News Release Archives

1989 - 2013

• February 25, 2013
  Findings by Scripps Research Institute Scientists Disclose a New and Much Needed Test for River Blindness Infection
  Scientists at The Scripps Research Institute have found a telltale molecular marker for Onchocerciasis or “river blindness,” a parasitic infection that affects tens of millions of people in Africa, Latin America and other tropical regions.
  
  
• February 24, 2013
  Scientists Find Surprising New Influence on Cancer Genes
  A new study led by scientists at The Scripps Research Institute shows how pseudogenes -- small stretches of DNA in the human genome thought to be non-coding “junk” DNA -- can regulate the activity of a cancer-related gene called PTEN.
  
  
• February 22, 2013
  Noted Vaccine and Bioinformatics Researcher Joins The Scripps Research Institute
  The Scripps Research Institute (TSRI) has appointed Jiang Zhu, PhD, to its faculty.
  
  
• February 15, 2013
  Scripps Research Institute Scientists Find Promising New Approach to Preventing Progression of Breast Cancer
  Doctors currently struggle to determine whether a breast tumor is likely to shift into an aggressive, life-threatening mode—an issue with profound implications for treatment.
  
  
• February 07, 2013
  Scripps Research Institute Professor Donna Blackmond Elected to National Academy of Engineering
  Donna Blackmond, PhD, a professor in the Department of Chemistry at The Scripps Research Institute (TSRI), has been elected as a member in the prestigious National Academy of Engineering (NAE), it was announced today.
  
  
• February 06, 2013
  Scripps Research Institute Scientists Discover How Chromosomes Keep Their Loose Ends Loose
  Scientists at The Scripps Research Institute have discovered key details of how the protein TRF2 performs a crucial chromosome-protecting function. The finding represents a significant advance in cell biology and also has implications for our understanding of cancer and the aging process.
  
  
• February 04, 2013
  Scripps Research Institute Scientists Find a Key Element of Lupus, Suggesting Better Drug Targets
  A team led by scientists at The Scripps Research Institute (TSRI) has identified specific cellular events that appear key to lupus, a debilitating autoimmune disease that afflicts tens of millions of people worldwide.
  
  
• January 23, 2013
  Scripps Research Institute Names David Blinder to Key Fundraising Position
  The Scripps Research Institute has appointed David Blinder, PhD, as senior vice president for external affairs at The Scripps Research Institute (TSRI).
  
  
• January 14, 2013
  Scripps Research Institute Scientists Discover Structure of Protein Essential for Quality Control, Nerve Function
  Using an innovative approach, scientists at The Scripps Research Institute (TSRI) have determined the structure of Ltn1, a recently discovered “quality-control” protein that is found in the cells of all plants, fungi and animals.
  
  
• January 08, 2013
  Scripps Research Institute Chemists Devise Inexpensive, Benchtop Method for Marking and Selecting Cells
  Chemists at The Scripps Research Institute (TSRI) have found an easier way to perform one of the most fundamental tasks in molecular biology.
  
  
• January 03, 2013
  Steroids that Only Nature Could Make on a Large Scale—Until Now
  Scientists at The Scripps Research Institute have achieved a feat in synthetic chemistry by inventing a scalable method to make complex natural compounds known as “polyhydroxylated steroids.” These compounds, used in heart-failure medications and other drugs, have been notoriously problematic to synthesize in the laboratory.
  
  

• December 23, 2012
  Chinese Medicine Yields Secrets to Scientists at The Scripps Research Institute
  The mysterious inner workings of Chang Shan—a Chinese herbal medicine used for thousands of years to treat fevers associated with malaria—have been uncovered thanks to a high-resolution structure solved at The Scripps Research Institute (TSRI).
  
  
• December 07, 2012
  Biologics Expert Dennis Fenton Joins Scripps Research Institute Board of Trustees
  Dennis M. Fenton, PhD, a manufacturing and biologics expert and former executive vice president for Amgen, has been elected to The Scripps Research Institute (TSRI) Board of Trustees.
  
  
• December 06, 2012
  Scripps Research Institute Scientists Identify Molecules in the Ear that Convert Sound into Brain Signals
  For scientists who study the genetics of hearing and deafness, finding the exact genetic machinery in the inner ear that responds to sound waves and converts them into electrical impulses, the language of the brain, has been something of a holy grail.
  
  
• December 02, 2012
  Scientists at Scripps Research Institute Discover How Two Proteins Help Keep Cells Healthy
  Scientists at The Scripps Research Institute (TSRI) have determined how two proteins help create organelles, or specialized subunits within a cell, that play a vital role in maintaining cell health.
  
  
• November 29, 2012
  Four Scientists from Scripps Research Institute Elected AAAS Fellows
  Four scientists from The Scripps Research Institute (TSRI) have been named fellows of the American Association for the Advancement of Science (AAAS).
  
  
• November 28, 2012
  Scripps Research Institute Chemists Invent Powerful Toolkit, Accelerating Creation of Potential New Drugs
  Scientists at The Scripps Research Institute (TSRI) have invented a set of chemical tools that is radically simplifying the creation of potential new drug compounds.
  
  
• November 27, 2012
  Scripps Research Institute Study Points to Potential New Therapies for Cancer and Other Diseases
  Researchers at The Scripps Research Institute (TRSI) are fueling the future of cancer treatment by improving a powerful tool in disease defense: the body’s immune system.
  
  
• November 22, 2012
  Scripps Research Institute Scientists Describe Elusive Replication Machinery of Flu Viruses
  Scientists at The Scripps Research Institute (TSRI) have made a major advance in understanding how flu viruses replicate within infected cells.
  
  
• November 19, 2012
  Scripps Research Institute Team Identifies a Potential Cause of Parkinson’s Disease that May Lead to New Treatment Options
  Deciphering what causes the brain cell degeneration of Parkinson’s disease has remained a perplexing challenge for scientists.
  
  
• November 09, 2012
  Scripps Research Institute Scientists Uncover a New Pathway that Regulates Information Processing in the Brain
  Scientists at The Scripps Research Institute (TSRI) have identified a new pathway that appears to play a major role in information processing in the brain.
  
  
• November 01, 2012
  Meth Vaccine Shows Promising Results in Early Tests
  Scientists at The Scripps Research Institute (TSRI) have performed successful tests of an experimental methamphetamine vaccine on rats.
  
  
• October 31, 2012
  New Inhibitors of Elusive Enzymes Promise to Be Valuable Scientific Tools
  Scientists at The Scripps Research Institute (TSRI) have discovered the first selective inhibitors of an important set of enzymes.
  
  
• October 25, 2012
  New Genomics Study Shows Ancestry Could Help Solve Disease Riddles
  Explosive advancement in human genome sequencing opens new possibilities for identifying the genetic roots of certain diseases and finding cures.
  
  
• October 24, 2012
  Scripps Research Institute Study Suggests Caution and Further Studies on Drugs Used to Treat Macular Degeneration
  Millions of people with “wet” macular degeneration are prescribed a class of medication known as anti-VEGF drugs.
  
  
• October 21, 2012
  Scripps Research Institute Discovery of Biological Energy-Sensing Switch Could Have Broad Implications for Biology and Medicine
  Biochemists at The Scripps Research Institute (TSRI) have discovered a genetic sequence that can alter its host gene’s activity in response to cellular energy levels.
  
  
• October 15, 2012
  Scripps Research Institute Study Suggests Intermittent Binge Drinking Could Cause Significant Brain Impairment Within Months
  A study of binge-drinking rodents suggests that knocking back a few drinks every few days may swiftly reduce one’s capacity to control alcohol intake.
  
  
• October 11, 2012
  Scripps Research Institute Professor Phil Baran Wins 2012 Distinguished Scientist Award
  Scripps Research Institute Professor Phil S. Baran has been named recipient of the 2012 Distinguished Scientist Award by the American Chemical Society (ACS)-San Diego.
  
  
• October 04, 2012
  Scripps Research Institute Appoints Dale Boger as Chair of Department of Chemistry; Thomas Kodadek, Vice Chair
  The Scripps Research Institute (TSRI) has named Dale Boger, PhD, as chair of its Department of Chemistry. In addition, Thomas Kodadek, PhD, has been appointed vice chair.
  
  
• October 04, 2012
  The Smell of Mom: Scientists Find Elusive Trigger of First Suckling in Mice
  A team led by biologists at The Scripps Research Institute has solved the long-standing scientific mystery of how mice first know to nurse or suckle.
  
  
• September 23, 2012
  New Chemistry Technique from The Scripps Research Institute Reproduces Nature’s Elusive Complexity
  Scientists at The Scripps Research Institute have shown how to synthesize in the laboratory an important set of natural compounds known as terpenes.
  
  
• September 19, 2012
  Scripps Research Institute Receives $20 Million to Shed Light on HIV Drug Resistance
  The Scripps Research Institute has received a grant totaling approximately $20 million over five years from the National Institutes of Health to research the development of drug resistance in HIV, the virus that causes AIDS.
  
  
• September 16, 2012
  Flu Antibody’s ‘One-Handed Grab’ May Boost Effort toward Universal Vaccine, New Therapies
  Scientists from The Scripps Research Institute and Sea Lane Biotechnologies have solved the co-crystal structure of a human antibody that can neutralize influenza viruses in a unique way.
  
  
• September 14, 2012
  Scripps Research Institute Scientists Show Protein Linked to Hunger Also Implicated in Alcoholism
  Researchers at The Scripps Research Institute have found new links between a protein that controls our urge to eat and brain cells involved in the development of alcoholism.
  
  
• September 13, 2012
  Scripps Research Scientists Reveal How Deadly Virus Silences Immune System
  Scientists at The Scripps Research Institute have determined the structure of a critical protein from the Marburg virus, a close cousin of Ebola virus.
  
  
• September 11, 2012
  Scripps Research Scientists Devise Powerful New Method for Finding Therapeutic Antibodies
  Scientists at The Scripps Research Institute have found a new technique that should greatly speed the discovery of medically and scientifically useful antibodies, immune system proteins that detect and destroy invaders such as bacteria and viruses.
  
  
• August 23, 2012
  Team Receives $22.5 Million to Shed Light on the Immune System
  A team led by a scientist at The Scripps Research Institute has received a $22.5 million, five-year project renewal from the National Institutes of Health to uncover the workings of the immune system.
  
  
• August 16, 2012
  Scripps Research Scientists Find Important Molecular Trigger for Wound-Healing
  Scientists at The Scripps Research Institute have made a breakthrough in understanding a class of cells that help wounds in skin and other epithelial tissues heal, uncovering a molecular mechanism that pushes the body into wound-repair mode.
  
  
• August 09, 2012
  Scripps Research Institute Scientists Show Copper Facilitates Prion Disease
  Many of us are familiar with prion disease from its most startling and unusual incarnations—the outbreaks of “mad cow” disease (bovine spongiform encephalopathy) that created a crisis in the global beef industry.
  
  
• August 09, 2012
  Team Describes Antibodies that Protect Against Large Variety of Flu Viruses
  A team led by scientists at The Scripps Research Institute and Crucell Vaccine Institute in the Netherlands describes three human antibodies that provide broad protection against Influenza B virus strains.
  
  
• August 09, 2012
  Scripps Research Neuroscientists Find Brain Stem Cells that May Be Responsible for Higher Functions, Bigger Brains
  Scientists from The Scripps Research Institute have identified a new stem cell population that may be responsible for giving birth to the neurons responsible for higher thinking.
  
  
• August 08, 2012
  Scripps Research Institute Scientists Show Two-Drug Combination Has Potential to Fight Cocaine Addiction
  A fine-tuned combination of two existing pharmaceutical drugs has shown promise as a potential new therapy for people addicted to cocaine—a therapy that would reduce their craving for the drug and blunt their symptoms of withdrawal.
  
  
• August 08, 2012
  Clinical Trials Start for Stroke Drug Developed by Scripps Research Institute, USC, and ZZ Biotech
  Clinical trials start this week for a stroke drug initially created by a team led by scientists at The Scripps Research Institute and the University of Southern California (USC), and further developed by biotech company ZZ Biotech.
  
  
• August 01, 2012
  Auditorium at TSRI Now Available for Event Booking
  The Auditorium at TSRI, a 352-seat, acoustically renowned facility on the Torrey Pines Mesa, is now available to commercial, corporate, and nonprofit groups to rent for the upcoming season from October 1, 2012, through September 30, 2013.
  
  
• July 19, 2012
  New Technique Reveals Cross-Talk Between Two Essential Cellular Processes
  Scientists at The Scripps Research Institute have simultaneously mapped two of the most important types of protein-modification in cells, revealing their extensive cooperation during an essential cellular process.
  
  
• July 12, 2012
  Large, Medically Important Class of Proteins Starts to Yield Its Secrets
  Readers of the top-ranked scientific journals Science and Nature might have noticed a recent wave of articles, most recently in the July 13, 2012 issue of Science, with deep importance for biology and medicine.
  
  
• July 11, 2012
  Scripps Research Institute Wins $77 Million to Develop AIDS Vaccine Center
  The Scripps Research Institute has been awarded a grant expected to total more than $77 million from the National Institutes of Health’s (NIH) National Institute of Allergy and Infectious Diseases (NIAID).
  
  
• July 01, 2012
  Scripps Research Institute Scientists Develop Alternative to Gene Therapy
  Scientists at The Scripps Research Institute have discovered a surprisingly simple and safe method to disrupt specific genes within cells.
  
  
• June 27, 2012
  Scripps Research Institute Scientists Find Easier Way to Make New Drug Compounds
  Scientists at The Scripps Research Institute have developed a powerful new technique for manipulating the building-block molecules of organic chemistry.
  
  
• June 15, 2012
  Scripps Research Institute Announces Five-Year Research Collaboration with Bristol-Myers Squibb
  The Scripps Research Institute today announced it has entered into a five-year collaboration with Bristol-Myers Squibb Company (NYSE:BMY) focused on applying novel chemistry to drug discovery and synthesis.
  
  
• June 13, 2012
  New Drug-Screening Method Yields Long-Sought Anti-HIV Compounds
  Scientists at The Scripps Research Institute have used a powerful new chemical-screening method to find compounds that inhibit the activity of human immunodeficiency virus (HIV), the virus that causes AIDS.
  
  
• June 13, 2012
  Scripps Research Scientists Show Lack of Single Protein Results in Persistent Viral Infection
  Scientists from The Scripps Research Institute have shown a single protein can make the difference between an infection clearing out of the body or persisting for life.
  
  
• June 10, 2012
  Scripps Research Scientists Develop New Tools to Unveil Mystery of the 'Glycome'
  Scientists at The Scripps Research Institute have developed chemical compounds that can make key modifications to common sugar molecules (“glycans”), which are found on the surface of all cells in our body.
  
  
• June 03, 2012
  Scripps Research Institute Study Suggests Expanding the Genetic Alphabet May Be Easier than Previously Thought
  A new study led by scientists at The Scripps Research Institute suggests that the replication process for DNA—the genetic instructions for living organisms that is composed of four bases (C, G, A and T)—is more open to unnatural letters than had previously been thought.
  
  
• June 01, 2012
  San Diego Medtech Entrepreneur Peter Farrell Elected to Scripps Research Institute Board of Trustees
  Peter Farrell, chairman and chief executive officer of San Diego-based ResMed, has been elected to The Scripps Research Institute’s Board of Trustees.
  
  
• May 31, 2012
  Scripps Research Institute’s Richard A. Lerner Wins Prince of Asturias Award for Scientific and Technical Research
  Scripps Research Institute Professor Richard A. Lerner, MD, has won a prestigious international honor, the Prince of Asturias Award for Scientific and Technical Research, according to an announcement made today by the Prince of Asturias Foundation. Lerner shares the award with British biochemist Sir Gregory Winter, PhD.
  
  
• May 28, 2012
  Study Reveals How the World's First Drug for Amyloid Disease Works
  Scientists from The Scripps Research Institute and Pfizer Inc. have published a new study showing how a new drug called tafamidis (Vyndaqel®) works.
  
  
• May 10, 2012
  New Screening Technique from Scripps Research Institute Yields Elusive Compounds to Block Immune-Regulating Enzyme
  Scientists at The Scripps Research Institute have found the first chemical compounds that act to block an enzyme that has been linked to inflammatory conditions such as asthma and arthritis, as well as some inflammation-promoted cancers.
  
  
• May 07, 2012
  Scripps Research Institute Scientists Show How Memory B Cells Stay 'In Class' to Fight Different Infections
  Scientists at The Scripps Research Institute have made an important discovery about the internal programming of B cells, the immune cells that make antibodies against infections.
  
  
• May 03, 2012
  Scripps Research Institute and UC San Diego Study Reveals Dynamic Changes in Gene Regulation in Human Stem Cells
  A team led by scientists at The Scripps Research Institute and the University of California (UC) San Diego has discovered a new type of dynamic change in human stem cells.
  
  
• May 03, 2012
  Scripps Research Institute Scientists Show How a Gene Duplication Helped our Brains Become 'Human'
  What genetic changes account for the vast behavioral differences between humans and other primates? Researchers so far have catalogued only a few, but now it seems that they can add a big one to the list.
  
  
• April 26, 2012
  Scripps Research Institute Scientists Find the Structure of a Key ‘Gene Silencer’ Protein
  Scientists at The Scripps Research Institute have determined the three-dimensional atomic structure of a human protein that is centrally involved in regulating the activities of cells.
  
  
• April 26, 2012
  Scripps Research Institute Scientists Solve a Mystery of Bacterial Growth and Resistance
  Scientists at The Scripps Research Institute have unraveled a complex chemical pathway that enables bacteria to form clusters called biofilms. Such improved understanding might eventually aid the development of new treatments targeting biofilms, which are involved in a wide variety of human infections and help bacteria resist antibiotics.
  
  
• April 23, 2012
  Scripps Research Scientists Find Anticonvulsant Drug Helps Marijuana Smokers Kick The Habit
  Scientists at The Scripps Research Institute have found clinical evidence that the drug gabapentin, currently on the market to treat neuropathic pain and epilepsy, helps people to quit smoking marijuana (cannabis).
  
  
• April 22, 2012
  Scripps Research Wins $10.2 Million Grant to Develop New Therapies for Eye Diseases
  A team led by a scientist from The Scripps Research Institute has been awarded a five-year, $10.2 million grant from the National Eye Institute (NEI) to develop a new type of treatment for diabetic retinopathy, macular degeneration, and other common vision disorders.
  
  
• April 19, 2012
  Scientist Wins $3 Million Renewal of One of Longest-Running NIH Grants to Scripps Research
  The Scripps Research Institute has received a $3 million grant renewal from the National Institutes of Health (NIH) for support of scientist James Hoch’s studies on bacterial signaling proteins.
  
  
• April 18, 2012
  Scripps Research Institute Scientists Develop Antidote for Cocaine Overdose
  Scientists at The Scripps Research Institute have shown that an injectable solution can protect mice from an otherwise lethal overdose of cocaine.
  
  
• April 17, 2012
  Scripps Research Institute Professor Gerald F. Joyce Elected to American Academy of Arts & Sciences
  Scripps Research Institute Professor Gerald F. Joyce, MD, PhD, has been elected to the American Academy of Arts & Sciences.
  
  
• April 03, 2012
  New Life Sciences Networking Group Announces Panel Discussion on Intellectual Property
  As one of its first events, a new life sciences networking group in town, Oxbridge Biotech Roundtable (OBR)-San Diego, will host a panel discussion on intellectual property’s role in creating successful businesses, scheduled for Wednesday, April 11, 6 to 9 PM.
  
  
• April 02, 2012
  Scripps Research Institute Scientists Find Promising Vaccine Targets on Hepatitis C Virus
  A team led by scientists at The Scripps Research Institute has found antibodies that can prevent infection from widely differing strains of hepatitis C virus (HCV) in cell culture and animal models.
  
  
• March 23, 2012
  The Scripps Research Institute Hosts NOBCChE Western Regional Meeting
  The Scripps Research Institute is hosting the Western regional meeting of the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE) this weekend.
  
  
• March 22, 2012
  Scripps Research Institute Team Wrests Partial Control of a Memory
  Scripps Research Institute scientists and their colleagues have successfully harnessed neurons in mouse brains, allowing them to at least partially control a specific memory.
  
  
• March 22, 2012
  Scripps Research Institute High School Program Receives CIRM Grant
  The Scripps Research Institute is one of the institutions that will receive funding from the California Institute for Regenerative Medicine (CIRM)—the state stem cell agency created by proposition 71—to foster creativity and scientific innovation in high school students and fund basic stem cell discoveries, CIRM announced today.
  
  
• March 21, 2012
  Interview and Photo Opportunity:
  The Scripps Research Institute Hosts NOBCChE Regional Meeting
  The Scripps Research Institute will host the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE) West Regional meeting, March 23-25, featuring scientific presentations, a tour of Scripps Research laboratories, student poster session, science teacher workshop, and participant networking.
  
  
• March 21, 2012
  Team led by Scripps Research Institute Scientists Finds Atomic Structure of Molecule that Binds to Opioids in the Brain
  Scientists have for the first time determined the three-dimensional atomic structure of a human opioid receptor, a molecule on the surface of brain cells that binds to opioids and is centrally involved in pleasure, pain, addiction, depression, psychosis, and related conditions.
  
  
• March 06, 2012
  Scripps Research Discoveries Lead to Newly Approved Drug for Infant Respiratory Distress Syndrome
  Scientific advances at The Scripps Research Institute have led to a new drug Surfaxin® (lucinactant), approved today by the U.S. Food and Drug Administration (FDA) to treat infant respiratory distress syndrome.
  
  
• February 21, 2012
  Scripps Research Scientists Unlock Evolutionary Secret of Blood Vessels
  The ability to form closed systems of blood vessels is one of the hallmarks of vertebrate development.
  
  
• February 19, 2012
  Scripps Research Scientists Identify Protein that Sends ‘Painful Touch’ Signals
  In two landmark papers in the journal Nature this week, scientists at The Scripps Research Institute report that they have identified a class of proteins that detect “painful touch.”
  
  
• February 16, 2012
  Scripps Research and Sanford-Burnham scientists shed light on how body fends off bacteria
  To invade organisms such as humans, bacteria make use of a protein called flagellin, part of a tail-like appendage that helps the bacteria move about.
  
  
• February 16, 2012
  Scripps Research Scientists Create New Molecular Map to Guide Development of New Treatments for Multiple Sclerosis and Other Diseases
  A team of scientists from The Scripps Research Institute, collaborating with members of the drug discovery company Receptos, has created the first high-resolution virtual image of cellular structures called S1P1 receptors, which are critical in controlling the onset and progression of multiple sclerosis and other diseases.
  
  
• February 09, 2012
  Ultraviolet Protection Molecule in Plants Yields Its Secrets to Scripps Research Team
  Lying around in the sun all day is hazardous not just for humans but also for plants, which have no means of escape.
  
  
• February 07, 2012
  Scripps Research and Technion Scientists Develop Biological Computer to Encrypt and Decipher Images
  Scientists at The Scripps Research Institute in California and the Technion–Israel Institute of Technology have developed a “biological computer” made entirely from biomolecules that is capable of deciphering images encrypted on DNA chips.
  
  
• February 02, 2012
  Team Led by Scripps Research Scientists Demonstrates Effective New ‘Biopsy in a Blood Test’ to Detect Cancer
  Scientists from The Scripps Research Institute, Scripps Health, and collaborating cancer physicians have successfully demonstrated the effectiveness of an advanced blood test for detecting and analyzing circulating tumor cells (CTCs)—breakaway cells from patients’ solid tumors—from cancer patients.
  
  
• February 02, 2012
  Scripps Research Alumnus Wins International Science & Engineering Visualization Challenge
  A powerful 3D animation tool created by Graham Johnson at The Scripps Research Institute has been selected as the winning video in the ninth annual International Science & Engineering Visualization Challenge.
  
  
• January 31, 2012
  Scripps Research Team Proves Plausibility of New Primordial Pathway to Life’s Chemical Building Blocks
  A group from The Scripps Research Institute has proven an alternative pathway to life-essential sugars called the glyoxylate scenario, which may push the field of pre-life chemistry past the formose reaction hurdle.
  
  
• January 26, 2012
  Scripps Research Scientists Illuminate Cancer Cells’ Survival Strategy During Dangerous Dissemination
  A team led by scientists at The Scripps Research Institute has discovered key elements of a strategy commonly used by tumor cells to survive when they spread to distant organs.
  
  
• January 25, 2012
  Scripps Research Institute Names Peter K. Vogt as Senior Vice President for Scientific Affairs
  The Scripps Research Institute has named Professor Peter K. Vogt, PhD, as senior vice president for scientific affairs.
  
  
• January 22, 2012
  Scripps Research Scientists Provide New Understanding of Chronic Pain
  Millions of people worldwide suffer from a type of chronic pain called neuropathic pain, which is triggered by nerve damage.
  
  
• January 02, 2012
  Michael A. Marletta Takes Office as New President of Scripps Research Institute
  Renowned biochemist Michael A. Marletta, PhD, assumed the post of president and CEO of The Scripps Research Institute January 1, succeeding Richard A. Lerner, MD, who led the institution for more than two decades.
  
  
• December 27, 2011
  Scripps Research Scientists Discover a Brain Cell Malfunction in Schizophrenia
  Scientists at The Scripps Research Institute have discovered that DNA stays too tightly wound in certain brain cells of schizophrenic subjects.
  
  
• December 13, 2011
  Two San Diego research groups named to Stand Up To Cancer Dream Team to pioneer personalized medicine approach to treating melanoma
  Two groups of San Diego researchers—one from Sanford-Burnham Medical Research Institute and the other a collaboration between The Scripps Research Institute and Scripps Health—were named today as part of a new “Dream Team” to find innovative new ways to fight melanoma using a personalized medicine approach.
  
  
• December 09, 2011
  Scripps Research Study Underlines Potential of Anti-Stress Peptide to Block Alcohol Dependence
  New research by scientists at The Scripps Research Institute has underlined the power of an endogenous anti-stress peptide in the brain to prevent and even reverse some of the cellular effects of acute alcohol and alcohol dependence in animal models.
  
  
• November 20, 2011
  Scripps Research Team Finds a Weak Spot on Deadly Ebolavirus
  Scientists from The Scripps Research Institute and the US Army’s Medical Research Institute of Infectious Diseases have isolated and analyzed an antibody that neutralizes Sudan virus, a major species of ebolavirus and one of the most dangerous human pathogens.
  
  
• November 17, 2011
  Scripps Research Scientists Identify New Class of Antimalarial Compounds
  A international team led by scientists from the Genomics Institute of the Novartis Research Foundation (GNF) and The Scripps Research Institute has discovered a family of chemical compounds that could lead to a new generation of antimalarial drugs capable of not only alleviating symptoms but also preventing the deadly disease.
  
  
• November 14, 2011
  Scripps Research Scientists Find Potential Achilles’ Heel on Lassa Fever and Related Viruses
  Scientists at The Scripps Research Institute have determined the atomic structure of a protein that the Lassa fever virus uses to make copies of itself within infected cells.
  
  
• November 06, 2011
  Scripps Research Team Achieves Critical Step for Opening Elusive Class of Compounds to Drug Discovery
  A group of Scripps Research Institute scientists has successfully achieved a major step toward the goal of synthetically producing Taxol® and other complex taxanes on a quest to harness chemical reactions that could enable research on previously unavailable potential drugs.
  
  
• October 20, 2011
  Scripps Research Scientists Discover Inflammation Is Controlled Differently in Brain and Other Tissues
  A team led by scientists from The Scripps Research Institute has identified a new metabolic pathway for controlling brain inflammation, suggesting strategies for treating it.
  
  
• October 13, 2011
  Scripps Research Scientists Reveal Surprising Picture of How Powerful Antibody Neutralizes HIV
  Researchers at The Scripps Research Institute have uncovered the surprising details of how a powerful anti-HIV antibody grabs hold of the virus.
  
  
• October 06, 2011
  Scripps Research Scientists Find Stem Cell Reprogramming Technique Is Safer than Previously Thought
  Stem cells made by reprogramming patients’ own cells might one day be used as therapies for a host of diseases, but scientists have feared that dangerous mutations within these cells might be caused by current reprogramming techniques. A sophisticated new analysis of stem cells’ DNA finds that such fears may be unwarranted.
  
  
• October 03, 2011
  Bruce Beutler Wins the 2011 Nobel Prize in Physiology or Medicine
  LA JOLLA, CA, October 3, 2011 – For Immediate Release – Bruce Beutler, M.D., Chair of the Department of Genetics at The Scripps Research Institute in La Jolla, CA, has won the 2011 Nobel Prize in Physiology or Medicine.
  
  
• September 27, 2011
  Scripps Research Scientist Wins $3.6 Million NIH MERIT Award to Study Alcoholism in Native Americans
  Scripps Research Institute Professor Cindy Ehlers has been awarded a prestigious $3.6 million MERIT (Method to Extend Research in Time) Award grant by the National Institutes of Health (NIH) to study the risk factors for alcoholism in Native Americans.
  
