The Carroll Lab

Publications

Updated 03/20/2013

Reviews & Book Chapters:

Pan, J.; Carroll, K. S.  "Chemical Biology Approaches to Study Protein Cysteine Sulfenylation."  Biopolymers. 2013, just accepted  [pdf available soon]

Paulsen, C. E.; Carroll, K. S.  “Cysteine-based redox signaling: Chemistry, biology, and tools for discovery.”  Chem. Rev. 2012, accepted.  [pdf]

Truong, T. H.; Carroll, K. S.  "Redox-regulation of EGFR signaling through cysteine oxidation." Biochemistry. 2012, 51(50), 9954-65.  [pdf]

LoConte, M.; Carroll, K. S.  "The chemistry of thiol oxidation and detection." Oxidative stress and redox regulation. Jakob, U. Ed.; Springer: New York 2012, Chapter 1.  [pdf]

Leonard, S. E.; Carroll, K. S.  “Chemical ‘omics’ approaches for understanding protein cysteine oxidation in biology.”  Curr. Opin. Chem. Biol. 2011, 15(1), 88-102.  [pdf]

Carroll, K. S.  “Metabolite imaging:  knock, nox-ROS there?”  Nat. Chem. Biol. 2011, 7(2), 71-2.  [pdf]

Paulsen, C. E.; Carroll, K. S.  “Orchestrating redox signaling networks through regulatory cysteine switches.”  ACS Chem. Biol. 2010, 5(1), 47-62.  [pdf]

Reddie, K. G.; Carroll, K. S.  “Expanding the functional diversity of proteins through cysteine oxidation.”  Curr. Opin. Chem. Biol. 2008, 12(6), 746-54.  [pdf]

Bhave, D. P.; Muse, W. B. 3rd; Carroll, K. S.  “Drug targets in mycobacterial sulfur metabolism.”  Infect. Disord. Drug Targets. 2007, 7(2), 140-58.  [pdf]

Research Articles:

Pan, J.; Carroll, K. S.  "Persulfide Reactivity in the Detection of Protein S-Sulfhydration."  ACS Chem. Biol. 2013, just accepted manuscript  [pdf]

Wu, J.; Cheng, Z.; Reddie, K.G.; Carroll, K. S.; Hammand, L. A.; Karty, J. A.; Bauer C. E.  "RegB Kinase Activity is Repressed by Oxidative Formation of Cysteine Sulfenic Acid."  J. Biol. Chem. 2013, 288(7), 4755-62.  [pdf]

Alili, L.; Sack, M.; von Montfort, C.; Giri, S.; Das, S.; Carroll, K. S.; Zanger, K.; Seal, S.; Brenneisen, P.  "Downregulation of Tumor Growth and Invasion by Redox-Active Nanoparticles."  Antioxid. Redox Signal. 2013, DOI: 10.1089/ars.2012.4831. [pdf]

Kulathu, Y.; Garcia, F. J.; Busch, M.; Mevissen, T.; Arnaudo, N.; Carroll, K. S.; Barford, D.; Komander, D.  "Regulation of A20 and other OTU DUBs by reversible oxidation."  Nat. Comm. 2012, accepted.  [pdf available soon]

Svoboda, L. K.; Reddie, K. G.; Zhang, L.; Vesely, E. D.; Williams, E.S.; Schumacher, S. M.; O'Connell, R. P.; Shaw, R.; Day, S. M.; Anumonwo, J. M.; Carroll, K. S.; Martens, J. R.  "Redox-sensitive sulfenic acid modification regulates surface expression of the cardiovascular voltage-gated potassium channel Kv1.5."  Circ. Res. 2012, 111(7), 842-53. [pdf]

Cheng, Z.; Wu, J.; Setterdahl, A.; Reddie, K. G.; Carroll, K. S., Bauer, C. E.; "Activity of the tetrapyrrole regulator CrtJ is controlled by oxidation of a redox active cysteine located in the DNA binding domain."  Mol. Micro. 2012, 85(4), 734-46.  [pdf]

Li, Y.; Karagoz, G. E.; Seo, Y. H.; Zhang, T.; Jiang, Y.; Yu, Y.; Duarte, A. M. S.; Schwartz S. J., Boelens, R.; Carroll, K. S.; Rudiger, S. G. D.; Sun, D. "Sulforaphane inhibits pancreatic cancer through disrupting Hsp90–p50 Cdc37 complex and direct interactions with amino acids residues of Hsp90"  J. Nutr. Biochem. 2012, 23(12), 1617-26. [pdf]

