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REGULATION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION
Laboratory of Alan McLachlan
Department of Cell Biology
The Scripps Research Institute
10550 North Torrey Pines Road
La Jolla, CA92037
Tel. No: (858)784-8097
Fax. No: (858)784-2513
E-mail: mclach@scripps.edu
Organization of the HBV genome
The HBV replication cycle
In my laboratory we study the regulation of HBV gene expression and its relationship to viral replication. In cell culture, we have identified and characterized many of the transcription factors that regulate HBV RNA synthesis and demonstrated a critical role of nuclear hormone receptors in viral tropism. Using HBV transgenic mice, the role of specific liver-enriched transcription factors in modulating HBV transcription and replication in vivo is currently under investigation. The importance of transcriptional regulation in controlling HBV replication in response to immune stimulation is also being characterized.