  
• September 20, 2011
  Two Scripps Research Scientists Win Prestigious NIH Innovator Awards
  Two Scripps Research Institute scientists have won prestigious National Institutes of Health (NIH) Director’s New Innovator Awards.
  
  
• September 15, 2011
  Scripps Research Team Discovers Treatable Mechanism Responsible for Often Deadly Response to Flu
  Researchers at The Scripps Research Institute have found a novel mechanism by which certain viruses such as influenza trigger a type of immune reaction that can severely sicken or kill those infected.
  
  
• September 08, 2011
  Scripps Research Team Overcomes Major Obstacle for Stem Cell Therapies and Research
  Stem cells show great potential to enable treatments for conditions such as spinal injuries or Lou Gehrig’s disease, and also as research tools.
  
  
• September 07, 2011
  Scripps Research Scientists Find Clue to Cause of Childhood Hydrocephalus
  Scientists at The Scripps Research Institute have found what may be a major cause of congenital hydrocephalus, one of the most common neurological disorders of childhood that produces mental debilitation and sometimes death in premature and newborn children.
  
  
• September 06, 2011
  Scripps Research Scientists Pinpoint Shape-Shifting Mechanism Critical to Protein Signaling
  In a joint study, scientists from the California and Florida campuses of The Scripps Research Institute have shown that changes in a protein's structure can change its signaling function and they have pinpointed the precise regions where those changes take place.
  
  
• September 04, 2011
  Scripps Research Scientists Produce First Stem Cells From Endangered Species in Hopes of Strengthening Populations
  Starting with normal skin cells, scientists from The Scripps Research Institute have produced the first stem cells from endangered species.
  
  
• September 01, 2011
  Discovery Suggests Way to Block Fetal Brain Damage Produced By Oxygen Deprivation
  Examining brain damage that occurs when fetuses in the womb are deprived of oxygen, researchers at The Scripps Research Institute have discovered that damage does not occur randomly but is linked to the specific action of a naturally occurring fatty molecule called LPA, acting through a receptor that transfers information into young brain cells.
  
  
• August 31, 2011
  Scripps Research Scientists Reveal How White Blood Cell Promotes Growth and Spread of Cancer
  Scientists at The Scripps Research Institute have shown that a particular white blood cell plays a direct role in the development and spread of cancerous tumors.
  
  
• August 29, 2011
  Scripps Research and Stanford Scientists Find New Drug Candidates for Set of Protein-Folding Diseases
  Collaborating researchers at Stanford University and The Scripps Research Institute have identified chemical compounds that show promise as potential therapeutics for a set of medical conditions caused by the abnormal clumping together of a protein known as transthyretin (TTR).
  
  
• August 24, 2011
  Scripps Research Scientists Reengineer an Antibiotic to Overcome Dangerous Antibiotic-Resistant Bacteria
  A team of scientists from The Scripps Research Institute have successfully reengineered an important antibiotic to kill the deadliest antibiotic-resistant bacteria.
  
  
• August 17, 2011
  AIDS Researchers Isolate New Potent and Broadly Effective Antibodies Against HIV
  A team of researchers at and associated with the International AIDS Vaccine Initiative (IAVI), The Scripps Research Institute, the biotechnology company Theraclone Sciences and Monogram Biosciences Inc., a LabCorp company, report in the current issue of Nature the isolation of 17 novel antibodies capable of neutralizing a broad spectrum of variants of HIV, the virus that causes AIDS.
  
  
• August 15, 2011
  Scripps Research Scientists Find Easier, Cheaper Way to Make a Sought-After Chemical Modification to Pharmaceuticals
  Scientists at The Scripps Research Institute have devised a much easier technique for performing a chemical modification used widely in the synthesis of drugs and other products.
  
  
• August 08, 2011
  Tenet Florida and The Scripps Research Institute Announce Collaboration to Build Academic Medical Center in Palm Beach Gardens, Florida
  Tenet Florida Inc. and The Scripps Research Institute are pleased to announce a collaboration to develop an academic medical center.
  
  
• July 20, 2011
  Scripps Research Scientists Create Vaccine Against Heroin High
  Researchers at The Scripps Research Institute have developed a highly successful vaccine against a heroin high and have proven its therapeutic potential in animal models.
  
  
• July 14, 2011
  Scripps Research Scientist Awarded Pre-doctoral Fellowship from Autism Speaks Foundation
  Autism Speaks, the nation’s largest autism science and advocacy group, has awarded a two-year Dennis Weatherstone Pre-Doctoral Fellowship to Kristopher Nazor of The Scripps Research Institute.
  
  
• July 13, 2011
  Scripps Research Institute Scientist Awarded Prestigious Cancer Research Fellowship
  Scripps Research Institute scientist Hua Lu, Ph.D., has been named a 2011 Damon Runyon Fellow, a prestigious award presented by the Damon Runyon Cancer Research Foundation to recognize early-career researchers.
  
  
• July 07, 2011
  Discovery of Natural Antibody Brings a Universal Flu Vaccine a Step Closer
  Annually changing flu vaccines with their hit-and-miss effectiveness may soon give way to a single, near-universal flu vaccine, according to a new report from scientists at The Scripps Research Institute and the Dutch biopharmaceutical company Crucell.
  
  
• July 06, 2011
  Scripps Research Scientists Find 'Brake-Override' Proteins that Enable Development of Some Cancers
  Scripps Research Institute scientists have discovered a basic mechanism that can enable developing cancer cells to sustain abnormal growth. The finding is expected to lead to the targeting of this mechanism with drugs and diagnostic techniques.
  
  
• July 04, 2011
  Scripps Research Scientists Solve Mystery of Nerve Disease Genes
  For several years, scientists have been pondering a question about a genetic disease called Charcot-Marie-Tooth (CMT) disease type 2D: how can different types of mutations, spread out across a gene, produce the same condition?
  
  
• July 01, 2011
  Scripps Receives $7.9 Million NIH Grant for Novel ‘Disease in a Dish’ Genomic Research into Finding Root Cause of Heart Attack
  Researchers looking to find a root cause for heart attacks and coronary artery disease will soon begin using a novel investigative approach that borders on science fiction as they work toward the holy grail of American medicine: preventing the nation’s No. 1 killer.
  
  
• June 28, 2011
  Scripps Research Scientists Discover New Molecular Pathway Involved in Wound Healing and Temperature Sensation
  Scientists from The Scripps Research Institute have identified a surprising new molecular pathway in skin cells that is involved in wound-healing and sensory communication.
  
  
• June 28, 2011
  Scripps Translational Science Institute Joins Jackson Laboratory’s National Tumor Consortium to Accelerate Targeted Cancer Therapies
  The Scripps Translational Science Institute (STSI) today announced it has joined a national consortium of research institutions headed by The Jackson Laboratory (JAX) that is building a library of primary human tumors with the goal of developing highly targeted cancer therapies.
  
  
• June 21, 2011
  Scripps Research Institute Scientist Knighted by Italian Republic
  Scripps Research Institute Associate Professor Marisa Roberto has been awarded the Cavaliere (knight) degree of the Italian Republic’s highest honor, the Ordine al Merito della Repubblica Italiana (Order of Merit), recognizing her scientific research in the neurobiology of addictive behavior.
  
  
• June 13, 2011
  Scripps Research Team Sheds New Light on How Blood Clots Form
  Scripps Research Institute scientists have discovered new elements of the blood clot-formation process. The findings could lead to better drugs for preventing heart attacks and other clot-related conditions.
  
  
• May 31, 2011
  Scripps Research Scientists Find Key Mechanism in Transition to Alcohol Dependence
  A team of Scripps Research Institute scientists has found a key biological mechanism underpinning the transition to alcohol dependence.
  
  
• May 25, 2011
  Study Suggests Enzyme Crucial to DNA Replication May Provide Potent Anti-Cancer Drug Target
  An enzyme essential for DNA replication and repair in humans works in a way that might be exploited as anti-cancer therapy, say researchers at The Scripps Research Institute and Lawrence Berkeley National Laboratory.
  
  
• May 15, 2011
  Scripps Research Scientists Find New Class of Compounds with Potentially Widespread Use in Basic Research and Drug Development
  Scientists from The Scripps Research Institute have identified a class of compounds that could be a boon to basic research and drug discovery.
  
  
• May 06, 2011
  Scripps Research Scientists Show How Shifts in Temperature Prime Immune Response
  Researchers at The Scripps Research Institute have found a temperature-sensing protein within immune cells that, when tripped, allows calcium to pour in and activate an immune response.
  
  
• May 05, 2011
  CIRM Awards Scripps Research Institute Scientists $3.5 Million
  Two Scripps Research institute investigators have been awarded a total of $3.5 million from the California Institute for Regenerative Medicine (CIRM).
  
  
• April 07, 2011
  Scripps Research Scientists Find E. Coli Enzyme Must Move to Function
  Slight oscillations lasting just milliseconds have a huge impact on an enzyme's function, according to a new study by Scripps Research Institute scientists.
  
  
• March 27, 2011
  Structure of DNA Repair Complex Reveals Workings of Powerful Cell Motor
  Over the last years, two teams of researchers at The Scripps Research Institute have steadily built a model of how a powerful DNA repair complex works. Now, their latest discovery provides revolutionary insights into the way the molecular motor inside the complex functions – findings they say may have implications for treatment of disorders ranging from cancer to cystic fibrosis.
  
  
• March 10, 2011
  Scripps Research Method Reveals New View of Human Nerve Cells, Opening Door to Potential Drug Targets
  Scientists at The Scripps Research Institute and University of Pennsylvania have found a way to uncover potential drug targets that have so far remained hidden from researchers' view.
  
  
• March 09, 2011
  New Lupus Drug Results from Scripps Research Technology
  For Immediate Release – Scientific advances at The Scripps Research Institute were key to laying the foundation for the new drug Benlysta® (belimumab), approved today by the U.S. Food and Drug Administration.
  
  
• March 08, 2011
  Scripps Research and MIT Scientists Discover Class of Potent Anti-Cancer Compounds
  Working as part of a public program to screen compounds to find potential medicines and other biologically useful molecules, scientists from The Scripps Research Institute and Massachusetts Institute of Technology (MIT) have discovered an extremely potent class of potential anti-cancer and anti-neurodegenerative disorder compounds.
  
  
• March 06, 2011
  Scripps Research Scientists Develop New Test for "Pluripotent" Stem Cells
  "Pluripotent" stem cells—which have the potential to mature into almost any cell in the body—are being widely studied for their role in treating a vast array of human diseases and for generating cells and tissues for transplantation.
  
  
• March 03, 2011
  Scripps Research Study Points to Liver, Not Brain, as Origin of Alzheimer’s Plaques
  Unexpected results from a Scripps Research Institute and ModGene, LLC study could completely alter scientists' ideas about Alzheimer's disease—pointing to the liver instead of the brain as the source of the "amyloid" that deposits as brain plaques associated with this devastating condition.
  
  
• February 20, 2011
  The Scripps Research Institute Names Michael A. Marletta as President
  Renowned biochemist Michael A. Marletta, PhD, has been named by the Board of Trustees today as the next president of The Scripps Research Institute, effective January 1, 2012.
  
  
• February 13, 2011
  Scripps Research Study Sheds Light on RNA “On/Off Switches”
  Scientists from The Scripps Research Institute have shed new light on a molecular switch that turns genes on or off in response to a cell’s energy needs.
  
  
• February 09, 2011
  Scripps Research Study Presents Surprising View of Brain Formation
  A study from The Scripps Research Institute has unveiled a surprising mechanism that controls brain formation. The findings have implications for understanding a host of diseases, including some forms of mental retardation, epilepsy, schizophrenia, and autism.
  
  
• February 08, 2011
  Scripps Research and UCSD Scientists Develop a Method to Identify Fleetingly Ordered Structures from Intrinsically Disordered Protein
  A team of scientists from The Scripps Research Institute and the University of California, San Diego (UCSD) have developed a novel technique to observe previously unknown details of how folded structures are formed from an intrinsically disordered protein.
  
  
• February 03, 2011
  Scripps Research Scientists Develop Powerful New Methodology for Stabilizing Proteins
  A team of scientists at The Scripps Research Institute has discovered a new way to stabilize proteins — the workhorse biological macromolecules found in all organisms.
  
  
• January 31, 2011
  Scripps Research Scientist Discovers Natural Molecule Indirectly Prevents Stable Clot Formation
  A scientist from The Scripps Research Institute has identified a new role for a natural signaling molecule in preventing blood clot formation.
  
  
• January 26, 2011
  Scripps Research Study Shows Map of Brain Connectivity Changes During Development
  Connected highways of nerve cells carry information to and from different areas of the brain and the rest of the nervous system. Scientists are trying to draw a complete atlas of these connections—sometimes referred to as the “connectome”—to gain a better understanding of how the brain functions in health and disease.
  
  
• January 20, 2011
  Scripps Research Scientists Find Measles’ Natural Nemesis
  Scientists at The Scripps Research Institute have found that a known enzyme in cells protects against measles virus, likely by altering the virus’s genetic material, RNA.
  
  
• January 19, 2011
  Scripps Research and University of Virginia Scientists Reveal Complete Structure of HIV’s Outer Shell
  A team of scientists at The Scripps Research Institute and the University of Virginia has determined the structure of the protein package that delivers the genetic material of the human immunodeficiency virus (HIV) to human cells.
  
  
• January 18, 2011
  Scripps Research Team Creates New Synthetic Compound with HIV-Fighting Promise
  Using chemical compounds found in a Japanese plant as a lead and the clever application of ultraviolet light, a Scripps Research Institute team has created a unique library of dozens of synthetic compounds to test for biomedical potential.
  
  
• January 13, 2011
  Scripps Research and Vanderbilt Launch Joint Institute to Advance Science at Interface of Chemistry and Medicine
  The Scripps Research Institute and Vanderbilt University have formed a partnership to advance science at the interface of chemistry and medicine, the institutions announced today.
  
  
• January 04, 2011
  Scripps Research and Cornell Scientists Create Novel Vaccine that Produces Strong Immunity Against Cocaine High
  Researchers from The Scripps Research Institute, Weill Cornell Medical College, and Cornell University have produced a long-lasting anti-cocaine immunity in mice by giving them a unique vaccine that combines bits of the common cold virus with a particle that mimics cocaine.
  
  
• December 15, 2010
  Scripps Research and UCSD Scientists Awarded Approximately $7.5 Million to Identify Potential Drug Candidates to Treat Nicotine Addiction
  The Scripps Research Institute and the University of California, San Diego, (UCSD) School of Medicine have been awarded approximately $7.5 million over five years to develop novel compounds that could eventually become drug candidates for the treatment of nicotine dependence, and possibly other drug addictions.
  
  
• December 6, 2010
  Scripps Research Institute's Martha Fedor Named Editor-in-Chief of Journal of Biological Chemistry
  Scripps Research Institute Associate Professor Martha Fedor has been named the next editor-in-chief of the Journal of Biological Chemistry (JBC), the journal announced today.
  
  
• December 2, 2010
  Scripps Research Scientists Home In on Chemicals Needed to Reprogram Cells
  Scripps Research Institute scientists have made a significant leap forward in the drive to find a way to safely reprogram mature human cells and turn them into stem cells, which can then change into other cell types, such as nerve, heart, and liver cells. The ability to transform fully mature adult cells such as skin cells into stem cells has potentially profound implications for treating many diseases.
  
  
• November 29, 2010
  Scripps Research Scientists Redefine the Role of Plasma Cells in the Immune System
  A team of scientists from The Scripps Research Institute have uncovered a previously unknown regulatory mechanism in the body’s response to eliminate pathogens, such as bacteria and viruses. The findings challenge a long-held dogma in the field of immunology and have potential implications for far-ranging topics from how vaccines should be administered to the origin of autoimmunity.
  
  
• November 18, 2010
  Scripps Research Scientists Report Molecular Structure of Dopamine Receptor
  A team led by scientists at The Scripps Research Institute has solved the structure of one of the receptors that responds to the neurotransmitter dopamine. Although dopamine transmission is essential to normal brain functioning, the biological assembly of the molecules involved in this crucial neuronal interplay had not been known—until now.
  
  
• November 17, 2010
  Scripps Research Scientists Devise Broad New Technique for Screening Proteins 
  A team led by scientists from The Scripps Research Institute has developed a powerful new method for detecting functional sites on proteins. The technique may have broad applications in basic research and drug development.
  
  
• November 4, 2010
  Scripps Research Team Implicates Wayward DNA-Repair Enzyme in Friedreich’s Ataxia
  Scripps Research Institute scientists have taken a step closer to understanding the cause of Friedreich’s Ataxia, a debilitating neurological condition that affects tens of thousands of people worldwide, and so far has no cure.
  
  
• November 3, 2010
  Scripps Research Scientists Find Nerve Cell Activity Drains Stem Cell Pool in Developing Brain
  Researchers at The Scripps Research Institute have shown that as the newly formed nerve cells start firing electrical signals, this activity slows down stem cell division, emptying out the stem cell pool in favor of nerve cell formation
  
  
• October 29, 2010
  Scripps Research Team "Watches" Formation of Cells' Protein Factories For First Time
  Work Could Help Unravel Complexities of the Cell and Lead to New Antibiotics and Disease Treatments
  
  
• October 28, 2010
  Scripps Research Scientists Describe New Approach for Identifying Genetic Markers for Common Diseases
  A group of researchers at The Scripps Research Institute and the Scripps Translational Science Institute has published a paper that reviews new strategies for identifying collections of rare genetic variations that reveal whether people are predisposed to developing common conditions like diabetes and cancer.
  
  
• October 21, 2010
  Entire Issue of Scientific Journal Devoted to Multi-Institutional Center Headed by Scripps Research Scientists
  A multi-institutional consortium led by The Scripps Research Institute scientists, the Joint Center for Structural Genomics (JCSG), is the sole focus of a special issue of the journal Acta Crystallographica Section F.
  
  
• October 7, 2010
  Scripps Research Scientists Reveal First Structure of a Class of Proteins that Sniff Out Signals Guiding Blood Cell Movement
  The Findings May Lead to New Drugs for Cancer, Immune Disorders, and AIDS
  
  
• October 6, 2010
  Scripps Research Scientists Develop Novel Test that Identifies River Blindness Parasite in its Active State
  The breakthrough will assist massive effort to eliminate the widespread tropical scourge.
  
  
• September 30, 2010
  Scripps Research Scientists Win $65 Million in New Grants to Reveal Form and Function of Important Proteins and Protein Complexes in Biology and Medicine
  TThe Grants Build on Institute's Leadership in Structural Studies.
  
  
• September 22, 2010
  Scripps Research Scientists Reveal Structure of Dangerous Bacteria's Powerful Multidrug Resistance Pump
  The Work May Lead to the Development of New Antibiotics as well as the Improvement of Crop Agriculture.
  
  
• September 16, 2010
  Scripps Research Team Wins $5.1 Million to Develop DNA Sequencing Technology
  Scripps Research Institute Professor Reza Ghadiri, Ph.D., has been awarded a four-year, $5.1 million grant as part of a National Institutes of Health (NIH) initiative to spur the development of the next generation of DNA sequencing technologies, which could enable biomedical researchers and health care workers to routinely sequence a person's DNA.
  
  
• September 15, 2010
  Scripps Research Scientists Develop Molecular Test Providing a New Pathway for Identifying Obesity and Diabetes Drugs
  Scientists at The Scripps Research Institute have designed a new molecular test that will allow researchers to look for potential drugs targeting a human metabolic enzyme believed to stimulate the appetite and play a role in diabetes.
  
  
• September 12, 2010
  Scripps Research Scientists Solve Long-Standing Mystery of Protein "Quality Control" Mechanism
  The Findings Could Lead to New Understanding of Neurodegenerative Diseases
  
  
• September 2, 2010
  Scripps Research Scientists Identify Molecules Involved in Touch and Other Mechanically Activated Systems
  Findings Could Lead to New Treatment Approaches in Pain, Deafness, and Cardiac Function
  
  
• September 2, 2010
  Two Teams of Scripps Research Scientists Discover the Mechanisms and Function of a Type of Mysterious Immune Cell
  In two closely related studies, two teams of Scripps Research Institute scientists have discovered the underlying mechanisms that activate a type of immune cell in the skin and other organs.
  
  
• September 2, 2010
  Team Led by Scientists from Scripps Research and Novartis Discover New Type of Anti-Malarial Compound
  Clinical Trials for Promising New Drug Candidate Are Planned
  
  
• August 26, 2010
  Scripps Research Scientists Unveil Structure of Adenovirus, the Largest High-Resolution Complex Ever Found
  The Results Could Lead to New Drugs and Gene Therapies
  
  
• August 22, 2010
  New Study by Scripps Research and Virginia Commonwealth Scientists Shed Light on Painkilling System in Brain
  The Findings Have Implications for Both Drug Development and Basic Science
  
  
• August 11, 2010
  Media Advisory and Photo Opportunity: San Diego Students to Present Research from Summer Internships at The Scripps Research Institute
  25 high-achieving high school students, many of whom are the first in their families to be headed for college, will give brief presentations highlighting their work in Scripps Research laboratories this summer.
  
  
• July 28, 2010
  Scripps Research Study Opens the Door to Developing a New Class of Drugs for Treating Epileptic Seizures
  A chemical compound that boosts the action of a molecule normally produced in the brain may provide the starting point for a new line of therapies for the treatment of epileptic seizures, according to a new study by scientists at The Scripps Research Institute.
  
  
• July 22, 2010
  Scripps Research Scientist Wins 2010 NIH Director's Pioneer Award
  Carlos F. Barbas III, Ph.D., professor at The Scripps Research Institute, has been named one of the winners of the National Institutes of Health's 2010 National Institutes of Health (NIH) Director's Pioneer Awards.
  
  
• June 7, 2010
  Scripps Research Scientists Find New Way to Attack Cancerous Cells
  The Findings Open the Door to the Development of More Effective Therapies for Lymphomas and Leukemias.
  
  
• June 1, 2010
  Scripps Research Scientists Determine Structure of Immune Molecule that Counteracts Many Strains of HIV
  The findings advance the effort to develop an AIDS vaccine.
  
  
• May 26, 2010
  Scripps Research Institute Dedicates Dorris Neuroscience Center
  The Scripps Research Institute dedicated the Dorris Neuroscience Center today, officially launching the newly consolidated center and honoring the woman who has supported work at the institute for many years. Her gifts include an endowment to support neuroscience research.
  
  
• May 17, 2010
  Team Led by Scripps Research Scientists Discovers Body’s Own Molecular Protection Against Arthritis
  The Results May Lead to New Approach to Therapies for Joint Disease
  
  
• May 12, 2010
  Scripps Research Study Overturns Decade-Old Findings in Neurobiology
  The New Research Suggests Potential Target for Drugs to Combat Alcohol Addiction.
  
  
• May 9, 2010
  Scripps Research Scientists Shed Light on Potential Treatment for Gaucher's Disease and Related Disorders
  The New Findings May Inspire Clinical Trials.
  
  
• May 2, 2010
  Scripps Research Team Provides Groundbreaking New Understanding of Stem Cells
  The Surprising Biochemical Findings May Improve Scientists' Ability to Manipulate Cell Fate and Promote Healing.
  
  
• April 26, 2010
  Scripps Research Scientists Solve Protein Structure Revealing Secrets of Cell Membranes
  The Findings May Lead to Better Methods to Deliver Drugs.
  
  
• April 22, 2010
  New Scripps Research and GNF Study Helps Explain How We Can Sense Temperatures
  The Findings Could Lead to the Development of Novel Therapies for Conditions Such as Acute and Chronic Pain.
  
  
• April 19, 2010
  Scripps Research Scientists Reveal How Genetic Mutations May Cause Type 1 Diabetes
  The Findings Point to a New Drug Target for Type 1 Diabetes and Other Autoimmune Diseases.
  
  
• April 13, 2010
  New Nano-Tool Synthesized at Scripps Research Institute
  Two chemists at The Scripps Research Institute have synthesized a new nano-scale scientific tool — a tiny molecular switch that turns itself on or off as it detects metallic ions in its immediate surroundings.
  
  
• April 12, 2010
  Scripps Research Scientists Solve Mystery of Fragile Stem Cells
  The Groundbreaking New Findings Will Speed Research on Potential Therapies.
  
  
• March 24, 2010
  Scripps Research Team Finds Structure of "Swine Flu" Virus
  The Findings Explain Why Young People Have Been More Vulnerable than Older Individuals in Recent Pandemic
  
  
• March 16, 2010
  5th Annual Szent-Györgyi Prize for Progress in Cancer Research Awarded to Peter K. Vogt, Ph.D., The Scripps Research Institute
  The National Foundation for Cancer Research announced today that renowned scientist Peter K. Vogt, Ph.D., Professor in the Department of Molecular and Experimental Medicine at The Scripps Research Institute, La Jolla, California, is the recipient of the 5th Annual Szent-Györgyi Prize for Progress in Cancer Research.
  
  
• March 1, 2010
  Scientists Identify Age-Associated Defects in Schizophrenia
  Gene Network-Based Analysis Reveals Unexpected Results
  
  
• February 17, 2010
  Scripps Research Institute Appoints Pete Herold as Vice President of Facilities Services
  The Scripps Research Institute has appointed Pete Herold as its new Vice President of Facilities Services.
  
  
• February 15, 2010
  Business Leader and Former U.S. House Leader Richard A. Gephardt Elected to Lead Scripps Research Institute Board of Trustees
  The Scripps Research Institute’s Board of Trustees has unanimously elected Richard A. Gephardt, president and CEO of Gephardt Government Affairs and a former U.S. Congressman and House Majority and Minority Leader, as its new Chairman of the Board. Ambassador Steven J. Green and San Diego Attorney Lynn Schenk were also elected to the biomedical research institute’s governing body.
  
  
• February 3, 2010
  Scripps Research Scientists Find Two Compounds that Lay the Foundation for a New Class of AIDS Drug
  Novel Therapies Could Improve Potency of Existing AIDS Treatments, Help to Combat Drug-Resistant Virus Strains
  
  
• February 3, 2010
  Scripps Research and GIS Scientists Map Epigenome of Human Stem Cells During Development
  Billions of Data Points Provide Big Picture of "Human Epigenome" During Critical Developmental Window
  
  
• January 27, 2010
  Scripps Research Scientists Find Potential New Way to Enhance Vaccines
  Blocking Key Protein in Mice Helps them Resist Viral Infection
  
  
• January 25, 2010
  Scripps Research Team Finds Stress Hormone Key to Alcohol Dependence
  The Findings Suggest Development of Drug Treatment for Substance Abuse
  
  
• January 7, 2010
  Scripps Research Team Wins Global Race to Achieve Landmark Synthesis of Perplexing Natural Product
  Compound's Complexity Had Confounded Chemists Since Discovery in 1993
  
  
• January 7, 2010
  Scripps Research Scientists Find Cancer Cells Co-opt Fat Metabolism Pathway to Become More Malignant
  The Work Provides Insight into Potential Therapeutic for Cancer and Eye Diseases
  
  
• December 29, 2009
  Team Led by Scripps Research Scientists Develops Technique to Determine Ethnic Origin of Stem Cell Line
  Cells More Representative of the U.S. and World Populations Could Lead to More Accurate Research and Safer, More Effective Therapies
• December 14, 2009
  Scripps Research Scientists Crack Mystery of Protein's Dual Function
  Researchers at The Scripps Research Institute have solved a 10-year-old mystery of how a single protein from an ancient family of enzymes can have two completely distinct roles in the body.
  
  
• December 9, 2009
  Scripps Research Team Uncovers Chemical Basis for Extra "Quality Control" in Protein Production
  Nature's Solution to Age-Old Chemical Paradox Provides Clues to Health and Disease.
  
  
• December 7, 2009
  Scripps Research Scientists Reveal Key Structure from Ebola Virus
  Scientists at The Scripps Research Institute have determined the structure of a critical protein from the Ebola virus, which, though rare, is one of the deadliest viruses on the planet killing between 50 and 90 percent of those infected.
  
  
• December 6, 2009
  Scripps Research Team Restores Some Function to Cells from Cystic Fibrosis Patients
  In an encouraging new development, a team led by Scripps Research Institute scientists has restored partial function to lung cells collected from patients with cystic fibrosis.
  
  
• December 3, 2009
  Scripps Research Team Develops Cheap, Easy "Kitchen Chemistry" to Perform Formerly Complex Synthesis
  A team at The Scripps Research Institute has made major strides in solving a problem that has been plaguing chemists for many years: how best to break carbon-hydrogen bonds and then to create new bonds to join molecules together
  
  
• November 30, 2009
  Scripps Research Study Describes Powerful New Tool in the Fight Against Autoimmune Diseases, Blood Cancers
  A study led by a Scripps Research Institute scientist describes a new, highly pragmatic approach to the identification of molecules that prevent a specific type of immune cells from attacking their host.
  
  
• November 19, 2009
  Scripps Research Scientists Find New Link Between Insulin and Core Body Temperature
  A team led by scientists at The Scripps Research Institute have discovered a direct link between insulin—a hormone long associated with metabolism and metabolic disorders such as diabetes—and core body temperature.
  