LoConte, M.; Carroll, K. S.  "Chemoselective ligation of sulfinic acids with aryl-nitroso compounds."  Angew. Chem. Int. Ed. Engl. 2012, 51(26), 6502-05.  [pdf]

Truong, T. H.; Carroll, K. S.  "Bioorthogonal chemical reporters for analyzing protein sulfenylation in cells."  Curr. Prot. Chem. Biol. 2012, 51(26), 101-22.  [pdf]

Barrett, T. J.; Pattison, D. I.; Leonard, S. E.; Carroll, K. S.; Davies, M. J.; Hawkins, C. L.  "Inactivation of thiol-dependent enzymes by HOSCN: Role of sulfenyl thiocyanate and sulfenic acid intermediates."  Free Radic. Biol. Med. 2012, 52(6), 1075-85.  [pdf]

Paulsen, C. E.; Truong, T. H.; Garcia, F. J.; Homann, A.; Gupta, V.; Leonard, S. E.; Carroll, K. S.  "Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity."  Nat. Chem. Biol. 2012, 8(1), 57-64.  [pdf]  Highlighted in C&E News [Link] and Sci. Signal  [Link]

Bhave, D. P.; Hong, J. A.; Keller, R. L.; Krebs, C.; Carroll, K. S.  "Iron-Sulfur Cluster Engineering Provides Insight into the Evolution of Substrate Specificity among the Family of Sulfonucleotide Reductases."  ACS Chem. Biol. 2012, 7(2), 306-15.  [pdf]

Bhave, D. P.; Han, W. G.; Pazicni, S.; Penner-Hahn, J. E.; Carroll, K. S.; Noodleman, L.  “Geometric and Electrostatic Study of the [4Fe-4S] Cluster of Adenosine-5’-Phosphosulfate Reducatse from Broken Symmetry Density Functional Calculations and Extended X-ray Absorption Fine Structure Spectroscopy.”  Inorg. Chem. 2011, 50(14), 6610-25.  [pdf]

Hong, J. A.; Carroll, K. S.  “Deciphering the role of histidine 252 in mycobacterial APS reductase catalysis.”  J. Biol. Chem. 2011, 286(32), 28567-73.  [pdf]

Truong, T. H.; Garcia, F. J.; Seo, Y. H.; Carroll, K. S.  “Isotope-coded chemical reporter and acid-cleavable affinity reagents for monitoring protein sulfenic acids.”  Bioorg. Med. Chem. Lett. 2011, 21(17), 5015-20.  [pdf]

Leonard, S. E.; Garcia, F. J.; Goodsell, D. S.; Carroll, K. S.  “Redox-Based Probes for Protein Tyrosine Phosphatases.”  Angew. Chem. Int. Ed. Engl. 2011, 50(19), 4423-27.  [pdf]

Seo, Y. H.; Carroll, K. S.  “Quantification of protein sulfenic acid modifications using isotope-coded dimedone and iododimedone.”  Angew. Chem. Int. Ed. Engl. 2011, 50(6), 1342-5.  [pdf]

Dorrestein, P. C.; Carroll, K. S.  “’Omics’ of natural products and redox biology.”  Curr. Opin. Chem. Biol. 2011, 15(1), 3-4. [pdf]

Bhave, D. P.; Hong, J. A.; Lee, M.; Jiang, W.; Krebs, C.; Carroll, K. S.  “Spectroscopic studies on the [4Fe-4S] cluster in adenosine 5’-phosphosulfate reductase from Mycobacterium tuberculosis.”  J. Biol. Chem. 2011, 286(2), 1216-26. [pdf]

Depuydt, M.; Leonard, S. E.; Vertommen, D.; Denoncin, K.; Morsomme, P.; Wahni, K.; Messens, J.; Carroll, K. S.; Collet, J. F.  “A periplasmic reducing system protects single cysteine residues from oxidation.”  Science. 2009, 326(5956), 1109-11. [pdf]

Seo, Y. H.; Carroll, K. S.  “Profiling protein thiol oxidation in tumor cells using sulfenic acid-specific antibodies.”  Proc. Natl. Acad. Sci. USA 2009, 106(38), 16163-8.  [pdf]

Hong, J. A.; Bhave, D. P.; Carroll, K. S.  “Identifiation of critical ligand binding determinants in Mycobacterium tuberculosis adenosine-5’-phosphosulfate reductase.”  J. Med. Chem. 2009, 52(17), 5485-95.  [pdf]

