ABSTRACT: The objectives of this review are to: (a) demonstrate that the male CBA/Ca mouse has several characteristics that make it an excellent animal for the study of leukemogenesis, (b) show that several of the genetic abnormalities observed in the male CBA/Ca mouse during the development of radiation induced acute myeloid leukemia (AML) are syntenic with those frequently detected in patients with myeloid disorders such as myelodysplastic syndrome and AML, (c) illustrate that leukemia-related chromosomal lesions are the indicators for high risk individuals.

Keywords: Leukemogenesis, radiation, benzene, cytogenetics.

Reprint requests to: K. Noy Rithidech, Department of Pathology, BHS T9 SUNY at Stony Brook, Stony Brook, New York 11794-8691, New York.