  
• October 26, 2009
  New Consortium Led by Scripps Research Scientists Awarded $10 Million by National Cancer Institute
  The National Cancer Institute of the National Institutes of Health (NIH) has awarded a $10 million, five-year grant to a new physics oncology center led by Scripps Research Institute scientists.
  
  
• October 22, 2009
  Team Led by Scripps Research and UC San Diego Scientists Reveals Secrets of Drought Resistance
  A team of biologists in California led by researchers at The Scripps Research Institute and the University of California (UC), San Diego has solved the structure of a critical molecule that helps plants survive during droughts.
  
  
• October 20, 2009
  Consortium Including Scripps Research Institute Receives $12.2 Million to Establish National Network of Scientists
  Imagine a Web site like Facebook, but instead of using it to share videos or post quizzes like "What '80s song are you?" scientists could scour a national network of researchers, only a few mouse clicks separating them from information needed for a scientific breakthrough.
  
  
• October 19, 2009
  Scripss Research Sientists Take a Major Step Forward in Making Better Stem Cells from Adult Tissue
  A team led by scientists from The Scripps Research Institute has developed a method that dramatically improves the efficiency of creating stem cells from human adult tissue, without the use of embryonic cells.
  
  
• October 13, 2009
  Scripps Research Scientists Illuminate Structure of Circulating Lung Cancer Cells
  The Scripps Research Institute has been able to determine the structural features of circulating tumor cells, which were collected from the blood of a woman with advanced lung cancer.
  
  
• October 1, 2009
  Scripps Research Scientists Find Missing Puzzle Piece of Powerful DNA Repair Complex
  Researchers at The Scripps Research Institute have found, crystallized, and biologically characterized a poorly defined component of a key molecular complex that helps people to avoid cancer, but that also helps cancer cells resist chemotherapy.
  
  
• September 30, 2009
  The Ray Romano and Kevin James Celebrity Golf Classic to Benefit Advancement in Vision Research
  The Ray Romano and Kevin James Celebrity Golf Classic will be held on Monday, November 16, 2009 at the El Caballero Country Club in Tarzana, California.
  
  
• September 25, 2009
  Mechanism for Potential Friedreich's Ataxia Drug Uncovered
  Using clever chemistry, a Scripps Research team has pinpointed the enzyme target of a drug group that stops the progression of the devastating disease Friedreich's ataxia in mice and may do the same for humans.
  
  
• September 24, 2009
  The Scripps Research Institute and IAVI Host Symposium to Launch Research Center Dedicated to Solving the Neutralizing Antibody Problem
  Today, the International AIDS Vaccine Initiative (IAVI) and The Scripps Research Institute officially launched a new research center, the IAVI Neutralizing Antibody Center at The Scripps Research Institute.
  
  
• September 18, 2009
  The Scripps Research Institute and IAVI Host Leading Scientists Searching for New Ways to Produce an HIV/AIDS Vaccine
  Media Advisory: Media Briefing will present recent significant progress and symposium highlights; interview opportunities; lab tour.
  
  
• September 17, 2009
  Rare Genetic Disease Successfully Reversed Using Stem Cell Transplantation
  A recent study by Scripps Research Institute scientists offers good news for families of children afflicted with the rare genetic disorder, cystinosis. In research that holds out hope for one day developing a potential therapy to treat the fatal disorder, the study shows that the genetic defect in mice can be corrected with stem cell transplantation.
  
  
• September 3, 2009
  Two New Antibodies Found to Cripple HIV
  Researchers at and associated with the International AIDS Vaccine Initiative (IAVI), at The Scripps Research Institute, and at the biotechnology companies Theraclone Sciences and Monogram Biosciences have discovered two powerful new antibodies to HIV that reveal what may be an Achilles heel on the virus.
  
  
• September 3, 2009
  Scripps Research Scientists Identify Genetic Cause for Type of Deafness
  A team led by scientists from The Scripps Research Institute has discovered a genetic cause of progressive hearing loss. The findings will help scientists better understand the nature of age-related decline in hearing and may lead to new therapies to prevent or treat the condition.
  
  
• September 2, 2009
  Scripps Research Scientists Illuminate Structure of Circulating Lung Cancer Cells
  Most cancer-related deaths are caused by metastases—the spread of cancer to other parts of the body—and tumor cells that circulate in the bloodstream are generally understood to be the cause of these dangerous secondary tumors. Now, for the first time, a collaboration led by scientists from The Scripps Research Institute has been able to determine the structural features of circulating tumor cells, which were collected from the blood of a woman with advanced lung cancer.
  
  
• August 17, 2009
  Scripps Research, UCSD, and University of Oslo Team Definitively Ties Genetic Variations to Brain Size for First Time
  Using advanced brain imaging and genomics technologies, an international team of researchers co-led by Scripps Research Institute scientists has shown for the first time that natural variations in a specific gene influence brain structure. By establishing this link, the researchers have opened the door to a range of potential research efforts that could reveal gene variations responsible for a number of neurological conditions such as autism.
  
  
• August 6, 2009
  Scripps Research Scientists Find Early Evolution Maximized the "Spellchecking" of Protein Sequences
  Scientists at The Scripps Research Institute have examined how an enzyme responsible for adding one amino acid, alanine, to proteins has come to have its own spellchecker. Professor Paul Schimmel and colleagues show that two separate functions—alanine adding and editing—were joined together in a single enzyme during early evolution, in a way that greatly enhances these activities. The findings provide a glimpse into how enzyme functions have evolved.
  
  
• August 3, 2009
  Scripps Research Team Reports Breakthrough in Creating Live Mice from Skin Cells
  Scripps Research Institute scientists are reporting a breakthrough in stem cell research in which they successfully created live mice from mouse skin cells, without using embryonic stem cells or cloning techniques that require eggs. This milestone opens the door to the development of exciting therapies, such as using a patient's own cells to grow replacement organs.
  
  
• July 31, 2009
  Scripps Research Structure of Virus Protein Reveals How Viruses Hijack Cell Proteins
  Viruses are masters at taking over a host cell's machinery and using it to their own advantage. In doing so, they often disrupt the cell's mechanisms for keeping cell growth and division in check, wreaking havoc. Researchers from The Scripps Research Institute describe for the first time the structure of a protein from a type of virus called adenovirus as it grabs hold of two cell proteins, preventing them from performing their normal jobs .
  
  
• July 21, 2009
  Scripps Research Studies Lead to a Promising First-in-Class Drug Candidate
  Discoveries by Scripps Research Institute scientists have led to a promising new drug candidate—the first in its class—for patients with a genetic protein-misfolding disease. In results announced by the biopharmaceutical firm FoldRx Pharmaceuticals, Inc. today, the new drug tafamidis significantly halts disease progression for patients with a disease called Transthyretin (TTR) amyloid polyneuropathy (ATTR-PN).
  
  
• July 13, 2009
  Scripps Research Scientists Uncover a New Protein Necessary for the Proper Formation of the Immune System
  Armies of immune cells patrol our blood, fending off invading viruses and bacteria, and even destroying cancer cells. Researchers have elucidated intricate cascades of signals that orchestrate the step-by-step development of different immune cells, endowing them with unique functions and specificities. Professor Nicholas R. J. Gascoigne, Ph.D., and colleagues at The Scripps Research Institute have now discovered a critical signal that has remained elusive—until now.
  
  
• July 10, 2009
  Two Scripps Research Institute Scientists Win Prestigious Presidential Early Career Awards
  Two scientists from The Scripps Research Institute—Associate Professor Erica Ollmann Saphire, Ph.D., and Associate Professor Marisa Roberto, Ph.D.—have been selected to receive a Presidential Early Career Award for Scientists and Engineers, the highest honor bestowed by the United States government on young professionals at the outset of their independent research careers.
  
  
• July 7, 2009
  Chris T. Sullivan and Leanna Landsmann to Lead Scripps Florida Council
  Businessman and philanthropist Chris T. Sullivan, chairman of OSI Restaurant Partners, Inc., which includes the Outback Steakhouse chain, and editor, publisher, and educator Leanna Landsmann have been named co-chairs of the newly formed Scripps Florida Council.
  
  
• July 6, 2009
  Scripps Research Institute Appoints Scott Forrest as Director of Business and Technology Development
  The Scripps Research Institute has appointed Scott Forrest, formerly of the University of North Carolina (UNC), Chapel Hill, as the institute's new director of business and technology development.
  
  
• June 29, 2009
  Scripps Research Scientists Find Key Culprits in Lupus
  The more than 1.5 million Americans with systemic lupus erythematosus (or lupus) suffer from a variety of symptoms that flare and subside, often including painful or swollen joints, extreme fatigue, skin rashes, fever, and kidney problems. Researchers at The Scripps Research Institute have now identified the main trigger for the development of this disease.
  
  
• June 24, 2009
  Scripps Research Scientists Observe Human Neurodegenerative Disorder in Fruit Flies
  A team of scientists from The Scripps Research Institute, Katholeike Universiteit Leuven, and the University of Antwerp, Belgium, among other institutions, has created a genetically modified fruit fly that mimics key features of Charcot-Marie-Tooth disease, a common neurodegenerative disorder that strikes about one out of every 2,500 people in the United States.
  
  
• June 19, 2009
  Researchers Observe Single Protein Dimers Wavering Between Two Symmetrically Opposed Structures
  Researchers at The Scripps Research Institute, the University of California, San Diego, and Ohio State University have used a very sensitive fluorescence technique to find that a bacterial protein thought to exist in one "natural" three-dimensional structure (shape), can actually twist itself into a second form, depending on the protein's chemical environment. One folded form is active and the other is inactive, but the protein can easily morph from one state to another.
  
  
• June 12, 2009
  New Study Reveals Structure of the HIV Protein Shell
  New research by scientists at The Scripps Research Institute and other institutions provides a close-up look at the cone-shaped shell that is the hallmark of human immunodeficiency virus (HIV), revealing how it is held together—and possible ways to break it apart.
  
  
• June 11, 2009
  Scripps Research Team Creates Simple Chemical System that Mimics DNA
  A team of Scripps Research scientists has created a new analog to DNA that assembles and disassembles itself without the need for enzymes. Because the new system comprises components that might reasonably be expected in a primordial world, the new chemical system could answer questions about how life could emerge.
  
  
• June 11, 2009
  Arlene & Arnold Goldstein Foundation Gives $1.5 Million to Scripps Research Institute for Research on Amyloidosis
  The Arlene & Arnold Goldstein Family Foundation has given $1.5 million to support research in The Scripps Research Institute's Department of Molecular and Experimental Medicine.
  
  
• June 8, 2009
  Scripps Research Scientists Uncover a Novel Mechanism Controlling Tumor Growth in the Brain
  As survival rates among some patients with cancer continue to rise, so does the spread of these cancers to the brain—as much as 40 percent of all diagnosed brain cancers are considered metastatic, having spread from a primary cancer elsewhere in the body. Now, scientists from The Scripps Research Institute have discovered a molecular mechanism that plays a pivotal role in controlling cancer growth in the brain. The discovery could provide a basis for potentially effective therapies for the treatment of brain metastasis.
  
  
• May 13, 2009
  Scripps Research Scientists Devise New Strategy for Simplifying the Synthesis of Important Chemical Class
  Terpenes are a massive class of chemicals that includes numerous biological and commercial products, from vitamin A to the successful cancer drug Taxol^TM. But, despite widespread use, chemists have remained frustrated in their attempts to synthesize terpenes in the laboratory at sufficient scale for commercial or, in many cases, even research purposes. But at last, a Scripps Research Institute team has devised a terpene production method that could prove widely applicable to even the most sought-after molecules, opening a range of new drug development and other possibilities.
  
  
• May 13, 2009
  Scripps Research Scientists Discover Molecular Defect Involved in Hearing Loss
  Scientists from The Scripps Research Institute have elucidated the action of a protein, harmonin, which is involved in the mechanics of hearing. This finding sheds new light on the workings of mechanotransduction, the process by which cells convert mechanical stimuli into electrical activity. Defects in mechanotransduction genes can cause devastating diseases, such as Usher's syndrome, which is characterized by deafness, gradual vision loss, and kidney disease, which can lead to kidney failure.
  
  
• April 30, 2009
  Scripps Research Scientists Determine Workings of Potentially Useful Virus
  A group of scientists at The Scripps Research Institute hope to enlist the help of one particular virus to treat disease. Their discovery that the tiny plant virus, cowpea mosaic virus (CPMV), attaches itself to a specific protein on mammalian cells brings them closer to achieving this mission.
  
  
• April 29, 2009
  Darwin in a Test Tube
  A group of scientists at The Scripps Research Institute has set up the microscopic equivalent of the Galapagos Islands -- an artificial ecosystem inside a test tube where molecules evolve to exploit distinct ecological niches, similar to the finches that Charles Darwin famously described in The Origin of the Species 150 years ago.
  
  
• April 23, 2009
  Scripps Research/Pfizer Team Produces a Potential New Painkiller
  Scientists from the Scripps Research Institute and Pfizer, Inc. have discovered an exquisitely potent new chemical compound that harnesses the endocannabinoid system—a natural pain-controlling pathway—to deliver profound pain reduction. The compound, called PF-3845, could be pursued as a lead for a drug candidate and should prove an invaluable tool for researchers studying how the endocannabinoid system functions.
  
  
• April 23, 2009
  A Major Breakthrough in Generating Safer, Therapeutic Stem Cells from Adult Cells
  A group of researchers at The Scripps Research Institute and other institutions have achieved a breakthrough in converting adult cells all the way back to the most primitive embryonic-like cells without using the dangerous genetic manipulations associated with previous methods. The new technique solves one of the most challenging safety hurdles associated with personalized stem cell-based medicine because for the first time it enables scientists to make stem cells in the laboratory from adult cells without genetically altering them. This discovery has the potential to spark the development of many new types of therapies for humans, for diseases that range from Type 1 diabetes to Parkinson's disease.
  
  
• April 17, 2009
  Scripps Research Team Invents First Technique for Producing Promising Anti-Leukemia Agent
  Kapakahines, marine-derived natural products isolated from a South Pacific sponge in trace quantities, have shown anti-leukemia potential, but studies have been all but stalled by kapakahines' lack of availability. A team from The Scripps Research Institute has established the first technique to synthesize kapakahines in the laboratory in large quantities. With supplies now in hand, and unlimited production potential established, research on the compound can proceed and may eventually lead to new drug treatments.
  
  
• April 13, 2009
  Scripps Research Scientists Uncover Mimicry at the Molecular Level in a Critical Pathway that Protects Genome Integrity
  Mimicry is common in nature, where it is used as a key survival mechanism. Now scientists from The Scripps Research Institute have discovered molecular mimicry in a genetic integrity pathway, which is implicated in many human diseases, from cancer to neurodegenerative disorders such as Alzheimer's, Parkinson's, and Huntington's diseases.
  
  
• April 10, 2009
  Scripps Research Scientists Model 3-D Structures of Proteins that Control Human Clock
  Researchers at The Scripps Research Institute say they have taken a leap forward in their quest to understand the proteins that control the human circadian clock – the 24-hour wake-sleep cycle that, when interrupted, can lead to jet lag and other sleep disturbances.
  
  
• March 25, 2009
  Scripps Research Scientists Find Structure of a Protein that Makes Cancer Cells Resistant to Chemotherapy
  A research team at the Scripps Research Institute has obtained the first glimpse of a protein that keeps certain substances, including many drugs, out of cells. The protein, called P-glycoprotein or P-gp for short, is one of the main reasons cancer cells are resistant to chemotherapy drugs. Understanding its structure may help scientists design more effective drugs.
  
  
• March 16, 2009
  Scripps Research Scientists "Watch" as Individual Alpha-Synuclein Proteins Change Shape
  Much remains to be understood about what role alpha-synuclein, a protein mostly associated with Parkinson's disease, plays in the brain, either in a normal or diseased state. Researchers at The Scripps Research Institute have now used high-sensitivity single-molecule methods to show that it is a highly mobile protein, and can rapidly switch shapes depending on its environment.
  
  
• March 2, 2009
  Scripps Research Scientists Engineer New Type of Vaccination that Provides Instant Immunity
  A team of scientists at the Scripps Research Institute has found a way to use specially programmed chemicals to elicit an immediate immune response in laboratory animals against two types of cancer. The experiments, thus far performed only in mice, appear to overcome a major drawback of vaccinations—the lag time of days, or even weeks, that it normally takes for immunity to build against a pathogen. This new method of vaccination could potentially be used to provide instantaneous protection against diseases caused by viruses and bacteria, cancers, and even virulent toxins.
  
  
• February 25, 2009
  Scripps Research Scientists Develop General-Purpose Method for Detecting Trace Chemicals
  A team of scientists at The Scripps Research Institute has developed a method of sensitively detecting specific chemicals in the laboratory—a discovery that may lead to a host of new ways to monitor a variety of chemicals in nature.
  
  
• February 24, 2009
  Scripps Research Team Finds Immune Molecule that Attacks Wide Range of Flu Viruses
  Researchers at The Scripps Research Institute report the characterization of an immune system molecule that targets what appears to be an "Achilles heel" of a wide range of influenza viruses—including the viruses responsible for past global pandemics, those causing current common infections, and strains of bird flu believed to pose future world threats.
  
  
• February 22, 2009
  Scripps Research Team Establishes Vastly Improved Technique for Studying Critical Protein Group
  A team of Scripps Research Institute scientists has now developed a technique that offers a 10-fold improvement in the critical process of labeling glycoproteins. This opens the possibility of new studies to identify cancer biomarkers that will allow early cancer diagnoses, among numerous applications.
  
  
• February 18, 2009
  Scripps Research Study Shows How Microscopic Changes to Brain Cause Schizophrenic Behavior in Mice
  Disrupting the function of a key molecule in the brain leads to microscopic brain abnormalities and schizophrenia-like behavior in mice. These abnormalities are similar to those seen in the autopsied brains of people who diagnosed with schizophrenia in life, according to a team of scientists at The Scripps Research Institute.
  
  
• February 17, 2009
  Scripps Research Institute Board of Trustees Elects Mark Pearson as Newest Member
  The Scripps Research Institute Board of Trustees has elected philanthropist and entrepreneur Mark Pearson as its newest member. "We warmly welcome Mark to the board," says Scripps Research President Richard A. Lerner, M.D. "Mark's business acumen and extensive leadership experience will be a great asset to the continuing success of the institute."
  
  
• February 13, 2009
  New Scripps Research Technique Clears Path for Developing Drugs and Vaccines for Hemorrhagic Fever Diseases
  A team from the Scripps Research Institute has developed a novel method for studying arenaviruses, rodent-borne viruses that can cause hemorrhagic fever diseases. Currently, no licensed vaccines are available against arenaviruses and drug therapies are extremely limited. This development opens new avenues for vaccine development and identification of anti-viral drugs to combat human pathogenic arenaviruses.
  
  
• February 9, 2009
  Scientists at Scripps Research Identify a Mutation that Causes Inflammatory Bowel Disease
  A team of scientists at The Scripps Research Institute has linked a mouse mutation to an increased susceptibility for developing inflammatory bowel disease (IBD)—represented in humans as Crohn's disease and ulcerative colitis, which together are estimated to affect more than a million people in the United States. The findings may one day lead to new and better treatments for the disease.
  
  
• February 8, 2009
  Scripps Research Scientists Create First Crystal Structure of an Intermediate Particle in Virus Assembly
  A research team at the Scripps Research Institute has been able to produce the first crystal structure of a virus particle caught in the midst of assembling its impenetrable outer protein coat.
  
  
• February 2, 2009
  Team Led by Scripps Research Scientists Increases Understanding of Two Types of Blindness, Bolsters Simple Prevention Strategy, and Develops Gene Therapy Option
  A collaborative team of scientists from the Scripps Research Institute and other institutions has shed light on the causes of and potential treatment for two blinding conditions known as macular telangiectasia (MacTel) and retinal angiomatous proliferation (RAP), types of macular degeneration. Though based on mouse studies, the research bolsters the idea that humans suffering from these and other eye conditions may be able to help preserve function by adding antioxidants to their diet, and explains why this would work. The team also devised a new cell-based gene therapy technique that could eventually offer another option for arresting vision loss from these diseases.
  
  
• January 27, 2009
  W. Mark Crowell Joins Scripps Research as VP, Business Development
  The Scripps Research Institute has announced that W. Mark Crowell, previously of University of North Carolina (UNC) at Chapel Hill, has joined the institute as vice president for business development.
  
  
• January 20, 2009
  Scripps Research Scientists Find Drug Lessens Body's Massive and Often Deadly Immune Response to Flu Virus
  A team led by scientists from The Scripps Research Institute has shown that a drug that acts on a specific aspect of the immune system—rather than by killing the virus itself—may mitigate the virulence of influenza infection. The drug impacts the cytokine response, the body's signature immune reaction to influenza infection that can itself be lethal.
  
  
• January 15, 2009
  Scripps Research Scientists Find New Structural Motif in Key Enzymes Is Essential to Prevent Autoimmune Disease
  Scientists from The Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation (GNF) have found a specific mutation that leads to the development of severe autoimmune kidney disease in mice. The research sheds light on the basic biology of the immune system, as well as on the effectiveness of drugs such as the anti-leukemia medication Gleevec®/Imatinib.
  
  
• January 13, 2009
  Scripps Research Team Develops New Technique to Tap Full Potential of Antibody Libraries
  Antibodies are the attack dogs of the immune system, fighting off bacterial and other invaders. Massive libraries of synthetic antibodies that mimic this natural response, for instance to attack proteins critical to a particular cancer, are also available, but current techniques have allowed scientists to screen these antibodies for effectiveness against only a very limited number of disease-causing agents.
  
  
• January 9, 2009
  Scripps Research Scientists Find Cause of Cartilage Degeneration in Osteoarthritis
  A team led by scientists at The Scripps Research Institute has found an important link between a protein that declines with age and the development of osteoarthritis, the most common disease of aging affecting nearly 27 million Americans. The finding opens the door to developing effective new treatments for osteoarthritis. Currently, no treatment for this degenerative disease exists apart from palliative drugs for pain and inflammation.
  
  
• January 8, 2009
  The Immortal Molecule: Scripps Research Scientists Develop First Examples of RNA that Replicates Itself Indefinitely Without Any Help from Biology
  One of the most enduring questions is how life could have begun on Earth. Molecules that can make copies of themselves are thought to be crucial to understanding this process as they provide the basis for heritability, a critical characteristic of living systems. Now, a pair of Scripps Research Institute scientists has taken a significant step toward answering that question. The scientists have synthesized for the first time RNA enzymes that can replicate themselves without the help of any proteins or other cellular components, and the process proceeds indefinitely. 

2008

• December 22, 2008
  New Technique is Quantum Leap Forward in Understanding Proteins
  Proteins drive critical functioning in the cells of everything from bacteria to humans. But deciphering genomic data to discover just how the thousands upon thousands of proteins in a given organism interact has emerged as one of the most confounding biological challenges of the new century. In this ongoing quest, a group of Scripps Research Institute scientists, along with colleagues from the University of California, San Diego, (UCSD) have borrowed from physics to deliver one of those research rarities—an unmitigated success. The group has devised a computational method that, with remarkable accuracy, predicts how bacterial proteins fold and interact.
  
  
• December 18, 2008
  Team Led by Scripps Research Scientists Develop Method for Generating Novel Types of Stem Cells
  A team led by Scripps Research Institute scientists has for the first time developed a technique for generating novel types of rat and human stem cells with characteristics similar to mouse embryonic stem cells, currently the predominant type of stem cells used for creating animal models of human diseases in research. The technique potentially provides scientists with new sources of stem cells to develop drugs and treatments for human diseases.
  
  
• December 11, 2008
  Scripps Research Scientists Watch Membrane Fission in Real Time, Identifying a Cellular Fission Machine
  Researchers at The Scripps Research Institute have solved one of biology's neatest little tricks: they have discovered how a cell's outer membrane pinches a little pouch from itself to bring molecules outside the cell inside—without making holes that leak fluid from either side of the membrane.
  
  
• November 24, 2008
  Scripps Research Scientists Shed Light on How DNA Is Unwound So That Its Code Can Be Read
  Researchers at The Scripps Research Institute have figured out how a macromolecular machine is able to unwind the long and twisted tangles of DNA within a cell's nucleus so that genetic information can be "read" and used to direct the synthesis of proteins, which have many specific functions in the body.
  
  
• November 21, 2008
  Scripps Research Scientists Identify Blood Component that Turns Bacteria Virulent
  Scientists from the Scripps Research Institute have discovered the key chemical that signals Bacillus anthracis, the bacterium that causes anthrax, to become lethal. This finding opens up new avenues of exploration for the development of treatments for bacterial infections.
  
  
• November 16, 2008
  Scripps Research and New York University Scientists Discover New Cause of Fatal Brain Injury from Acute Viral Meningitis
  What was once thought to be the culprit responsible for fatal brain damage in acute viral meningitis has now been found to be only an accomplice, say researchers at The Scripps Research Institute and New York University.
  
  
• November 14 , 2008
  San Diego Philanthropist John Moores Gives $2.1 Million to Scripps Research Institute
  San Diego philanthropist, businessman, and community leader John J. Moores has contributed the first gift of $2.1 million to The Scripps Research Institute's new $50 million initiative to recruit new world-class researchers and sustain and expand the work of current scientists at the renowned La Jolla- and Florida-based biomedical organization, the Institute announced.
  
  
• November 10, 2008
  Scripps Research Scientists Uncover New Mechanism Closely Linked to Neurodegeneration and Alzheimer's
  Scientists from The Scripps Research Institute have uncovered a novel mechanism that may play a significant role in the development of Alzheimer's disease and a host of other neurodegenerative conditions. The discovery of this mechanism points towards potential new targets that could lead to treatments to enhance neuron survival.
  
  
• November 5, 2008
  Scripps Research Scientists Identify Exciting New Compounds for Stem Cell Production from Adult Cells
  Scientists from The Scripps Research Institute have identified a combination of small molecules that significantly improve the reprogramming of general adult cells into pluripotent stem cells, which can then develop into all cell types.
  
  
• October 27, 2008
  Scripps Research Scientists Develop A New Strategy to Fight Obesity
  Scientists from The Scripps Research Institute have discovered a catalytic antibody that degrades a known appetite stimulant. The antibody works against the gastric hormone ghrelin, which has been linked to weight gain and fat storage through its metabolic actions. These findings point towards a potentially novel treatment for obesity that would interfere directly with the some of the biological mechanisms determining weight.
  
  
• October 23, 2008
  Pioneering Neuroscientist Hollis T. Cline Joins The Scripps Research Institute
  The Scripps Research Institute has announced the appointment of innovator and neuroscientist Hollis "Holly" T. Cline, Ph.D., as professor in the institute's Departments of Cell Biology and Chemical Physiology.
  
  
• October 21, 2008
  Scripps Research Scientists Enhance Immune System Attacks on Cancer
  Researchers at The Scripps Research Institute have tweaked, prodded, and pushed immune system cells into successfully attacking tumors in laboratory and animal studies. They say their new strategy could prove to be safer than some treatments now being used to stimulate cancer immunity in humans.
  
  
• October 17, 2008
  Scripps Research Team Sheds Light on Immune System Suppression
  Diseases such as HIV, tuberculosis, and measles claim countless lives by weakening immune systems in ways that have remained unclear. But a team from The Scripps Research Institute has for the first time pinpointed a clear mechanism for immunosuppression. They have shown how an initial viral infection can block production of critical immune system proteins known as type I interferons, leading to susceptibility to other, potentially deadly infections.
  
  
• October 12, 2008
  Team Led by Scripps Research Scientists Uncovers New Way to Limit Damaging Production of Nitric Oxide
  Excess nitric oxide production by one enzyme has been tied to human illnesses ranging from inflammation to cancer, but adequate treatments for the problem have been elusive. Now, work led by scientists at The Scripps Research Institute has revealed a new method for chemically targeting this single enzyme to block troubling nitric oxide production, without limiting its beneficial production by other closely related enzymes.
  
  
• October 8, 2008
  Scripps Research Team Solves Structure of "Beneficial" Virus
  Researchers at The Scripps Research Institute have, for the first time, solved the structure of a virus that can infect specific cancer cells. This new knowledge may help drug designers tweak the pathogen enough so that it can attack other tumor subtypes.
  
  
• October 3, 2008
  Study Unveils Structural Details of Enzyme Vital to DNA Repair
  Working in close collaboration, two groups of scientists at The Scripps Research Institute have revealed for the first time details of the crucial role played by the enzyme Mre11 in DNA repair, a process critical to cell survival and good health.
  
  
• October 2, 2008
  Scientists Define Structure of Important Neurological Receptor, Establishing a Platform to Understand G Protein-Coupled Receptors
  Scientists from The Scripps Research Institute have determined the structure of an adenosine receptor that plays a critical role in a number of important physiological processes including pain, breathing, and heart function. The findings could lead to the development of a new class of therapeutics for treating numerous neurological disorders, including Parkinson's and Huntington disease.
  
