X-Ray Crystallography Core

Description

The X-Ray Facility at Scripps Research is a single crystal X-Ray structure determination facility for small inorganic or organic molecules.  It serves the Scripps investigators along with pharmaceutical and biotech companies around the San Diego area.

Equipment

A Bruker Smart-APEX instrument equipped with a CCD detector and Molybdenum sealed X-ray tube serves as the main equipment.  The facility also has a low temperature device to collect data on unstable crystals.

Services

The facility provides all aspects of small molecule crystallography such as:

• Crystallization
• Sample examination and evaluation
• Data collection
• Structure solution and refinement
• Graphical presentation of the structure
• Preparation of tables and CIF files for publication
• File submission to the Cambridge Crystallographic Data Center
• Archival of structural data

The ORTEP diagram of the structure is generally prepared in less than 24 hours of the crystal submission.

Fees

The facility charges the Scripps investigators a flat fee of $1500 for complete structure determination, $750 for data collection part only, $250 for unit cell determination.  Outside investigators pay overhead charges as per Institute policy.  No extra fee is charged for disordered or twin crystals or for crystals which lose solvent or decay. The flat fee of $1500 is charged only if a structure is solved to a publishable quality, and if not achievable only a fee of $750 is charged.

Contact

Raj K. Chadha, Ph.D. has been the Director of the facility since 1991.  He has solved more than 1000 organic and inorganic structures in his career of 30 years as a crystallographer, both at Scripps Research and in operations he led elsewhere previously.  The facility is located in the Stein Research Building Room 28.  You may contact him at:

The Scripps Research Institute
SR-28
10550 N Torrey Pines Rd
La Jolla, CA 92037

Tel No.858-784-7572 (Office) 858-784-7573 (Lab)
Fax 858-784-7564

e-mail: rkchadha@scripps.edu