The Scripps Research Institute Department of Cell Biology Mail Drop MB6, Room 114 10550 North Torrey Pines Road La Jolla, California 92037 (USA) SLSchmid@scripps.edu

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Pucadyil, T.J., and S.L. Schmid. (2009). Conserved functions of membrane active GTPases in coated vesicle formation. Science. 325:1217-20. (PubMed).

Liu, A.P., D. Loerke, S.L. Schmid, and G. Danuser. (2009). Global and local regulation of clathrin-coated pit dynamics detected on patterned substrates. Biophys. J. 97:1038-47. (PubMed).

Chappie, J.S., S. Acharya, Y.W. Liu, M. Leonard, T.J. Pucadyil, and S.L. Schmid. (2009). An Intramolecular Signaling Element that Modulates Dynamin Function In Vitro and In Vivo. Mol. Biol. Cell. (PubMed).

Mettlen, M., M. Stoeber, D. Loerke, C.N. Antonescu, G. Danuser, and S.L. Schmid. (2009). Endocytic Accessory Proteins Are Functionally Distinguished by Their Differential Effects on the Maturation of Clathrin Coated Pits. Mol. Biol. Cell. (PubMed).

Shan, S.O., S.L. Schmid, and X. Zhang. (2009). Signal recognition particle (SRP) and SRP receptor: A new paradigm for multi-state regulatory GTPases. Biochemistry (Mosc). (PubMed).

Loerke, D., M. Mettlen, D. Yarar, K. Jaqaman, H. Jaqaman, G. Danuser, and S.L. Schmid. (2009). Cargo and Dynamin Regulate Clathrin-Coated Pit Maturation. PLoS Biol. 7:e57. (PubMed).

Bashkirov, P.V., S.A. Akimov, A.I. Evseev, S.L. Schmid, J. Zimmerberg, and V.A. Frolov. (2008). GTPase cycle of dynamin is coupled to membrane squeeze and release, leading to spontaneous fission. Cell. 135:1276-86. (PubMed).

Pucadyil, T.J., and S.L. Schmid. (2008). Real-time visualization of dynamin-catalyzed membrane fission and vesicle release. Cell. 135:1263-75.(PubMed)

Liu, Y.W., M.C. Surka, T. Schroeter, V. Lukiyanchuk, and S.L. Schmid. (2008). Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells. Mol Biol Cell. 19:5347-59 .(PubMed).

Jaqaman, K., D. Loerke, M. Mettlen, H. Kuwata, S. Grinstein, S.L. Schmid, and G. Danuser. (2008). Robust single-particle tracking in live-cell time-lapse sequences. Nature methods. 5:695-702.(PubMed).

Yarar, D., M.C. Surka, M.C. Leonard, and S.L. Schmid. (2008). SNX9 Activities are Regulated by Multiple Phosphoinositides Through both PX and BAR Domains. Traffic (Copenhagen, Denmark). 9:133-46.(PubMed).

Ramachandran, R., and S.L. Schmid. (2008). Real-time detection reveals that effectors couple dynamin's GTP-dependent conformational changes to the membrane. EMBO J. 27:27-37.(PubMed).

Alto, N.M., A.W. Weflen, M.J. Rardin, D. Yarar, C.S. Lazar, R. Tonikian, A. Koller, S.S. Taylor, C. Boone, S.S. Sidhu, S.L. Schmid, G.A. Hecht, and J.E. Dixon. (2007). The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol. 178:1265-78. (PubMedAbstract).

Yarar, D., M.C. Surka, M.C. Leonard, and S.L. Schmid. (2007). SNX9 Activities are Regulated by Multiple Phosphoinositides Through both PX and BAR Domains. Traffic. (PubMedAbstract).

Yarar, D., C.M. Waterman-Storer, and S.L. Schmid. (2007). SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis. Dev Cell. 13:43-56. (PubMedAbstract).

Ramachandran, R., M. Surka, J.S. Chappie, D.M. Fowler, T.R. Foss, B.D. Song, and S.L. Schmid. (2007). The dynamin middle domain is critical for tetramerization and higher-order self-assembly. Embo J. 26:559-66.(PubMedAbstract)

Soulet, F., S.L. Schmid, and H. Damke. (2006). Domain requirements for an endocytosis-independent, isoform-specific function of dynamin-2. Exp Cell Res. 312:3539-45.(PubMedAbstract)

Miwako, I. and Schmid, S.L. (2006). A cell-free biochemical complementation assay reveals complex and redundant cytosolic requirements for LRP endocytosis. Exp Cell Res, 312, 1335-1344.(PubMedAbstract).