  
• October 1, 2008
  The Scripps Research Institute and the International AIDS Vaccine Initiative Launch World's First Dedicated HIV Neutralizing Antibody Center
  The Scripps Research Institute and the International AIDS Vaccine Initiative (IAVI), the world's only global non-profit organization focused solely on AIDS vaccine development, announced the establishment of a new research center dedicated exclusively to solving the most pressing challenge facing AIDS vaccine researchers today.
  
  
• September 15, 2008
  Team Led by Scripps Research Scientists Finds Gene Critical to Normal Hearing
  Researchers at The Scripps Research Institute have discovered a new gene they say is essential for both hearing and balance in mice and humans. They found that a mutation in this gene causes a form of deafness that has nothing to do with structural proteins in the inner ear—commonly altered in hereditary deafness. On the contrary, the mutation affects an enzyme with a known catalytic function, which gives hints as to how the problem might be preventable with novel drug therapy.
  
  
• September 15, 2008
  Scripps Research Team Reverses Huntington's Disease Symptoms in Mice
  There is no cure for Huntington's disease, or even treatments that can reverse or slow progression of the devastating movement deficits and cognitive dysfunction that occur with the condition. But, now, an agent developed by scientists at The Scripps Research Institute has shown dramatic therapeutic efficacy in experimental mice, and did so with minimal toxicity.
  
  
• September 9, 2008
  Scripps Research Study Topples the One Drug-One Disease Paradigm for Combating Protein-Folding Diseases
  Scientists at The Scripps Research Institute have discovered that a single small molecule may be effective in treating multiple protein-folding diseases, breaking the one drug-one disease approach that has guided the pharmaceutical and biotechnological industries for so many years.
  
  
• August 25, 2008
  Scripps Research Scientists Find Gene Expression Profile Shared by Pluripotent Stem Cells
  An international team of researchers led by Professor Jeanne Loring, Ph.D., of The Scripps Research Institute has developed a novel method to identify pluripotent stem cells--cells that can differentiate into multiple distinct cell types. These pluripotent cells hold great promise for drug development and treatment of many devastating disorders.
  
  
• August 21, 2008
  New Protein Survey by Scripps Research Scientists Upends Understanding of Cell Death Process
  Results from a Scripps Research Institute study have nearly tripled the number of proteins known to be involved in the critical process of programmed cell death, and have shot down a long-held idea about the life cycle of proteins. The work opens doors for potential new drug discoveries, and may open countless more as the new technique that enabled the work, dubbed the PROTOMAP, is applied to studies of other cellular functions.
  
  
• August 8, 2008
  New Scripps Research Study Solves Structural Mystery of Cellular Protein Transport
  Scientists at The Scripps Research Institute have determined the structure of the protective protein coat surrounding intracellular vesicles or sacs that are needed to transport proteins out of the cell. Understanding this structure could shed critically needed light on many loss-of-function diseases such as atherosclerosis, diabetes, obesity and cystic fibrosis and lead to potential new therapies.
  
  
• August 7, 2008
  Scripps Research Scientists Find Modified Protein Containing an Unnatural Amino Acid that Breaks Immune Tolerance
  Scientists at The Scripps Research Institute have produced a powerful immune response in mice by incorporating an unnatural amino acid into a target protein. This novel approach could prove useful in the development of new vaccines for cancer, infectious diseases, and other disorders.
  
  
• August 6, 2008
  Scripps Research Team Unravels New Cellular Repair Mechanism
  A Scripps Research team has unraveled a new biochemical pathway that triggers a critical repair response to correct errors in the DNA replication process that could otherwise lead to harmful or fatal mutations in cells.
  
  
• July 9, 2008
  Scripps Research Scientists Reveal Key Structure from Ebola Virus
  Scientists at The Scripps Research Institute have determined the structure of a critical protein from the Ebola virus, which, though rare, is one of the deadliest viruses on the planet killing between 50 and 90 percent of those infected.
  
  
• June 27, 2008
  Scripps Research Study of Disease-Causing Mutations Uncovers Surprising Pattern
  A new Scripps Research Institute survey of genetic mutations definitively tied to diseases has revealed clustering in a specific region of an important class of enzymes. The pattern was so clear it suggests that other mutations contributing to a wide range of diseases are likely to be tied to the region. New searches focused there may therefore lead to a wealth of new targets for drug treatments.
  
  
• June 24, 2008
  Business Executive Amin J. Khoury Elected To Scripps Research Institute Board Of Trustees
  International business leader and entrepreneur Amin J. Khoury has been elected to the Board of Trustees of The Scripps Research Institute, a world leader in biomedical science with laboratories in La Jolla, California, and Palm Beach County, Florida.
  
  
• June 19, 2008
  Scripps Research Scientists Find Pathogen Uses Unique Strategy to Inhibit Human Immune Response
  Scientists at The Scripps Research Institute have uncovered a unique strategy used by some common bacteria to disrupt the human immune system, maintaining persistent infections and ensuring the bacteria's survival.
  
  
• June 10, 2008
  Research Unveils New Stabilizing and Signaling Properties of Cholesterol in Key Human Receptors
  Scientists at The Scripps Research Institute have structurally shown for the first time that cholesterol acts as a stabilizing factor for an important family of cell receptors.
  
  
• June 4, 2008
  Researchers Discover Synthetic Chemicals that Create Pluripotent Stem Cells from Adult Cells
  Scientists at The Scripps Research Institute report that they have significantly improved upon a revolutionary technique that uses genes to turn skin cells from an adult back into pluripotent stem cells.
  
  
• May 29, 2008
  NIH awards $20 million CTSA grant to Scripps Translational Science Institute
  The National Institutes of Health (NIH) announced today that Scripps Translational Science Institute (STSI) is one of 14 research centers to receive a highly competitive $20 million Clinical and Translational Science Award (CTSA) this year. STSI, led by Eric J. Topol, M.D., is a collaborative program between The Scripps Research Institute and Scripps Health, partnering with a number of institutions in San Diego.
  
  
• May 29, 2008
  Scripps Research Crystal Structure Reveals Mystery Behind Three Rare Childhood Disorders
  Researchers at The Scripps Research Institute have figured out how it is that tiny mutations in a single gene can produce three strikingly different childhood diseases—disorders that increase cancer risk thousands of times in some young patients and premature aging or a complete failure to develop in others. Investigators say that knowing more about the mechanisms of these diseases may provide insights into how therapeutic drugs can be designed.
  
  
• May 27, 2008
  Scripps Research Scientists Find Seizure Drug Reverses Cellular Effects of Alcohol Addiction in Models
  New findings from scientists at The Scripps Research Institute provide evidence that the drug gabapentin affects certain components of the alcohol addiction cycle in the brain, supporting the idea that the medication, which is approved by the U.S. Food and Drug Administration for treating seizures and pain, also holds potential for the treatment of alcohol dependence.
  
  
• May 20, 2008
  Scripps Research Institute Awarded Patent for Remarkable Chemical Technology
  The Scripps Research Institute has been awarded U.S. Patent No. US 7,375,234 B2, which covers a broad class of chemical reactions that mimic biological efficiency and opens the door to a new world of chemistry. The patent's diverse potential applications include the development of new drugs, bioactive nanomaterials, anti-bacterial and non-immunogenic coatings for medical implants, coatings for semiconductors, coatings and adhesives for ships' hulls, self-healing materials, microelectronics and responsive nanomaterials, and surface-sensitive adhesives, to name a few.
  
  
• May 15, 2008
  Scripps Research Team Devises Innovative Method to Produce Highly Sought-After Drug
  A team of Scripps Research Institute scientists has developed an inexpensive and in many ways astonishing new method for economically producing a promising pharmaceutical steroid. The molecule, called cortistatin A, which was isolated in 2006 from a marine sponge discovered over 100 years ago, has shown huge promise for treating conditions ranging from macular degeneration to cancer.
  
  
• May 7, 2008
  New International Agreement Advances Scripps Research Study of Alcoholism
  The Scripps Research Institute in La Jolla, California, and the Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg, France, have entered into an agreement that aims to advance research on the biological basis of alcohol abuse. The research may uncover keys to vulnerability to alcoholism and help to develop new approaches for treating the condition.
  
  
• May 1, 2008
  Scripps Research Study Identifies Protein Critical for Iron Absorption
  Scientists at The Scripps Research Institute have pinpointed an important protein that is essential for the normal absorption of iron in the body. The discovery could lead to novel therapies to block anemia during chronic diseases or to treat hemochromatosis, a genetic disease caused by an overabundance of iron.
  
  
• April 29, 2008
  Three Scripps Research Scientists Elected to National Academy of Sciences
  Three members of The Scripps Research Institute faculty have been elected to the U.S. National Academy of Sciences, it was announced today. Scripps Research is the only independent research institution in the nation to have three faculty members chosen this year.
  
  
• April 14, 2008
  Scientists Create First Successful Libraries of Avian Flu Virus Antibodies
  An international group of American and Turkish research scientists, led by Sea Lane Biotechnologies, has created the first comprehensive monoclonal antibody libraries against avian influenza (H5N1) using samples from survivors of the 2005/2006 "bird flu" outbreak in Turkey. These antibody libraries hold the promise for developing a therapy that could stop a pandemic in its tracks and provide treatment to those infected, as well as potentially pointing the way towards the development of a universal flu vaccine. The expanded treatment and containment options offered by Sea Lane's antibody libraries could help provide healthcare officials, researchers, and governments with unprecedented resources to combat this serious global health threat.
  
  
• April 11, 2008
  New Scripps Research Study Finds T Cell Multiplication Unexpectedly Delayed After Infection
  In a surprising outcome that overturns the conventional wisdom on the body's immune response to infection, scientists at The Scripps Research Institute have shown that T cells do not begin proliferation until up to three days after infection.
  
  
• April 10, 2008
  Small RNAs May Play Big Role in Embryonic Stem Cells
  An international team led by scientists at The Scripps Research Institute has used a new method to discover an unusual molecular signature in human embryonic stem cells that may lead to development of new cell-based therapeutics.
  
  
• April 8, 2008
  Scripps Research Scientists Automate Molecular Evolution
  Under the control of a computer at The Scripps Research Institute, a population of billions of genes morphed through 500 cycles of forced adaptation to emerge as molecules that could grow faster and faster on a continually dwindling source of chemical fuel—a feat that researchers describe as an example of "Darwinian evolution on a chip."
  
  
• March 26, 2008
  Renowned Stem Cell Researcher Jeanne F. Loring Heads New Center at The Scripps Research Institute
  Professor Jeanne F. Loring, Ph.D., has been named founding director of the newly created Center for Regenerative Medicine at The Scripps Research Institute in La Jolla, California.
  
  
• March 14, 2008
  Scripps Research Team Wins $4 Million Grant to Study Effects of Chronic Marijuana Use
  A group of investigators led by The Scripps Research Institute's Professor Barbara Mason has won a $4 million grant from the National Institute of Drug Abuse (NIDA) of the National Institutes of Health (NIH) to study the effects of chronic marijuana use, including influence on brain function and the consequences of withdrawal.
  
  
• March 10, 2008
  Scripps Research Scientists Identify Potential New Target for Treating Metastatic Cancer
  A team of scientists at The Scripps Research Institute have identified a human protein that may be a new target for future cancer therapies. By experimentally blocking the action of this protein, called CD151, the team showed they could stop cancer cells from metastasizing, or spreading from one tumor to establish new tumors elsewhere.
  
  
• February 28, 2008
  Bright Lights: Mystery of Glowing Antibody Solved by Scripps Research Scientists
  A chance discovery of a uniquely luminescent monoclonal antibody nearly ten years ago has proven to be far more interesting—and far more tenacious—than anyone might have suspected. Now, a group of Scripps Research scientists have shown that EP2-19G2, one of a panel of fluorescent monoclonal antibodies that were first reported in 2000, produces its distinctive bright blue glow through a rare and highly complex recombination of electrical charge.
  
  
• February 27, 2008
  Scripps Research Scientists Devise Approach that Stops HIV at Earliest Stage of Infection
  Researchers at The Scripps Research Institute have developed a new two-punch strategy against HIV and they have already successfully tested aspects of it in the laboratory.
  
  
• February 27, 2008
  Scripps Research Institute Scientists Studying Sepsis in Mice Find Potential Drug Targets for Deadly Disease
  Scientists at The Scripps Research Institute have uncovered a connection between blood coagulation and the immune system that may have important implications for people with sepsis, a severe and difficult to treat disease that kills tens of thousands of Americans a year.
  
  
• February 21, 2008
  Scripps Research Study Uncovers New Mechanism of Long-Term Memory Formation
  Scientists at The Scripps Research Institute have identified specific features of neurons that are critical components of the learning process and the development of long-term memory.
  
  
• February 13, 2008
  Scripps Research Scientists Find Protein May Protect Against Alzheimer's Disease
  Scientists at The Scripps Research Institute report that a protein capable of producing what has been called "Alzheimer's of the heart" has been found to protect against development of Alzheimer's disease in the brain in rodent models.
  
  
• February 8, 2008
  In Memoriam: Frank J. Dixon, 1920-2008
  Frank J. Dixon, pioneering immunologist and founder of The Scripps Research Institute, died in San Diego, California, on Friday, February 08, 2008. He was 87.
  
  
• February 7, 2008
  Scripps Research Team Finds Genetic Mutation May Lead to Increased Autoimmunity
  Scientists at The Scripps Research Institute have discovered that a mutation in a known DNA recombination mechanism may result in the onset of autoimmunity and an overexpression of autoreactive antibodies—molecules that attack the host—in animal models.
  
  
• February 4, 2008
  Scripps Research Scientists Find That Calcium Channel Blockers Help Normalize Lysosomal Storage Disease Patient-Derived Cells
  Scientists at The Scripps Research Institute have discovered that two widely available prescription drugs restore partial cellular folding, trafficking, and function to a variety of mutant enzymes responsible for three distinct lysosomal storage diseases, maladies involving multiple organ system failure.
  
  
• January 23, 2008
  Scripps Research Scientists Discover New Gene Linked to Fragile X Syndrome
  Scientists at The Scripps Research Institute have discovered a new gene involved in fragile X syndrome, a condition that often shares many symptoms of autism. The discovery may lead to new tests or treatments for several neurological disorders.
  
  
• January 17, 2008
  Scripps Research Scientists Find New Genetic Mutation that Halts the Development of Lupus
  Scientists at The Scripps Research Institute have uncovered a specific genetic mutation that suppresses the development of systemic lupus, an incurable autoimmune disease that causes the body to attack itself. The research suggests potential targets for future drug development.
  
  
• January 16, 2008
  Scripps Research Scientists: Naturally Occurring Peptide Inhibits Common Viral Infection
  Scientists at The Scripps Research Institute have found that a naturally occurring peptide known for its antibacterial action can also inhibit viral infection.
  
  
• January 3, 2008
  Renowned Immunologist Richard Ulevitch Retires from Scripps Research Institute
  The Scripps Research Institute today announced the retirement of Professor Richard Ulevitch, chairman of the Immunology Department and an internationally renowned researcher in the field of innate immunity.
  
  
• January 2, 2008
  Scripps Research Scientists Discover Remarkable Editing System For Protein Production
  Even small mistakes made by cells during protein production can have profound disease effects, but the processes cells use to correct mistakes have been challenging to decipher. Recent work by scientists at The Scripps Research Institute, however, has uncovered two surprising new methods for such editing. 

2007

• December 20, 2007
  Scripps Research and St. Jude's Team Finds a Widely Used Anti-Malarial Drug Prevents Cancer Development
  Scientists at The Scripps Research Institute and St. Jude's Children's Research Hospital have found that a commonly prescribed anti-malarial drug effectively prevents the development of certain types of human cancer in mouse models.
  
  
• December 18, 2007
  Scripps Research Discovery Leads to Broad Potential Applications in CovX-Pfizer Deal
  A catalytic antibody discovery made at The Scripps Research Institute has formed the basis of the upcoming acquisition of biotechnology venture CovX by pharmaceutical giant Pfizer, Inc.
  
  
• December 6, 2007
  Scripps Research Scientists Discover Chemical Triggers for Aggression in Mice
  A group of scientists at The Scripps Research Institute has discovered specific pheromone compounds responsible for eliciting aggressive behavior in mice. They have also identified the first step in the neurological pathway that triggers the aggressive response.
  
  
• December 5, 2007
  Richard Lerner to Receive Research!America Advocacy Award
  Richard A. Lerner, MD, president of The Scripps Research Institute in La Jolla, California, has been named Research!America's 2008 Builders of Science award recipient. He will accept the award at Research!America's 12th Annual Advocacy Awards Gala on March 18, 2008, at the Andrew W. Mellon Auditorium in Washington, DC.
  
  
• December 5, 2007
  Scripps Research Scientists Find White Blood Cells Deliver Boost to Tumors
  Scientists at The Scripps Research Institute have found that a specific type of white blood cell carries with it an unusually potent catalyst of tumor growth. The catalyst promotes angiogenesis, the formation of new blood vessels, which are critical to tumor growth.
  
  
• November 14, 2007
  Scripps Research Scientists Develop Modeling Method that Increases Our Understanding of Diseases like Cystic Fibrosis and Alzheimer's
  A team of scientists at The Scripps Research Institute has come up with a simple but comprehensive way of probing the parts of our biological machinery that controls protein folding, packaging, and export from our cells.
  
  
• October 30, 2007
  Scripps Research Team Blocks Bacterial Communication System to Prevent Deadly Staph Infections
  In hopes of combating the growing scourge of antibiotic-resistant bacteria, in particular drug-resistant staph bacteria, a team of scientists from The Scripps Research Institute has designed a new type of vaccine that could one day be used in humans to block the onset of infection. The advantage of the new vaccine is that it would work not only on current bacterial resistant stains but also would not induce the potential for new bacterial resistance because, rather than killing bacterial cells, it blocks their communication system, preventing the shift from harmless to virulent, thus allowing the body's natural defenses to combat the bacteria.
  
  
• October 30, 2007
  Mass Spectrometry Metabolomics Unveils Unique Markers for Childhood Disorders
  For the first time, scientists at The Scripps Research Institute have applied untargeted mass spectrometry-based metabolomics to uncover a number of unique molecular markers in two inherited childhood metabolic disorders. This new method could prove useful in diagnosis and patient clinical evaluation.
  
  
• October 26, 2007
  Scripps Research Wins $51 Million Contract to Study Critical Immune Response Mechanisms
  The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has awarded a $51 million five-year contract to The Scripps Research Institute to study innate and adaptive immune responses to a number of pathogens, including the influenza virus. Richard Ulevitch, Scripps Research professor and chairman of the Department of Immunology, will lead the project as principal investigator.
  
  
• October 25, 2007
  New Scripps Research Mass Spectrometry NanoTechnology Delivers Significant Advances
  Scientists at The Scripps Research Institute have developed a new mass spectrometry technology for studying small biomolecules. The new highly sensitive and robust technology, called Nanostructure-Initiator Mass Spectrometry (NIMS), enables the analysis of single cells, tissue imaging, and rapid blood and urine analysis with no advanced sample preparation.
  
  
• October 11, 2007
  Novel Yeast Protein Plays a Key Role in Repairing Double-Strand DNA Breaks
  Scientists at The Scripps Research Institute have uncovered a novel protein in yeast that plays a key role in controlling the repair of double-strand breaks in DNA. The discovery of the protein, Ctp1, and its role, strongly suggests that the same mechanism works in regulating DNA damage repair in human cells and may point the way to future cancer therapies.
  
  
• October 4, 2007
  Scripps Research Scientists Develop Innovative Dual Action Anthrax Vaccine-Antitoxin Combination
  Scientists at The Scripps Research Institute and The Salk Institute for Biological Studies have developed a new and highly effective agent that provides protection against anthrax by combining a fast-acting anthrax toxin inhibitor with a vaccine in a single compound.
  
  
• October 4, 2007
  New Pearson Family Chair at Scripps Research to Support Forward-Looking Alcohol and Addiction Research
  The Scripps Research Institute has announced that Professor Barbara Mason, Ph.D., has been appointed the first recipient of The Pearson Family Chair, a newly endowed position in alcohol and addiction research at the institute.
  
  
• October 4, 2007
  Structure of HIV Capsid Protein Reveals Potential Weakness at Inner Core of Virus
  Scientists at The Scripps Research Institute have published a detailed molecular model of the full-length HIV CA protein—a viral protein that forms a cone-shaped shell around the genome of HIV. This structure reveals a never-before-seen molecular interaction that may be a weakness at the core of the virus.
  
  
• October 1, 2007
  Scripps Research Study Reveals Mechanism Behind Nicotine Dependency
  Many more people try to quit smoking than succeed in giving up this nicotine-delivering habit. Now, a group of scientists at The Scripps Research Institute has identified one neurobiological mechanism that contributes to nicotine dependence, and to the anxiety and craving experienced upon withdrawal. The findings also suggest a new approach to developing drugs that could help smokers quit.
  
  
• September 5, 2007
  Scripps Research Scientists Shed New Light on How Antibodies Fight HIV
  Leading an international team of scientists, immunologists at The Scripps Research Institute have uncovered the first evidence that an HIV antibody is most effective when it binds not only to the virus, but also to host immune cells. The findings suggest that antibody efficiency depends on both directly neutralizing the virus and activating the host immune response.
  
  
• September 5, 2007
  Scripps Research Scientists Reveal Pivotal Hearing Structure
  A team of scientists made up of two laboratory groups from The Scripps Research Institute and one from the National Institutes of Health has shed light on how our bodies convert vibrations entering the ear into electrical signals that can be interpreted by the brain. Exactly how the electrical signal is generated has been the subject of ongoing research interest.
  
  
• September 4, 2007
  Scripps Research Institute Scientist Bruce Beutler Awarded 2007 Balzan Prize
  Bruce Beutler, M.D., chair of the Genetics Department at the Scripps Research Institute, has been awarded the prestigious 2007 Balzan Prize for his work in innate immunit. He shares the $827,000 prize with Jules Hoffmann of the Academie des Sciences in Paris.
  
  
• August 30, 2007
  New Study Pinpoints Specific Neurons Involved In Memory Formation
  In a remarkable new study, scientists at The Scripps Research Institute have unlocked one of the secrets of how memory is formed. Working with a unique breed of transgenic mice, the new study has shown for the first time that the same neurons activated during fear conditioning are, in fact, reactivated during memory retrieval.
  
  
• July 17, 2007
  New "Checkmate" Method from The Scripps Research Institute Provides Powerful New Tool for Preventing Spread of Future Epidemics
  Scientists from The Scripps Research Institute have developed a breakthrough methodology that can be used to rapidly predict how viruses such as avian influenza H5N1, a dangerous strain of "bird flu," will mutate in response to attacks by the immune system. The new approach, dubbed "checkmate analysis," may also predict which antibodies or small molecule therapeutics will best neutralize these viral mutations before they can develop into global epidemics.
  
  
• June 25, 2007
  Scripps Research Study Links Chronic Methamphetamine Abuse and Cardiovascular Disease
  Scientists at The Scripps Research Institute have found that chronic abuse of the highly addictive drug methamphetamine may be an unrecognized risk factor in the development of a number of potentially serious cardiovascular disorders frequently reported by methamphetamine abusers.
  
  
• June 20, 2007
  Scripps Research Institute President Richard A. Lerner Receives Honorary Degree from Oxford University
  Richard A. Lerner, M.D., president of The Scripps Research Institute, was recognized today with an honorary doctor of science degree from the University of Oxford for his innovative work as a chemist.
  
  
• June 19, 2007
  Kristin Baldwin of Scripps Research Institute Named To Highly Selective Pew Scholars Program
  The Pew Charitable Trusts and the University of California at San Francisco (UCSF) announced today that Kristin K. Baldwin, Ph.D., was named one of 20 exceptional researchers selected as 2007 Pew Scholars in the Biomedical Sciences. As a Pew Scholar, each scientist will receive a $240,000 award over four years to help support his or her research, as well as gain inclusion into a unique community of scientists that encourages collaboration and the exchange of ideas. The program is funded by Pew through a grant to UCSF.
  
  
• June 19, 2007
  Scripps Research Scientists Show Protein Accelerates Breast Cancer Progression in Animal Models
  Scientists at The Scripps Research Institute have shown for the first time that a cytokine called pleiotrophin stimulates the progression of breast cancer in both animal and cell culture models. The study, which tested three separate models to determine the role of inappropriate expression of pleiotrophin, found that it produced striking increases in aggressiveness of the breast cancer cells themselves.
  
  
• June 18, 2007
  Scripps Research Scientists Discover Mouse Appetite Suppressant
  A protein called interleukin-18 (IL-18), previously known mainly for its role in the immune system, is also a powerful appetite suppressant for mice once they reach the equivalent of adulthood, according to scientists at The Scripps Research Institute. Members of the research team hope the work will eventually lead to the development of new treatments for preventing obesity in humans. Unlike similar proteins, IL-18 suppresses appetite without unwanted side effects such as fever or sickness behavior, suggesting it might be a particularly good target for further study.
  
  
• May 29, 2007
  Scripps Research Institute Team Awarded $17 Million Grant to Develop Therapeutic Use of Adult Stem Cells to Treat Eye Diseases
  A group of scientists at The Scripps Research Institute has been awarded a five-year, $17,037,185 grant from the National Eye Institute (NEI), part of the National Institutes of Health. The grant, starting June 1, 2007, will support the development of the use of adult stem cells as a therapy for treating the most common types of vision loss.
  
  
• May 23, 2007
  Study Reveals Process Linking Disordered Protein Folding and Binding
  A group of scientists at The Scripps Research Institute and the Skaggs Institute for Chemical Biology have uncovered one of the processes by which disordered or unstructured proteins become bound to specific cellular sites. The findings offer valuable insights into how proteins carry out their genetically encoded functions, and may provide promising new targets for future drug development.
  
  
• May 3, 2007
  Study Led by Scripps Research Scientist Reveals Little-Known Cell Networks Vital to Circadian Rhythm
  In a wide-ranging systems biology study of circadian rhythm, a multi-institutional collaboration led by Scripps Research Institute Professor Steve Kay has uncovered some little-known cellular mechanisms for sustaining circadian rhythm and limiting the impact of genetic clock mutations in mammals. The new findings could have important implications for future circadian studies, and point researchers toward new ways to manipulate human circadian rhythm at the molecular level to treat diseases such as bipolar disorder.
  
  
• May 2, 2007
  Scripps Research Team Sheds Light on Long-Sought Cold Sensation Gene
  Scientists from The Scripps Research Institute and the Novartis Research Foundation have shown that a gene called TRPM8 is responsible for the bulk of this ability in mice. The discovery, reported in the May 3 issue of the journal Neuron, might one day lead to the development of drugs that induce cold sensation as an analgesic, or block it to prevent certain forms of chronic pain associated with cold sensation.
  
  
• April 10, 2007
  Scripps Research Team Unravels Drug Target for Parasitic Diseases
  The ongoing search for better treatments for devastating parasitic diseases such as Chagas' disease and African sleeping sickness now has a new target, thanks to research by a team from The Scripps Research Institute. The group now understands better a critical DNA-protein binding event that, if blocked, can kill the parasites that cause the diseases. The researchers are already working to screen drugs that will block this mechanism.
  
  
• April 9, 2007
  Study Shows Humans and Plants Share Common Regulatory Pathway
  Scientists at The Scripps Research Institute have shown for the first time that humans and plants share a common pathogen recognition pathway as part of their innate immune systems. The data could help shed fresh light on how pathogen recognition proteins function and the role they play in certain chronic inflammatory diseases.
  
  
• April 5, 2007
  Scripps Research Scientists Identify New Regulatory Mechanism for Critical Protein Signaling Domain
  In a study with far-reaching implications, scientists at The Scripps Research Institute and other institutions have for the first time identified a new in vivo regulatory mechanism for the PH Domain, a component of many proteins that allows them to move from a cell's interior to the cell membrane in response to stimulation of cell surface receptors. The findings offer a promising avenue for the development of novel therapies for immunodeficiency or autoimmune diseases.
  
  
• April 4, 2007
  Scripps Research Team Reveals Major Role for Novel Neurotransmitter System in Regulating Drug Intake
  A team of researchers at The Scripps Research Institute has provided strong new evidence that a novel neurotransmitter system in the brain is involved in alcohol and opiate addiction. The group found that levels of endogenous cannabinoids increase or decrease in direct proportion to the amount of alcohol or opiates consumed. By providing insight into possible new targets for drug therapy, this work opens up novel avenues for regulating addiction.
  
  
• March 28, 2007
  Scripps Research Institute Presents Latest on Treatments for Cardiovascular Diseas, Stroke, Alzheimer's, and Arthritis
  Three leading scientists at the Scripps Research Institute will give a free lecture titled "Current Research and Developing New Treatments for Cardiovascular Disease, Stroke, Alzheimer's, and Arthritis—On the Front Lines of Hope," Wednesday evening, April 25 in La Jolla.
  
