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Detection of & Protection
from Warfare Agents
Biochemical Reactivity
of Drugs of Abuse
Catalytic Antibodies
Bacterial Cell-Cell Communication
Phage Display Technology
Drug Addiction & Abuse: Immunopharmacotherapy
Environmental Detection
of Heavy Metals
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Combinatorial Chemistry & Polymer Synthesis
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Authors, Title
Journal, Volume, Pages, (Year)
372
Zhou, B., Pellett, S., Tepp, W.H., Zhou, H., Johnson, E.A., Janda, K.D., "Delineating the susceptibility of botulinum neurotoxins to denaturation through thermal effects"
FEBS Letters, 582, 1526 (2008)
371
Kaufmann, G.F., Park, J., Mee, J.M., Ulevitch, R.J., Janda, K.D., "The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone"
Molecular Immunology, 45, 2710 (2008)
370
Yoneda, Y., Steiniger, S.C.J., Capkova, K., Mee, J.M., Liu, Y., Kaufmann, G.F., Janda, K.D., "A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy"
Bioorg. Med. Chem. Lett., 18, 1632 (2008)
369
Zhou, B., Carney, C., Janda, K.D., "Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin"
Bioorg. Med. Chem., 16, 1903 (2008)
368
Meijler, M.M., Kaufmann, G.F., Qi, L., Mee, J.M., Coyle, A.R., Moss, J.A., Wirsching, P., Matsushita, M., Janda, K.D., "Fluorescent cocaine probes: A tool for the selection and engineering of therapeutic antibodies"
J. Am. Chem. Soc., 127, 2477 (2005)
367
Willis, B., Eubanks, L.M., Wood, M.R., Janda, K.D., Dickerson, T.J., Lerner, R.A.L., "Biologically templated organic polymers with nanoscale order"
PNAS, 105(5), 1416 (2008)
366
Zarebski, L.M., Vaughan, K., Sidney, J., Peters, B., Grey, H., Janda, K.D., Casadevall, A., Sette, A., "Analysis of epitope information related to Bacillus anthracis and Clostridium botulinum"
Expert Rev. Vaccines, 7(1), 55 (2008)
365
Dickerson, T.J., Janda, K.D., "Recent advances for the treatment of cocaine abuse: Central nervous system immunopharmacotherapy"
The AAPS Journal, 7(3), E579 (2005)
364
Brogan, A.P., Dickerson, T.J., Janda, K.D., "Nornicotine-organocatalyzed aqueous reduction of alpha, beta-unsaturated aldehydes"
Chem. Commun., 46, 4952 (2007)
363
Richardson, H.N., Zhao, Y., Fekete, E.M., Funk, C.K., Wirsching, P., Janda, K.D., Zorrilla, E.P., Koob, G.F., "MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist"
Pharmacology, Biochemistry, and Behavior, 88, 497 (2007)
362
Zhou, H., Zhou, B., Ma, H., Carney, C., Janda, K.D., "Selection and characterization of human monoclonal antibodies against Abrin by phage display"
Bioorg. Med. Chem. Lett., 17, 5690 (2007)
361
Park, J., Jagasia, R., Kaufmann, G.F., Mathison, J.C., Ruiz, D.I., Moss, J.A., Meijler, M.M., Ulevitch, R.J., Janda, K.D., "Infection control by antibody disruption of bacterial quorum sensing signaling"
Chemistry & Biology, 14, 1119 (2007)
360
Capcova, K., Yoneda, Y., Dickerson, T.J., Janda, K.D., "Synthesis and structure-activity relationships of second-generation hydroxymate botulinum neurotoxin A protease inhibitors"
Bioorg. Med. Chem. Lett., 17, 6463 (2007)
359
Xu, Y., Hixon, M.S., Dawson, P.E., Janda, K.D., "Development of o FRET assay for monitoring of HIV gp41 core disruption"
J. Org. Chem., 72(18), 6700 (2007)
358
Treweek, J., Wee, S., Koob, G.F., Dickerson, T.J., Janda, K.D., "Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease"
PNAS, 104(28), 11580 (2007)
357
Ino, A., Dickerson, T.J., Janda, K.D., "Positional linker effects in haptens for cocaine immunopharmacotherapy"
