The Carroll Lab

RESEARCH

Updated 7/26/2011

Chemical tools to map redox signaling pathways

Oxidative thiol modiications have emerged as a central mechanism for dynamic post-translational regulation of all major protein classes and correlate with many disease states. We focus on the development and application of chemoselective probes as tools to proile these modiications in cell-based systems and to identify biomarkers of oxidative stress.

Reviews:

Leonard, S. E.; Carroll, K. S.  “Chemical ‘omics’ approaches for understanding protein cysteine oxidation in biology.”  Curr. Opin. Chem. Biol. 2011, 15(1), 88-102. [PubMed Link]

Carroll, K. S.  “Metabolite imaging:  knock, nox-ROS there?”  Nat. Chem. Biol. 2011, 7(2), 71-2.  [PubMed Link]

Paulsen, C. E.; Carroll, K. S.  “Orchestrating redox signaling networks through regulatory cysteine switches.”  ACS Chem. Biol. 2010, 5(1), 47-62. [PubMed Link]

Reddie, K. G.; Carroll, K. S.  “Expanding the functional diversity of proteins through cysteine oxidation.”  Curr. Opin. Chem. Biol. 2008, 12(6), 746-54. [PubMed Link]

Research Articles:

Truong, T. H.; Garcia, F. J.; Seo, Y. H. and Carroll, K. S.  “Isotope-coded chemical reporter and acid-cleavable affinity reagents for monitoring protein sulfenic acids.”  Bioorg. Med. Chem. Lett. 2011 [PubMed Link]

Seo, Y. H.; Carroll, K. S.  “Quantification of protein sulfenic acid modifications using isotope-coded dimedone and iododimedone.”  Angew. Chem. Int. Ed. Engl. 2011, 50(6), 1342-5. [PubMed Link]

Seo, Y. H.; Carroll, K. S.  “Profiling protein thiol oxidation in tumor cells using sulfenic acid-specific antibodies.”  Proc. Natl. Acad. Sci. USA 2009, 106(38), 16163-8. [PubMed Link]

Leonard, S. E.; Reddie, K. G.; Carroll, K. S.  “Mining the thiol proteome for sulfenic acid modifications reveals new targets for oxidation in cells.”  ACS Chem. Biol. 2009, 4(9), 783-99. [PubMed Link]

Paulsen, C. E.; Carroll, K. S.  “Chemical dissection of an essential redox switch in yeast.”  Chem. Biol. 2009, 16(2), 217-25. [PubMed Link]

Seo, Y. H.; Carroll, K. S.  “Facile synthesis and biological evalutaion of a cell-permeable probe to detect redox-regulated proteins.”  Bioorg. Med. Chem. Lett. 2009, 19(2), 356-9. [PubMed Link]

Reddie, K. G.; Seo, Y. H.; Muse III, W. B.; Leonard, S. E.; Carroll, K. S.  “A chemical approach for detecting sulfenic acid-modified proteins in living cells.”  Mol. Biosyst. 2008, 4(6), 521-31. [PubMed Link]

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