  
• March 19, 2007
  Synthetic Production of Potential Pharmaceuticals Dramatically Simplified by Scripps Research Team
  A team of researchers at The Scripps Research Institute has developed new techniques that dramatically reduce the time, complexity, and cost of synthesizing natural products with pharmaceutical potential. The work dislodges previously entrenched beliefs in the organic chemistry field about how such products must be produced, and could help to advance and expand the use of natural products in drug discovery programs.
  
  
• February 27, 2007
  New Scripps Research Monoclonal Antibody Destroys Methamphetamine In Vitro
  Scientists at The Scripps Research Institute have developed a new monoclonal antibody that destroys the highly addictive drug methamphetamine. These new findings suggest an entirely new way to treat the global epidemic of methamphetamine abuse.
  
  
• February 12, 2007
  Scripps Research Study Reveals Structural Dynamics of Single Prion Molecules
  Using a combination of novel technologies, scientists at The Scripps Research Institute and the Whitehead Institute for Biomedical Research have revealed for the first time a dynamic molecular portrait of individual unfolded yeast prions that form the compound amyloid, a fibrous protein aggregate associated with neurodegenerative diseases such as Alzheimer's disease and variant Creutzfeldt-Jacob disease—the human version of mad cow disease.
  
  
• February 12, 2007
  Scripps Research Team Discovers a Chemical Pathway that Causes Mice to Overeat and Gain Weight
  Researchers from The Scripps Research Institute who are studying how body temperature and energy metabolism are regulated have discovered a pathway that appears to play a critical role in the onset of obesity. Further study of the pathway could lead to better understanding of the physiological foundation of obesity in humans and even the discovery of new treatments for the condition.
  
  
• February 5, 2007
  Scripps Research Scientists: Compounds Show Significant Promise Against Potential Bioweapon Toxins
  Scientists at The Scripps Research Institute and the University of Wisconsin have identified two small molecules with promising activity against neurotoxins produced by the Clostridium botulinum, a compound so deadly it has been labeled one of the six highest-risk bioterrorism agents by the Centers for Disease Control and Prevention (CDC).
  
  
• January 25, 2007
  Scripps Research Study Reveals New Function of Protein Kinase Pathway in Tumor Suppression
  Scientists at The Scripps Research Institute have discovered a surprising new function of a well-known signaling pathway that, when activated, can inhibit tumor development. This finding may lead to the development of drugs that can serve as an effective cancer therapy by artificially activating this pathway in cancer cells.
  
  
• January 21, 2007
  Scripps Research Study Reveals New Activation Mechanism for Pain Sensing Channel
  A group of scientists at The Scripps Research Institute has identified a mechanism that enables certain compounds to activate a pain sensing protein. The findings could lead to the development of potential new therapies for managing acute and chronic pain.
  
  
• January 9, 2007
  Scripps Research Combination Therapy Obliterates New Vessel Growth in Tumors and Retinopathy
  Using a new and dramatically effective treatment approach, scientists at The Scripps Research Institute have for the first time achieved complete inhibition of new blood vessel growth in animal models of a highly vascular brain tumor and of neovascular eye diseases with little or no effect on normal tissue vasculature.
  
  
• January 4, 2007
  Study Reveals Dynamic Interface of Molecular Clutch in Cell Migration
  Using a remarkable new technology, scientists at The Scripps Research Institute have identified a number of key protein interactions that allow cells to migrate throughout the body. These findings, which describe in detail how cells transmit molecular information into physical movement, provide the first direct analysis of cellular movement and may point the way to potential treatments for a variety of diseases including cancer.

2006

• December 26, 2006
  Study Identifies Glucose "Sensor" That Plays Dual Role in Glucose Metabolism and Fat Synthesis
  In a new study, scientists at The Scripps Research Institute have described for the first time a glucose activated sensor that acts as a switch to decrease production of endogenous glucose in the liver, and increase conversion of glucose to fat for storage in adipose tissue. This dual action makes the sensor, Liver X Receptor, a potential target for new therapies aimed at obesity and diabetes. The research may also have implications for heart disease and stroke.
  
  
• December 20, 2006
  Scripps Research Study Questions Need for Potential Vaccine Additive
  A team of scientists at The Scripps Research Institute has published a study that questions the need for incorporating an ingredient—TLR ligands— in vaccines to increase their effectiveness. Excluding TLR ligands would help keep down manufacturing costs and would avoid this ingredient’s potential side effects, such as inflammation and autoimmune syndromes.
  
  
• November 30, 2006
  The Scripps Research Institute Enters Major Five-Year $100 Million Collaboration with Pfizer
  The Scripps Research Institute announced it has entered into a five year research collaboration with Pfizer Global Research and Development to advance scientific knowledge of uncured diseases and novel ways to treat them, making full use of emerging technologies and resident talent from both organizations.
  
  
• November 17, 2006
  Scientists Identify Cells That Promote Repair of Blood Vessels in the Eye
  Scientists at The Scripps Research Institute have discovered a method of repairing and normalizing blood vessels in the eye through the use of stem cells derived from bone marrow. These findings may point to a new approach for developing treatments for a certain type of eye diseases.

• November 16, 2006
  Protein "Chaperone" Interactions Found to Play Major Role in Cystic Fibrosis
  Scientists at The Scripps Research Institute have described for the first time key protein interactions that contribute to the development of cystic fibrosis. These findings may provide a new framework for the correction of cystic fibrosis and other protein folding diseases.
  
  
• November 2, 2006
  Reduced Body Temperature Extends Lifespan in Study from The Scripps Research Institute
  Scientists at The Scripps Research Institute have found that reducing the core body temperature of mice extends their median lifespan by up to 20 percent. This is the first time that changes in body temperature have been shown to affect lifespan in warm-blooded animals.
  
  
• October 31, 2006
  Scientists Identify Synthetic Compound That Keeps Stem Cells Young
  A team of scientists from The Scripps Research Institute, the Genomics Institute of the Novartis Research Foundation, and the Max Planck Institute for Molecular Biomedicine has discovered a new synthetic compound that can support growth and self-renewal of mouse embryonic stem cells, offering a simple alternative to current growth conditions that may vary batch-to-batch and confuse experimental results.
  
  
• October 20, 2006
  Study Offers Innovative Profile of Enzyme That Aids Tumor Growth
  Using an innovative profiling strategy, scientists at The Scripps Research Institute have characterized an enzyme that is "highly elevated" in aggressive human tumor cells. When the enzyme, KIAA1363, was inactivated, it impaired tumor growth and migration in both ovarian and breast cancer cells, suggesting that inhibitors of this enzyme may prove valuable in the treatment of multiple types of cancer.
  
  
• October 19, 2006
  New Study Shows How Genetic Repair Mechanism Helps Seal DNA Breaks
  A new study by researchers from The Scripps Research Institute, Lawrence Berkeley National Laboratory, the Washington University School of Medicine, and the University of Maryland has provided a clearer picture of the final steps of a critical DNA repair process. When these repair processes go awry, cells can malfunction, die, or become cancerous.
  
  
• October 5, 2006
  $38 Million Grant Awarded to Alcohol Research Consortium Led by Scripps Research Institute Scientist
  The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has funded a five-year, $38 million Integrative Neuroscience Initiative on Alcoholism grant to support a consortium led by a scientist at The Scripps Research Institute. The multi-institutional group aims to identify the molecular basis of alcoholism, establishing a platform upon which future treatments can be built.
  
  
• September 19, 2006
  Study Details Structural Changes of a Key Catalytic Enzyme
  Scientists at The Scripps Research Institute have detailed a new hypothesis of how a key catalytic enzyme, dihydrofolate reductase (DHFR)--which is the target of several anticancer and antibiotic therapies--cycles through structural changes as it plays a critical role in promoting cell growth and proliferation.
  
  
• September 14, 2006
  New Study Pinpoints Unique Genetic Susceptibility for Viral Encephalitis
  Working in close collaboration with a group of French researchers, scientists from The Scripps Research Institute have helped uncover a unique genetic immunodeficiency that leaves patients vulnerable to herpes simplex encephalitis, a rare yet devastating infection of the brain that affects a small minority of people infected with a common virus.
  
  
• September 13, 2006
  The Scripps Research Institute, McDonald's Align to Fight Childhood Obesity and Type 2 Diabetes
  The Scripps Research Institute and McDonald's today announced a collaboration regarding research and educational initiatives to drive progress toward a solution to childhood obesity and Type 2 diabetes. McDonald's will contribute $2 million to The Scripps Research Institute to address these critical health issues facing America's youth.
  
  
• September 8, 2006
  Study Shows Enzyme Builds Neurotransmitters Via Newly Discovered Pathway
  Scientists at The Scripps Research Institute have uncovered a previously unknown function of an enzyme that appears to play a primary role in the biosynthesis of a large class of lipids that help modulate diverse physiological processes, including anxiety, inflammation, learning and memory, and appetite.
  
  
• September 7, 2006
  Consortium for Functional Glycomics Awarded $40.7 Million "Glue" Grant
  The Scripps Research Institute's Consortium for Functional Glycomics has received a $40.7 million "glue" grant for the international group of some 300 participating scientists to continue collaborative study of the complex dynamics of protein-carbohydrate interactions. The five-year grant, provided by The National Institute of General Medical Science (NIGMS), is the second NIGMS grant the consortium has received. The first, awarded in 2001, was a five-year grant of $34 million.
  
  
• August 31, 2006
  New Study Unveils Structure of Key Component of Antibiotic Resistant Bacteria
  Working in close collaboration with other researchers, scientists from The Scripps Research Institute have uncovered for the first time the structural chemistry behind the "astonishing multi-functionality" of the bacterial GC (for gonococcal) Type IV pilus filament, which plays an essential role in Neisseria gonorrhoeae pathogenesis. The Type IV pili allow antibiotic-resistant strains of N. gonorrhoeae to escape the immune system and cause persistent and recurrent gonorrhea infections.
  
  
• August 20, 2006
  Scripps Research Team Reverses Friedreich's Ataxia Defect in Cell Culture
  A team from The Scripps Research Institute and the University of California School of Medicine has developed compounds that reactivate the gene responsible for the neurodegenerative disease Friedreich's ataxia, offering hope for an effective treatment for this devastating and often deadly condition.
  
  
• August 10, 2006
  Scientists Discover Age-Regulated Cellular Activities That Protect Against Protein Aggregation
  By disrupting the aging process in an organism, scientists at The Scripps Research Institute and the Salk Institute for Biological Studies have discovered two mechanisms in an animal model of Alzheimer's disease that protect cells against protein aggregation that leads to damage called "proteotoxicity." Since proteotoxicity appears to cause the neurodegeneration in disorders such as Alzheimer's and Parkinson's diseases, these findings have important therapeutic implications.
  
  
• August 9, 2006
  Marijuana's Active Ingredient Shown to Inhibit Primary Marker of Alzheimer's Disease
  Scientists at The Scripps Research Institute have found that the active ingredient in marijuana, tetrahydrocannabinol or THC, inhibits the formation of amyloid plaque, the primary pathological marker for Alzheimer's disease. In fact, the study said, THC is "a considerably superior inhibitor of [amyloid plaque] aggregation" to several currently approved drugs for treating the disease.
  
  
• July 31, 2006
  Scripps Research Scientists Successfully Test New Anti-Obesity Vaccine
  In what may be the first published breakthrough of its kind in the global battle against obesity, scientists at The Scripps Research Institute have developed an anti-obesity vaccine that significantly slowed weight gain and reduced body fat in animal models.
  
  
• July 30, 2006
  Newly Discovered Genetic Abnormality Shown to Cause Acute Myeloid Leukemia
  Working in collaboration with international researchers, scientists from The Scripps Research Institute have uncovered a new genetic abnormality that results in the rapid development of acute myeloid leukemia (AML) in animal models. These findings could lead to new ways of diagnosing and controlling development of a variety of human diseases, including leukemia and other cancers that result from certain types of genetic defects.
  
  
• July 24, 2006
  "An Intimate Evening with Craig Chaquico"
  Craig Chaquico, the renowned lead guitarist of Jefferson Airplane/Starship and highly acclaimed contemporary instrumental artist, will perform at a dinner on August 13 to benefit the Molly Baber Research Fund at The Scripps Research Institute. The intimate event, from 6 to 10 PM, will feature a multi-station dinner under the stars at the Bernardo Heights Country Club, as well as an auction of a Craig Chaquico Model Carvin Guitar.
  
  
• July 10, 2006
  Researchers Unveil Strategy for Creating Actively Programmed Anti-Cancer Molecules
  Scientists at The Scripps Research Institute and The Skaggs Institute for Chemical Biology have developed a unique assembly strategy to produce an anti-cancer targeting antibody, an approach that combines the merits of small molecule drug design with immunotherapy. Among the potential therapeutic advantages is a dramatically increased circulatory half-life of the compound, which could give patients greater exposure to the benefits of any treatment.
  
  
  
• July 9, 2006
  Researchers Use New Chemical Probe to Manipulate Protective Inner Barriers
  Scientists at The Scripps Research Institute and the University of California, Irvine, have developed a chemical tool that allows them to manipulate control of the passage of substances through the barriers between blood and organ tissues. The findings have important therapeutic implications for a range of conditions, including organ transplants, autoimmune disease, multiple sclerosis, and adult respiratory distress syndrome.
  
  
• July 6, 2006
  Prion Disease Agent Causes Heart Damage in Mouse Study
  A team of researchers at The Scripps Research Institute, the University of California, San Diego (UCSD), and Rocky Mountain Laboratories of the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH), has shown for the first time that laboratory mice infected with the agent of scrapie—a brain-wasting disease of sheep—demonstrate high levels of the scrapie agent in their heart 300 days after being infected in the brain. These findings raise the possibility that heart infection could be a new aspect of prion diseases, including those that affect humans and livestock, and that these diseases could travel through the blood.
  
  
• June 26, 2006
  Biogen Idec Foundation Funds Summer Teacher Internship Program At The Scripps Research Institute
  The Biogen Idec Foundation has donated $25,000 to support three teachers from San Diego public schools in The Scripps Research Institute's Summer Internship Program for Teachers.
  
  
• June 22, 2006
  Researchers Map Infectious Hepatitis B Virus
  Scientists at The Scripps Research Institute have analyzed the structure of hepatitis B virus and found that it has unique features that distinguish it from other enveloped viruses such as influenza and herpes virus.
  
  
• June 8, 2006
  Study Uncovers "Significant" Functional Differences of Novel Estrogen Receptor
  Scientists at The Scripps Research Institute, working in collaboration with researchers from Creighton University and the Medical College of Zhejiang University (P.R. China), have discovered a novel variant of a known human estrogen receptor (hER-a66).
  
  
• May 31, 2006
  Study Links Effects of Withdrawal to Compulsive Drug Use and Craving
  A team of scientists at The Scripps Research Institute; the National Institutes of Health Animal Center; and the University of Tokushima Graduate School (Japan) has provided some of the first evidence that compulsive drug use stems not from obtaining a drug’s pleasurable effects, but from an aversion to drug withdrawal. The finding could be used to help develop human therapies to block aspects of drug craving.
  
  
• May 22, 2006
  John J. Moores Elected Chair of Scripps Research Institute Board of Trustees
  The Scripps Research Institute Board of Trustees today elected San Diego business leader and philanthropist John J. Moores as its new chair. Mr. Moores has been a Scripps Research trustee since 1997.
  
  
• May 18, 2006
  New Study Suggests Virus Uses Pressure to Sense when Full of DNA
  A team of scientists from The Scripps Research Institute, the University of Alabama, and the University of Utah have created a three-dimensional reconstruction of the complete structure of the virus P22. This structure suggests that the virus uses a pressure mechanism to stop DNA loading, a mechanism that offers a potential drug target. Although P22 only infects bacteria, its structure is similar to the herpes virus, types of which cause oral and genital herpes, chicken pox, and mononucleosis.
  
  
• May 17, 2006
  Study Details Hepatitis C Ability to Block Immune System Response
  A team of scientists at The Scripps Research Institute has shed light on one mechanism the hepatitis C virus uses to inhibit the immune system and promote its own survival. Results of the study may help in the development of new approaches to the treatment of hepatitis C virus.
  
  
• May 15, 2006
  New Study Reveals Signaling Pathways Required for Expansion of Pancreas Stem Cells
  A team of scientists at The Scripps Research Institute has published a new study of important signaling pathways that are required for the expansion of pancreas stem cells, work that may lead to strategies to prevent or reverse insulin-dependent diabetes mellitus (IDDM). 
  
  
• May 2, 2006
  Study Results Offer Guidance in Treatment of Alcohol Dependence
  A large-scale study of different treatment approaches for alcohol dependence underlines that medication can play a key role in treatment. 
  
  
• April 26, 2006
  Immune Response to HIV in the Brain a "Double-Edged Sword"
  A team of researchers at The Scripps Research Institute has shed new light on the molecular basis of problems with brain function in models chronically infected with an immune deficiency virus similar to human immunodeficiency virus (HIV), the cause of acquired immune deficiency syndrome (AIDS). The findings may ultimately lead to new therapeutic interventions to prevent or reverse nervous system disorders in HIV-infected individuals. 
  
  
• April 25, 2006
  Revealing the Secrets of WRN
  A team of scientists from Lawrence Berkeley National Laboratory and the Scripps Research Institute has determined the crystal structure and molecular mechanisms of a key part of WRN, a protein that protects humans from premature aging and cancer. 
  
  
• April 20, 2006
  Lack of a Key Enzyme Dramatically Increases Resistance to Sepsis
  Scientists at The Scripps Research Institute, The La Jolla Institute of Allergy and Immunology, and Merck Research Laboratories have uncovered a "fundamentally new role" for an enzyme that when present in vivo in certain forms impedes the immune response to bacterial infection. According to the new study, the presence of caspase-12, which appears to modulate inflammation and innate immunity in humans, increases the body's "vulnerability to bacterial infection and septic shock" while a deficiency confers strong resistance to sepsis. This new discovery suggests that caspase-12 antagonists could be a potentially useful in the treatment of sepsis and other inflammatory and immune disorders." 
  
  
• April 18, 2006
  Study Shows Gene Candidates for Predisposition to Alcohol Abuse
  A collaborative study by scientists at The Scripps Research Institute as part of the Integrative Neuroscience Initiative on Alcoholism Consortium (INIA) have identified some 3,800 "unique genes" that may determine a predisposition for a high degree of alcohol intake. The meta analysis, which examined more than 4.5 million data points on more than 100 microarrays from mouse models, also identified more than 1,300 functional groups, including signaling and transcription pathways, which may also play an important role in establishing a capacity for a "high level of alcohol consumption." 
  
  
• April 6, 2006
  Enzyme Crystal Structure Reveals "Unexpected" Genome Repair Functions
  Scientists at The Scripps Research Institute and Lawrence Berkeley National Laboratory have determined the crystal structure of an enzyme called xeroderma pigmentosum group B (XPB) helicase, identifying several unexpected functions and helping to address important questions about the enzyme's role in DNA transcription and repair. The research illuminated, for the first time, the roles played by the important XPB protein in recognizing blockages in reading the DNA code and in initiating an efficient method of repair. The discovery may be useful in the quest to develop new forms of chemotherapy.
  
  
• March 24, 2006
  New Class of Enzyme Inhibitors Block Replication of SARS Virus
  Scientists at The Scripps Research Institute have discovered a class of compounds that block the SARS virus from replicating, a finding that may open the door to new drug targets against the deadly disease.
  
  
• March 24, 2006
  "Accelerated Evolution" Converts RNA Enzyme to DNA Enzyme In Vitro
  Scientists at The Scripps Research Institute have successfully converted an RNA enzyme (ribozyme) into a DNA enzyme (deoxyribozyme) through a process of accelerated in vitro evolution. The molecular conversion or transfer of both genetic information and catalytic function between these two different genetic systems, which are both based on nucleic acid-like molecules, is exactly what many scientists believe occurred during the very earliest period of earth's existence.
  
  
• March 17, 2006
  Four of the Nation's Preeminent Research Institutions Announce Stem Cell Research Alliance
  Four of the nation's preeminent research institutions, all based in San Diego, have announced their commitment to join forces in establishing an independent, non-profit consortium dedicated to stem cell research.
  
  
• March 16, 2006
  Minor Mutations in Avian Flu Virus Increase Chances of Human Infection
  Scientists at The Scripps Research Institute, the Centers for Disease Control, and the Armed Forces Institute of Pathology have identified what the researchers described as a possible pathway for a particularly virulent strain of the avian flu virus H5N1 "to gain a foothold in the human population."
  
  
• March 14, 2006
  Newly Discovered Small Molecules "Superactivate" Botox
  Scientists at The Scripps Research Institute have discovered several small molecules that can "superactivate" the botulinum neurotoxin (BoNT), the commonly used cosmetic treatment for wrinkles known as Botox that has a number of therapeutic uses.
  
  
• March 9, 2006
  Novel Method Reveals How Menthol Creates Cold Sensations
  Scientists at The Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation (GNF) have developed a method that can aid in understanding how certain proteins can be activated. The group used this new methodology to study the molecular mechanism by which menthol, the cooling compound derived from mint leaves, enhances the activity of TRPM8, an ion channel protein involved in our ability to feel cold temperature through the skin.
  
  
• February 27, 2006
  Fluorescent Viral Nanoparticles Permit High Resolution In Vivo Vascular Imaging
  Scientists at The Scripps Research Institute have shown that cowpea mosaic virus (CPMV) can be used as an "exceptionally bright" imaging agent that permits high resolution in vivo visualization of the vascular endothelium, the cells that line the inside of blood vessels, for as long as 72 hours. These results strongly suggest that fluorescently dyed CPMV nanoparticles could become a "powerful tool" to image tissues deep inside living organisms in the laboratory and, potentially, in a clinical setting as well.
  
  
• February 20, 2006
  New Study Shows Antibody-Interleukin Complexes Stimulate Immune Responses
  Scientists at The Scripps Research Institute have shown that injections of a certain cytokine together with the right monoclonal antibody increases white blood cells that coordinate immune responses to tumor and infected cells. These results may point the way to an improved cancer therapy that helps patients boost their own immune response to the disease. The findings could also be significant for developing new ways to help patients with autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, or juvenile diabetes.
  
  
• February 7, 2006
  High Resolution "Snapshots" Detail Dynamics of a Cocaine Antibody
  Scientists at The Scripps Research Institute have revealed for the first time a series of molecular structures of a specific cocaine-degrading monoclonal antibody Fab' fragment during the complete catalytic process—a chain of events that breaks the drug into nontoxic pieces. Understanding these significant structural changes of the antibody 7A1 could help in the development of a treatment for cocaine addiction. A monoclonal antibody is cloned from a single type of immune cell.
  
  
• February 6, 2006
  Scientists Re-engineer a Well-Known Antibiotic to Counter Drug Resistance
  Scientists at The Scripps Research Institute have successfully re-engineered a well-known antibiotic to insure its effectiveness against sensitive as well as resistant enterococci, a common strain of bacteria responsible for widespread hospital infections.
  
  
• January 31, 2006
  Protein Found to Control Tumor Growth in Certain Breast Cancers
  Scientists from The Scripps Research Institute and the Xiamen University School of Life Sciences, Fujian, People's Republic of China, have uncovered a new and potentially important function for the protein Nod1, inhibiting the growth of estrogen sensitive human breast cancer cells.
  
  
• January 16, 2006
  New Technology Effectively Gauges Specificity of Influenza Strains, Including 1918 Spanish Flu
  A team of researchers led by scientists from The Scripps Research Institute has used a new technology called a glycan array to survey samples of coat proteins from various strains of human and avian viruses, including from the deadly 1918 influenza outbreak know as the Spanish Flu.
  
  
• January 13, 2006
  Study Reveals Unusual Structure of Cellular Transport Nanocage
  A new study by scientists at The Scripps Research Institute has revealed for the first time the structure of Sec13/31, a "nanocage" that transports a large body of proteins from the endoplasmic reticulum (ER), which makes up more than half the total internal cell membrane, to other regions of the cell. 

2005

• December 12, 2005
  Scientists Discover Small Molecule That Generates Neurons from Adult Stem Cells
  A group of scientists from The Scripps Research Institute and the Salk Institute for Biological Studies have uncovered a synthetic small molecule that generates functional neurons from adult neural stem cells.
  
  
• December 2, 2005
  Researchers Map a Complex Molecular Assembly "Landscape" For the First Time
  For the first time, scientists at The Scripps Research Institute have developed a highly detailed kinetic and thermodynamic landscape that describes the mechanisms of macromolecular synthesis, findings that may help spur advances in the global challenges of antibiotic drug resistance. In their study, the researchers showed that assembly of the 30S ribosomal subunit is a "complex dance" in which 20 smaller proteins bind to ribosomal RNA (rRNA) as it folds, allowing it to play a major role in the translation of messenger RNA (mRNA), which encodes and carries information from DNA to protein synthesis sites.
  
  
• November 29, 2005
  "Unprecedented" Functional Amyloid Found to Play Beneficial Role In Human Cells
  A group of scientists at The Scripps Research Institute have shown that the amyloid protein structure, which has been linked to neurodegeneration in diseases including Alzheimer's, Parkinson's, and Huntington's, carries out an important functional role in human physiology. The discovery raises the possibility that current research into curtailing amylolid formation to treat these diseases might ultimately do as much harm as good. The discovery of functional amyloid in a range of organisms, which now includes humans, suggests that it was present early in evolution, and was retained for a fundamental role in normal mammalian cell physiology.
  
  
• November 22, 2005
  Scripps Research Institute Team Shows Chemical Chaperones Help Increase Deficient Enzyme Activity in Gaucher Disease
  Scientists at The Scripps Research Institute have discovered that certain chemical chaperones help increase the activity of various types of glucocerebrosidase, the enzyme lacking in patients with Gaucher (go-SHAY) disease. This discovery suggests that the active levels of glucocerebrosidase can be improved through the use of select site-directed small molecules or chemical chaperones, which bind and stabilize proteins and prevent their degradation. These findings could lead to the development of first-in-class drugs for the treatment of the disease.
  
  
• November 21, 2005
  World Community Grid Targets AIDS in Giant Research Effort
  IBM today launched a new research effort to help battle AIDS using the massive computational power of World Community Grid, a global community of computer users who have joined the philanthropic technology initiative by simply donating unused time on their personal computers.  With computational power already placing it among the top 10 supercomputers in the world, World Community Grid will be the first virtual supercomputer devoted specifically to AIDS research. Working with the renowned Scripps Research Institute, a private, non-profit research organization engaged in basic biomedical science based in San Diego, World Community Grid will host its second major project—the Internet-based FightAIDS@Home, an evolutionary research project dedicated to finding new AIDS therapies.
  
  
• November 13, 2005
  The Scripps Research Institute and Oxford University Open International Biotechnology Conference Today
  The Scripps Research Institute and Oxford University today opened the inaugural Scripps/Oxford International Biotechnology Conference at the Breakers in Palm Beach, Florida.
  
  
• October 26, 2005
  Multi-Million Dollar Deal to Benefit Medical Research
  The Medical Research Council is to receive US$191m as part of one of the biggest deals to come out of breakthroughs by British scientists. The money comes from the development of a drug created using patented technology which arose from research at the MRC Laboratory of Molecular Biology and The Scripps Research Institute.
  
  
• October 4, 2005
  Chemical Extracted from Soy Beans Inhibits Disease Process Known as Amyloidogenesis
  Scientists at The Scripps Research Institute have discovered that a compound extracted from soy beans is a natural and potent inhibitor of a pathological process involved in a number of "amyloid" diseases, including a cluster of ailments called the familial amyloidoses.
  
  
• September 30, 2005
  Scripps Research Scientist Wins 2005 NIH Director's Pioneer Award
  Clare Waterman-Storer, Ph.D., an associate professor in the Department of Cell Biology at The Scripps Research Institute, has been named one of the winners of the National Institutes of Health’s 2005 NIH Director’s Pioneer Awards, which includes a research budget of up to $500,000 in direct costs per year for five years.
  
  
• September 28, 2005
  "Memory" of Nicotine Lingers in the Brain, Say Scripps Research Scientists
  Scientists at The Scripps Research Institute and Scripps Florida are reporting the results of one of the first studies looking at the long-term neurological effects of nicotine addiction on the brain's reward system. Their findings may have significant implications for people who are trying to quit smoking.
  
  
• September 26, 2005
  John J. Moores Donates $4 Million to Scripps Research Institute to Combat Worm-based Diseases Afflicting Millions Worldwide
  San Diego business leader and philanthropist John J. Moores has contributed $4 million to The Scripps Research Institute to establish the Worm Institute for Research and Medicine (WIRM) to combat the painful, disfiguring, and debilitating diseases borne by worms that afflict hundreds of millions of people in much of the world, it was announced today.
  
  
• September 1, 2005
  Mysterious Molecules Begin to Yield Their Secrets
  A team of investigators at The Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation (GNF) have discovered a way to screen hundreds and potentially thousands of "noncoding" RNA molecules to discover their functions within cells.
  