Bioorg. Med. Chem. Lett., 17, 4280 (2007)
356
Dickerson, T.J., Janda, K.D., "The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication"
Chem. Biol., 2(4), 359 (2007)
355
Debler, E.W., Kaufmann,G.F., Kirchdoerfer, R.N., Mee, J.M., Janda, K.D., Wilson, I.A., "Crystal structures of a quorum-quenching antibody"
J. Mol. Biol., 368(5), 1392 (2007)
354
Silvaggi, N.R., Boldt, G.E., Hixon, M.S., Kennedy, J.P., Tzipori, S., Janda, K.D., "Structures of Clostridium botulinum neurotoxin serotype A light chain complexed with small-molecule inhibitors highlight active-site flexibility"
Chemistry & Biology, 14, 533 (2007)
353
Eubanks, L.E., Dickerson, T.J., Janda, K.D., "Technological advancements for the detection of and protection against biological and chemical warfare agents"
Chem. Soc. Rev., 36(3), 441 (2007)
352
Liu, Y., Steiniger, S.C.J., Kim, Y., Kaufmann, G.F., Felding-Habermann, B., Janda, K.D., "Mechanistic studies of a peptidic GRP78 ligand for cancer celll-specific drug delivery"
Molecular Pharmaceutics, 4(3), 435 (2007)
351
Brogan, A.P., Eubanks, L.M., Koob, G.F., Dickerson, T.J., Janda, K.D., "Antibody-catalyzed oxidation of delta-9-tetrahydrocannabinol"
J. Am. Chem. Soc., 129, 3698 (2007)
350
De Lamo Marin, S., Xu, X., Meijler, M.M., Janda, K.D., "Antibody catalyzed hydrolysis of a quorum sensing signal found in Gram-negative bacteria"
Bioorg. Med. Chem. Lett., 17, 1549 (2007)
349
McAllister, L.A., Hixon, M.S., Schwartz, R., Kubitz, D.S., Janda, K.D., "Synthesis and application of a novel ligand for affinity chromatography based removal of endotoxin from antibodies"
Bioconj. Chem., 18, 559 (2007)
348
Xu, Y., Hixon, M.S., Yamamoto, N., McAllister, L.A., Wentworth, A.D., Wentworth, Jr., P., Janda, K.D., "Antibody-catalyzed anaerobic destruction of methamphetamine"
PNAS, 104(10), 3681 (2007)
347
Steiniger, S.C.J., Altobell III, L., Zhou, B., Janda, K.D., "Selection of human antibodies against cell surface-associated oligomeric anthrax protective antigen"
Molecular Immunology, 44, 2749 (2007)
346
Eubanks, L.M., Hixon, M.S., Jin, W., Hong, S., Clancy, C.M., Tepp, W.H., Baldwin, M.R., Malizio, C.J., Gooodnough, M.C., Barbieri, J.T., Johnson, E.A., Boger, D.L., Dickerson, T.J., Janda, K.D., "An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists"
Proc. Natl. Acad. Sci. U.S.A., 104(8), 2602 (2007)
345
Rogers, C.J., Eubanks, L.M., Dickerson, T.J., Janda, K.D., "Unexpected acetylcholinesterase activity of cocaine esterases"
J. Am. Chem. Soc., 128, 15364 (2006)
344
McKenzie, K.M., Mee, J.M., Rogers, C.J., Hixon, M.S., Kaufmann, G.F., Janda, K.D., "Identification and characterization of single chain anti-cocaine catalytic antibodies"
J.Mol. Bio., 365, 722 (2006)
343
Kravchenko, V.V., Kaufmann, G.F., Mathison, J.C., Scott, D.A., Katz, A.Z., Woood, M.R., Brogan, A.P., Lehmann, M., Mee, J.M., Iwata, K., Pan, Q., Fearns, C., Knaus, U.G., Meijler, M.M., Janda, K.D., Ulevitch, R.J., "N-(3-Oxo-acyl)homoserine llactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways"
Journal of Biological Chemistry, 281(39), 28822 (2006)
342
Eubanks, L.M., Rojers, C.J., Beuscher IV, A.E., Koob, G.F., Olson, A.J., Dickerson, T.J., Janda, K.D. , "A molecular link between the active component of marijuana and Alzheimer's disease pathology"
Molecular Pharmaceutics, 3(6), 773 (2006)
341
Brogan, A.P., Dickerson, T.J., Janda, K.D., "Enamine-based aldol organocatalysis in water: Are they really "all wet"?"
