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Quigley Laboratory


Biographical Sketch (pdf)


Name      
Quigley, James P.
Professor		      
Institution & Location Degree
(if applicable) 		Year(s) Field of Study
Manhattan College,
New York, NY 		B.S. 1965 Chemistry
John Hopkins U. School Medicine, Baltimore, MD Ph.D. 1970 Biochemistry
Rockefeller University, New York, NY PostDoc 1970-1973 Tumor Virology


A. Positions and Honors
     
Positions and Employment
1973-1977 Assistant Professor, Rockefeller University, Dept. of Chemical Biology, New York, NY
1974-1984 Adjunct Associate Professor, The Rockefeller University, New York, NY
1975-1978 Assistant Professor, SUNY Downstate, Dept. of Microbiology and Immunology, Brooklyn, NY
1978-1982 Associate Professor, SUNY Downstate, Dept. of Microbiology and Immunology, Brooklyn, NY
1980-1981 Visiting Professor, Oxford University - Sir William Dunn School of Pathology, Oxford, UK
1982-1987 Professor, SUNY Downstate, Dept. of Microbiology and Immunology, Brooklyn, NY
1987-1999 Professor, SUNY Stony Brook, Dept. of Pathology, Stony Brook, NY
1993-1994 Visiting Professor, U.C.S.F. Medical Center, Dept. of Pharmaceutical Chemistry, San Francisco, CA
1999-2001 Professor, The Scripps Research Institute, Dept. of Vascular Biology, La Jolla, CA
2001-present Professor, The Scripps Research Institute, Dept. of Cell Biology, La Jolla, CA
2002-present Adjunct Professor, UCSD, Dept. of Pathology, La Jolla, CA
 
Other Experience and Professional Memberships
American Association of Cancer Research, American Society for Biochemistry & Molecular Biology; American Society for Cell Biology, Federation of Biological Chemists, Marine Biological Laboratory-Corporation Member; The Biochemical Society; American Society for Matrix Biology-Council Member
 
Selected Appointments and Honors
1970 - 1972 Leukemia Society of America Fellow at Rockefeller University
1978 - 1980 Sinsheimer Foundation Scholar at SUNY Downstate
1980 - 1981 Fogarty International Scholar at Oxford University
1981 - 1986 Member - Cellular Physiology Study Section of NIH
1987 - 1991 Co-chairman/Biochemistry Study Section of American Cancer Society
1988 - 1990 Catacosinos Cancer Research Professorship at SUNY Stony Brook
1992 - 1996 Member - Pathobiochemistry Study Section of the NIH
1996 - 2006 Editorial Board - The Journal of Biological Chemistry
2009-present Editorial Board - The Journal of Biological Chemistry
 