Leonard, S. E.; Reddie, K. G.; Carroll, K. S.  “Mining the thiol proteome for sulfenic acid modifications reveals new targets for oxidation in cells.”  ACS Chem. Biol. 2009, 4(9), 783-99.  [pdf]

Paulsen, C. E.; Carroll, K. S.  “Chemical dissection of an essential redox switch in yeast.”  Chem. Biol. 2009, 16(2), 217-25.  [pdf]

Seo, Y. H.; Carroll, K. S.  “Facile synthesis and biological evalutaion of a cell-permeable probe to detect redox-regulated proteins.”  Bioorg. Med. Chem. Lett. 2009, 19(2), 356-9.  [pdf]

Cosconati, S.; Hong, J. A.; Novellino, E.; Carroll, K. S.; Goodsell, D. S.; Olson, A. J.  “Structure-based virtual screening and biological evaluation of Mycobacterium tuberculosis adenosine 5’-phosphosulfate reductase inhibitors.”  J. Med. Chem. 2008, 51(21), 6627-30.  [pdf]

Reddie, K. G.; Seo, Y. H.; Muse III, W. B.; Leonard, S. E.; Carroll, K. S.  “A chemical approach for detecting sulfenic acid-modified proteins in living cells.”  Mol. Biosyst. 2008, 4(6), 521-31.  [PubMed Link]

Chang, M. W.; Belew, R. K.; Carroll K. S.; Olson, A. J.; Goodsell, D. S.  “Empirical entropic contributions in computational docking:  evaluation in APS reductase complexes.”  J. Comput. Chem. 2008, 29(11), 1753-61.  [pdf]

Chartron, J.; Shiau, Cl; Stout, C. D.; Carroll, K. S.  “3’-Phosphoadenosine-5’-phosphosulfate reductase in complex with thioredoxin:  a sructural snapshot in the catalytic cycle.”  Biochemistry. 2007, 18(2), 167-78.  [pdf]

Gao, H.; Leary, J.; Carroll, K. S.; Bertozzi, C. R., Chen. H.  “Noncovalent complexes of APS reductase from M. tuberculosis:  delineating a mechanistic model using ESI-FTICR MS.”  J. Am. Soc. Mass. Spectrom. 2007, 18(2), 167-78.  [pdf]

Chartron, J.; Carroll, K. S.; Shiau, C.; Gao, H.; Leary, J. A.; Bertozzi, C. R.; Stout, C. D.  “Substrate recognition, protein dynamics, and iron-sulfur cluster in Pseudomonas aeruginosa adenosine 5’-phosphosulfate reductase.”  J. Mol. Biol. 2006, 364(2), 152-69.  [pdf]

Carroll, K. S.; Gao, H.; Chen, H.; Leary, J. A.; Bertozzi, C. R.  “Investigation of the iron-sulfur cluster in Mycobacterium tuberculosis APS reductase:  implication for substrate binding and catalysis.”  Biochemistry. 2005, 44(44), 14647-57.  [pdf]

Carroll, K. S.; Gao, H.; Chen, H.; Stout, C. D.; Leary, J. A.; Bertozzi, C. R.  “A conserved mechanism for sulfonucleotide reduction.”  PLoS Biol. 2005, 3(8), e250.  [pdf]

Kraut, D. A.; Carroll, K. S.; Herschlag, D.  “Challenges in enzyme mechanism and energetics.”  Annu. Rev. Biochem. 2003, 72, 517-71.  [pdf]

Karbstein, K.; Carroll, K. S.; Herschlag, D.  “Probing the Tetrahymena group I ribozyme reaction in both directions.”  Biochemistry. 2002, 41(37), 11171-83.  [pdf]

Carroll, K. S.; Hanna, J.; Simon, I.; Krise, J.; Barbero, P.; Preffer, S. R.  “Role of Rab9 GTPase in facilitating receptor recruitment by TIP47.”  Science. 2001, 292(5520), 1373-6. [pdf]

Lin, S. W.; Kochendoerfer, G. G.; Carroll, K. S.; Wang, D.; Mathies, R. A.; Sakmar, T. P.  “Mechanisms of spectral tuning in blue cone visual pigments.  Visible and raman spectroscopy of blue-shifted rhodopsin mutants.”  J. Biol. Chem. 1998, 273(38), 24583-91.  [pdf]

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