  
• August 26, 2005
  Scripps Research Scientists Describe Smoker's Enzyme
  A team of scientists at The Scripps Research Institute has solved the structure of a human molecule called CYP2A6, which is the principal enzyme in the body that degrades nicotine.
  
  
• August 22, 2005
  The Scripps Research Institute and Oxford University to Host International Biotechnology Conference
  The Scripps Research Institute and Oxford University will jointly host the inaugural Scripps/Oxford International Biotechnology Conference November 14-15 at the Breakers in Palm Beach, Florida.
  
  
• August 8, 2005
  NIH Awards $4.2 Million Grant to Scientists at Scripps Research to Speed DNA Sequencing Technologies
  A team of scientists at The Scripps Research Institute in California and Oxford University in England have been awarded a $4.2 million five-year grant to conduct basic science aimed at speeding the rate at which the next generation of DNA sequencing technologies will become available to scientists and clinicians. 
  
  
• July 27, 2005
  How Do You Spell Recognition? C-O-R-E-C-E-P-T-O-R
  Scripps Research Scientists Describe How T-Cell Receptors and Coreceptors Interact During an Immune Response
  A group of scientists at The Scripps Research Institute has solved a mystery that has dogged immunologists for many years: how T-cell receptors interact with their coreceptor proteins at the beginning of an immune response. 
  
  
• July 1, 2005
  Scripps Research Institute-Based Center Awarded More than $50 Million by NIH in Massive Effort to Solve Protein Structures
  A consortium of scientists at The Scripps Research Institute and several other California institutions has been awarded a $52.7 million grant by the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health. The grant is part of the second phase of a $600 million national effort called the Protein Structure Initiative that ultimately seeks to find the three-dimensional shapes of all types of proteins. This structural information will help reveal the roles that proteins play in health and disease and will help point the way to designing new medicines. 
  
  
• June 28, 2005
  Wet Lungs or Dry?
  Scripps Research Scientists Discover New Key to Pulmonary Edema in Respiratory Distress Syndrome
  Scripps Research Hugh Rosen and his colleagues are reporting a new molecular mechanism that controls how the lungs are kept dry and under what conditions they permit fluids to enter. The mechanism involves a protein called the S1P₃ receptor expressed on the surface of the cells lining the lung's air sacs. When the receptor is activated, the lungs become leaky, causing pulmonary edema. 
  
  
• June 20, 2005
  Scripps Research Scientists Solve Structure of a Critical Innate Immune System Protein
  Scientists at The Scripps Research Institute have solved the structure of a crucial human immune system molecule called TLR3, an acronym for Toll-like receptor three. In an upcoming issue of the journal Science, the protein is described as a large horseshoe-shaped coil composed of 23 leucine-rich repeats (LRRs). 
  
  
• June 16, 2005
  National Institutes of Health Awards $10.4 Million to Scripps Research Institute and Scripps Florida
  First grant for research at both campuses is part of NIH effort to speed the progress of discoveries from lab bench to patient bedside
  A group of researchers at the La Jolla, California, and Palm Beach County, Florida, campuses of The Scripps Research Institute has been awarded a $10.4 million dollar grant from the National Institutes of Health (NIH) to establish The Scripps Research Institute Molecular Screening Center. This is a pilot program to discover small molecule tools for translating basic biomedical discoveries more quickly into medically relevant applications.  
  
  
• June 13, 2005
  Scripps Research Scientists Identify the Target of an Immune Suppression Molecule Called CD22--Itself
  Scientists at The Scripps Research Institute have applied an innovative approach to studying human proteins that bind to sugar molecules on the surface of human cells to discover how one crucial aspect of our immune system works. They identified the target of a regulatory molecule called CD22 that is expressed on the surface of the type of immune system cell known as the B lymphocyte.  
  
  
• June 6, 2005
  The Scripps Research Institute is Recipient of Clubmom Dollar Drive For Charity
  The Scripps Research Institute has been selected as one of the leading nonprofit organizations in the United States to participate in the ClubMom Dollar Drive for Charity initiative. For every mom recruited by Scripps Research to join ClubMom between now and March 31, 2006, ClubMom will donate $1 to the Institute.  
  
  
• May 25, 2005
  Vampires Beware:
  Scripps Research Scientists Describe the Molecular Basis of Raw Garlic's Pungency
  A group of scientists from The Scripps Research Institute, the Genomics Institute of the Novartis Research Foundation, and the Korea University College of Medicine describe the cellular and molecular basis of raw garlic's pungency.  
  
  
• May 18, 2005
  To Stop Evolution: New Way of Fighting Antibiotic Resistance Demonstrated by Scripps Research Scientists
  A team of scientists at The Scripps Research Institute and the University of Wisconsin have demonstrated a new way of fighting antibiotic resistance: by stopping evolution.  
  
  
• May 4, 2005
  Scripps Research Scientists Identify Infertility Molecule "LPA Receptors" Affect Implantation of Embryos in Womb
  Scientists at The Scripps Research Institute are reporting that mice created to lack a certain type of molecule known as an LPA receptor have fertility problems, which suggests that these receptors play a major role in conception. 
  
  
• April 7, 2005
  Scripps Research Institute President Richard Lerner Honored by New York University Biotechnology Study Center
  Scripps Research Institute President Richard A. Lerner, M.D., has been selected to receive the prestigious DART/NYU Biotechnology Achievement Award from the Biotechnology Study Center of the New York University School of Medicine. He is being cited for his discovery that ozone, a metabolic product of inflammation, may play a role in atherosclerosis ("clogged arteries") and Alzheimer's disease.
  
  
• April 7, 2005
  Why Do Amyloid Diseases Strike Different Tissues? Part of the Answer Lies in the Secretory Aptitude of These Tissues, Say Scripps Research Scientists
  Researchers at The Scripps Research Institute are reporting the results of a recent study that addresses why different tissues in the human body vary in their susceptibility to "amyloid" diseases, which include Alzheimer's disease and a cluster of ailments called the familial amyloidoses.
  
  
• March 31, 2005
  Louis L. Gonda and Mark S. Skaggs Join Scripps Research Institute Board of Trustees
  Business executives and philanthropists Louis L. Gonda of Beverly Hills, California, and Mark S. Skaggs of Boise, Idaho, have been elected to the Board of Trustees of The Scripps Research Institute of California and Florida, one of the world's largest independent, nonprofit biomedical research organizations.
  
  
• March 24, 2005
  Scripps Research Scientists Describe New Way of Interacting with the Unseen World of Proteins and DNA
  A group of scientists at The Scripps Research Institute has developed a new way of looking at and interacting with molecules so small that they cannot be seen even with the world's most powerful microscopes.
  
  
• March 10, 2005
  Cooperation is Key--A New Way of Looking at MicroRNA and How it Controls Gene Expression
  A group of scientists at The Scripps Research Institute is reporting a discovery that sheds light on an area of research fundamental to everything from the normal processes that govern the everyday life of human cells to the aberrant mechanisms that underlie many diseases, including cancer and septic shock.
  
  
• March 3, 2005
  Molecular Thermometers on Skin Cells Detect Heat and Camphor
  In recent years, biologists and neuroscientists have been trying to discover the basic molecules and mechanisms that underlie this complicated communication system that is our senses, and one group of researchers from The Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation (GNF), has been making headway in trying to understand those that mediate our sense of touch.
  
  
• February 22, 2005
  Antibody that Neutralizes Most HIV Strains Described by Scientists at The Scripps Research Institute
  A group of scientists from The Scripps Research Institute and several other institutions has solved the structure of a rare human antibody that broadly neutralizes human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS).
  
  
• February 17, 2005
  Floyd Bloom to Retire as Scripps Research Department Chair; Focus on Neurome Neurodegeneration Programs
  Floyd E. Bloom, M.D., and The Scripps Research Institute today announced Dr. Bloom's retirement as chairman of the Scripps Research Department of Neuropharmacology. Bloom will be named Professor Emeritus at Scripps Research and also intends to devote substantial efforts to the work of Neurome, Inc.
  
  
• February 3, 2005
  Molecular Component of Innate Immunity Discovered
  Professor Bruce Beutler and colleagues at The Scripps Research Institute have identified one of the molecules that mediates innate immune recognition—CD36.
  
  
• January 7, 2005
  Renowned Scientist Edward Roberts Joins Scripps Research Institute as Professor of Translational Chemistry and Medicine
  The Scripps Research Institute announced the appointment of world-renowned chemist Edward Roberts, Ph.D., as Professor of Translational Chemistry and Medicine in the Institute's Department of Chemistry. 

2004

• December 7, 2004
  Research Consortium Led by Scientists at The Scripps Research Institute Develops New Tool for Biology
  An international consortium of scientists lead by Dr. James Paulson of The Scripps Research Institute has created a technology that will advance our understanding of the role of complex sugar chains (glycans or carbohydrates) that decorate the surface of cells in the body.
  
  
• December 2, 2004
  "Fossil Record" of the Human Immune System Reveals Antibodies that Block Cancer Metastasis
  A team of researchers at The Scripps Research Institute has reconstructed the "fossil record" of the immune systems of a group of human cancer patients to investigate if they had ever produced antibodies against their disease.
  
  
• November 23, 2004
  Scientists at The Scripps Research Institute Develop New Technology For a "Kit" to Screen for Mercury Contamination
  Scientists at The Scripps Research Institute and Xenobe Research Institute have developed an improved screening method that can detect mercury contamination in biological samples including fish. At the heart of the new method is a chemical "ligand" the scientists synthesized that binds to mercury and other toxic heavy metals.
  
  
• November 19, 2004
  Detecting the Genes That Contribute to Transplant Rejection
  A group of physicians and scientists led by Associate Professor Daniel Salomon, M.D., of the Department of Molecular and Experimental Medicine at The Scripps Research Institute, has been awarded a new federal research grant of more than $12 million over five years to apply cutting-edge genomic technologies to advance our understanding of kidney transplantation.
  
  
• November 1, 2004
  Innovative Approaches to Fighting Breast Cancer: Department of Defense Awards Grants to Five Investigators at The Scripps Research Institute
  Five scientific investigators at The Scripps Research Institute were recently awarded research grants from the U.S. Department of Defense (DoD) Breast Cancer Research Program, which according to the DoD web site, aims to promote research to eradicate breast cancer.
  
  
• October 25, 2004
  Scientists at Scripps Research Institute Use Drug to Stabilize Blood Vessels and Block Metastatic Cancer Cells from Leaving the Bloodstream
  A team of scientists at The Scripps Research Institute has identified a potential treatment strategy against metastatic cancer cells that has never been tried before.
  
  
• October 7, 2004
  Study Suggests Component of Volcanic Gas May Have Played a Significant Role in the Origins of Life on Earth
  Scientists at The Scripps Research Institute and the Salk Institute for Biological Studies are reporting a possible answer to a longstanding question in research on the origins of life on Earth—how did the first amino acids form the first peptides?
  
  
• October 1, 2004
  NIH Awards New $14.5 Million, Five-year Grant to The Scripps Research Institute
  The Scripps Research Institute announced today that it has been awarded a $14.5 million, five-year grant from The National Institute of General Medical Sciences (NIGMS), a component of the National Institutes of Health (NIH). The grant, which is titled "JCSG Center for Innovative Membrane Protein Technologies," funds structural biology research on membrane proteins - an area of immense medical potential.
  
  
• September 15, 2004
  Stem Cells Delivered into the Back of the Eye Hold Promise for People with Retinitis Pigmentosa and Other Retinal Degenerations
  A team of researchers from The Scripps Research Institute was able to preserve visual function in mice that were genetically predisposed to developing a profound degenerative disease that destroys their retinas.
  
  
• September 14, 2004
  Scripps Research Institute Board of Trustees Elects Three New Members
  The Scripps Research Institute Board of Trustees has elected three new members, two recommended by the Scripps Florida Funding Corporation, which oversees state funding for the Institute's new operations in Palm Beach County, and the third a prominent Florida business leader.
  
  
• August 20, 2004
  Scripps Research Institute Scientists Describe How Chemical Turns Progenitor Stem Cells into Bone Cells
  A group of researchers from The Skaggs Institute for Chemical Biology at The Scripps Research Institute and from the Genomics Institute of the Novartis Research Foundation (GNF) have described how a small synthetic molecule called "purmorphamine" causes a type of stem cell to selectively differentiate into adult bone cells. Purmorphamine, or a similar compound that has the same effect, may have significant clinical value someday for treating the bone-weakening disease osteoporosis.
  
  
• August 19, 2004
  Shark Protein Structure Solved by Scientists at The Scripps Research Institute and the University of Maryland
  A team of scientists at The Scripps Research Institute and at the University of Maryland School of Medicine has determined the structure of an antibody isolated from Ginglymostoma cirratum—a nurse shark.
  
  
• August 18, 2004
  New "Clock Gene" Uncovered
  A team of scientists from The Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation (GNF), led by Steve Kay, Ph.D., and John Hogenesch, Ph.D., recently revealed a new genetic component of the mammalian clock—a protein known as "Rora." This discovery may someday help people with jet lag, shift workers who feel wiped out after working a night shift, and people with more serious sleep disorders, many of which are related to circadian rhythms.
  
  
• July 7, 2004
  Structure Solved at Scripps Research Institute Shows How One Human Protein Reduces the Potency of Chemotherapy
  A team of researchers led by scientists at The Skaggs Institute for Chemical Biology at The Scripps Research Institute have solved the structure of a human protein called AGT that is known to interfere with the action of certain chemotherapy drugs.
  
  
• July 1, 2004
  Renowned Physician and Biochemist Bernard M. Babior Dies at 69
  Bernard M. Babior, a distinguished medical scientist, died in San Diego, California on June 29, 2004, after a long battle with prostate cancer. For the past 18 years, he was a Professor and Head of the Division of Biochemistry at The Scripps Research Institute and a Staff Physician at the Scripps Clinic, both in La Jolla.
  
  
• July 1, 2004
  The Key to Cell Motility
  Scientists at The Scripps Research Institute have described the regulatory mechanism of an important human protein called Rac that controls a number of biological processes and is directly implicated in several human diseases.
  
  
• June 23, 2004
  Protein Believed to Control Formation of Memory Identified by Scripps Research Institute & UCSD Scientists
  Scientists at The Scripps Research Institute and the University of California, San Diego (UCSD) School of Medicine have demonstrated that the action of a protein called CBP is essential for the stabilization of long-term memory, a discovery that may help children with a rare but debilitating developmental disorder.
  
  
• June 21, 2004
  Treating Cocaine Addiction with Viruses
  Scientists at The Scripps Research Institute have designed a potentially valuable tool for treating cocaine addiction by creating a modified "phage" virus that soaks up the drug inside the brain.
  
  
• May 11, 2004
  22-Amino Acid Bacterium Created by Scientists at The Scripps Research Institute
  A team of investigators at The Scripps Research Institute and its Skaggs Institute for Chemical Biology in La Jolla, California has modified a form of the bacterium Escherichia coli to use a 22-amino acid genetic code.
  
  
• April 15, 2004
  A New Hypothesis About Autoimmunity—Is it Possible to be Too Clean?
  A group of scientists at The Scripps Research Institute have found a connection between poor T cell survival in the body and the development of autoimmunity.
  
  
• April 2, 2004
  Scripps Research Scientist Wins 2004 Koch Prize
  Professor Bruce Beutler, M.D., of The Scripps Research Institute has won the 2004 Robert Koch Award together with Professor Shizuo Akira of Osaka, Japan and Professor Jules A. Hoffmann of Strasbourg, France, the Robert Koch Foundation has announced.
  
  
• March 29, 2004
  Scripps Research Scientists Find Deafness Gene's Function
  A group of scientists at The Scripps Research Institute, at the University of California, San Diego, and at the Oregon Hearing Research Center and Vollum Institute at Oregon Health & Science University have discovered a key molecule that is part of the machinery that mediates the sense of hearing.
  
  
• March 15, 2004
  New Approach Limits Damage After Heart Attack and Improves Survival, Say Scripps Research Scientists
  A team led by scientists at The Scripps Research Institute has developed a potential new treatment for heart attacks. The therapy inhibits fluid leakage from cardiac blood vessels following a heart attack and thereby significantly prevents long-term heart damage and improves survival.
  
  
• March 15, 2004
  A New Hypothesis about Alzheimer's Disease
  A group of scientists at The Scripps Research Institute has proposed a new theory about the cause of Alzheimer's disease, the progressive neurodegenerative disorder that currently afflicts some 4.5 million Americans.
  
  
• March 4, 2004
  Scientists at Scripps Research Institute Describe Dangerous Cocktail of Alcohol, Brain Peptides, and Neurotransmitters
  A team of scientists at The Scripps Research Institute has described the cellular mechanism underlying the brain's response to alcohol, which suggests a possible method for treating alcoholism.
  
  
• February 17, 2004
  Chemical that Turns Mouse Stem Cells into Heart Muscles Discovered by Scientists at The Scripps Research Institute
  A group of researchers from The Skaggs Institute for Chemical Biology at The Scripps Research Institute and from the Genomics Institute of the Novartis Research Foundation (GNF) has identified a small synthetic molecule that can control the fate of embryonic stem cells.
  
  
• February 13, 2004
  Structure Solved by Scientists at Scripps Research Shows One Way that Body Controls Gene Expression
  A group of scientists at The Scripps Research Institute has solved the structure of a protein that regulates the expression of genes by controlling the stability of mRNA—an intermediate form of genetic information between DNA genes and proteins.
  
  
• February 11, 2004
  Nano-Origami: Scientists at Scripps Research Create Single, Clonable Strand of DNA That Folds into an Octahedron
  A group of scientists at The Scripps Research Institute has designed, constructed, and imaged a single strand of DNA that spontaneously folds into a highly rigid, nanoscale octahedron that is several million times smaller than the length of a standard ruler and about the size of several other common biological structures, such as a small virus or a cellular ribosome.
  
  
• February 11, 2004
  Genetic Mutation Protects Against HIV and Plague?
  Not So, Say Scientists at Scripps Research
  A group of scientists at The Scripps Research Institute have provided strong evidence that a popular hypothesis concerning the origins of a genetic mutation common among Caucasians of Northern European descent that protects against human immunodeficiency virus (HIV) is wrong.
  
  
• February 5, 2004
  Scientists at Scripps Research Institute Describe Structure of Receptor on Surface of 1918 Flu Virus, the World's Most Deadly Outbreak
  A team of scientists at The Scripps Research Institute has described for the first time the structure of a protein from the deadly 1918 "Spanish Flu" virus—a virus that took more lives than World War I and became the largest and deadliest influenza outbreak in recorded history. Their work reveals some of the virus' deadly secrets.
  
  
• January 29, 2004
  A New Twist on the Mad Cow—Scientists at The Scripps Research Institute Discover the Normal Prion Protein May Contribute Directly to Disease
  A team of scientists at The Scripps Research Institute are presenting evidence that mad cow disease prions cannot kill neurons on their own and that normal, healthy cellular prion protein may be a direct accomplice in unleashing neuronal destruction.
  
  

2003

• December 22, 2003
  Regenerative Chemical Turns Muscle Cells into Stem Cells, Say Scientists at The Scripps Research Institute
  A group of researchers from The Scripps Research Institute has identified a small synthetic molecule that can induce a cell to undergo dedifferentiation—to move backwards developmentally from its current state to form its own precursor cell.
  
  
• December 18, 2003
  Linking the Immune System with Lipid Metabolism
  A team of researchers led by scientists at The Scripps Research Institute has discovered a family of proteins that connect the immune system to the body's lipids—the fat molecules that are a major building block of the human body.
  
  
• December 15, 2003
  Scripps Research Institute Receives $3 Million Anonymous Donation to Establish The Pearson Center for Alcoholism and Addiction Research
  The Scripps Research Institute recently received a $3 million gift to establish The Pearson Center for Alcoholism and Addiction Research that will combine biomedical research with clinical application to fight this deadly and costly disease
  
  
• December 2, 2003
  NIH Funds Scripps Research–Novartis Collaboration To Target New Treatments for Depression and Nicotine Addiction
  A group of researchers from The Scripps Research Institute and Novartis Pharma AG have been awarded a $3.45 million grant to collaborate on the design of new ways to treat depression and nicotine addiction.
  
  
• November 21, 2003
  Scientists at The Scripps Research Institute Describe the Biochemistry of Vaccine Adjuvants
  A team of scientists at The Scripps Research Institute (TSRI) has published a paper that explains how adjuvants work in greater biochemical detail than has been known previously.
  
  
• November 19, 2003
  Love and Flower Power—Scripps Scientists Discover Protein that Senses Daylight and Regulates Flowering
  A group of scientists at The Scripps Research Institute (TSRI) are publishing a paper in which they describe a new class of proteins that regulate the timing of the flower cycle in one small leafy weed, a relative of the mustard plant called Arabidopsis thaliana.
  
  
• November 18, 2003
  Fat Molecules Make Bigger Brains, Say Scientists at The Scripps Research Institute
  A team of scientists at The Scripps Research Institute (TSRI) is publishing a study that describes the effects of a particular phospholipid molecule on the development of mammalian brains.
  
  
• November 14, 2003
  Filmmaker Warren Beatty and Mervyn's Mervin Morris Join TSRI Board
  Actor and Academy Award-winning director and producer Warren Beatty and California businessman Mervin G. Morris, the founder of the Mervyn's chain of retail stores, have been elected to the Board of Trustees of The Scripps Research Institute (TSRI).
  
  
• November 14, 2003
  $9.2 Million Grant Enables Scripps Scientists to Design Anthrax Antitoxin Nanosponges
  A large, multi-center program project grant has been awarded to a team of scientists at The Scripps Research Institute (TSRI), Harvard Medical School, and The Salk Institute for Biological Studies to discover and develop novel anthrax antitoxins and ways of delivering them.
  
  
• November 7, 2003
  Scientists at The Scripps Research Institute Discover a Genetic Cause for Primary Iron Overload
  Three new studies describe the discovery of a genetic mutation that could be responsible for causing the metabolic disorder, primary iron overload, common among people of African descent. Professor Ernest Beutler, M.D., in The Scripps Research Institute (TSRI) and The Skaggs Institute for Chemical Biology at TSRI led one of the studies and is coauthor of another.
  
  
• November 6, 2003
  Scripps Scientists Link Ozone to Atherosclerosis, Detection of Toxic "Atheronal" Molecules May Lead to New Diagnostics
  A team of investigators led by The Scripps Research Institute (TSRI) President Richard A. Lerner, M.D., and TSRI Associate Professor Paul Wentworth, Jr., Ph.D., are reporting evidence for the production of ozone in fatty atherosclerotic plaques taken from diseased arteries.
  
  
• October 30, 2003
  AAAS and The Scripps Research Institute Announce 2003 Fellows
  Dale L. Boger and Bernard Babior of The Skaggs Institute for Chemical Biology at The Scripps Research Institute (TSRI) in La Jolla, CA have been awarded the distinction of AAAS fellows.
  
  
• October 30, 2003
  $11.4 Million CDC Grant Goes to The Scripps Research Institute to Study Immune Response to Anthrax Toxins
  The U.S. Centers for Disease Control and Prevention (CDC) has awarded a group of researchers at The Scripps Research Institute (TSRI) a multi-year, $11.4 million grant to study the interaction of the human immune system with toxins of the bacterium Bacillus anthracis, the causative agent of the disease anthrax.
  
  
• October 28, 2003
  The Scripps Research Institute Restructures Its Top-Ranked Graduate Programs
  The Scripps Research Institute (TSRI) announced the restructuring of the graduate programs at its Kellogg School of Science and Technology.
  
  
• October 9, 2003
  The Scripps Research Institute to Open Major Science Center in Palm Beach County, Florida
  The Scripps Research Institute (TSRI) announced plans to establish a major science center in Palm Beach County, Florida, focusing on biomedical research, technology development, and drug design.
  
  
• September 11, 2003
  The Scripps Research Institute and Oxford University Establish Joint Program for Doctoral Degree In Biology, Chemistry, and Biochemistry
  The Scripps Research Institute (TSRI) in La Jolla, California, and the University of Oxford Department of Biochemistry in Britain announced today their intention to offer a joint graduate program to train young scientists at the doctoral level at both world-renowned institutions.
  
  
• September 4, 2003
  Study at The Scripps Research Institute Links Dozens of Proteins to Several Rare Muscle and Nerve Degeneration Diseases
  A team of scientists at The Scripps Research Institute (TSRI) has identified more than 50 previously unknown proteins and associates several of them with rare human muscle and nerve degeneration diseases. The team is publishing their findings this week in the journal Science.
  
  
• August 14, 2003
  Scientists at The Scripps Research Institute Create New Strain of Yeast with 21-Amino Acid Genetic Code
  A team of investigators at The Scripps Research Institute (TSRI) and its Skaggs Institute for Chemical Biology is introducing revolutionary changes into the genetic code of organisms like yeast that allow these cellular factories to mass produce proteins with unnatural amino acids.
  
  
• July 31, 2003
  Global Survey Maps Function of Thousands of Malaria Genes, Report Scientists at The Scripps Research Institute
  A team of researchers led by scientists at The Scripps Research Institute (TSRI) describes a comprehensive global profile of genes in the malaria parasite.
  
  
• July 20, 2003
  Protein That Fights Bacteria and Viruses Cloned by Scientists at The Scripps Research Institute
  A team of researchers at The Scripps Research Institute (TSRI) has identified a protein, called Trif, that directly responds to the signals the innate immune system sends when it recognizes both bacteria and viruses.
  
  
• June 26, 2003
  Towards an AIDS Vaccine: Unusual Antibody That Targets HIV Described by Scientists at The Scripps Research Institute
  A group of scientists from The Scripps Research Institute (TSRI) and several other institutions has solved the structure of an antibody that effectively neutralizes human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS).
  
  
• June 16, 2003
  Scientists at The Scripps Research Institute Find A Beneficial Link Between A Nicotine Metabolite and Alzheimer's Disease
  Two scientists at The Scripps Research Institute (TSRI) have discovered that a chemical called nornicotine modifies proteins that misfold and form the fibril plaques that are abundant in the brains of patients with Alzheimer's disease. Nornicotine is naturally present in tobacco and is also produced as a major metabolite of nicotine.
  
  
• June 2, 2003
  Chemical Turns Stem Cells into Neurons Say Scientists at The Scripps Research Institute
  A group of researchers from The Scripps Research Institute (TSRI) and the Genomics Institute of the Novartis Research Foundation (GNF) have identified a small chemical molecule that controls the fate of embryonic stem cells.
  
  
• May 22, 2003
  Cholera Protein Structure—a Target for Vaccines and Antibiotics—Described by Scientists at The Scripps Research Institute
  A group of researchers from The Scripps Research Institute (TSRI) has solved structures of a bacterial protein called pilin, which is required for infection by pathogens that cause human diseases like meningitis, gonorrhea, diarrheal diseases, pneumonia, and cholera.
  
  
• May 21, 2003
  New Type of Vaccine Against Nicotine Addiction Developed by Scientists at The Scripps Research Institute
  A group of scientists at The Scripps Research Institute (TSRI) have designed a new way to make vaccines against drugs of abuse that could become a valuable tool for treating addiction by helping the body clear the drug from the bloodstream.
  
  
• April 28, 2003
  TSRI Scientists Show that Rare Genetic Mutations Increase Susceptibility to Sepsis
  A group of researchers from The Scripps Research Institute (TSRI) have discovered rare genetic mutations in a subset of people who come down with a particular kind of severe sepsis, an acute and often deadly disease.
  
  
• April 16, 2003
  Programmable Antibodies—A Hybrid Cancer Therapy Described by Scientists at The Scripps Research Institute
  A group of scientists at The Scripps Research Institute (TSRI) has designed a "hybrid" anticancer compound that physically combines the potent punch of a cancer cell-targeting agent with the long-lasting dose of an antibody.
  
  
• April 4, 2003
  Former Superior Court Judge Alice Sullivan to Chair The Scripps Research Institute Board of Trustees
  The Honorable Alice D. Sullivan (Ret.), a former Alameda County Superior Court Judge, has been elected Chair of the Board of Trustees at The Scripps Research Institute (TSRI). Judge Sullivan replaces former Chair John D. Diekman, Ph.D., who remains on the board.
  
  
• April 2, 2003
  Scientists Identify a Protein Channel that Mediates the Body's Ability to Feel Frigid Temperatures
  A group of researchers from The Scripps Research Institute (TSRI) and the Genomics Institute of the Novartis Research Foundation (GNF) have identified and isolated a novel protein that mediates the body's ability to sense cold through the skin.
  
  
• March 10, 2003
  Catalytic Antibodies Combine Properties of Antibodies and Enzymes
  Immunologists Richard A. Lerner and Peter G. Schultz to receive the Paul Ehrlich and Ludwig Darmstaedter Prize 2003.
  
  
• February 27, 2003
  Scientists at The Scripps Research Institute Make Strides in Addressing Mysteries of Ozone in the Human Body
  In what is a first for biology, a team of investigators at The Scripps Research Institute (TSRI) is reporting that the human body makes ozone.
  