B. Selected peer-reviewed publications (in chronological order).
(Publications selected from 129 peer-reviewed publications)
  1. Brooks PC, Stromblad S, Sanders LC, von Schalscha TL, Aimes RT, Stetler-Stevenson WG, Quigley JP, Cheresh DA. Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin v3. Cell 1996;85:683-693.
  2. Sipley JD, Alexander DS, Testa JE, Quigley JP. Introduction of an RRHR Motif into Chicken Urokinase-type Plasminogen Activator (ch-uPA) Confers Sensitivity to Plasminogen Activator Inhibitor (PAI)-1 and PAI-2. Proc Natl Acad Sci USA 1997;94:2933-2938. PMCID: PMC20300.
  3. Alexander DS, Sipley JD, Quigley JP. Autoactivation of Avian Urokinase-Type Plasminogen Activator (uPA): A Novel Mode of Initiation of the uPA/Plasmin Cascade. J Biol Chem. 1998;273:7457-7461.
  4. Quigley JP, Armstrong PG. Tumor Cell Intravasation Alu-cidated: The Chick Embryo Opens the Window. Cell 1998;94:281-284.
  5. Ramos-Desimone N, Hahn-Dantona E, Sipley J, Nagase H, French DL, Quigley JP. Activation of Matrix Metalloproteinase-9 (MMP-9) via a Converging Plasmin/Stromelysin-1 Cascade Enhances Tumor Cell Invasion. J Biol Chem. 1999;274:13066-13076
  6. Testa JE, Brooks PC, Lin J.-M, Quigley JP. Eukaryotic Expression Cloning with an Antimetastatic Monoclonal Antibody Identifies a Tetraspanin (PETA-3/CD151) as an Effector of Human Tumor Cell Migration and Metastasis. Cancer Res. 1999;59:3812-3820.
  7. Hahn-Dantona EA, Aimes RT, Quigley JP. The Isolation, Characterization, and Molecular Cloning of a 75kDa Gelatinase B-like Enzyme, A Member of the Matrix Metalloproteinase (MMP) Family. J Biol Chem. 2000;275:40827-40838.
  8. Seandel M, Noack-Kunnmann K, Zhu D, Aimes RT, Quigley JP. Growth Factor-Induced Angiogenesis in vivo Requires Specific Cleavage of Fibrillar Type I Collagen. Blood 2001;97:2323-2332.
  9. Hooper JD, Clements JA, Quigley JP, Antalis TM. Type II Transmembrane Serine Proteases - Insights into an Emerging Class of Cell Surface Proteolytic Enzymes. J Biol Chem. 2001;276:857-860.
  10. Rozanov DV, Deryugina EI, Ratnikov BI, Monosov EZ, Marchenko GN, Quigley JP, Strongin AY. Mutation analysis of membrane Type-1 matrix metalloproteinase (MT1-MMP). J Biol Chem. 2001;276:25705-25714.
  11. Zijlstra A, Mellor R, Panzarella G, Aimes RT, Hooper JD, Marchenko N, Quigley JP. A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction. Cancer Res. 2002;62:7083-7092.
  12. Aimes RT, Regazzoni K and Quigley JP. Human/Chicken Urokinase Chimeras Demonstrate Sequences Outside the Serine Protease Domain that Dictate Autoactivation. Thromb. Haemos. 2003;89:382-92.
  13. Hooper JD, Zijlstra A, Aimes RT, Liang H, Claassen GF, Test JE, Tarin D, Quigley JP. Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. Oncogene 2003;22:1783-1794.
  14. Hooper JD, Campagnolo L, Goodarzi G, Truong TN, Stuhlmann H, Quigley JP. Mouse matriptase-2, identification, characterization and comparative mRNA expression analysis with mHepsin in adult and embryonic tissues. Biochem J. 2003;373:689-702. PMCID: PMC1223555.
  15. Hooper JD, Campagnolo L, Goodarzi G, Truong TN, Stuhlmann H, Quigley JP. Mouse matriptase-2, identification, characterization and comparative mRNA expression analysis with mHepsin in adult and embryonic tissues. Biochem J. 2003;373:689-702. PMCID: PMC1223555.
  16. Wilson S, Greer B, Zijlstra A, Hooper J, Quigley JP, Hawthorne S. The membrane-anchored serine protease, TMPRSS2, activates PAR-2 on prostate cancer cells. Biochem J. 2005;388:967-972.
  17. Blancafort P, Chen EI, Gonzalez B, Bergquist S, Zijlstra A, Guthy D, Brachat A, Brakenhoff RH, Quigley JP, Erdmann D, Barbas CF, 3rd. Genetic reprogramming of tumor cells by zinc finger transcription factors. Proc Natl. Acad, Sci, USA 2005;102:11716-11721. PMCID: PMC1187960.
  18. Deryugina EI, Zijlstra A, Partridge JJ, Kupriyanova TA, Madsen M, Papagiannakopoulos T and Quigley JP. Unexpected effect of matrix metalloproteinase downregulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination. Cancer Res. 2005;65:10959-69.