Angew. Chem. Int. Ed., 45, 8100 (2006)
340
Zorilla, E.P., Iwasaki, S., Moss, J.A., Chang, J., Otsuji, J., Inoue, K., Meijler, M.M., Janda, K.D., "Vaccination against weight gain"
PNAS, 103(35), 13226 (2006)
339
Kim, Y., Lillo, A.M., Steiniger, S.C.J., Liu, Y., Ballatore, C., Anichini, A., Mortarini, R., Kaufmann, G.F., Zhou, B., Felding-Habermann, B., Janda, K.D., "Targeting heat shock protiens on cancer cells: Selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand"
Biochemistry, 45 (31), 9434 (2006)
338
Dickerson, T.J., Janda, K.D., "The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication"
ACS Chemical Biology, 1 (6), 359 (2006)
337
Boldt, G.E., Eubanks, L.M., Janda, K.D., "Identification of a botulinum A protease inhibitor displaying efficacy in a cellular model"
Chem. Commun., 3063 (2006)
336
Ma, H., Zhou, B., Kim, Y., Janda, K.D., "A cyclic peptide-polymer probe for the detection of Clostridium botulinum neurotoxin serotype A"
Toxicon, 47, 901 (2006)
335
Fu, Z., Chen, S., Baldwin, M.R., Boldt, G.E., Crawford, A., Janda, K.D., Barbieri, J.T., Kim, J.-J.P., "Light chain of botulinum neurotoxin serotype A: Structural resolution of a catalytic intermediate"
Biochemistry, (2006)
334
Boldt, G.E., Kennedy, J.P., Hixon, M.S., Mcallister, L.A., Barbieri, J.T., Tzipori, S., Janda, K.D., "Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin A inhibitors"
J. Comb. Chem., 8, 513 (2006)
333
Xu, Y., Lu, H., Kennedy, J.P., Yan, X., McAllister, L.A., Yamamoto, N., Moss, J.A., Boldt, G.E., Jiang, S., Janda, K.D., "Evaluation of "credit-card" libraries for inhibition of HIV-1 gp41 fusogenic core formation"
J. Comb. Chem., 8, 531 (2006)
332
Boldt, G.E., Kennedy, J.P., Janda, K.D., "Identification of a potent botulinum nneurotoxin A protease inhibitor using in situ lead identification chemistry"
Org. Lett., 8, 1729 (2006)
331
Xu, Y., Shi, J., Yamamoto, N., Moss, J.A., Vogt, P.K., Janda, K.D., "A credit-card library approach for disrupting protein-protein interactions"
Bioorg. Med. Chem., 14, 2660 (2006)
330
Kaufmann, G.F., Sartorio, R., Lee, S.-H., Mee, J.M., Altobell, III, L.J., Kujawa, D.P., Jeffries, E., Clapham, B., Meijler, M.M., Janda, K.D., "Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing"
J. Am. Chem. Soc., 128, 2802 (2006)
329
McAllister, L.A., Hixon, M.S., Kennedy, J.P., Dickerson, T.J., Janda, K.D., "Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: A new wrinkle in botulinum neurotoxin"
J. Am. Chem. Soc., 128, 4176 (2006)
328
Zhu, X., Dickerson, T.J., Rogers, C.J., Kaufmann, G.F., Mee, J.M., McKenzie, K.M., Janda, K.D., Wilson, I.A., "Complete reaction cycle of a cocaine catalytic antibody at atomic resolution"
Structure, 14, 205 (2006)
327
Shigenaga, S., Moss, J.A., Ashley, F.T., Kaufmann, G.F., Janda, K.D., "Solid-phase synthesis and cyclative cleavage of quorum sensing depsipeptide analogues by acylphenyldiazene activation"
SYNLETT, 4, 551 (2006)
326
Moss, J.A., Stokols, S., Hixon, M.S., Ashley, F.T., Chang, J.Y., Janda, K.D., "Solid-phase synthesis and kinetic characterization of fluorogenic enzyme-degradable hydrogel cross-linkers"
Biomacromolecules, 7, 1011 (2006)
325
Boldt, G.E., Dickerson, T.J., Janda, K.D., "Emerging chemical and biological approaches for the preparation of discovery libraries"
Drug Disc. Today, 11, 143 (2006)
324
Rogers, C.J., Dickerson, T.J., Janda, K.D., "Kinetic isotope and thermodynamic analysis of the nornicotine-catalyzed aqueous aldol reaction"
