Structure of INIA- An Overview

 

 

The structure of INIA is envisioned as two domains, Dependence-induced drinking and Binge drinking, comprised of multiple U01 research grants. The flow of information within each domain moves from molecular, to cellular, to neurocircuitry levels of analysis. These U01s share information with the core facilities, which act as data depositories. The Administrative Core coordinates the flow of information among the Domains and Cores and disseminates the information back to the U01s (see Figure 1).

A Pilot Project program will identify exciting new areas for research and the continual recruitment of new investigators to the alcohol field. The INIA program is directed by an Administrative Core in close cooperation with the Animal Models, Gene Array and Neurocircuitry Cores via a Steering Committee and with the continual advice of the Scientific Advisory Committee.

Detailed Structure

Administrative Core :

PI and Consortium Director,
Chair of the Steering Committee:
George F. Koob

Co-Chair of the Steering Committee,
Scientific Director Steering Committee:
Adron Harris

Administrative Specialist
Program Coordinator
Technical Writer
Michael Arends

Administrative Core Coordinator
Lisa Maturin

Executive Committee:

George F. Koob - The Scripps Research Institute (Chair)
Adron Harris - University of Texas, Waggoner Center (Co-Chair)
Antonio Noronha - National Institute on Alcohol Abuse and Alcoholism

Steering Committee:

G. Koob,TSRI
R.A. Harris, UT Austin
B. Tabakoff, UC Denver
J. Crabbe, OHSU
A Pfefferbaum, SRI Intl
E. Sullivan, Stanford
R Hitzemann, OHSU
P. Hoffman, UC Denver
W. McBride, IU Sch Med
H. Edenberg, IU Sch Med
A. Noronha, NIAAA
M. Egli, NIAAA

 

Cores:

- Bell, Richard Rat Animal Models And Gene Testing Core Indiana University School of Medicine, Indianapolis, Indiana
- Hitzemann, Bob Neurocircuitry Mapping and Genotyping Core Oregon Health and Science University, Portland, Oregon
- Homanics, Greg Genetically engineered rodent core University of Pittsburgh, Pittsburgh, Pennsylvania
- Koob, George Admin Core, The Scripps Research Institute, La Jolla, California
- Kosten, Therese Target Validation Core Rats, Baylor College of Medicine, Houston, Texas
- Lasek, Amy RNA Interference Core Ernest Gallo Clinic and Research Center, University of California, San Francisco, California
- Roberts, Amanda Mouse Target Assessment Core, The Scripps Research Institute, La Jolla, California

Research U01 Grants:

- Blednov, Yuri Biochemical and Genetic Determinants of Alcohol Consumption, University of Texas, Austin, Texas
- Contet, Candice Role of BK Channel Interactome in Excessive Ethanol Drinking, The Scripps Research Institute, La Jolla, California
- Crabbe, John Selective Breeding for Drinking in the Circadian Dark, Portland VA Medical Center, Portland, Oregon Oregon Health and Science University, Portland, Oregon
- Edenberg, Howard Early binge drinking and gene regulation, Indiana University School of Medicine, Indianapolis, Indiana
- Heberlein, Ulrike Regulation of excessive alcohol consumption by the Lmo-Alk axis, University of California, San Francisco, San Francisco, California
- Hoffman, Paula Modulation of alcohol consumption by chromatin modification, University of Colorado Health Sciences Center, Aurora, Colorado
- Kieffer, Brigitte Nr4a1 and GPR88 as novel gene targets for alcoholism: mouse genetic approaches, behavior and neuroimaging, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
- Mayfield, Dayne Next Generation Sequencing of Human Alcoholic Brain, University of Texas, Austin, Texas
- Moore, Scott Ethanol actions on ion channels in the extended amygdala, Duke University, Durham, North Carolina
- Morrisett, Rick Target validation by accumbal plasticity screening, University of Texas, Austin, Texas
- Pfefferbaum, Dolf Sullivan, Edie Neuroimaging of Alcohol-induced Neuroadaptation: Translation from Animals to Humans, SRI International, Menlo Park, California
- Ryabinin, Andrey Ghrelin antagonism and excessive drinking, Oregon Health and Science University, Portland, Oregon
-Sanna, Pietro Histone modifications in transcriptional regulation by alcohol dependence, The Scripps Research Institute, La Jolla, California
-Siggins, George Electrophysiology of Alcohol in Extended Amygdala, The Scripps Research Institute, La Jolla, California


Current Pilot Projects:

- Cunningham, Chris Role of the ghrelin receptor in dependence-induced intragastric alcohol consumption in mice, School of Medicine, OHSU
- Hopf, Frederic W Optogenetic characterization of different CRF-containing inputs to the central amygdala, Gallo Research Center, Emeryville, CA
-Schweitzer, Paul Electrophysiological Study of the Role of Lmo3/4 and Alk in Ethanol-Dependence, The Scripps Research Institute, La Jolla, California
- Wright, Casey W. and Duvauchelle, Christine L. Regulation Of Alcohol Consumption By NF-kappaB Signaling, The University of Texas at Austin

INIA Home   INIA Structure   Administrative Core
Animal Models Core   Gene Array Core   Neurocircuitry Core   Neuroinformatics Resources
Subgroups   Current Grants   Conference Abstracts   Publications   Links