen, A. Pfaltz, H. Yamamoto, Springer-Verlag, N.Y., Vol. III, p. 1403 (1999) |
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Taylor, M.J., Hoffman, T.Z., Yli-Kauhaluoma, J.T., Lerner, R.A., Janda, K.D., "A light-activated antibody catalyst" J. Am. Chem. Soc., 120, 12783 (1998) |
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Wentworth, P. Jr., Liu, Y., Wentworth, A.D., Fan, P., Foley, M.J., Janda, K.D., "A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis" Proc. Natl. Acad. Sci. USA, 95, 5971 (1998) |
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Lin, C.-H., Hoffman, T.Z., Xie, Y., Wirsching, P., Janda, K.D., "An antibody transesterase derived from reactive immunization that utilizes a wide variety of alcohol substrates" Chem. Commun., 1075 (1998) |
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Lerner, R.A., Barbas III, C.F., Janda, K.D., "Making Enzymes, The Harvey Lectures" Series 92, Wiley-Liss, Inc., p. 1 (1998) |
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Gao, C., Lavey, B.J., Lo, C.-H.L., Datta, A., Wentworth, P. Jr., Janda, K.D., "Direct selection for catalysis from combinatorial antibody libraries using a boronic acid probe: Primary amide bond hydrolysis" J. Am. Chem. Soc., 120, 2211 (1998) |
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Heine, A., Stura, E.A., Yli-Kauhaluoma, J.T., Gao, C. Deng, Q., Beno, B.R., Houk, K.N., Janda, K.D., Wilson, I.A., "An antibody exo-Diels-Alderase inhibitor complex at 1.95 Angstrom resolution" Science, 279, 1934 (1998) |
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Wentworth, P. Jr., Janda, K.D., "Catalytic antibodies" Current Opinion in Chemical Biology, 2, 138 (1998) |
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Lin, C.-H., Hoffman, T.Z., Wirsching, P., Barbas III, C.F., Janda, K.D., Lerner, R.A., "On roads not taken in the evolution of protein catalysts: Antibody steroid isomerases that use an enamine mechanism" Proc. Natl. Acad. Sci. USA, 94, 11773 (1997) |
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Gao, C., Lin, C.-H., Lo, C.-H.L., Mao, S., Wirsching, P., Lerner, R.A., Janda, K.D., "Making chemistry selectable by linking it to infectivity" Proc. Natl. Acad. Sci. USA, 94, 11777 (1997) |
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Lo, C.-H.L., Wentworth, P. Jr., Jung, K.W., Yoon, J., Ashley, J.A., Janda, K.D., "Reactive immunization strategy generates antibodies with high catalytic proficiencies" J. Am. Chem. Soc., 119, 10251 (1997) |
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Hasserodt, J., Janda, K.D., Lerner, R.A., "Formation of bridge-methylated decalins by antibody-catalyzed tandem cationic cyclization" J. Am. Chem. Soc., 119, 5993 (1997) |
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Hasserodt, J., Janda, K.D., "Syntheses of octahydroquinoline-N-oxides: Haptens designed to elicit catalytic antibodies that control a terpenoid-like cascade cyclization" Tetrahedron, 53, 11237 (1997) |
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Wentworth, P. Jr., Janda, K.D., "Synthesis of oxorhenium (V) and oxotechnetium (V) complexes as inhibitors of ribonucleases and for the generation of catalytic antibodies" Synlett, 5, 537 (1997) |
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Weiner, D.P., Wiemann, T., Wolfe, M.M., Wentworth, P. Jr., Janda, K.D., "A pentacoordinate oxorhenium (V) metallochelate elicits antibody catalysts for phosphodiester cleavage" J. Am. Chem. Soc., 119, 4088 (1997) |
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Li, T., Lerner, R.A., Janda, K.D., "Antibody-catalyzed cationic reactions: The rerouting of chemical transformations via antibody catalysis" Acc. Chem. Res., 30, 115 (1997) |
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Janda, K.D., Lo, L.-C., Lo, C.-H.L., Sim, M.-M., Wang, R., Wong, C.-H., Lerner, R.A., "Chemical selection for catalysis in combinatorial antibody libraries" Science, 275, 945 (1997) |
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Hasserodt, J., Janda, K.D., Lerner, R.A., "Antibody catalyzed terpenoid cyclization" J. Am. Chem. Soc., 118, 11654 (1996) |
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Lo, C.-H.L., Gao, C., Mao, S., Matsui, K., Janda, K.D., "Chain shuffling: Investigations into the specificity and selectivity of antibody catalysis" Israel Journal of Chemistry, 36, 195 (1996) |
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Lavey, B.J., Janda, K.D., "Catalytic antibody mediated hydrolysis of paraoxon" J. Org. Chem., 61, 7633 (1996) |
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Janda, K.D., Shevlin, C.G., Lo, C.-H.L., "Catalytic Antibodies: Chemical and Biological Approaches" In: Comprehensive Supramolecular Chemistry, eds., J.M. Lehn, J.C. Atwood, J.E.D. Davies, D.D. MacNicol, F. Vogtle, Pergamon, UK, USA, Vol. 4, p. 43 (1996) |
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Lo, L.-C., Lo, C.-H.L., Kassel, D.B., Raushel, F.M., Janda, K.D., "A versatile mechanism based reaction probe for the direct selection of biocatalysis" Bioorg. & Med. Chem. Lett., 6, 2117 (1996) |
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Yli-Kauhaluoma, J.T., Janda, K.D., "Catalytic antibodies: The rerouting of chemical reactions towards electrophilic aromatic substitution by carbon dioxide" N.Y. Academy of Sciences, 799, 26 (1996) |
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Lavey, B.J., Janda, K.D., "Antibody catalyzed hydrolysis of a phosphotriester" Bioorg. Med. Chem. Lett., 6, 1523 (1996) |
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Yli-Kauhaluoma, J.T., Ashley, J.A., Lo, C.-H.L., Coakley, J., Wirsching, P., Janda, K.D., "Catalytic antibodies with peptidyl-prolyl cis-trans isomerase activity" J. Am. Chem. Soc., 118, 5496 (1996) |
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Sakurai, M., Wirsching, P., Janda, K.D., "Synthesis of a nucleoside hapten with a [P(O)-O-N] linkage to elicit catalytic antibodies with phosphodiesterase activity" Bioorg. Med. Chem. Lett., 6, 1055 (1996) |
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Li, T., Janda, K.D., Lerner, R.A., "Cationic cyclopropanation by antibody catalysis" Nature, 379, 326 (1996) |
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