Conner, S. D., and S. L. Schmid. (2005). CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2. J Biol Chem 280:21539-44.(PubMedAbstract).

Leonard, M., Song, B.D., Ramachandran, R. and Schmid, S.L. (2005). Robust colorimetric assays for dynamin's basal and stimulated GTPase activities. Methods Enzymol, 404, 490-503.(PubMedAbstract).

Miwako, I. and Schmid, S.L. (2005). Clathrin-coated vesicle formation from isolated plasma membranes. Methods Enzymol, 404, 503-511.(PubMedAbstract).

Narayanan, R., M. Leonard, B. D. Song, S. L. Schmid, and M. Ramaswami. (2005). An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function. J Cell Biol 169:117-26.(PubMedAbstract).

Reubold, T.F., Eschenburg, S., Becker, A., Leonard, M., Schmid, S.L., Vallee, R.B., Kull, F.J. and Manstein, D.J. (2005). Crystal structure of the GTPase domain of rat dynamin 1. Proc Natl Acad Sci U S A.(PubMedAbstract).

Schmid, S.L. (2005). Molecular Biology of the Cell: It's Our Journal. Mol Biol Cell, 16, i.(PubMedAbstract).

Soulet, F., D. Yarar, M. Leonard, and S. L. Schmid. (2005). SNX9 Regulates Dynamin Assembly and Is Required for Efficient Clathrin-mediated Endocytosis. Mol Biol Cell. 16:1058-2067. (PubMedAbstract).

Yarar, D., C. M. Waterman-Storer, and S. L. Schmid. (2005). A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis. Mol Biol Cell 16:964-75. (PubMedAbstract).

Song, B. D., M. Leonard, and S. L. Schmid. (2004). Dynamin GTPase domain mutants that differentially affect GTP binding, GTP hydrolysis, and clathrin-mediated endocytosis. J Biol Chem 279:40431-6. (PubMedAbstract)

Song, B. D., D. Yarar, and S. L. Schmid. (2004). An assembly-incompetent mutant establishes a requirement for dynamin self-assembly in clathrin-mediated endocytosis in vivo. Mol Biol Cell 15:2243-52. (PubMedAbstract).

Schlunk, G., H. Damke, W.B. Kiosses, N. Rusk, M. Symons, S.L. Schmid, and M.A. Schwartz. (2004). Dynamin dependent trafficking regulates Rac localization and function. Mol Biol Cell. 15:256-67. (PubMedAbstract).

Conner, S.D., T. Schröter and S.L. Schmid. (2003). AAK1-mediated m2 phosphorylation is stimulated by assembled clathrin. Traffic. 4:885-890.(PubMedAbstract).

Miwako, I., T. Schröter and S.L.Schmid. (2003). Clathrin-and dynamin-dependent coated vesicle formation from isolated plasma membranes. Traffic.4:376-389. (PubMedAbstract).

Conner, S.D., and S.L. Schmid. (2003). Differential requirements of AP2 in clathrin-mediated endocytosis. J Cell Biol. 162:773-779. (PubMedAbstract).

Conner, S.D., and S.L. Schmid. (2003). Regulated portals of entry into the cell. Nature. 422:37-44. (PubMedAbstract).

Song, B.D., and S.L. Schmid. (2003). A molecular motor or a regulator? Dynamin's in a class of its own. Biochemistry. 42:1369-1376. (PubMedAbstract).

Chang, H.C., S.L. Newmyer, M.J. Hull. M. Ebersold, S.L. Schmid and I. Mellman. (2002): Hsc70 is required for endocytosis and clathrin function in Drosophila J. Cell Biol. 159:477-487. (PubMedAbstract).

Conner, S.D., and S.L. Schmid. ( 2002). Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. J Cell Biol. 156:921-9. (PubMedAbstract)

Ricotta, D., S.D. Conner, S.L. Schmid, K. von Figura, and S. Honing. (2002). Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals. J Cell Biol. 156:791-5. (PubMedAbstract).

Schmid, S.L., and A.D. Sorkin. (2002). Days and knights discussing membrane dynamics in endocytosis: meeting report from the Euresco/EMBL Membrane Dynamics in Endocytosis, 6--11 October in Tomar, Portugal. Traffic. 3:77-85. (PubMedAbstract).