  19. Zijlstra A, Seandel M, Kupriyanova TA, Partridge JJ, Madsen M, Hahn-Dantona EA, Quigley JP, Deryugina EI. Pro-angiogenic role of neutrophil-like inflammatory heterophils during neovascularization induced by growth factors and human tumor cells. Blood 2006;107:317-27. PMCID: PMC1895349.
  20. Deryugina EI and Quigley JP. Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 2006;25:9-34.
  21. Lewis JD, Destito G, Zijlstra A, Quigley JP, Manchester M, Stuhlmann H. Viral nanoparticles (VNPs) as tools for in vivo vascular imaging. Nat Med. 2006;12(3):354-360. PMCID: PMC2536493.
  22. Madsen MA, Deryugina EI, Niessen S, Cravatt B, Quigley JP. Activity based protein profiling implicates urokinase (uPA) activation as a key step in human fibrosarcoma intravasation. J Biol Chem. 2006;281(23):15997-6005.
  23. Zijlstra A and Quigley JP. The DARC side of metastasis: Shining a light on KAI1-mediated metastasis suppression in the vascular tunnel. (Preview) Cancer Cell 2006;10:177-178.
  24. Partridge JJ, Madsen MA, Ardi VC, Papagiannakopoulos T, Kupriyanova TA, Quigley JP and Deryugina EI. Functional analysis of MMPs and TIMPs differentially expressed by variants of HT-1080 fibrosarcoma exhibiting high and low levels of intravasation and metastasis. J Biol Chem 2007;282(49):35964-77.
  25. Ardi VC, Kupriyanova TA, Deryugina EI and Quigley JP. Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis. Proc. Natl. Acad. Sci. USA 2007;104(51):20262-7. PMCID: PMC2154419.
  26. Zijlstra A, Lewis J, DeGryse B, Stuhlman H and Quigley JP. The inhibition of tumor cell intravasation and subsequent metastasis through the regulation of in vivo tumor cell motility by the tetraspanin CD151. Cancer Cell 2008;13(3):221-34.
  27. Ramsay AJ, Reid JC, Velasco G, Quigley JP, Hooper JD. The type II transmembrane serine protease Matriptase-2 - identification, structural features, enzymology, expression pattern and potential roles. Front Biosci. 2008;13:569-79.
  28. Kamikubo Y, Dellas C, Loskutoff DJ, Quigley JP and Ruggeri ZM. Contribution of leptin receptor N-linked glycans to leptin binding. Biochem. J. 2008;410(3):595-604.
  29. Conn EM, Madsen MA, Cravatt BF, Ruf W, Deryugina EI and Quigley JP. Cell surface proteomics identifies molecules functionally linked to tumor cell intravasation. J Biol. Chem. 2008;283(39):26518-27. NIHMS42910.
  30. Deryugina EI and Quigley JP. Chapter 2. Chick embryo chorioallantoic membrane models to quantify angiogenesis induced by inflammatory and tumor cells or purified effector molecules. Methods Enzymol. 2008;444:21-41. PMCID: PMC2699944.
  31. Deryugina EI and Quigley JP. Chick embryo chorioallantoic membrane model systems to study and visualize human tumor cell metastasis. Histochem Cell Biol. 2008;130(6):1119-30. PMCID: PMC2699943.
  32. Blouse GE, Boetkjaer KA, Deryugina E, Byszuk AA, Jensen JM, Mortensen KK, Quigley JP, Andreasen P.A. A novel mode of intervention with serine protease activity: Targeting zymogen activation. J Biol Chem. 2009;284(7):4647-4657. PMCID: PMC2640953.
  33. Wortmann A, He Y, Deryugina EI, Quigley JP, Hooper JD. The cell surface glycoprotein CDCP1 in cancer-Insights, opportunities, and challenges. IUBMB Life. 2009;61(7):723-730.
  34. Deryugina EI, Conn EM, Wortmann A, Partridge, JJ, Kupriyanova TA, Ardi VC, Hooper JD and Quigley JP. Functional Role of Cell Surface CUB Domain-Containing Protein 1 (CDCP1) in Tumor Cell Dissemination. Mol Cancer Res. 2009;7(8):1197-211.
  35. Conn, EM, Botkjaer KA, Kupriyanova TA, Andreasen PA, Deryugina EI and Quigley JP. Comparative Analysis of Metastasis Variants Derived from Human Prostate Carcinoma Cells: Roles in Intravasation of VEGF-Mediated Angiogenesis and uPA-Mediated Invasion. Am J Pathol 2009;175(4):1638-52..
  36. Ardi VC, Van den Steen PE, Opdenakker G, Schweighofer B, Deryugina EI and Quigley JP. Neutrophil proMMP-9, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via an FGF-2/FGFR2 pathway. J Biol Chem. 2009;38:25854-66.

 

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