  
• January 30, 2003
  Scientists at The Scripps Research Institute Discover a New Approach for Treating "Misfolding Diseases"
  Professor Jeffery W. Kelly, Ph.D., and his colleagues in the Department of Chemistry and The Skaggs Institute for Chemical Biology at The Scripps Research Institute (TSRI) have demonstrated a new approach for treating "amyloid" diseases—particularly transthyretin amyloid diseases, which are similar to Parkinson's and Alzheimer's.
  
  
• January 15, 2003
  Growing Human Antibodies in Algae is an Inexpensive and Fast Route to Large-Scale Production, Say Scientists at The Scripps Research Institute
  A group of scientists at The Scripps Research Institute (TSRI) have used algae to express an antibody that targets herpes virus. This antibody could potentially be an ingredient in an anti-herpes topical cream or other anti-herpes treatments, but more importantly the algae expression technology that the TSRI team used could facilitate production of any number of human antibodies and other proteins on a massive scale.
  
  
• January 14, 2003
  Expanding the Genetic Code—Scientists at The Scripps Research Institute Synthesize 21-Amino-Acid Bacterium
  Scientists at The Scripps Research Institute (TSRI) report in an upcoming article in the Journal of the American Chemical Society their synthesis of a form of the bacterium Escherichia coli with a genetic code that uses 21 basic amino acid building blocks to synthesize proteins—instead of the 20 found in nature.
  
  
• January 8, 2003
  $24-Million Grant Funds Local Researchers to Create Encyclopedia of the Innate Immune System
  The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a multi-year, $24- million grant to a group of researchers at The Scripps Research Institute (TSRI) in La Jolla, the Institute for Systems Biology (ISB) in Seattle, Washington, and The Rockefeller University in New York, New York.
  
  
• January 8, 2003
  Scripps Research Institute Professor Featured in Technology Review as Industry Pioneer in Glycomics, One of the Top Ten Technologies That Will Change the Future
  James Paulson's Consortium for Functional Glycomics aims to figure out the functions of carbohydrates in the human body
  The Scripps Research Institute today announced that Professor James Paulson, Ph.D., has been chosen as a global leader in the field of glycomics by Technology Review, The Massachusetts Institute of Technology's magazine of innovation. The magazine's February 2003 issue identifies ten emerging technologies it says will change the world. 

2002

• December 26, 2002
  Work of Four Scientists at The Scripps Research Institute Included in Science Magazine's Top-Ten Breakthroughs of 2002
  The work of four scientists at The Scripps Research Institute (TSRI) was cited by Science magazine among three of the journal's annual list of the top-ten breakthroughs of the year.
  
  
• December 18, 2002
  "Binary" Enzyme Created by Scientists at The Scripps Research Institute Demonstrates Darwinian Evolution at its Simplest
  Two scientists at The Scripps Research Institute (TSRI), Research Associate John S. Reader, D.Phil, and Professor Gerald F. Joyce, M.D., Ph.D., both of the institute's Department of Molecular Biology, have succeeded in creating an enzyme based on a "binary" genetic code—one containing only two different subunits.
  
  
• December 17, 2002
  Blasting Antibodies with Lasers Provides Direct Way of Measuring Their Flexibilities
  A group of scientists at The Scripps Research Institute (TSRI) and San Diego Supercomputer Center at the University of California at San Diego (UCSD) have used a powerful laser in combination with innovative quantum mechanical computations to measure the flexibility of mouse antibodies.
  
  
• December 12, 2002
  Gene Responsible for Rewinding Body's "Clock" Described—Research May Lead to Relief of Sleep Disorders and Jet Lag
  A group of scientists at The Scripps Research Institute (TSRI) and the Genomics Institute of the Novartis Research Foundation (GNF) has demonstrated that the gene Opn4, which codes for the protein Melanopsin, is the elusive pigment gene that captures light and keeps your body tuned to a daily cycle—called a circadian rhythm.
  
  
• November 28, 2002
  How Do You Solve Relief—Structure of Pain-Modulating Enzyme Described by Scientists at The Scripps Research Institute
  A group of researchers from The Scripps Research Institute (TSRI) have solved the structure of an enzyme that modulates central nervous system (CNS) functions such as pain perception, cognition, feeding, sleep, and locomotor activity.
  
  
• November 14, 2002
  Ozone is Produced by Antibodies During Bacterial Killing and in Inflammation, Say Scientists at The Scripps Research Institute
  Professor Richard A. Lerner, M.D., Associate Professor Paul Wentworth, Jr., Ph.D., and a team of investigators at The Scripps Research Institute (TSRI) is reporting that antibodies can destroy bacteria, playing a hitherto unknown role in immune protection. Furthermore, the team found that when antibodies do this, they appear to produce the reactive gas ozone.
  
  
• November 13, 2002
  Sepsis Vaccine Proves Protective in Preliminary Studies by Scientists at The Scripps Research Institute
  A group of researchers from The Scripps Research Institute (TSRI) have designed a vaccine that might be used to protect against the pernicious consequences of severe sepsis, an acute and often deadly disease that is estimated to strike 700,000 Americans a year and millions more worldwide.
  
  
• November 4, 2002
  Potential New Treatment for Gaucher Disease Developed by Scientists at The Scripps Research Institute
  A group of scientists at The Scripps Research Institute (TSRI) have developed a compound that could potentially be used as a new treatment for Gaucher disease, the most common genetic disorder affecting Jewish people of Eastern European ancestry. Although not tested in humans, the compound has shown great promise in human cell lines cultured from patients who suffer from the disease.
  
  
• November 4, 2002
  A Group at The Scripps Research Institute Designs DNA Vaccine that Inhibits Growth of Cancerous Tumors
  A group of researchers at The Scripps Research Institute (TSRI) have developed a novel DNA vaccine that helps the body resist the growth of cancerous tumors by choking off the tumors' blood supply.
  
  
• October 28, 2002
  A Nicotine By-Product Reacts with Proteins, Say Scientists at The Scripps Research Institute
  Two researchers at The Scripps Research Institute (TSRI) have discovered that a chemical called nornicotine which is naturally present in tobacco and is also produced as a metabolite of nicotine may contribute to the pathology of diabetes, cancer, aging, and Alzheimer's disease.
  
  
• October 9, 2002
  Kurt Wüthrich of The Scripps Research Institute Wins 2002 Nobel Prize in Chemistry
  Second Nobel Prize in a Row for TSRI
  Kurt Wüthrich, Ph.D., who is Cecil H. and Ida M. Green Visiting Professor of Structural Biology at The Scripps Research Institute and a member of TSRI's Skaggs Institute for Chemical Biology; and Professor of Biophysics at Eidgenössische Technische Hochschule Zürich (ETHZ), Switzerland, was awarded the 2002 Nobel Prize in Chemistry today for applying the technique of nuclear magnetic resonance (NMR) to solving the structures of biological macromolecules.
  
  
• October 1, 2002
  Scientists at The Scripps Research Institute Identify Thousands of Proteins Associated with the Deadliest Form of Malaria
  Two scientists at The Scripps Research Institute (TSRI) led a collaborative effort involving 18 researchers at half a dozen laboratories in the United States and Great Britain to determine the "proteome" of the most deadly form of the malaria pathogen—Plasmodium falciparum.
  
  
• October 1, 2002
  Scientists at The Scripps Research Institute Develop New Technology to Map Spread of Malarial Drug Resistance
  Scientists at The Scripps Research Institute (TSRI), Harvard University and the Genomics Institute of the Novartis Research Foundation have found a way to use a relatively new but readily available technology to quickly detect markers in the DNA of the most deadly type of malaria pathogen.
  
  
• September 18, 2002
  Flower Hour: Scientists at The Scripps Research Institute Discover How a Plant Times Its Flowering Cycle
  Two scientists at The Scripps Research Institute (TSRI) have described how a plant grown in their laboratory uses two sets of proteins to detect the seasons so that it can flower at the right time. And by tinkering with those proteins, the scientists were able to make the plant flower at will.
  
  
• August 19, 2002
  Scientists at The Scripps Research Institute Receive $9.6 Million to Develop Treatment for Common Cause of Vision Loss
  A group of researchers at The Scripps Research Institute (TSRI), who recently discovered a potent inhibitor of angiogenesis, a process implicated in cancer and one of the leading causes of blindness in the United States, have been awarded a five-year, $9.6 million grant from the National Eye Institute to study this inhibitor further and develop ways to use it in patients with neovascular eye disease.
  
  
• July 26, 2002
  Adult Stem Cells Selectively Delivered into the Eye and Used to Control Angiogenesis by Scientists at The Scripps Research Institute
  A team of researchers from The Scripps Research Institute (TSRI) has discovered a way to use adult bone marrow stem cells to form new blood vessels in the eye or to deliver chemicals that will prevent the abnormal formation of new vessels.
  
  
• July 15, 2002
  Making the Most of Lymphopenia—Study at The Scripps Research Institute Suggests Powerful New Way to Treat Cancer
  A study undertaken by investigators at The Scripps Research Institute (TSRI) suggests a new, potentially more effective way to battle cancer—hit the immune system with cancer vaccines or cancer cells when it's down and it will bounce back swinging harder than ever against those cancer cells.
  
  
• July 9, 2002
  Two Scientists From The Scripps Research Institute Receive Funding for New Approach to Breast Cancer Research
  Two scientists at The Scripps Research Institute (TSRI) were recently awarded seed funding from the California Breast Cancer Research Program for design of breast cancer drugs. The award is part of a pool of state money earmarked for breast cancer and set aside to fund innovative research that has the potential to have a high impact.
  
  
• June 27, 2002
  Anti-Cancer Nanoparticles: Scientists at The Scripps Research Institute Design Gene-Tipped Tumor Regressor "Smartbombs"
  A group of researchers from The Scripps Research Institute (TSRI) have demonstrated what, in principle, could be a new way of treating cancer and several other diseases where angiogenesis occurs. Angiogenesis, the formation and differentiation of new blood vessels, is a crucial process in cancer, and, when blocked, improves a patient's prognosis.
  
  
• June 14, 2002
  TSRI Graduate and Postdoc Wins Prestigious Career Award
  Stephen W. Santoro, Ph.D., a postdoctoral fellow at The Scripps Research Institute (TSRI) has been selected as a recipient of a 2002 Burroughs Wellcome Fund Career Award in the Biomedical Sciences. The awards provide $500,000 over five years for young scientists, spanning the period that includes their advanced postdoctoral training and their early years as a faculty member of an academic research institution.
  
  
• May 31, 2002
  Lerner to Receive UC Presidential Medal
  Richard A. Lerner, M.D., president of The Scripps Research Institute, will receive the University of California Presidential Medal on Friday, May 31. The medal is the highest award the university can bestow.
  
  
• May 22, 2002
  Scientist at The Scripps Research Institute Named One of World's Top 100 Young Innovators by Magazine at MIT
  Benjamin F. Cravatt, Ph.D., a scientist at The Scripps Research Institute (TSRI), has been selected as one of the top 100 innovators under the age of 35 in a special report just released by Technology Review, the world's oldest technology magazine.
  
  
• May 16, 2002
  "Warm to the Touch" Gene Found
  A group of researchers from The Scripps Research Institute (TSRI) and the Genomics Institute of the Novartis Research Foundation (GNF) have identified and cloned the first-known gene that makes skin cells able to sense warm temperatures.
  
  
• April 30, 2002
  Two TSRI Scientists Elected Members of the National Academy of Sciences
  Two professors from The Scripps Research Institute (TSRI)—Drs. Francis V. Chisari and Chi-Huey Wong—were elected to membership in the National Academy of Sciences today in recognition of "their distinguished and continuing achievements in original research."
  
  
• April 26, 2002
  Promoting Wound Repair—One of the First Known Biological Roles for Mysterious Gamma-Delta T Cells Discovered by Researchers at TSRI
  Researchers at The Scripps Research Institute (TSRI) have identified a major role in promoting wound repair played by a mysterious type of immune cell that resides mainly in the skin and gut—the gamma-delta T cell.
  
  
• April 17, 2002
  Dramatic Footage of Immune System at Work Caught on Tape by Scientists at The Scripps Research Institute
  Using a new technique that allows scientists to see the internal machinery of a living cell, a team of researchers at The Scripps Research Institute (TSRI) addressed one of the most fundamental issues in immune research—the early events in the immune system's recognition of foreign invaders, such as bacteria and viruses, in the body.
  
  
• April 16, 2002
  Structure of Important Tumor Growth Protein—A Target for Cancer Therapy—Solved at The Scripps Research Institute (TSRI)
  A team of scientists at The Scripps Research Institute (TSRI) have solved a structure of a protein that is crucial for cancer tumor growth. Blocking this protein has already proven to be an effective way of stopping tumor growth in animal models, and the unforeseen molecular details revealed by the structure are like a road map for the development of future anti- cancer therapeutics.
  
  
• April 16, 2002
  Human Antibodies Against Spores Found by TSRI Researchers Suggest Powerful New Tool for Detection and Treatment of Anthrax
  Human antibodies against Bacillus spores, of which one species is the cause of anthrax, have been identified by researchers at The Scripps Research Institute (TSRI). These antibodies could be used to detect the presence of anthrax and other harmful spores in powders and to protect those exposed against lethal infections.
  
  
• April 15, 2002
  The Scripps Research Institute Names Graduate College Kellogg School of Science and Technology in Honor of Janet and W. Keith Kellogg II
  In honor of their extraordinary contributions to science and education, The Scripps Research Institute (TSRI) today named its graduate college the Kellogg School of Science and Technology for philanthropists Janet R. ("Jean") Kellogg and W. Keith Kellogg II.
  
  
• April 10, 2002
  Center for Integrative Molecular Biosciences Opens at The Scripps Research Institute
  Seeking to speedily obtain and analyze the structures of the tiny machines that buzz with activity inside cells, the Center for Integrative Molecular Biosciences (CIMBio) officially opens at The Scripps Research Institute (TSRI)
  
  
• March 15, 2002
  Tricking Diseases into Synthesizing Their Own Worst Enemies: A Revolutionary Strategy for Drug Discovery at The Scripps Research Institute (TSRI) Succeeds on an Enzyme
  In a first attempt to test a new general strategy for drug discovery, chemists at The Scripps Research Institute (TSRI) and TSRI's Skaggs Institute for Chemical Biology created the most potent blocking agent known against an enzyme implicated in Alzheimer's disease.
  
  
• March 4, 2002
  Cool-Temperature-Sensing Protein Found by The Scripps Research Institute Investigators
  A group of researchers from The Scripps Research Institute (TSRI) and the Genomics Institute of the Novartis Research Foundation (GNF) have identified and isolated a protein that mediates the body's ability to sense cold through the skin.
  
  
• February 1, 2002
  Researchers at The Scripps Research Institute (TSRI) Turn Viruses into Enhanced Nanochemical Building Blocks
  Using a combination of chemistry and molecular genetics, researchers at The Scripps Research Institute (TSRI) and The Skaggs Institute for Chemical Biology have found a way to attach a wide range of molecules to the surface of a virus, essentially enhancing the virus with the properties of those molecules.
  
  
• January 31, 2002
  Folding Upon Binding: Unique Protein Activation Mechanism Found by Scientists at The Scripps Research Institute
  A group of scientists at The Scripps Research Institute (TSRI) have solved the structure of two critical human proteins that are normally unstructured in the cell, but fold synergistically so that together they form an active biological structure.
  
  
• January 24, 2002
  Nanoencapsulation: Chemists at The Scripps Research Institute Discover a New and Simple Way of Controlling Reactions
  A group of scientists at The Scripps Research Institute (TSRI) were able to demonstrate complex system behavior among small, reacting organic molecules by putting them in and out of a nanocapsule.
  
  
• January 19, 2002
  Scientists at The Scripps Research Institute Show Most People with the Genetic Mutation for an Iron-Storage Disease Stay Healthy
  A disease that was once thought to be the most common genetic disorder of Europeans has now been shown by scientists at The Scripps Research Institute (TSRI) to be relatively rare.
  
  
• January 2, 2002
  Nature's Own Medicine for Vision Loss: Inhibitor of Angiogenesis Found by Biologists at The Scripps Research Institute
  A potentially potent inhibitor of angiogenesis, the process whereby new blood vessels are formed from existing ones, can be found in one of the very molecules involved in the same process. This finding, made by two scientists from The Scripps Research Institute (TSRI), may lead to new therapies, as abnormal angiogenesis is the leading cause of vision loss in the United States. 

2001

• November 9, 2001
  Crucial Genetic Diversity Enzyme Long Sought by Biologists Discovered by Scientists at The Scripps Research Institute
  Simultaneous reports by two teams at The Scripps Research Institute (TSRI), led by Professor Paul Russell, Ph.D., and Associate Professor Clare H. McGowan, Ph.D., identify the "resolvase" enzyme that may be responsible for generating genetic diversity during sexual reproduction and could be a target for improved anti-cancer therapy.
  
  
• October 22, 2001
  $35 Million Alcohol Grant Awarded to Consortium led by Researchers at The Scripps Research Institute
  The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has funded a multi-year consortium headed by researchers at The Scripps Research Institute (TSRI) to identify the molecular basis of alcoholism.
  
  
• October 12, 2001
  Molecules Caught in the Act-- Scientists at The Scripps Research Institute Solve Elusive Enzyme Mechanism
  A collaboration between Professors Ian A. Wilson, Ph.D., Chi-Huey Wong, Ph.D., and their colleagues in the Departments of Chemistry, Molecular Biology, and The Skaggs Institute for Chemical Biology at The Scripps Research Institute (TSRI) has yielded one of the best views ever of an enzyme caught in the act of catalyzing a reaction on its substrate. This research should prove invaluable as a tool for drug synthesis.
  
  
• October 10, 2001
  K. Barry Sharpless is Awarded the 2001 Nobel Prize in Chemistry
  K. Barry Sharpless, Ph.D., W.M. Keck Professor of Chemistry at The Skaggs Institute for Chemical Biology and the Department of Chemistry at The Scripps Research Institute (TSRI), has been awarded the 2001 Nobel Prize in Chemistry.
  
  
• October 9, 2001
  Former FDA Commissioner Becomes TSRI's Newest Board Member
  Jane E. Henney, a prominent leader in the health sciences and former commissioner of the Food and Drug Administration (FDA) has been elected a member of the Board of Trustees of The Scripps Research Institute.
  
  
• October 5, 2001
  NIGMS Awards "Glue Grant" to Study Cell Talk
  To begin to untangle huge biomedical problems like teasing apart the roles carbohydrates and proteins play in cellular communication, the National Institute of General Medical Sciences has provided a "glue grant" of $7.4 million (for the first year of funding) to a consortium of basic scientists dedicated to studying carbohydrate function. NIGMS anticipates spending a projected total of $34 million on the project over the course of five years.
  
  
• September 28, 2001
  Scientists at The Scripps Research Institute Discover a Therapeutic Strategy for "Misfolding Diseases" Analogous to Alzheimer's Disease
  Professor Jeffery W. Kelly, Ph.D., and his colleagues in the Department of Chemistry and The Skaggs Institute for Chemical Biology at The Scripps Research Institute (TSRI) have uncovered a potentially useful strategy to treat the rare disease familial amyloid polyneuropathy (FAP)--an approach that may be generally useful for intervention in other amyloid diseases.
  
  
• September 7, 2001
  Scientists at The Scripps Research Institute Discover a Previously Unknown Role for Antibodies
  A team of scientists lead by Professor Richard Lerner, Ph.D., President of The Scripps Research Institute (TSRI) have discovered that antibodies have a novel catalytic ability unique among proteins which could possibly mean they do more to protect our bodies than scientists had previously thought. In the current issue of the journal Science, the team demonstrates that antibodies can catalyze the formation of hydrogen peroxide from singlet oxygen.
  
  
• August 16, 2001
  Scientists at The Scripps Research Institute Find a Way to Block Prions that Cause Mad Cow Disease
  Scientists working at The Scripps Research Institute (TSRI) and at the University of California, San Francisco, have published a paper in the current issue of the scientific journal Nature that describes an antibody that clears prion infection in cell culture. This finding may point the way to a treatment for mad cow disease and its human equivalent.
  
  
• August 10, 2001
  Structure Solved by Scientists at The Scripps Research Institute Marks Important Milestone in Effort to Develop HIV Vaccine
  Scientists working in The Skaggs Institute for Chemical Biology at The Scripps Research Institute (TSRI) and at the Glycobiology Institute at Oxford University in the United Kingdom, have elucidated the structure of an antibody that effectively neutralizes human immunodeficiency virus (HIV), reported in the current issue of the journal Science.
  
  
• July 25, 2001
  Poking Holes in Pathogens: Scientists at The Scripps Research Institute Build a New Class of Nanotube "Smart Drugs"
  Scientists at The Skaggs Institute for Chemical Biology, a part of The Scripps Research Institute (TSRI), have published a paper in the current issue of Nature that describes a broad nanochemical approach for designing drugs to combat such problems as infections with antibiotic resistant bacteria.
  
  
• June 8, 2001
  The World's Most Powerful NMR Spectrometer, 900 MHz, Arrives at The Scripps Research Institute
  The most powerful, high-resolution nuclear magnet resonance (NMR) spectrometer ever constructed was delivered today to The Scripps Research Institute (TSRI). According to Peter Wright, Ph.D., Chairman, Department of Molecular Biology, the new NMR, referred to by the frequency at which it operates, 900 MHz, will become the centerpiece of one of the world's most prominent collections of NMR instruments.
  
  
• May 1, 2001
  Scientist at The Scripps Research Institute Elected to National Academy of Sciences
  Gerald F. Joyce, M.D., Ph.D., a scientist at The Scripps Research Institute (TSRI), has been elected a member of the National Academy of Sciences. He is one of 72 new members and 15 foreign associates named "in recognition of distinguished and continuing achievements to original research." Election to membership in the Academy is considered one of the highest honors that can be conferred on a U.S. scientist or engineer. The election was held this morning during the 138th annual meeting of the Academy.
  
  
• April 20, 2001
  Simultaneous Reports by Scientists at The Scripps Research Institute Show How they Made Bacteria Do What Nature Doesn't
  Scientists at The Skaggs Institute for Chemical Biology at The Scripps Research Institute (TSRI), have published two separate papers in the current issue of the journal Science in which they describe two different ways of engineering bacterial cells to encode "unnatural" proteins. Principal Investigators Peter Schultz, Ph.D., Scripps Family Chair, The Skaggs Institute and Department of Chemistry; and Paul Schimmel, Ph.D., Ernest and Jean Hahn Professor and Chair, The Skaggs Institute, and Departments of Molecular Biology and Chemistry, led the two separate efforts.
  
  
• April 12, 2001
  Scientists at The Scripps Research Institute Develop a New "Kit" to Screen Mercury in Fish
  Scientists at The Scripps Research Institute (TSRI), have developed a screening method, similar to a home pregnancy test, that can detect mercury contamination in fish. According to Kim D. Janda, Ph.D., Eli R. Callaway Chair in Chemistry and Professor, The Skaggs Institute for Chemical Biology, the strategy could be used both by consumers and environmental professionals.
  
  
• March 26, 2001
  President of The Scripps Research Institute to Receive Honorary Degree
  Richard A. Lerner, M.D., President of The Scripps Research Institute (TSRI), has been named a recipient of an honorary degree from the Technion Israel Institute of Technology, in Haifa, Israel. The conferral ceremony will be held in June, 2001, to coincide with the Technion's annual International Board of Governors meeting.
  
  
• February 15, 2001
  New Study by Scientists at The Scripps Research Institute Suggests an Answer for One of the Oldest Questions in Biology
  Scientists at The Skaggs Institute for Chemical Biology (TSRI) have published a paper in the current issue of Nature that suggests a possible answer to how one of the early steps necessary for the origins of life arose. Principal Investigator M. Reza Ghadiri, Ph.D., Professor of Chemistry at TSRI, has created a biological polymer that can discriminate between two types of building blocks, taking those that are similar and building a copy of itself with them.
  
  
• January 31, 2001
  Scientists at The Scripps Research Institute Suggest Novel Therapy to Limit Tissue Damage Following Stroke
  Scientists at TSRI, along with their colleagues at Henry Ford Health Sciences Center, Detroit, report findings in the current issue of Nature Medicine suggesting a novel therapeutic target that appears to prevent tissue damage caused by stroke. According to lead author David A. Cheresh, Ph.D., Professor, Departments of Immunology and Vascular Biology at TSRI, "Our findings suggest a possible new modality to complement the effects of thrombolytic therapy, the only therapeutic option currently available for stroke patients."
  
  
• January 24, 2001
  Sharpless Named Recipient of 2001 Benjamin Franklin Medal
  K. Barry Sharpless, Ph.D., W.M. Keck Professor of Chemistry, Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, has been named the recipient of a 2001 Benjamin Franklin Medal from the Franklin Institute in Philadelphia. He joins other scientists whose breakthrough work in the fields of cancer, artificial intelligence, wireless communications, astronomy, computers and engineering also is being honored.
  
  
• January 16, 2001
  Sharpless Wins Wolf Prize
  K. Barry Sharpless, Ph.D., W.M. Keck Professor of Chemistry, Department of Chemistry and The Skaggs Institute for Chemical Biology at The Scripps Research Institute, has won the 2001 Wolf Prize in Chemistry. Sharpless, who has been with TSRI since 1990, is cited by the Wolf Prize jury for his "pioneering, creative, and crucial work in developing asymmetric catalysis for the synthesis of chiral molecules, greatly increasing mankind's ability to create new products of fundamental and practical importance." 

2000

• October 26, 2000
  TSRI Scientist Wins Presidential Early Career Award
  Geoffrey Chang, Ph.D., Assistant Professor, Department of Molecular Biology, was named by President Clinton as one of the recipients of the fifth annual Presidential Early Career Awards for Scientists and Engineers. Eight Federal departments and agencies join together annually to nominate the most meritorious young scientists and engineers who will broadly advance the science and technology that will be of the greatest benefit to fulfilling the agencies' missions.
  
  
• September 26, 2000
  New Genomic Center Funded To Advance HighThroughput Protein Structure Determination
  The Joint Center for Structural Genomics (JCSG), a consortium of California scientific research organizations, has received a National Institutes of Health (NIH) grant of $24 million over a five- year period to expand on the body of knowledge made av ailable by the completion of the human and other genome sequencing projects. Its goal is to determine the three-dimensional structure of up to 2000 proteins by developing state-of-the-art high-throughput technology, thereby advancing efforts to understand structure-function relationships important for diseases and their treatments.
  
  
• August 4, 2000
  TSRI Scientists Clone Gene that Regulates Circadian Rhythms in Plants
  Scientists at TSRI have cloned a gene that regulates circadian rhythms in plants, providing an increased understanding -- on a molecular level -- of the processes that enable organisms to anticipate and adapt to daily variations in the environment. Further, researchers believe that understanding internal "clocks" in plants might also elucidate how clocks work in other species, including humans. The study, "Cloning of the Arabidopsis Clock Gene TOC1, an Autoregulatory Response Regulator Homolog," appears in today's issue of Science. Its authors are Drs. Carl Strayer, Tokitaka Oyama, Thomas F. Schultz, Ramanujam Raman, David E. Somers, Paloma Mas, Satchidananda Panda, Joel A. Kreps, and Steve A. Kay.
  
  
• July 6, 2000
  Chi-Huey Wong, Ph.D., Receives 2000 Presidential Green Chemistry Award
  Chi-Huey Wong, Ph.D., Professor, Department of Chemistry and The Skaggs Institute at The Scripps Research Institute (TSRI), has been selected to receive a 2000 Presidential Green Chemistry Challenge Award, jointly presented by the Director of the United States Environmental Protection Agency, the Director of the White House Office of Science and Technology and President of the American Chemical Society. The award program provides national public recognition for organizations that are successfully researching, developing and implementing outstanding green chemical technologies.
  
  
• June 1, 2000
  Sandra L. Schmid, Ph.D., Named to Head Department of Cell Biology
  Professor Sandra L. Schmid, Ph.D., The Scripps Research Institute (TSRI), has been named Chairman of the Department of Cell Biology, effective July 1, 2000, according to Richard A. Lerner, M.D., TSRI President. She will replace Norton B. Gilula, Ph.D., current Department Chairman and Dean of Graduate Studies. While he will continue to head the graduate program, he also recently was named Vice President, Scientific Affairs.
  
  
• May 25, 2000
  Ian A. Wilson, D.Phil., Elected to Royal Society
  Ian A. Wilson, D.Phil., Professor, Department of Molecular Biology and The Skaggs Institute for Chemical Biology at The Scripps Research Institute (TSRI), has been elected to fellowship in the Royal Society, the independent scientific academy of the United Kingdom, dedicated to promoting excellence in science.
  
  
• March 31, 2000
  The Genetics of Aging
  Gradual genetic changes may be the source of many, if not all illnesses of aging, including breast cancer, osteoporosis, Alzheimer's disease and arthritis. A new study by scientists in The Skaggs Institute for Chemical Biology at The Scripps Research Institute in La Jolla and the Genomics Institute of the Novartis Research Foundation, published in the March 31 issue of Science, concludes that human aging and its associated diseases and conditions can be traced to a gradual increase in cell division errors in tissues throughout the body. This functional change begins slowly in middle age and increases gradually with advancing age. The authors of the paper, "Mitotic Misregulation and Human Aging," are Drs. Danith H. Ly, David J. Lockhart, Richard A. Lerner, and Peter G. Schultz.
  
