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Abstracts from Miscellaneous Meetings 2005ISMRM 2005
Poster presentation at the annual meeting of the International Society of Magnetic Resonance in Medicine, Miami, FL, April 2005
AN IN VIVO RAT MODEL OF WERNICKE'S ENCEPHALOPATHY IMAGED ON A HUMAN 3T SCANNER
Pfefferbaum A, Adalsteinsson E, Bell R, McBride W, Sullivan EV
Neuroscience Program, SRI International, Department of Electrical Engineering and Computer Science and Massachusetts Institute of Technology Harvard-MIT Division of Health, Sciences, Technology, Massachusetts Institute of Technology, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Department of Psychiatry, Indiana University School of Medicine
Introduction: An animal model of voluntary alcohol consumption provides the opportunity to examine many aspects of human alcoholism which are difficult to control in the natural condition. For instance, in addition to the potential direct neurotoxic effects of alcohol are the effects of accompanying nutritional deficiency such as are seen in Wernicke's Encephalopathy, caused by thiamine deficiency. In human alcoholics Wernicke's Encephalopathy presents with characteristic neurological symptoms and radiological signs involving thalamus, mammillary nuclei, and inferior colliculi. Here we present quantitative, longitudinal brain MR analysis of a rat model of Wernicke's Encephalopathy conducted on a human 3T MR system.
Poster presentation at the annual meeting of the International Society of Magnetic Resonance in Medicine, Miami, FL, April 2005
PROTON MR SPECTROSCOPY FOR IN VIVO QUANTIFICATION OF SAMLL ANIMAL BRAIN ALCOHOL KINETICS
E Adalsteinsson, EV Sullivan, A Pfefferbaum
Neuroscience Program, SRI International, Menlo Park, CA; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA; Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA
Introduction: The in vivo kinetics of acute alcohol brain levels can be monitored in real time with proton magnetic resonance spectroscopy (MRS). We measured the uptake and clearance of brain ethanol in rats after intraperitoneal (IP) alcohol injection over a 1-1.5 hour duration with temporal resolution ranging from 4 minutes to 4s. The observed time course of alcohol brain concentration followed a consistent pattern characterized by a rapid absorption, an intermediate distribution, and a linear clearance. In a sample of 8 healthy Wistar rats, the intercept of the linear clearance term, extrapolated to time of injection, correlated with the administered dose per unit of lean body mass.