The Catz Laboratory

Selected Publications

Gennaro Napolitano, Jennifer L. Johnson, Celine J Rocca, Jlenia Monfregola, Stephanie Cherqui and Sergio D. Catz. Deficiency of cystinosin causes impaired chaperone-mediated autophagy independent of lysosomal overload. EMBO Molecular Medicine 2015, 7(2):158-74.

Jing He, Jennifer L. Johnson, Jlenia Monfregola, Mahalakshmi Ramadass, Kersi Pestonjamasp and Sergio D. Catz. Munc13-4 interacts with syntaxin 7, regulates late endosomal  maturation, endosomal signaling and TLR9-initiated cellular responses. 2016, Molecular Biology of the Cell. 27(3):572-87.

Jennifer L. Johnson, Jing He, Mahalakshmi Ramadass, Kersi Pestonjamasp, William Kiosses,  Jinzhong Zhang and Sergio D. Catz. Munc13-4 is a Rab11-binding protein that regulates Rab11-positive vesicle trafficking and docking at the plasma membrane. 2016, Journal of Biological Chemistry, 291(7):3423-38

Laura Rita Rega; Elena Polishchuk; Sandro Montefusco;Gennaro Napolitano; Giulia Tozzi; Jinzhong Zhang; Francesco Bellomo; Anna Taranta; Anna Pastore; Roman Polishchuk; Fiorella Piemonte; Diego Luis Medina; Sergio D. Catz; Olivier Devuyst; Andrea Ballabio; Francesco Emma. Activation of the transcription factor EB promotes clearance of lysosomal cystine and rescues abnormalities of the lysosomal compartment in cystinotic cells". 2016, Kidney International, 89(4):862-73.

Mahalakshmi Ramadass and Sergio D. Catz. Molecular Mechanisms Regulating Secretory Organelles and Endosomes in Neutrophils and their Implications for Inflammation. 2016, Immunological Reviews, 273(1):249-65

Angela R M Kurz, Monika Pruenster, Ina Rohwedder, Mahalakshmi Ramadass, Kerstin Schäfer, Ute Harrison, Gabriel Gouveia, Claudia Nussbaum, Roland Immler, Johannes R Wiessner, Andreas Margraf, Dae-Sik Lim, Barbara Walzog, Steffen Dietzel, Markus Moser, Christoph Klein, Dietmar Vestweber, Rainer Haas, Sergio D. Catz and Markus Sperandio. MST1-dependent vesicle trafficking regulates neutrophil transmigration through the basement membrane. Journal of Clinical Investigation, 2016, 126(11):4125-4139.

Jennifer L. Johnson,  Mahalakshmi Ramadass, Jing He, Steve Brown,  William Kiosses,  Jinzhong Zhang, Nikolaos Biris, Evripidis Gavathiotis, Hugh Rosen and Sergio D. Catz. Identification of Nexinhibs, small-molecule inhibitors of neutrophil exocytosis and inflammation. Druggability of the small GTPase Rab27a. 2016, J. Biol. Chem. 2016. 291(50):25965-25982.

Mahalakshmi Ramadass, Jennifer L. Johnson, and Sergio D. Catz. Rab27a regulates GM-CSF-dependent priming of neutrophil exocytosis. Journal of Leukocyte Biology, 2017, 101(3):693-702.

Sergio D. Catz. The Secrets of Secretion. Journal of Leukocyte Biology. 2017 Jul;102(1):4-6.

Jinzhong Zhang, Jennifer L. Johnson, Jing He, Gennaro Napolitano, Mahalakshmi Ramadass, Celine Rocca, William B. Kiosses, Cecilia Bucci, Evripidis Gavathiotis, Ana M. Cuervo, Stephanie Cherqui and Sergio D. Catz. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 May 2. 23;292(25):10328-10346 doi: 10.1074/jbc.M116.764076.

Jennifer L. Johnson, Mahalakshmi Ramadass, Ariela Haimovich, Matthew D. McGeough, Hal M. Hoffman, Sergio D. Catz. Increased neutrophil secretion induced by NLRP3 mutation links the inflammasome to azurophilic granule exocytosis. Front Cell Infect Microbiol. 2017; 7:507

Angela R.M. Kurz, Sergio D. Catz, and Markus Sperandio, Differential regulation of leukocytes by MST1. Trends in Immunology. 2018 Aug;39(8):656-669. doi: 10.1016/j.it.2018.05.003.

Tatiana Lobry, Roy Miller, Nathalie Nevo, Celine J. Rocca, Jinzhong Zhang, Sergio D. Catz, Anne Bailleux, Chiara Guerrera, Marie-Claire Gubler, Cheung W. Wilson, Robert Mak, Tristan Montier, Corinne Antignac, Stephanie Cherqui. Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis. Kidney International (2019), doi: https://doi.org/10.1016/j.kint.2019.01.029.

Mahalakshmi Ramadass, Jennifer L. Johnson, Alex Marki, Jinzhong Zhang, Dennis Wolf, William B. Kiosses, Kersi Pestonjamasp, Klaus Ley and Sergio D. Catz. The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration. J Leukoc Biol. 2019 105(6):1209-1224. doi: 10.1002/JLB.1VMA0818-320R. PMID: 30748033
Klaus Ley,  Hal Hoffman, Paul Kubes, Marco Cassatella, Arturo Zychlinsky, Hedrick CC and Sergio D. Catz. Neutrophils: New insights and open questions.  Science Immunology.  2018 Dec 7;3(30). pii: eaat4579. doi: 10.1126/sciimmunol.aat4579

Zhang J, He J, Johnson JL, Rahman F, Gavathiotis E, Cuervo AM, Catz SD. Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells. Front Endocrinol (Lausanne). 2019 Feb 1;10:21. doi: 10.3389/fendo.2019.00021. eCollection 2019. PubMed PMID:30774622; PubMed Central PMCID: PMC6367655.

Jinzhong Zhang, Jing He, Jennifer L. Johnson, Mahalakshmi Ramadass and Sergio D. Catz. Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency. Autopahgy. 2019. r 20:1-19. doi: 10.1080/15548627.2019.1596475.

Ina Rohwedder, Angela R.M. Kurz, Monika Pruenster, Roland Immler, Robert Pick, Tanja Eggersmann, Sarah Klapproth, Jennifer Johnson, Clifford A Lowell, Attila Mócsai, Sergio D. Catz, and Markus Sperandio. Src Family Kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration. Haematologica. 2019 Nov 7. pii: haematol.2019.225722. doi: 10.3324/haematol.2019.225722.

Sergio D. Catz and Kenneth R. McLeish. Therapeutic Targeting of Neutrophil Exocytosis
Journal of Leukocyte Biology, 2020. Accepted.