Ceresa, B. P., Lotscher, M., and Schmid, S. L. (2001): Receptor and membrane recycling can occur with unaltered efficiency despite dramatic rab5(q79l)-induced changes in endosome geometry. J Biol Chem 276, 9649-54. (PubMedAbstract)

Damke. H., Binns, D.D., Ueda H., Schmid, S.L.and Baba, T. (2001). Dynamin GTPase domain mutants block endocytic vesicle formation at morphologically distinct stages. Mol Biol Cell. 12:2578-89. (PubMedAbstract).

Damke, H., A.B. Muhlberg, S. Sever, S. Sholly, D.E. Warnock, and S.L. Schmid. (2001). Expression, purification, and functional assays for self-association of dynamin-1. Methods Enzymol. 329:447-57. (PubMedAbstract).

Newmyer, S., Schmid, S. L. (2001). Dominant-interfering hsc70 mutants disrupt multiple stages of the clathrin-coated vesicle cycle in vivo. J Cell Biol 152, 607-20. (PubMedAbstract).

Ceresa, B. P., and Schmid, S. L. (2000). Regulation of signal transduction by endocytosis. Curr Opin Cell Biol 12, 204-10. (PubMedAbstract)

Fish, K. N., Schmid, S. L., and Damke, H. (2000). Evidence that dynamin-2 functions as a signal-transducing GTPase. J Cell Biol 150, 145-54.(PubMedAbstract)

Fujimoto, L. M., Roth, R., Heuser, J. E., and Schmid, S. L. (2000). Actin assembly plays a variable, but not obligatory role in receptor- mediated endocytosis in mammalian cells. Traffic 1:161-71. (PubMedAbstract).

Sever, S., Damke, H., and Schmid, S. L. (2000): Dynamin:GTP controls the formation of constricted coated pits, the rate limiting step in clathrin-mediated endocytosis. J Cell Biol 150, 1137-48.(PubMedAbstract).

Sever, S., Damke, H., and Schmid, S. L. (2000). Garrotes, springs, ratchets, and whips: putting dynamin models to the test. Traffic 1, 385-92. (PubMedAbstract).

Sever, S., Muhlberg, A. B., and Schmid, S. L. (1999). Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis. Nature 398, 481-6.(PubMedAbstract).

Simpson, F., Hussain, N. K., Qualmann, B., Kelly, R. B., Kay, B. K., McPherson, P. S., and Schmid, S. L. (1999). SH3-domain-containing proteins function at distinct steps in clathrin- coated vesicle formation. Nat Cell Biol 1, 119-24.(PubMedAbstract).

Hannan, L. A., Newmyer, S. L., and Schmid, S. L. (1998). ATP- and cytosol-dependent release of adaptor proteins from clathrin- coated vesicles: A dual role for Hsc70. Mol Biol Cell 9, 2217-29.(PubMedAbstract).

Jost, M., Simpson, F., Kavran, J. M., Lemmon, M. A., and Schmid, S. L. (1998): Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation. Curr Biol 8, 1399-402.(PubMedAbstract).

Muhlberg, A. B., Warnock, D. E., and Schmid, S. L. (1997). Domain structure and intramolecular regulation of dynamin GTPase. Embo J 16, 6676-83.(PubMedAbstract).

Schmid, S. L. (1997). Clathrin-coated vesicle formation and protein sorting: an integrated process. Annu Rev Biochem 66, 511-48.(PubMedAbstract).

Lamaze, C., Chuang, T. H., Terlecky, L. J., Bokoch, G. M., and Schmid, S. L. (1996). Regulation of receptor-mediated endocytosis by Rho and Rac. Nature 382, 177-9.(PubMedAbstract).

Vieira, A. V., Lamaze, C., and Schmid, S. L. (1996). Control of EGF receptor signaling by clathrin-mediated endocytosis. Science 274, 2086-9.(PubMedAbstract).

Warnock, D. E., and Schmid, S. L. (1996). Dynamin GTPase, a force-generating molecular switch. Bioessays 18, 885-93.(PubMedAbstract).

Damke, H., Baba, T., van der Bliek, A. M., and Schmid, S. L. (1995.: Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin. J Cell Biol 131, 69-80. (PubMedAbstract)

Hinshaw, J. E., and Schmid, S. L. (1995). Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding. Nature 374, 190-2.(PubMedAbstract).