  
• January 28, 2000
  Software for the Genome Created by TSRI Scientists
  Scientists at TSRI have developed a method of producing and combining proteins as modular building blocks capable of functioning as genetic switches to turn on or off genes on demand. The study, "Positive and Negative Regulation of Endogenous Genes by Designed Transcription Factors," by Drs. Roger R. Beerli, Birgit Dreier, and Carlos F. Barbas, III, appears in the January 28 on-line edition of The Proceedings of the National Academy of Sciences.
  
  
• January 26, 2000
  Scientists Discover Evolutionary Adaptation to DNA Repair in Human Cells
  Researchers studying a key human DNA repair enzyme have discovered an evolutionary adaptation that highlights a fundamental advantage in the way human cells repair damage to their DNA. The study, "DNA-Bound Structure and Mutants Reveal A Basic DNA Binding by APE1 Coordinates DNA Repair," appears in the January 27 issue of Nature.
  
  
• January 21, 2000
  K. Barry Sharpless Receives National Academy of Sciences Award in Chemical Sciences
  K. Barry Sharpless, Ph.D., W.M. Keck Professor of Chemistry in the Department of Chemistry and The Skaggs Institute for Chemical Biology, has been selected to receive the National Academy of Sciences Award in Chemical Sciences. The prize is awarded annually for innovative research in the chemical sciences that, in the broadest sense, contributes to a better understanding of the natural sciences and to the benefit of humanity.
  
  

1999

• December 17, 1999
  X-Sci/2000, A Celebration of Science in the New Millennium
  San Diego high school students and high school science teachers to attend X-Sci/2000, a Celebration of Science in the New Millennium, at TSRI on January 7, 2000.
  
  
• December 9, 1999
  Scientists Discover New Approach to Inhibiting Integrins
  TSRI scientists and their colleagues at Beth Israel Deaconess Medical Center and Harvard Medical School, have discovered a protein-protein interaction important for the function of a class of integrin cell surface receptors that are involved in migration of cells which contribute to chronic inflammation.
  
  
• December 1, 1999
  Scientists at The Scripps Research Institute Determine Role of Human Protein in HIV Infection
  Scientists at TSRI have determined how a human protein, cyclophilin A, is helping the human immunodeficiency virus type-1 (HIV-1) to enter human cells.
  
  
• November 19, 1999
  Tamas Bartfai Named to Head Harold L. Dorris Neurological Research Center at The Scripps Research Institute
  Noted neuroscientist, Tamas Bartfai, Ph.D., has been named director of the newly established Harold L. Dorris Neurological Research Center at The Scripps Research Institute. In addition, he will hold the Harold L. Dorris Chair in Neuroscience. The center was formed with a $10 million commitment from Helen L. Dorris of San Diego.
  
  
• August 24, 1999
  Role of Genetics in Narcolepsy
  Scientists at TSRI and their colleagues at several other medical research institutions have received grant funding from the National Institutes of Health to study the genetic basis for narcolepsy, a potentially disabling, life-long condition estimated to afflict about one in every 1,000 people in this country.
  
  
• August 6, 1999
  $10 Million Gift Creates Neurological Research Center
  at The Scripps Research Institute
  The Harold L. Dorris Neurological Research Center has been established at The Scripps Research Institute with a $10 million commitment from Helen L. Dorris of San Diego, founder of the Harold L. Dorris Neurosciences Foundation.
  
  
• June 28, 1999
  K.C. Nicolaou Wins International Aspirin Prize
  for Solidarity Through Chemistry
  K.C. Nicolaou, Ph.D., Chairman, Department of Chemistry and Professor, The Skaggs Institute for Chemical Biology, and Professor, Department of Chemistry and Biochemistry, University of California, San Diego, has been awarded the first International Aspirin Prize for Solidarity Through Chemistry by Quimica Farmaceutica Bayer, S.A. (Barcelona). The worldwide, biennial prize has been established to mark the centenary of the synthesis of a pure and stable form of acetylsalicylic acid, the active ingredient of aspirin in 1897 and the registration of Aspirin as a trademark in 1899 by Bayer.
  
  
• June 14, 1999
  Poison Gas Test That Fits in Your Pocket
  (Angewandte Chemie press release)
  They are feared as the "poor country's nuclear weapon": the chemical weapons - also known as nerve gasses - sarin and soman. They are easy to produce, and the necessary starting materials are cheap and relatively easy to obtain. Sarin and its relatives are deadly and internationally monitored. Inspections of potential poison gas production plants serve this purpose, but are difficult. Until now, the procedure has consisted of taking soil samples on location and analyzing them with complicated special equipment, usually in a distant laboratory. A portable test kit, whose fundamentals have been introduced by a research group working with Kim D. Janda and Peter Wirsching at TSRI could change this.
  
  
• May 18, 1999
  Paul Schimmel Elected to American Philosophical Society
  Paul R. Schimmel, Ph.D., Professor, Departments of Molecular Biology and Chemistry, and The Skaggs Institute for Chemical Biology, was elected to membership in the American Philosophical Society.
  
  
• May 4, 1999
  Bernard Babior, M.D., Ph.D., Elected to National Academy of Sciences
  Bernard M. Babior, M.D., Ph.D., Professor, Department of Molecular and Experimental Medicine, has been elected to membership in the National Academy of Sciences.
  
  
• April 30, 1999
  New Study by TSRI Scientists Sheds Light
  on Viral Clearance in Acute Hepatitis B Infection
  A study published this week in Science by scientists at The Scripps Research Institute demonstrates a new paradigm in viral immunology, that the immune system can cure viral infections without destroying the infected cells. They conclude that nondestructive antiviral mechanisms can contribute to viral clearance by eliminating a virus from inside the cell without killing it.
  
  
• January 12, 1999
  TSRI Scientist Named Recipient of Rous-Whipple Award
  Francis V. Chisari, M.D., Professor and Head of the Division of Experimental Pathology at The Scripps Research Institute, has been named winner of the 1999 Rous-Whipple Award from the American Society for Investigative Pathology.
  
  
• January 1, 1999
  Novel Therapeutic Approach to Treatment of Arthritic Disease
  is Explored by Scientists at The Scripps Research Institute
  TSRI scientists have studied an investigational anti-angiogenesis treatment -- previously employed against various forms of cancer -- to assess its impact on arthritic disease in an animal model. Their results, published in the January 1, 1999, issue of The Journal of Clinical Investigation, provides evidence for a central pathogenic contribution of angiogenic blood vessels to the maintenance and severity of arthritic disease, and the potential viability of anti-angiogenic therapy for the treatment of rheumatoid arthritis.
  
  

1998

• October 16, 1998
  TSRI Chemists Expand the DNA Alphabet to Build Protein-Like DNA Enzymes.
  TSRI chemists Carlos F. Barbas, III, Ph.D., and Kandasamy Sakthivel, Ph.D., have added to the four letters making up the simple chemical alphabet of DNA. The purpose of the work is to make DNA derivatives that would be able to carry out various chemical processes in the laboratory in one go, similar to natural enzymes.
  
  
• September 10, 1998
  TSRI Scientists Receive Awards from the American Chemical Society
  Four professors at The Scripps Research Institute have been named 1999 recipients of national awards from the American Chemical Society for a broad range of scientific contributions in the discipline.
  
  
• July 13, 1998
  John Moores makes contribution to TSRI to create new Institute for Childhood and Neglected Diseases
  TSRI announces the establishment of a new Institute for Childhood and Neglected Diseases on its campus in La Jolla, California. Its purpose is to apply the new molecular understanding of biology to address, reduce and treat recalcitrant illnesses in two major categories childhood diseases, and neglected diseases that effect populations primarily in developing countries. A unique collection of 26 exceptional automobiles has been contributed as a lead gift for this new effort by businessman, San Diego Padres owner, and philanthropist John Moores and his wife, Becky. The new initiative will build on the strength that TSRI has achieved at the nexus of biology and chemistry through the establishment of The Skaggs Institute for Chemical Biology, according to TSRI President and CEO, Richard A. Lerner, M.D.
  
  
• May 7, 1998
  Severity of Brain Changes During Nicotine Withdrawal Comparable to Those for Other Drugs of Abuse
  Scientists at The Scripps Research Institute have discovered that dramatic changes in the brain's pleasure circuits during withdrawal from chronic nicotine use rival the magnitude and duration of similar changes observed during withdrawal from other abused drugs, including cocaine, opiates, amphetamines and alcohol. This knowledge may assist in the development of treatments to deal with withdrawal symptoms that interfere with people's success in quitting smoking.
  
  
• May 5, 1998
  The Scripps Research Institute Receives Grant for Teacher Training from the Arthur Vining Davis Foundations
  TSRI is the recipient of a $125,000 grant from the Arthur Vining Davis Foundations to help fund an endowment for high school teacher training as part of its summer research internship program. The funding will be used to strengthen the teachers' opportunities to enhance discovery-based learning in the classroom.
  
  
• April 28, 1998
  Scientists at TSRI and R.W. Johnson Pharmaceuticals Develop New Antibacterial Agents
  Scientists at The Scripps Research Institute and R.W. Johnson Pharmaceutical Research Institute have developed a series of new antibacterial compounds designed to target the biological mechanisms by which bacteria establish an infection in the host. With resistance to antibiotics an increasing public health threat, the compounds offer the potential to provide protection against Staphylococcus aureus, vancomycin-resistant enterococci, and penicillin-resistant Staphylococcus pneumoniae. The study appeared in the April 28, 1998, issue of Proceedings of the National Academy of Sciences.
  
  
• April 16, 1998
  K. Barry Sharpless to Receive Harvey Prize for Outstanding Contributions in Chemistry
  K. Barry Sharpless, Ph.D., W.M. Keck Professor of Chemistry at The Scripps Research Institute, receives the prestigious Harvey Prize for his outstanding contributions to chemistry from the Technion-Israel Institute of Technology, Israel's premier science and technology university. Established in 1972, the prize honors major contributions to human progress in science, technology, literature of the Middle East and the advancement of peace in the Middle East. Sharpless is best known for using metal catalysts to create useful new methods for synthesizing organic molecules and asymmetric compounds in particular.
  
  
• April 13, 1998
  Mark Yeager, M.D., Ph.D., awarded Burroughs Wellcome Fund's Clinical Scientist Award
  Mark Yeager, M.D., Ph.D., Associate Professor in the Departments of Cell Biology, Molecular Biology and Vascular Biology, has received a Clinical Scientist Award in Translational Research from the Burroughs Wellcome Fund. The awards are intended to foster the development and productivity of outstanding physician-scientists who will strengthen translational research -- the two-way transfer between basic research and patient care. Yeager has been awarded $750,000 over five years to study the structure and function of cardiac gap junction membrane channels.
  
  
• March 30, 1998
  K.C. Nicolaou, Ph.D., to receive the Gustavus John Esselen Award for Chemistry in the Public Interest
  K.C. Nicolaou, Ph.D., Chairman, Department of Chemistry, and Member, The Skaggs Institute for Chemical Biology, is this year's recipient of the Gustavus John Esselen Award for Chemistry in the Public Interest for outstanding achievement in scientific work which contributes to the public well being and "in recognition of his revolutionary approach to natural science." The award is sponsored by the Northeastern Section of the American Chemical Society. Nicolaou's research interest focuses on chemical synthesis, molecular design and recognition, and the biological actions of molecules. He is perhaps best known for his work on the synthesis of Taxol.
  
  
• March 27, 1998
  Structure of active form of the enzyme producing nitric oxide
  TSRI scientists and their colleagues at the Cleveland Clinic have determined the molecular structures of the complete active site of the enzyme responsible for generating nitric oxide (NO). Knowledge of these structures advances understanding of how NO is produced and regulated in mammalian cells. According to the researchers, this will provide important information in enabling rational drug design for the potential control of many NO-dependent processes in humans, including blood pressure regulation, digestion, muscular contraction, the immune response, learning and memory. The work appeared in the March 27 issue of Science.
  
  
• March 13, 1998
  A glimpse of the earliest events in biological light sensing
  A team of TSRI scientists, led by Elizabeth Getzoff, Ph.D., has succeeded in freezing a light sensing protein less than one billionth of a second after it absorbed a light particle. The researchers comment that this discovery has opened the pathway to a detailed understanding of the properties of biological light sensors. The report in Nature describes the structure of a photoreceptor just after it was activated by light but before the sensor was able to transform the captured light into a biological signal. The structure corresponds to the protein as it exists less than one billionth of a second after it captured a photon.
  
  
• February 6, 1998
  Disruption of angiogenesis by PEX
  Angiogenesis, the process whereby new blood vessels are formed from pre-existing ones, plays a key role in a number of diseases including cancer, diabetic retinopathy, macular degeneration and arthritis. TSRI scientists report in Cell that they have not only uncovered a mechanism to help explain angiogenesis activity, but have developed a recombinant form of a protein fragment that blocks the process as well as tumor growth in an in vivo experimental model. This may provide a potentially novel therapeutic approach for diseases associated with neovascularization. 

1997

• December 19, 1997
  Antibody aldolases with enzymic rates but broader scope
  For the first time, scientists have developed a catalytic antibody with an efficiency rate and mechanism equal to that of a natural enzyme essential to life. They compared aldolases that use the same chemical mechanisms but differ in their origin. The work solves the dilemma of whether the immune system is capable of creating efficient catalysts by altering its selection criteria from simple binding to function. The scientists believe the discovery will have numerous applications in industrial synthesis, including the synthesis of some of the most important anticancer compounds. The work appeared in the December 19 issue of Science.
  
  
• November 28, 1997
  Biological clocks no longer found only in the brain
  A discovery by a team of scientists at TSRI and Brandeis University challenges the belief that 24-hour rhythms, or biological clocks, are centrally controlled from the brain. Using the fruit fly as a genetic model system, the research sought to determine if individual body parts would respond to changes in the light/dark cycle without any help from the head. As reported in the November 28 issue of Science, in each separately cultured segment, so-called clock genes turned on and off in unison, according to rhythms set by environmental light manipulations. The hope is that understanding the location of such clocks will yield insights into human circadian rhythms that could lead to new strategies for the treatment of disorders associated with jet lag, shift work and seasonal depression.
  
  
• November 19, 1997
  Total synthesis of eleutherobin and...
  The first total chemical synthesis of a number of promising new anticancer compounds, first isolated from a rare species of corals, has been performed by a scientific team at TSRI. The group assembled the compounds by designing a multistep strategy using simple chemical building blocks such as carvone, an oil readily available from caraway or dill seeds, frequently used as a commodity chemical in perfumes and foods. The scientists hope to produce synthetic analogues for biological screening purposes that could ultimately lead to more effective and safer therapeutic agents than the original compound. The work appeared in the Journal of the American Chemical Society, November 19, 1997.
  
  
• November 10, 1997
  Prominent scientists join TSRI
  TSRI has recruited a number of prominent scientists to its staff, all of whom hold dual appointments in The Skaggs Institute for Chemical biology as well as in other institutional departments. They are Paul Schimmel, Ph.D., former John D. and Catherine T. MacArthur Professor of Biochemistry and Biophysics at MIT; Jeffery W. Kelly, Ph.D., Former Professor, Department of Chemistry, Texas A&M; Martha J. Fedor, Ph.D., former Assistant Professor, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical Center; and James R. Williamson, Ph.D., former Associate Professor, Department of Chemistry, MIT.
  
  
• October 31, 1997
  Affordable, hand-held biosensor for diagnostics
  A portable, hand-held biosensor capable of detecting a wide range of medically important chemical compounds has been created by a team of researchers from TSRI and University of California, San Diego. The instrument, which changes colors to signal the presence of specific molecules, may represent a new type of device for a variety of medical applications, including the screening of drugs and the diagnosing of illness at the bedside. The work is published in Science.
  
  
• October 17, 1997
  Structure of Nitric Oxide Synthase...
  Researchers at TSRI and the Cleveland Clinic have solved the structure of the active site of the enzyme that regulates the activity of nitric oxide (NO).

• 09/11/97 -- Long-haul truckers sleep study
• 09/08/97 -- Buddy Taub $5 million gift to fund Center for Molecular...
• 07/09/97 -- Oldstone receives J. Allyn Taylor Int'l Prize in Medicine
• 06/27/97 -- Effects of long-term marijuana use on the brain
• 06/18/97 -- Pew Scholarship Award to Roberta Gottlieb
• 05/15/97 -- Total synthesis of epothilone B
• 05/08/97 -- Roger Beachy elected to National Academy of Sciences
• 04/11/97 -- Francis V. Chisari receives Jung Prize
• 03/07/97 -- Scientists catch a biological light sensor in the act

1996

• 10/21/96 -- Immunomedics Science Prize to Ralph A. Reisfeld
• 10/11/96 -- Three-dimensional structure of TCR
• 10/02/96 -- Non-infectious foot-and-mouth disease virus
• 09/15/96 -- Structures of dUTPase
• 09/12/96 -- Brain hormone, urocortin, suppresses appetite.
• 07/25/96 -- EPO (erythropoietin) receptor complex.
• 05/21/96 -- Major philanthropic gift launches new Skaggs Institute for Chemical Biology
• 05/02/96 -- K.C. Nicolaou elected to National Academy of Sciences.
• 04/24/96 -- Beckman Center for Chemical Sciences.
• 04/16/96 -- Sleep patterns related to human performance errors.
• 04/15/96 -- Link between cystic fibrosis mutation and clinical symptoms.
• 03/26/96 -- Richard A. Lerner, California Scientist of the Year.
• 01/17/96 -- Link between the immune system and sleep.

1995

• 12/15/95 -- Reactive immunization.
• 12/14/95 -- Cocaine vaccine.

1994

• 1/12/94 -- Staff Announcement: Frank Mitzel, Tom Thistle, Greg Benjamin
• 2/4/94 -- Structure Of Catalytic Antibodies - Hilvert, Wilson
• 2/10/94 -- Total Synthesis Of Taxol - Nicolaou
• 2/14/94 -- Rsv Fab Therapy- Burton, Barbas, Williamson
• 3/09/94 -- Charter Society Young Scientist Program
• 3/17/94 -- Charter Society Young Scientist Program/Photos
• 4/22/94 -- Inhibiting Growth Of Malignant Tumors - Cheresh
• 05/05/94 -- Cladribine (2-Cda) Alters Clinical Course Of Progressive Multiple Sclerosis - Beutler, Romine, Sipe
• 5/16/94 -- TSRI & Sandoz Sign Research Collaboration Agreement
• 5/26/94 -- Peptide Nanotubes - Ghadiri
• 6/29/94 -- Kip Guy Receives Roche Award For Excellence In Organic Chemistry
• 7/1/94 -- Cladribine/Ms Study Reported In Lancet-- Media Advisory
• 7/29/94 -- Thea Volpe Appointed Associate Dean Of Office Of Graduate Studies
• 8/24/94 -- Beutler Receives 1994 City Of Medicine Award

1993

• 03-00-93 -- Jan Coughlin Receives New ASCP Regional Award
• 03-11-93 -- The Scripps Institute Testifies before Congress
• 03-18-93 -- Area Students Attend Young Scientists Program at The Scripps Research Institute & Scripps Clinic
• 04-01-93 -- Sloan Foundation Awards $2.7 Milion for Research Fellowships
• 04-05-93 -- The Scripps Research Institute to Host Winner of Prestigious Summer Teacher Research Fellowship
• 04-06-93 -- Dr. Michael Oldstone Presented Rous-Whipple Award by American Association of Pathologists
• 04-21-93 -- Scripps Researchers Develop Insights into How Proteins Recognize DNA and RNA to Regulate Gene Expression
• 04-23-93 -- Scripps Scientists Honored with Inventor of the Year Award
• 04-24-93 -- Statement from The Scripps Research Institute re The Importance of Animals in Biomedical Research
• 04-30-93 -- Scripps Scientists Develop Procedure for Isolating Human Monoclonal Antibodies to Fight Infectious Diseases
• 05-03-93 -- Researcher at The Scripps Research Institute Recipient of Prestigious NIH Award
• 05-10-93 -- Charles C. Edwards, MD, Announces Retirement as President of Scripps Institutions of Medicine and Science
• 05-18-93 -- Dr. Ernest Buetler, Internationallly Recognized Scientist, is Awarded Honorary Doctorate for Pioneering Work in Hematology
• 05-28-93 -- Molecule That Could Aid Organ Transplantation Synthesized by La Jolla Researchers
• 06-10-93 -- Prominent Scientist to Join The Scripps Research Institute
• 06-16-93 -- Media Advisory Press Briefing with Oliver Sacks, MD
• 06-18-93 -- Scripps Scientists Discover Involvement of New Receptor in Cocaine Abuse
• 06-23-93 -- Role of Female Hormones in Breathing Disorders to be Studied by Scripps Researchers
• 07-01-93 -- The Scripps Research Institute and Sandoz Pharmaceuticals Extend Contract Deadline
• 07-02-93 -- Scientists Determine 3-D Structure of Myosin -- a Muscle Protein Critical to Life
• 07-21-93 -- Scripps Scientist Awarded Grant for Educational Fellowships in Chemistry
• 11-29-93 -- Scripps Scientist Discusses Techniques and Strategies for Improving Development of Catalytic Antibodies
• 09-02-93 -- Maxwell H. and Muriel Gluck Child Care Center Opens on Scripps Campus
• 09-22-93 -- Scripps Scientist to Receive Prestigious International Chemistry Award
• 10-15-93 -- Scripps Scientists Solve Protein Structure that Could Lead to New Anti-Cancer Drug Design
• 11-03-93 -- Dr. Richard Lerner Receives Prestigious Humboldt Award
• 11-30-93 -- Scripps Scientists Discover New Pathway to Inhibit Spread of Viral Plant Disease
• 12-15-93 -- The Fletcher Jones Foundation Awards $300,000 to The Scripps Research Institute to Fund Graduate Studies
• 12-16-93 -- San Diego Scientists Provide New Clues to the Biochemistry of Fertilization

1992

• 02/27/92 -- Nearly 200 High School Students to Attend "Young Scientist" Program at Scripps Clinic
• 03/04/92 -- Media Advisory: Scripps Clinic And Research Foundation's Young Scientist Lecture Series for San Diego County High School Students
• 05/15/92 -- Beckman Foundation to Give $5 Million to the Scripps Research Institute
• 05/18/92 -- Single Treatment with Experimental Drug Generates Significant Hairy Cell Leukemia Remissions
• 05/21/92 -- "Trojan Horse" Anti-Cancer Agents Designed and Synthesized by La Jolla Scientists
• 06/04/92 -- Mirror-Image World of Biological Molecules Explored by Scripps Researchers
• 06/29/92 -- Scripps Researchers One of Five Nationwide Selected for Cancer Research Institute Investigator Award
• 08/06/92 -- TSRI Researcher Helps Japanese with New Program on Glycoscience
• 08/07/92 -- NIH Awards $1 Million to Scripps Researcher
• 08/24/92 -- San Diego Chemists Honored by American Chemical Society
• 10/16/92 -- Scripps Researchers Determine Structure of DNA Repair Enzyme
• 11/23/92 -- Researchers & Physicians Receive $9.1 Million to Study Vascular Disease
• 12/02/92 -- Media Advisory: La Jolla Researchers are First to Achieve Total Synthesis of Natural Form of Complex Calicheamicin Molecule
• 12/03/92 -- Research Reported in New England Journal of Medicine Indicates Gaucher Disease can be Treated More Effectively, Less Expensively
• 12/11/92 -- Scripps Researchers Report 1st Successful Use of Antisense for Treatment of Tumors

1991

• 01/07/91 -- World-Renowned Brain-Research Think Tank Announces Move from Rockefeller University to The Scripps Research Institute
• 01/25/91 -- Researchers Synthesize Material Essential for Lung Function; May Alleviate Respiratory Distress Syndrome
• 02/06/91 -- Largest U.S. Private Biomedical Research Foundation Orders Cray Y-MP System
• 02/11/91 -- Prominent Protein Chemist Joins Research Institute of Scripps Clinic
• 02/20/91 -- New Treatment for Genetic Disease Cited in New England Journal
• 02/20/91 -- Cell Biologist from the Research Institute of Scripps Clinic Wins National Award
• 02/28/91 -- Media Advisory: High School Science Students to Learn About Cancer, See High-Tech Diagnostic & Treatment Equipment
• 03/04/91 -- Roger Beachy to Receive Common Wealth Award
• 03/27/91 -- Local High School Science Students Attend Scripps Clinic Program
• 04/19/91 -- Scripps Clinic Chemist Wins Prestigious Searle Scholar Award
• 05/01/91 -- Enzyme Replacement Therapy for Gaucher Disease to be Discussed at Major Meeting of Clinical Researchers
• 05/15/91 -- Photo Caption: Four North County Students Receive Awards from Charter Society of Scripps Clinic
• 05/29/91 -- New Cell Biology Department Announced at Research Institute of Scripps Clinic
• 08/02/91 -- $5 Million Award to The Scripps Research Institute Supports Unique Cell Biology Research
• 08/21/91 -- French and American Scientists Establish Laboratory to Develop Disease-Resistant, Healthier Crops for Developing Nations
• 09/06/91 -- Scientists at The Scripps Research Institute Win Prestigious Chemistry Awards
• 09/11/91 -- Richard Cramer to Head TSRI Board
• 11/13/91 -- Researchers Discover Gene Mutation in Gaucher Disease; Makes Screening Possible to Determine Couples at Risk
• 12/05/91 -- Scientsist at The Scripps Research Institute Wins American Heart Association Award

1990

• 01/15/90 -- W. M. Keck Foundation Gives $2.9 Million to Research Institute of Scripps Clinic for Department of Chemistry
• 03/06/90 -- Dr. Richard Lerner to be Honored by Prestigious Karolinska Institutet
• 03/30/90 -- Scripps Clinic Cardiologist Receives National Award
• 04/13/90 -- Biomagnetic Technologies and Scripps Clinic Sign Agreement for 37-Channel Biomagnetometer
• 06/21/90 -- Robin Goldsmith Named Vice President at Scripps Clinic & Research Foundation
• 06/26/90 -- Dr. John Curnutte Presented Outstanding Young Investigator Award
• 07/12/90 -- Prominent Chemist to Join Staff of Scripps Clinic and Research Foundation
• 07/18/90 -- Scripps Clinic Chemistry Department Grows with Recruitment of Another Prominent Chemist
• 08/02/90 -- Dr. Frank J. Dixon Presented Jean Hamburger Award
• 08/28/90 -- Donations from Scripps Clinic Research Council Reach $5 Million
• 08/30/90 -- Carol A. Fulcher, Ph.D., Awarded the International Prize of the French Association of Hemophilia
• 10/05/90 -- Scripps Clinic Announces Re-Election of Trustees and Formation of National Board
• 10/12/90 -- Scripps Clinic Receives $14 Million Grant to Study Dementia
• 10/17/90 -- Waterford Award Winner Announced
• 12/17/90 -- Gluck Foundation Makes Lead Gift to Establish Child Care Center at Scripps Clinic

1989

• 01/05/89 -- Noted Scientist, Dr. Sydney Brenner, Receives Waterford Award
• 01/17/89 -- Major Land Acquisition to Nearly Double Size of Scripps Clinic
• 03/07/89 -- Scripps Clinic Retains Architects Tucker, Sadler & Associates for New Lusk Research Center
• 03/31/89 -- Research Institute of Scripps Clinic Awarded $13 Million for Blood Clot Study
• 04/06/89 -- Area High School Students Chosen for Scripps Clinic "Young Scientist" Program
• 04/19/89 -- Media Advisory: Young Scientists Lecture Series
• 05/24/89 -- Joint Recruitment by UCSD and Scripps Clinic Brings World-Renowned Organic Chemist to San Diego
• 06/20/89 -- Dr. Janda Speaks at 4th Annual Conference on Biotechnology Research
• 06/28/89 -- Prominent Chemists to Join Research Institute of Scripps Clinic
• 06/29/89 -- Scripps Clinic Researcher Receives Award from Sloan-Kettering Cancer Center
• 07/11/89 -- Building Industry Association Announces Endorsement of Scripps Clinic Lusk Research Center
• 08/11/89 -- Scripps Clinic Researchers Develop Method To Predict Severity of Gaucher's Disease
• 09/13/89 -- Scripps Clinic Research Institute Director Emeritus Receives Klemperer Award
• 10/23/89 -- Noted Cell Biologist Will Receive Scripps Clinic Waterford Award
• 11/02/89 -- Media Advisory: Great America Smokeout Story Idea: Group Attempts to Quit on Monday, Nov. 6
• 12/01/89 -- Major Technological Advance Announced by Research Institute of Scripps Clinic
• 12/26/89 -- Prominent La Jollans Donate $1 Million for Scripps Clinic Department of Chemistry

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