The Scripps Research Next Generation Sequencing Core Facility was established in 2009 and currently runs an Illumina HiSeq system. The core also has a Roche 454 GS junior system (typical read lengths are 300-500 bases with 20-100K reads per run). We encourage parties interested in using our facility to set up a meeting with the Core Directors (Steven Head and Phil Ordoukhanian, call 858-784-2263 or internal 4-2263) to discuss details and specifics about experimental design, sample preparation, and costs. Our facility has extensive experience in preparation of libraries for sequencing as well as novel sequencing technology applications.