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Chemistry - California Campus

Faculty

Gunnar Joerg F Kaufmann, Ph.D.

Assistant Professor Adjunct
Department of Chemistry
California Campus
kaufmann@scripps.edu
(858) 784-2517

Scripps Research Joint Appointments

Assistant Professor of Chemical Immunology, Department of Immunology and Microbial Science

Education

Ph.D., Macromolecular and Cellular Structure & Chemistry (MCSC), The Scripps Research Institute, 2006
M.S., Human Biology, University of Greifswald (Germany), 2001

Professional Experience

Gunnar F. Kaufmann was born in Germany and studied Human Biology in Marburg and Greifswald where he received his Diploma in 2001. He then joined Professor Kim D. Janda’s group at The Scripps Research Institute and obtained his Ph.D in Macromolecular and Cellular Structure and Chemistry in 2006, working on generation and engineering of antihapten antibodies as well as bacterial quorum sensing as target of immunotherapy. During his postdoctoral studies, he investigated the effect of bacterial quorum sensing molecules on the mammalian host in a joint position between Professor Janda’s group and the laboratory of Professor Richard J. Ulevitch at TSRI.

Selected References

 Gao C, Mao S, Kaufmann G, Wirsching P, Lerner RA, Janda KD. A method for the generation of combinatorial antibody libraries using pIX phage display. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12612-6

Meijler MM, Hom LG, Kaufmann GF, McKenzie KM, Sun C, Moss JA, Matsushita M, Janda KD.

Synthesis and biological validation of a ubiquitous quorum-sensing molecule.

Angew Chem Int Ed Engl. 2004 Apr 13;43(16):2106-8

Carrera MR‡, Kaufmann GF‡, Mee JM, Meijler MM, Koob GF, Janda KD.

Treating cocaine addiction with viruses.

         Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10416-21

Kaufmann GF, Sartorio R, Lee SH, Rogers CJ, Meijler MM, Moss JA, Clapham B, Brogan AP, Dickerson TJ, Janda KD.

Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones.

         Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):309-14

Kaufmann GF, Meijler MM, Sun C, Chen DW, Kujawa DP, Mee JM, Hoffman TZ, Wirsching P, Lerner RA, Janda KD.

Enzymatic incorporation of an antibody-activated blue fluorophore into DNA.

         Angew Chem Int Ed Engl. 2005 Mar 29;44(14):2144-8

Kravchenko VV‡, Kaufmann GF‡, Mathison JC, Scott DA, Katz AZ, Wood MR, Brogan AP, Lehmann M, Mee JM, Iwata K, Pan Q, Fearns C, Knaus UG, Meijler MM, Janda KD, Ulevitch RJ.

N-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways.

J Biol Chem. 2006 Sep 29;281(39):28822-30

Debler EW, Kaufmann GF, Kirchdoerfer RN, Mee JM, Janda KD, Wilson IA.

Crystal structures of a quorum-quenching antibody.

         J Mol Biol. 2007 May 18;368(5):1392-402

Stranges PB, Watson J, Cooper CJ, Choisy-Rossi CM, Stonebraker AC, Beighton RA, Hartig H, Sundberg JP, Servick S, Kaufmann G, Fink PJ, Chervonsky AV.

Elimination of antigen-presenting cells and autoreactive T cells by fas contributes to prevention of autoimmunity.

         Immunity. 2007 May;26(5):629-41

Park J, Jagasia R, Kaufmann GF, Mathison JC, Ruiz DI, Moss JA, Meijler MM, Ulevitch RJ, Janda KD.

Infection Control by Antibody Disruption of Bacterial Quorum Sensing Signaling.

         Chem Biol. 2007 Oct 26;14(10):1119-1127

Debler EW, Kaufmann GF, Meijler MM, Heine A, Mee JM, Pljevaljčić G, Di Bilio AJ, Schultz PG, Millar DP, Janda KD, Wilson IA, Gray HB, Lerner RA

Deeply Inverted Electron-Hole Recombination Triggers Intensely Blue Luminescence in an Antibody-Stilbene Complex

Science. 2008 Feb 29;319:1232-5

Yoneda Y, Steiniger SC, ÄŒapková K, Mee JM, Liu Y, Kaufmann GF, Janda KD

A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy

         Bioorg Med Chem Lett. 1 March 2008; 18 (5):1632-1636

Kaufmann GF, Park J, Mee JM, Ulevitch RJ, Janda KD

The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone

         Molecular Immunology, May 2008;45(9):2710-2714

Kaufmann GF, Park J, Janda KD

Bacterial quorum sensing: a target for anti-infective immunotherapy

         Expert Opinion on Biological Therapy, Jun 2008;8(6):719-24

Kravchenko VV, Kaufmann GF, Mathison JC, Scott DA, Katz AZ, Grauer DC, Lehmann M, Meijler MM, Janda KD, Ulevitch RJ

A small bacterial molecule specifically alters gene expression via disruption of NF-κB signaling

         Science, 2008 Jul 11;321(5886):259-63

Lowery CA, Park J, Kaufmann GF, Janda KD

An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic DPD analogs

J Am Chem Soc, 2008 Jul 23;130(29):9200-1

Park J, Kaufmann GF, Bowen JP, Arbiser JL, Janda KD Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum sensing signalling in Pseudomonas aeruginosa

         J Infect Dis, 2008 Oct 15;198(8):1198-1201

Lowery CA, Park J, Gloeckner C, Meijler MM, Mueller RS, Boshoff HI, Ulrich RL, Barry 3rd CE, Bartlett DH, Kravchenko VV, Kaufmann GF*, Janda KD*

Defining the Mode of Action of Tetramic Acid Antibacterials Derived from Pseudomonas aeruginosa Quorum Sensing Signals

         J Am Chem Soc, 2009 Oct 14;131(40):14473-9

Lowery CA, Abe T, Park J, Eubanks LM, Sawada D, Kaufmann GF, Janda KD.

Revisiting AI-2 Quorum Sensing Inhibitors: Direct Comparison of Alkyl-DPD Analogues and a Natural Product Fimbrolide.

         J Am Chem Soc, 2009 Nov 4;131(43):15584-5

Gloeckner C, Garner AL, Mersha F, Oksov Y, Tricoche N, Lustigman S, Kaufmann GF, Janda KD

Repositioning of an Old Drug for the Neglected Tropical Disease Onchocerciasis

         Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3424-9

Lowery CA, Salzameda NT, Sawada D, Kaufmann GF, Janda KD

Medicinal Chemistry as a Conduit for the Modulation of Quorum Sensing

         J. Med. Chem, 2010 Jul 29.

Amara N, Krom BP, Kaufmann GF, Meijler MM

Macromolecular Inhibition of Quorum Sensing: Enzymes, Antibodies and Beyond

Chemical Reviews, accepted

Kaufmann GF*, Park J, Mayorov AV, Kubitz DM, Janda KD

Generation of quorum quenching antibodies

         Methods in Molecular Biology, accepted