Tetrahedron, 62, 352 (2006)
323
Shimomura, O., Lee, B.S., Meth, S., Suzuki, H., Mahajan, S., Nomura, R., Janda, K.D., "Synthesis and application of polytetrahydrofuran-grafted polystyrene (PS-PTHF) resin supports for organic synthesis"
Tetrahedron, 61, 12160 (2005)
322
Rogers, C.J., Dickerson, T.J., Wentworth, Jr.,P., Janda, K.D., "A high-swelling reagent scaffold suitable for use in aqueous and organic solvents"
Tetrahedron, 61, 12140 (2005)
321
Zhang, L., Long, H., Boldt, G.E., Janda, K.D., Schatz, G.C., Lewis, F.D., "alpha- and beta-Stilbenosides as base-pair surrogates in DNA hairpins"
Org. Biomol. Chem., 4, 314 (2006)
320
Wu, W., Luo, Y., Sun, C., Liu, Y., Kuo, P., Varga, J., Xiang, R., Reisfeld, R., Janda, K.D., Edgington, T.S., Liu, C., "Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms"
Cancer Res., 66(2), 1 (2006)
319
Kim, Y., Lillo, A., Moss, J.A., Janda, K.D., "A contiguous stretch of methionine residues mediates the energy-dependent internalization mechanism of a cell-penetrating peptide"
Molecular Pharmaceutics, 2(6), 528 (2005)
318
Lillo, A.M., McKenzie, K.M., Janda, K.D., "Phage-Displayed Antibody Libraries"
Cell Biology: A Laboratory Handbook, Chp. 59, 491-496 (2006)
317
Qi, L., Yamamoto, N., Meijler, M.M., Altobell, III, L.J., Koob, G.F., Wirsching, P., Janda, K.D., "Delta-9-tetrahydrocannabinol immunochemical studies: Haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta-9-tetrahydrocannabinol"
J. Med. Chem., 48, 7389 (2005)
316
Dickerson, T.J., Beuscher IV, A.E., Rogers, C.J., Hixon, M.S., Yamamoto, N., Xu, Y., Olson, A.J., Janda, K.D. , "Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library"
Biochemistry, 44, 14845 (2005)
315
Shute, T.S., Matsushita, M., Dickerson, T.J., La Clair, J.J., Janda, K.D., Burkart, M.D., "A site-specific bifunctional protein labeling system for affinity and fluorescent analysis"
Bioconjugate Chem., 16, 1352 (2005)
314
Matsushita, M., Meijler, M.M., Wirsching, P., Lerner, R.A., Janda, K.D., "A blue fluorescent antibody-cofactor sensor for mercury"
Org. Lett., 7, 4943 (2005)
313
Eubanks, L.M., Dickerson, T.J., Janda, K.D., "Vitamin B2-mediated cellular photoinhibition of botulinum neurotoxin A"
FEBS Letters, 579, 5361 (2005)
312
Carrera, M.R.A., Trigo, J.M., Wirsching,P., Roberts, A.J., Janda, K.D., "Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose"
Pharmacology, Biochemistry and Behavior, 81, 709 (2005)
311
McKenzie, K.M., Meijler, M.M., Lowery, C.A., Boldt, G.E., Janda, K.D., "A furanosyl-carbonate autoinducer in cell-to-cell communication of V. harveyi"
Chem. Commun., 4863 (2005)
310
Toker, J.D., Tremblay, M.R., Yli-Kauhaluoma, J., Wentworth, A.D., Zhou, B., Wentworth, Jr., P., Janda, K.D., "Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction"
J. Org. Chem., 70, 7810 (2005)
309
Xu, Y., Yamamoto, N., Ruiz, D.I., Kubitz, D.S., Janda, K.D., "Squaric monoamide monoester as a new class of reactive immunization hapten for catalytic antibodies"
Bioorg. Med. Chem. Lett., 15, 4304 (2005)
308
Yamashita, M., Lee, S.-H., Koch, G., Zimmermann, J., Clapham, B., Janda, K.D., "Solid-phase synthesis of oxazolones and other heterocycles via Wang resin-bound diazocarbonyls"
Tetrahedron Lett., 46, 5495 (2005)
307
Rogers, C.J., Mee, J.M., Kaufmann, G.F., Dickerson, T.J., Janda, K.D., "Toward cocaine esterase therapeutics"
