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Abstracts from Miscellaneous Meetings 2004ISMRM 2004
Poster presented at the annual meeting of the International Society of Magnetic Resonance Imaging (2004)
IN VIVO ALCOHOL UPTAKE KINETICS IN RAT BRAIN
A. Pfefferbaum1, E. Adalsteinsson2, E. V. Sullivan3, D. Mayer2, N. Sailasuta4, R. Hurd4
1Neuroscience Program, SRI International, Menlo Park, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States, 4GE Medical Systems, Menlo Park, CA, United States
Introduction. Individual differences in alcohol uptake kinetics may contribute to the development of problem drinking. The animal model of alcohol preferring (P) and non-preferring (NP) Wistar rats offers an opportunity to study alcohol uptake kinetics in vivo under controlled conditions. Here we report the feasibility of monitoring brain ethanol uptake and kinetics in the native P/NP Wistar stock.