J. Am. Chem. Soc., 127(28), 10016 (2005)
306
Brogan, A.P., Dickerson, T.J., Boldt, G.E., Janda, K.D., "Altered retinoid homeostasis catalyzed by a nicotine metabolite: Implications in macular degeneration and normal development"
Proc. Natl. Acad. Sci. U.S.A., 102(30), 10433 (2005)
305
Lee, B.S., Mahajan, S., Janda, K.D., "Molecular iodine-catalyzed imine activation for three-component nucleophilic addition reactions"
Synlett, 8, 1325 (2005)
304
Lee,B.S., Mahajan, S., Janda, K.D., "Asymmetric dihydroxylation catalyzed by ionic polymer-supported osmium tetroxide"
Tetrahedron Lett., 46, 4491 (2005)
303
Dickerson, T.J., Kaufmann, G.F., Janda, K.D., "Bacteriophage-mediated protein delivery into the central nervous system and its application in immunopharmacotherapy"
Expert Opin. Biol. Ther., 5(6), 773 (2005)
302
Lowery, C.A., McKenzie, K.M., Qi, L., Meijler, M.M., Janda, K.D., "Quorum sensing in Vibrio harveyi: probing the specificity of the LuxP binding site"
Bioorg. Med. Chem. Lett., 15, 2395 (2005)
301
Rogers, C.L., Dickerson, T.J., Brogan, A.P., Janda,K.D., "Hammett correlation of nornicotine analogues in the aqueous aldol reaction: Implications for green organocatalysis"
J. Org. Chem., 70(9), 3705 (2005)
300
Zorrilla, E., Fekete, E., Mason, B.J., Wirsching, P., Janda, K.D., "CRF1 antagonists for anxiety"
European Neuropsychopharmacology, 13 (Suppl. 4), s130 (2003)
299
Kaufmann, G.F., Meijler, M.M., Sun, C., Chen, D.-W., Kujawa, D.P., Mee, J.M., Hoffman, T.Z., Wirsching, P., Lerner, R.A., Janda, K.D., "Enzymatic incorporation of an antibody-activated blue fluorophore into DNA"
Angew. Chem. Int. Ed., 44, 2144 (2005)
298
Lee, B.S., Mahajan, S., Janda, K.D., "Cross-linked poly(4-vinylpyridine/styrene) copolymers as a support for immobilization of ytterbium triflate"
Tetrahedron, 61, 3081 (2005)
297
Reed, N.N., Dickerson, T.J., Boldt, G.E., Janda, K.D., "Enantioreversal in the Sharpless asymmetric epoxidation reaction controlled by the molecular weight of a covalently appended achiral polymer"
J. Org. Chem., 70(5), 1728 (2005)
296
Moss, J.A., Lillo, A., Kim, Y.S., Gao, C., Ditzel, H., Janda, K.D., "A dimerization 'switch' in the internalization mechanism of a cell-penetrating peptide"
J. Am. Chem. Soc., 127, 538 (2005)
295
Lee, B.S., Mahajan, S., Janda, K.D., "Novel method for catalyst immobilization using an ionic polymer: A case study using recyclable yttterbium triflate"
Tetrahedron Letters, 46, 807 (2005)
294
Kaufmann, G.F., Sartorio, R., Lee, S.-H., Rogers, C.J., Meijler, M.M., Moss, J.A., Clapham, B., Brogan, A.P., Dickerson, T.J., Janda, K.D., "Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones"
Proc. Natl. Acad. Sci. USA, 102(2), 309 (2005)
293
Felding-Habermann, B., Lerner, R.A., Lillo, A., Zhuang, S., Weber, M.R., Arrues, S., Gao, C., Mao, S., Saven, A., Janda, K.D., "Combinatorial antibody libraries from cancer patients yield ligand mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis"
Proc. Natl. Acad. Sci. USA, 101(49), 17210 (2004)
292
Dickerson, T.J., Reed, N.N., La Clair, J.J., Janda, K.D., "A precipitator for the detection of thiophilic heavy metals in aqua"
J. Am. Chem. Soc., 126(50), 16582 (2004)
291
Lee, S.-H., Yoshida, K., Matsushita, H., Clapham, B., Koch, G., Zimmermann, J., Janda, K.D., "N-H insertion reactions of primary ureas: The synthesis of highly substituted imidazolones and imidazoles